• 한국농림기상학회지
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• 제23권3호
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• pp.156-162
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• 2021

본 인스턴스 분할 모델은 위성을 이용해 촬영된 원격탐지 영상 내의 객체 탐지에 높은 정확도를 갖는다는 것을 입증하였으며, 불법으로 가설된 시설 하우스를 발견하는데 활용될 수 있다. 즉, 특정 지역 및 일정시기를 기준으로 시설하우스를 인식시키고 그 이후에 신축된 하우스를 분별하는데 사용할 수 있을 것이다. 또한 본 기술을 응용하여, 토지피복도 조사와 같은 인력중심의 작업을 빠르게 해결할 수 있다. 앞으로 이 모델은 지리정보시스템(Geographic Information System)과 연계하여 중앙정부 차원의 단일화된 관리체계를 수립할 수 있을 것이며 또한 시설하우스 면적 통계 수치계산에도 쉽게 응용될 수 있을 것으로 판단된다.

• 셀메드
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• 제5권1호
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• pp.4.1-4.4
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• 2015

Yoga is an ancient Indian system of life, encompassing various practices including practices for self-discipline and also for regulating the health states of the individual, being practiced for thousands of years. The present study aims at understanding the effect of two high frequency breathing practices over autonomic nervous system. Forty healthy male volunteers of age $21{\pm}2$ years with $9{\pm}3$ months of Yoga practice experience were recruited. The two high frequency Yoga breathing practices, kapalabhati (KB) and bhastrika (BH) were given as interventions randomly on either of the two days to minimise laboratory bias. They were assessed before and immediately after the interventions for heart rate, respiratory rate, heart rate variability (HRV), blood pressure and peripheral oxygen saturation. There was a significant increase in heart rate (p<0.01; p<0.001), systolic blood pressure (p<0.01; p<0.001), NN50 (p<0.01; p<0.001) component of HRV for both KB and BH groups respectively. There was a significant reduction in respiratory rate in both the groups (p<0.001, and p<0.05, BH and KB respectively) immediately following intervention. A significant increase in LF component of HRV and reduction in Diastolic blood pressure and high frequency (HF)component following KB was also observed (p<0.05, for all comparisons). The Mean peripheral oxygen saturation remained unaltered in both the groups (p>0.05).The results suggest that high frequency yoga breathing practices induce physiological arousal immediately as evidenced by increased blood pressure and heart rate. The sympathetic arousal was more following KB session as evidenced by an increased diastolic blood pressure, LF power and a decrease in HF power of HRV as compared to the BH session.

• 대한의용생체공학회:의공학회지
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• 제28권4호
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• pp.503-511
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• 2007

Heart rate variability(HRV) is the clinical consequence of various influences of the autonomic nervous system(ANS) on heart beat. HRV can estimate the potential physiologic rhythm from the interval between consecutive beats(RR interval or HRV data), but cardiovascular system governed by ANS is in relation to respiration and autonomic regulation. It is known as RSA representing respiration-related HR rhythmic oscillation. Because the mechanism linking the variability of HR to respiration is complex, it has so far been unknown well. In this paper, we tried to evaluate 5-min RR interval segments under control of respiration in order to find out a proper respiration rate that can estimate the ANS function. 10 healthy volunteers were included to evaluate 5-min HRV data under 4 different respiration-controlled environments; 0.03Hz, 0.1Hz, 0.2Hz, and 0.4Hz respiration. HRV data were analyzed both in the frequency and the time domain, with cross-correlation coefficient(cross-coeff.) for HRV and respiration signal. The results showed maximum cross-coeff. of 0.84 at 0.1 Hz and minimum that of 0.16 at 0.4Hz respiration. Cross-coeff was decreased at a faster rate from 0.1Hz respiration. All mean SDNN, RMSSD, and pNN50 of time domain measures were 108.7ms, 71.85ms, and 28.47%, respectively, and LF, HF, and TP of frequency domain measures were $12,722ms^2,\;658.8ms^2$, and $7,836.64ms^2$ at 0.1Hz respiration, respectively. In conclusion, 0.1Hz respiration was observed to be very meaningful from time domain and frequency domain analysis in relation to respiration and autonomic regulation of the heart.

