• Asian Pacific Journal of Cancer Prevention
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• 제15권5호
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• pp.2021-2026
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• 2014

Aim: Recent research suggests that nucleophosmin (NPM) may be a prognostic marker in colorectal carcinomas (CRC). We here tested its use to predict the survival of CRC patients. Methods: We investigated NPM expression by immunohistochemistry in histologically normal to malignant colorectal tissues and evaluated its association with clinicopathological variables. Overall and disease-free survival after tumor removal were calculated by the Kaplan-Meier method, and differences in survival curves were analyzed by the log-rank test. The Cox proportional hazards model was used for multivariate analysis of prognostic factors. Results: NPM expression was found significantly upregulated in CRC compared to adjacent colorectal tissue, villous adenoma, tubular adenoma and normal colorectal mucosa (p<0.05 for all). NPM expression was statistically linked to cancer embolus, lymph node metastasis, differentiation grade, and recurrence of CRC. Overall and disease-free survival of NPM-negative CRC patients tended to be better than those for patients with NPM-positive lesions (log-rank statistic, p<0.05 for all). Multivariate analysis indicated NPM expression as an independent prognostic indicator for CRC patients (p<0.05 ). Conclusion: Our results suggest that NPM expression can predict the survival of CRC patients. Prognosis of CRC is determined by not only many known prognostic factors but also by NPM expression.

• Asian Pacific Journal of Cancer Prevention
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• 제14권10호
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• pp.5615-5620
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• 2013

Nucleophosmin (NPM1) is a protein of highly conserved nature which works as a molecular chaperone and is mostly found in nucleoli. NPM also involved in the maturation of preribosomes and duplication of centrosomes. Furthermore, it is also active in control and regulation of the ARF-p53 tumor suppressor pathway. A high rate of incidence and prognostic involvement is reported by various authors in AML patients. In AML it behaves as a favorable prognostic marker. NPM mutations are more frequently associated with normal-karyotype AML and are usually absent in patients having abnormal or poor cytogenetic. NPM mutations are not frequent in other hematopoietic tumors. Two main types of mutations have been described to date. Both of these cause abnormal cytoplasmic localization of NPM1. Their high incidence rate in normal karyoptype and their favorable nature m ake those mutations hot spot or front face mutations which should be checked before treatment starts.

• Asian Pacific Journal of Cancer Prevention
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• 제16권9호
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• pp.4095-4101
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• 2015

IDH1/2 mutations which result in alternation in DNA methylation pattern are one of the most common methylation associated mutations in Acute myeloid leukaemia. IDH1/2 mutations frequently associated with higher platelet level, normal cytogentics and NPM1 mutations. Here we analyzed IDH1/2 mutations in 200 newly diagnosed unselected Indian adult AML patients and investigated their correlation with clinical, cytogenetic parameters along with cooperating NPM1 mutation. We detected 5.5% and 4% mutations in IDH1/2 genes, respectively. Except IDH2 c.515_516GG>AA mutation, all the other identified mutations were reported mutations. Similar to reported c.515G>A mutation, the novel c.515_516GG>AA mutation replaces $172^{nd}$ arginine to lysine in the active site of the enzyme. Even though there was a preponderance of IDH1/2 mutations in NK-AML, cytogenetically abnormal patients also harboured IDH1/2 mutations. IDH1 mutations showed significant higher platelet count and NPM1 mutations. IDH2 mutated patients displayed infrequent NPM1 mutations and lower WBC count. All the NPM1 mutations in the IDH1/2 mutated cases showed type A mutation. The present data suggest that IDH1/2 mutations are associated with normal cytogenetics and type A NPM1 mutations in adult Indian AML patients.

