• Clinical and Experimental Pediatrics
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• v.53 no.12
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• pp.1022-1025
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• 2010

Thanatophoric dysplasia (TD) is a short-limb neonatal dwarfism syndrome that is usually lethal in the perinatal period. It is characterized by shortening of the limbs, severely small thorax, large head with a prominent forehead, macrocephaly, curved femur, and flattened vertebral bodies. These malformations result from the mutation in fibroblast growth factor receptor 3 (FGFR-3) gene which is located on the short arm of chromosome 4. A definite diagnosis should be established by molecular genetic analysis to find out the abnormal mutations in the $FGFR3$ gene. We confirmed by detection of a R248C mutation in the $FGFR3$ gene in DNA analysis.

• 대한임상약리학회:학술대회논문집
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• 1996.12a
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• pp.39-39
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• 1996

• Journal of Microbiology and Biotechnology
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• v.14 no.2
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• pp.426-429
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• 2004

Eleven fungal strains previously isolated from the Mexican desert were evaluated for their capacity to use catechin as carbon source in submerged cultures. At 2 g/l of catechin, all strains grew better than the control strains, Aspergillus niger Aa-20. Aspergillus niger PSH and Penicillium commune EH2 degraded 79.33％ and 76.35％ with degradation rates of 0.0065 and 0.0074 g/l/h, respectively, when an initial catechin concentration of 3 g/l was used. Obtained results demonstrated the potential biotechnological capacity of these fungal strains to use condensed tannins as carbon source.

• Korean Journal of Pharmacognosy
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• v.11 no.3_4 s.43
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• pp.153-162
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• 1980

1) The hydroxy-substitution in the simple phenolic compounds follows an additivity rule in the chemical shifts of their aromatic carbon atoms. In para-and ortho-effects is a good agreement between calculated and measured values, but the meta-effect is not certain. 2) The additivity rule was applied to assign the chemical shifts of catechins. 3) The nuclear overhauser effect was applied to assign the chemical shifts of C-8 and C-6 atoms of catechins and their polymer. The signal of C-8 is lower in intensity and appear in lower field than C-6. 4) The results of the NOE were applied to determine the bonding positions of catechin units in the catechin dimer and trimer. The bonding positions are C-8a and C-8b atoms of the second and third catechin units. 5) It was tried to determine the conformation of the catechin dimer and trimer by analysing the signal shapes of C-3' and C-4' atoms in the catechol moieties. The catechol moieties lie in opposite side in the dimer and trimer structure. A combined analysis of $^{13}C-and\;^1H-NMR$ results lead to the suggestion that such a catechin polymer is a zigzag planar form.

• Proceedings of the KAIS Fall Conference
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• 2009.05a
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• pp.382-385
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• 2009

본 논문에서는 최근 정보통신의 다양한 분야에서 응용되고 있는 USN과 LBS 기술을 이용하여 사회복지 인프라를 위한 서비스 체계화, 상대적 소외계층을 위한 안전체계 구축, 첨단 IT 기술 접목의 복지통신정책 실현, 공공 u-Wellbeing 서비스 시스템 구축을 목적으로 u-Care 서비스 시스템을 설계 구현하였다. 이 서비스는 독거 또는 치매노인, 장애인을 위한 사회복지 서비스로 거주지 실내 활동 현황 모니터링이 가능하며, 초소형 GPS 기반의 위치추적 단말기를 이용하여 실시간 위치정보 및 상태 정보에 이상이 생겼을 시에는 사회복지 관련 기관, 경찰, 119, 가족 등에게 SMS로 자동 발송하는 서비스 방식이다.

• Journal of Convergence Society for SMB
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• v.4 no.3
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• pp.21-25
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• 2014

Group communications are becoming popular in Internet applications such as video conferences, on-line chatting programs, games, and gambling. Secure and efficient group communication is needed for message integration, confidentiality, and system usability. However, the conventional group key agreement protocols are too much focused on minimizing the computational overhead by concentrating on generating the common group key efficiently for secure communication. As a result, the common group key is generated efficiently but a failure in authentication allows adversaries to obtain valuable information during the group communication. After achieving the secure group communication, the secure group communication should generate the group key efficiently and distribute it to group members securely, so the balance of security and system usage must be considered at the same time. Therefore, this research proposes the software architecture model of a secure and efficient group communication that will be imbedded into networking applications.

• Bulletin of the Korean Chemical Society
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• v.31 no.6
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• pp.1515-1518
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• 2010

Regio- and diastereoselective 1,3-dipolar cycloaddition reactions of nitrones {(Z)-${\alpha}$-phenyl-N-methylnitrone (1a) and (Z)-${\alpha}$-propyl-N-butylnitrone (1b)} with electron-deficient perfluoro-2-methyl-2-pentene (2) lead to novel isoxazolidines {5-fluoro-5-pentafluoroethyl-4,4-bis-trifluoromethyl-2-methyl-3-phenyl-isoxazolidine (3a) and 2-butyl-5-fluoro-5-pentafluoroethyl-4,4-bis-trifluoromethyl-3-propyl-isoxazolidines (3b) respectively} as major constituents. These derivatives were characterized by IR, $^1H$ and $^{19}F$ NMR, GC-MS and NOE measurements, and the absolute structure of 3a was confirmed by X-ray crystallography.

• Journal of the Korean Institute of Intelligent Systems
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• v.18 no.6
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• pp.849-855
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• 2008

The Diagnostic Unit of CLINAID can infer working diagnoses for general diseases from the information provided by a user. This user-provided information in the form of signs and symptoms, however, is usually not sufficient to make a final decision on a working diagnosis. In order for the Diagnostic Unit to reach a diagnostic conclusion, it needs to select suitable clinical investigations for the patients. Because different investigations can be selected for the same patient, we need a process that can optimize the selection procedure employed by the Diagnostic Unit. This process, called a selection algorithm, must work with the fuzzy relational method because CLINAID uses fuzzy relational structures extensively for its knowledge bases and inference mechanism. In this paper we present steps of the selection algorithm along with simulation results on this algorithm using fuzzy relational products, both harsh product and mean product. The computation results of applying several different fuzzy implication operators are compared and analyzed.

• Journal of the Korean Magnetic Resonance Society
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• v.1 no.1
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• pp.21-29
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• 1997

Three typical solvent suppression methods employed for measuring the NOE data that are used for structure determination of polypeptides by modeling were discussed and compared with one another. In the experiments with several peptides composed of 10 to 65 amino acids the presaturation method was found to give severely distorted signal intensities of exchangeable protons, thus making the results based on this method much less reliable.

• Bulletin of the Korean Chemical Society
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• v.21 no.11
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• pp.1071-1076
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• 2000

Temperature dependent data of 13C spin-lattice relaxation times and NOE factors for methylene carbons at 50.3MHz and 125.5 MHz have been used to probe the local chain dynamics of poly(butylene terephthalate) (PBT) in solution phase. The interpretation of the relaxation data for methylene chain carbons in PBT was attempted on the basis of several proposed motional models, among which the DLM model was found to be superior. Analysis based on the DLM model indicated that the motion of the $OCH_2groups$ was more restricted compared with the central methylene carbon, which is consistent with conclusions from solid state experiments reported by other investigators. Librational amplitudes of terminal and central carbon of PBT were estimated to be $29.84^{\circ}$ and $32.01^{\circ}respectively.