• Asian Pacific Journal of Cancer Prevention
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• 제16권7호
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• pp.2923-2928
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• 2015

Background: Gallbladder carcinoma (GBC) has been stated as an Indian disease, with the highest number of cases being reported from certain districts of northeast India, which has an ethnically distinct population. Unfortunately there are no scientific reports on the underlying molecular mechanisms associated with the pathogenesis of the disease from this region. Aim: The present study evaluated the role of differential expression of human telomerase reverse transcriptase (hTERT) in the development of gall bladder anomalies. Materials and Methods: Blood and tissue samples were collected from patients undergoing routine surgical resection for clinically proven cases of gallbladder disease {cholelithiasis (CL, n=50), cholecystitis (CS, n=40) and GBC (n=30) along with adjacent histopathologically proved non-neoplastic controls (n=15)} with informed consent. Whole blood was also collected from age and sex matched healthy controls (n=25) for comparative analysis. Differential hTERT mRNA expression was evaluated by semi-quantitative rt-PCR and real-time PCR based analysis using ${\beta}$-actin as an internal control. Evaluation of differential hTERT protein expression was studied by Western blot analysis and immunoflourescence. Statistical analysis for differential expression and co-relation was performed by SPSSv13.0 software. Results: Gallbladder anomalies were mostly prevalent in females. The hTERT mRNA and protein expression increased gradiently from normal

• 동의신경정신과학회지
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• 제22권4호
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• pp.87-100
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• 2011

Objectives : This study aims to evaluate the relationship between HRV indices and scores of emotional questionnaires and to find out the effective way to assess patients emotional and physical condition. Methods : We selected 144 patients who had both HRV data and BDI, STAI and STAXI scores on the chart among outpatients from July 2006 to December 2010. The relationship between the scores rated from the questionnaires and HRV indices are analyzed. And the HRV indices of patients included in the top 30 percent group and the bottom 30% group are compared. Results : 1. There were no significant correlations between HRV indices and scores of BDI, STAI and trait anger of STAXI. 2. SDNN and TP of HRV significantly decreased with higher state anger scores of STAXI. The top 30 percent group of state anger had lower SDNN, TP, LF, HF and HRV-index and higher pNN50 than the bottom 30 percent group. 3. RMSSD of HRV significantly decreased with higher anger-in scores of STAXI. The top 30 percent group of anger-in had lower RMSSD than the bottom 30 percent group. Conclusions : HRV can be used to evaluate emotional and physical changes related to state anger and inappropriate anger expression.

• International Journal of Computer Science & Network Security
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• 제21권2호
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• pp.120-130
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• 2021

The spinal cord or CSF surgery is a very complex process. It requires continuous pre and post-surgery evaluation to have a better ability to diagnose the disease. To detect automatically the suspected areas of tumors and symptoms of CSF leakage during the development of the tumor inside of the brain. We propose a new method based on using computer software that generates statistical results through data gathered during surgeries and operations. We performed statistical computation and data collection through the Google Source for the UK National Cancer Database. The purpose of this study is to address the above problems related to the accuracy of missing hybrid KNN values and finding the distance of tumor in terms of brain cancer or CSF images. This research aims to create a framework that can classify the damaged area of cancer or tumors using high-dimensional image segmentation and Laplace transformation method. A high-dimensional image segmentation method is implemented by software modelling techniques with measures the width, percentage, and size of cells within the brain, as well as enhance the efficiency of the hybrid KNN algorithm and Laplace transformation make it deal the non-zero values in terms of missing values form with the using of Frobenius Matrix for deal the space into non-zero values. Our proposed algorithm takes the longest values of KNN (K = 1-100), which is successfully demonstrated in a 4-dimensional modulation method that monitors the lighting field that can be used in the field of light emission. Conclusion: This approach dramatically improves the efficiency of hybrid KNN method and the detection of tumor region using 4-D segmentation method. The simulation results verified the performance of the proposed method is improved by 92% sensitivity of 60% specificity and 70.50% accuracy respectively.

• 한국균학회지
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• 제31권3호
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• pp.161-167
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• 2003

삼색도장버섯으로부터 중성염용액, 열수, 및 메탄올 추출물을 분리하였다. 세포독성 실험 결과, 열수 추출물은 $0{\sim}2,000\;{\mu}g/ml$의 농도에서 암세포에 대한 세포독성이 없었으나, 중성염용액 추출물과 메탄올 추출물에서는 약간의 독성을 나타내었다. Sarcoma 180 복수암에 대한 항암 효과는 중성염용액 추출물을 투여한 실험군에서 77.4%의 높은 생명 연장 효과를 나타내었다. 삼색도장버섯의 중성염용액 추출물과 열수 추출물은 대조군에 비해 비장세포를 $1.7{\sim}2.4$배 증가시켰고, B 임파구의 alkaline phosphatase 활성을 $2.2{\sim}8.7$배 증가시킴으로써 비장세포의 증식능과 B 임파구의 면역 활성 효과를 증가시켰다. 대식세포주 RAW 264.7에 $50;{\mu}g/ml$의 농도로 중성염용액 추출물을 처리하였을 경우, 양성 대조군이 $79\;{\mu}M$의 nitric oxide(NO)를 발생시킨 것에 비해 다소 높은 $90\;{\mu}M$의 NO를 발생되었다. 또한 중성염용액 추출물을 50 mg/kg body weight의 농도로 마우스 복강에 투여하였을 시 대조군에 비하여 복강세포수가 10배 증가하였으며 혈액 내 백혈수 또한 2배 증가를 나타내었다. 따라서 삼색도장버섯의 중성염추출물은 항암 효과와 숙주의 면역을 활성화시키는 것으로 사료된다.