• 생물환경조절학회지
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• 제21권3호
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• pp.213-219
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• 2012

과채류 공정육묘에서 접목작업 후 버려지는 재사용 상토의 이화학적 특성을 개선할 목적으로 재사용상토와 perlite의 혼합비율이 상토의 이화학적 특성과 과채류 묘소질에 미치는 영향을 조사하였다. 재사용 상토의 적정 혼합비율을 구명하기 위한 시험구는 신규상토(NPM: new plug media)와 1회 사용상토구(UPM: used plug media)및 용적대비 재사용상토의 첨가비율을 25, 50 및 75%로 첨가한 5개의 처리구를 설계한 뒤, 각 처리구별 이화학적 특성과 오이 및 토마토 묘의 묘소질에 미치는 영향을 조사하였다. 또, 재사용 상토의 물리성 개선을 위한 적정 펄라이트 첨가 비율을 구명하기 위한 시험구는 UPM에 용적대비 펄라이트를 0, 5, 10 및 20% 첨가구와 NPM과 UPM을 1 : 1(v : v)로 혼합한 혼합상토(Mixed Soil)에 펄라이트를 0, 5, 10 및 20%를 첨가한 8개의 처리구를 설계하여 각 처리구별 이화학적 특성과 오이 및 토마토 묘의 묘소질에 미치는 영향을 대조구(NPM)와 비교하였다. UPM에 NPM의 혼합비율이 증가할수록 상토의 물리적 특성이 개선되는 경향을 보여 50% 이상 첨가구에서는 신규상토와 공극율, 용적밀도, 보수력은 물론 전반적인 묘소질도 NPM과 유의적인 차이를 나타내지 않았다. 상토의 이화학적 특성, 플러그묘의 근권형성 정도, 묘소질 등을 종합적으로 고려한 UPM의 물리성 개선을 위한 펄라이트의 적정 혼합비율은 UPM 단용구에서는 20%, NPM과 UPM을 1 : 1(v : v)로 혼합한 상토에서는 10%인 것으로 판단되었다.

• 토지주택연구
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• 제12권3호
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• pp.1-10
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• 2021

공공관리 패러다임은 공기업의 경영관리 및 기재부의 공공기관 경영평가 결과에 직접적인 영향을 미치기 때문에 중요성이 매우 크다. 이러한 차원에서 본 연구는 1980년대 이후 공공관리 이론으로 주목받았던 신공공관리론, 신공공거버넌스론, 신공공서비스론의 주요 이론적 요소에 대해 검토하였다. 분석결과 이러한 공공관리 이론들은 효율성, 네트워크 그리고 공공서비스라는 차원을 각각 대표하고 있으며 나름대로의 장점과 단점을 갖는 것을 확인하였다. 이를 바탕으로 공기업을 둘러싼 환경변화에 적절히 대응하기 위해서는 공공관리에 대한 통합적이고 다차원적인 이해가 필요함을 제시하였다.

• The Journal of Asian Finance, Economics and Business
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• 제8권2호
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• pp.165-173
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• 2021

This study examined the effect of Debt Equity Ratio (DER), Net Profit Margin (NPM), and Size on stock prices with company performance as measured by Return on Assets (ROA) as a mediating variable. The sample used is 136 manufacturing companies listed on the Indonesia Stock Exchange (IDX) in the 2014-2018 period. This research was tested using a Warp PLS statistical test tool to prove the proposed hypothesis. The results showed that DER has a significant negative effect on ROA and a significant positive effect on Stock Price. NPM has a significant positive effect on ROA as well as a significant positive effect on Stock Price. While Size has a significant positive effect on ROA but has no effect on Stock Price. ROA has a significant positive effect on Stock Price. ROA does not act as a mediating variable in the relationship between Size and Stock Price; however, ROA acts as a mediating variable in the DER and Stock Price relationship, as well as, in the relationship between NPM and Stock Price. The implications of the results of this study can be used by investors in making investment decisions, paying attention to the company's financial aspects, namely DER, NPM, Size, and ROA.

• 한국인쇄학회지
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• 제16권3호
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• pp.61-80
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• 1998

To investigate in influence of photosensitizer used with benzophenone(BP) in the curing rate and physical properties of UV curable hard coating on plastic, we prepared UV curable clear and pigmented coatings with DEA, DMA, NPM and TEA as photosensitizer, respectively. The curing rate calculated from the decrease of the absorbance of acrylic double bond measured by FT-IR spectroscopy increased s follows; DEA>DMA>NPM>TEA. this order could be explained by the reactivity of diethylamino group of DEA and the ease of formation of activated complex between BP and photosensitizer during the curing process. In UV curable pigmented coatings, the order of curing rate increased as follows; DEA>DMA>TEA>NPM. It was found that the curing rate of the pigmented coating can be increased by light scattering of TiO$_2$. The hardness of coating film cured by photosensitization of DEA and DMA is higher than other photosensitizers due to the crosslinking reaction of DEA and DMA radical bound to polymer backbone.