• 동의신경정신과학회지
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• 제19권1호
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• pp.107-124
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• 2008

We investigated the effects of distilled Astragali Radix Herbal Acupuncture on autonomic nervous system with the Heart Rate Variability(HRV) in adult man. as well as we tried to observe how distilled Astragali Radix Herbal Acupuncture on the balance of the autonomic nervous system. Methods : We investigated on 61 healthy volunteers consisted of 31 subjects in experiment(distilled Astragali Radix Herbal Acupuncture) group and 30 subjects in control(Normal Saline) group. Study form was a randomized, placebo-controlled, double-blind clinical trial. 31 subjects in experiment group were injected distilled Astragali Radix Herbal Acupuncture at GB21(Kyonjong) and 30 subjects in control group were injected Normal Saline at GB21(Kyonjong). except of 2 subjects(in control group) who can't be measured and 10 subjects(6 in experiment group and 4 in control group) who move or make unforceable error during measuring. Finally 25 subject in experiment group and 24 subject in control group are studied. We measured HRV by PolyG-I on 7 times : before and after injection per 5 minutes during 30 minutes. The SPSS 10.0 for windows was used to analyze the data and the paired t test(in group) and Student t test(between two groups) were used to verify the result. Results : I. After distilled Astragali Radix Herbal Acupuncture injection, SDNN is significantly high from 5 minute to 10 minute and from 15 minute to 30 minute, Complexity is significantly low from 20 minute to 30minute. HRV index is significantly mgb for first 20 minute and from 25 minute to 30 minute, RMSSD is significantly high only from 15 minute to 20 minute. 2. HRV index of distilled Astragali Radix Herbal Acupuncture Group significantly increased from 25 minute to 30 minute, pNN50 of distilled Astragali Radix Herbal Acupuncture Group significantly decreased from 25 minute to 30 minute and RMSSD of distilled Astragali Radix Herbal Acupuncture Group significantly increased from 25 minute to 30 minute compared with those of Normal Saline group. 3. After distilled Astragali Radix Herbal Acupuncture injection, Ln(TP) is significantly high from 5 minute to 10 minute and from 15 minute to 30 minute. Ln(VLF) is significantly high after 5 minute, Ln(LF) is significantly high after 15 minute and Ln(HF) is significantly high from 5 minute to 10 minute and 25 minute to 30 minute, but significantly low for first 5 minute and from 10 minute to 20 minute. Normalized LF is significantly high after 20 minute and Normalized LF is significantly low after 20 minute. Conclusions : The results suggest that distilled Astragali Radix Herbal Acupuncture in healthy adult man tend to activate the autonomic nervous system within normal range. This result is derived from that parasympathetic nervous system was continuously activated and sympathetic nervous system was activated a little later.

• 대한약침학회지
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• 제11권1호
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• pp.83-97
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• 2008

Objectives : We investigated the effects of distilled Rehmannia glutinosa Herbal Acupuncture on autonomic nervous system with the Heart Rate Variability(HRV) in adult man. as well as we tried to observe how distilled Rehmannia glutinosa Herbal Acupuncture on the balance of the autonomic nervous system. Methods : We investigated on 58 healthy volunteers consisted of 28 subjects in experiment(distilled Rehmannia glutinosa Herbal Acupuncture) group and 30 subjects in control(Normal Saline) group. Study form was a randomized, placebo-controlled, double-blind clinical trial. 28 subjects in experiment group were injected distilled Rehmannia glutinosa Herbal Acupuncture at $GB_{21}$(Kyonjong) and 30 subjects in control group were injected Normal Saline at $G_{21}$(Kyonjong). except of 2 subjects(in control group) who can't be measured and 6 subjects(2 in experiment group and 4 in control group) who move or make unforceable error during measuring. Finally 26 subject in experiment group and 24 subject in control group are studied. We measured HRV by PolyG-I on 7 times : before and after injection per 5 minutes during 30 minutes. The SPSS 10.0 for windows was used to analyze the data and the paired t-test(in group) and Student t-test(between two groups) were used to verify the result. Results : 1. After distilled Rehmannia glutinosa Herbal Acupuncture injection, Mean HRV is significantly low only for first 5 minute, SDNN is significantly high after 5 minute, Complexity is significantly low only from 20 minute to 25 minute. HRV index is significantly high for first 5minute and from 10 minute to after 10 minute. 2. HRV index of distilled Rehmannia glutinosa Herbal Acupuncture Group significantly increased from 25 minute to 30 minute, and pNN50 of Rehmannia glutinosa Herbal Acupuncture Group significantly decreased from 20 minute to 30 minute compared with those of Normal Saline group. 3. After distilled Rehmannia glutinosa Herbal Acupuncture injection, Ln(TP) and Ln(VLF) are significantly high after injection. Normalized LF is significantly high from 5 minute to 20 minute and from 25 minute and 30 minute. Normalized HF is significantly low from 5minute to 20 minute and from 25 minute and 30 minute. 4. Ln(TP) and Ln(VLF) of distilled Rehmannia glutinosa Herbal Acupuncture Group significantly increased from 20 minute to 25 minute compared with those of Normal Saline group. Conclusions : The results suggest that Rehmannia glutinosa Herbal Acupuncture in healthy adult man tend to activate the autonomic nervous system and parasympathetic nervous system compared to Normal Saline within normal range.