• 생물환경조절학회지
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• 제21권3호
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• pp.207-212
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• 2012

현재 국내에서 농가에 보급되는 플러그 묘중 가지과 작물의 토마토와 박과작물의 오이, 참외, 수박은 평균 70% 이상이 연작에 의한 토양전염성 병해를 회피할 목적 등으로 접목육묘를 한다. 접목작업 후 대목 또는 접수용으로 사용된 상토의 일부는는 전량 폐기되는데 이를 재사용하려는 시도가 일부 육묘장에서 이루어지고 있으나 대목용으로 사용되었던 상토는 병발생 위험성은 물론 물리성과 화학성이 신규상토와 달라 육묘 관리에 많은 문제점이 상존하고 있다. 따라서, 본 연구는 시판용 상토(NPM)와 과채류 대목용으로 1회 사용한 후에 재사용을 위해 증기 소독된 상토(UPM)의 이화학적 특성과 이들 상토가 과채류 묘소질에 미치는 영향을 조사하여 플러그 상토의 재활용을 위한 기초자료를 얻고자 수행하였다. 토양삼상계를 이용하여 고상용적, 기상용적, 입자밀도, 공극율, 용적밀도 등 상토의 물리적 특성을 조사하였고, 화학적 특성은 토양분석기를 이용하여 $NO_3$-N, $P_2O_5$, K, Mg, Ca, $SiO_2$, CEC, 유기물 함량 등을 조사하였다. 상토의 이화학적 특성을 비교한 결과 UPM이 NPM보다 공극율은 25%, 보수력은 15% 정도 낮았으나, 용적 및 입자밀도는 2배 이상 높아 단위 용적당 상토무게도 2.5배 무거운 것으로 나타났으며, pH와 EC는 유의적 차이를 보이지 않았으나, 양이온치환능력은 재사용 상토가 40% 정도 낮았다. 오이와 토마토 재배 결과 신규 상토에 비해 재사용 상토의 무기이온의 흡수능력과 묘소질이 전반적으로 불량하여 육묘상토의 재활용을 위해서는 재사용 상토의 물리성을 개선하기 위한 조치가 필요하다고 판단되었다.

• Current Optics and Photonics
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• 제2권3호
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• pp.261-268
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• 2018

Stimulated polariton scattering (SPS) from the $A_1$ transverse optical (TO) modes of $BaTiO_3$ bulk crystal generating a terahertz (THz) wave with the noncollinear phase-matching (NPM) condition is theoretically investigated. To our best knowledge, this is the first report on THz wave generation from $BaTiO_3$ bulk crystal via SPS. Phase-matching (PM) characteristics in the NPM configuration are analyzed. Effective parametric gain lengths for the Stokes and THz waves in the NPM configuration are calculated. The effective parametric gain coefficient and absorption coefficient of the THz wave in $BaTiO_3$ are theoretically simulated. The THz phonon flux densities generated via SPS in $BaTiO_3$ are theoretically calculated by solving the coupled wave equations under the NPM condition. The PM characteristics and THz-wave parametric gain characteristics in $BaTiO_3$ are compared to those in $MgO:LiNbO_3$. The results of the analysis indicate that $BaTiO_3$ is an attractive optical crystal for efficient THz wave generation via SPS.

• 산업경영시스템학회지
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• 제30권4호
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• pp.62-70
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• 2007

Recently, the increasing trend for the transshipment traffic of Busan port in Korea is slowing down because of the extensive development plan of domestic ports in china. For solving this problem, Korea is going on the project for preoccupying the transshipment port for attraction of port traffic from the newly potential markets(NPM) based on the Northeast Asia area. As a part of the project, this paper proposes the efficient methodology for selecting the optimal shipping network and strategic transshipment port within NPM using the mathematical models and simulation analysis. For that, we firstly find the alternative transshipment ports within NPM through the status analysis of the current port traffic and shipping network and then, we choose the candidate transshipment-ports in order of minimizing the transport costs through the mathematical approach. With the scenarios based on the selected transshipment-ports, we perform the simulation analysis for choosing the optimal transshipment-ports and the shipping network minimizing the total costs and times concurrently. We expect that the results of this paper will be used efficiently when korea select the strategic transshipment-port in the future.