• 수면정신생리
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• 제19권2호
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• pp.68-76
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• 2012

목 적: 수면 장애는 자율신경계의 변화를 유발하여 심혈관계에 영향을 준다. 일차성 불면증(primary insomnia, 이하 PI)은 수면부족 및 각성으로, 폐쇄성 수면무호흡 증후군(obstructive sleep apnea syndrome, 이하 OSAS)은 수면 중 빈번한 각성, 저산소증 등으로 교감신경계 항진을 유발한다. 이에 OSAS와 PI 사이에서 심박동률 변이도(heart rate variability, 이하 HRV) 분석을 통해 자율신경계의 변화 정도를 비교하고자 하였다. 방 법: 임상병력 및 야간수면다원검사(nocturnal polysomnography, 이하 NPSG)로 선택된 PI와 OSAS 전체 315 명의 대상자 중 OSAS는 무호흡-저호흡 지수(apnea-hypopnea index, 이하 AHI)에 따라서 경도, 중등도, 중증도 OSAS로 분류하여 PI를 포함하여 4개의 군으로 분류되었다. 이후 연령, 성별, 군간 개체수를 고려하여 최종적으로 110명의 대상자가 선택되었고, PI군(평균나이 41.50, 표준편차 13.16, AHI <5, n=20), 경도 OSAS군(평균나이 43.67, 표준편차 12.11, AHI 5~15, n=30), 중등도 OSAS군(평균나이 44.93, 표준편차 12.38, AHI 16~30, n=30), 중증도 OSAS군(평균 나이 45.87, 표준편차 12.44, AHI >30, n=30)의 4개 군으로 나누었다. 이후 NPSG를 통해 얻은 각 군의 HRV 지수 비교를 위하여 연령과 체질량지수(body weight index, BMI)를 공변량으로 하여 공분산분석(analysis of covariance, ANCOVA)를 실시한 후 사후분석으로 Sidak test를 실시하였다. 결 과: HRV 지수의 비교 결과 PI군과 경도, 중등도의 OSAS군 간에 유의한 차이는 없었다. 그러나 PI군과 중증도 OSAS군 사이에는 유의한 차이가 있었다. 군간비교에서 통계적으로 가장 현저한 차이를 보인 PI군과 중증도 OSAS군에서 HRV 지수 중 통계적으로 의미 있는 각각의 값은 다음과 같았다. Average RR interval은 $991.1{\pm}27.1$과 $875.8{\pm}22.0$ ms(p=0.016), standard deviation of NN interval(SDNN)은 $85.4{\pm}6.6$과 $112.8{\pm}5.4$ ms(p=0.022), SDNN index는 $57.5{\pm}5.2$과 $87.6{\pm}4.2$(p<0.001), total power는 $11893.5{\pm}1359.9$과 $8097.0{\pm}1107.2ms^2$(p=0.008), very low frequency(VLF)는 $7534.8{\pm}1120.1$과 $11883.8{\pm}912.0ms^2$(p=0.035), low frequency(LF)는 $2724.2{\pm}327.8$과 $4351.6{\pm}266.9ms^2$였다(p=0.003). 결 론: 본 연구에서는 PI군에 비해 중증도의 OSAS군에서 HRV 지수 중 교감신경계의 영향을 많이 받는 VLF, LF 등이 상승하는 양상을 보였고, 이를 통해 PI에 비해 중증도의 OSAS가 교감신경계 활동증가에 보다 더 큰 영향을 끼치는 것을 알 수 있었다.