• 대한의생명과학회지
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• 제15권1호
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• pp.47-53
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• 2009

Urinary bladder cancer is diagnosed through urine cytology and cytoscopy with biopsy. An atypical urothelial cast is often found by voided urine cytology in a papillary urothelial cell carcinoma. The objective of this study is to demonstrate the significance of the evaluation of urinary nuclear matrix protein (NMP22) level and Sure Path Liquid-based cytology (SP-LBC) as compared to the examination of atypical urothelial cast in voided urine sediment for monitoring bladder cancer. From October 2007 to January 2008, we observed 3240 patients who visited the emergency laboratory of urology of Soonchunhyang University, Cheonan Hospital. Both NMP22 measurement and SP-LBC were performed in 31 patients who were positive in an atypical urothelial cast test. In particular, 26 men and 5 women were found to be atypical urothelial cast-positive persons. The average age for both men and women is 61.8. NMP22 test is positive in 23 of 31 cases (74.2%) from patients with atypical urothelial cast, while the test is negative in 8 of 31 cases (25.8%). The percentages of negativity, atypicality, suspicious malignancy, and malignancy in SP-LBC are 25.8% (8/31), 58.1% (18/31), 9.7% (3/31), and 6.5% (2/31), respectively. The relation of NMP22 positivity with the malignant degree in LBC is significant (P<0.01). Two malignant patients resulting from SP-LBC show the same results in histological examination. Overall, the study suggests the usefulness of NMP22 measurement and LBC as well as the examination of atypical urothelial cast for the diagnosis of early bladder cancer.

• Asian Pacific Journal of Cancer Prevention
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• 제15권15호
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• pp.6283-6286
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• 2014

In patients with microscopic hematuria there is a need for better identification of those who are at greater risk of harbouring bladder tumors. The RisikoCheck(C) questionnaire has a strong correlation with the presence of urothelial carcinoma (UC) of the bladder and in combination with other available tests may help identify patients who require detailed clinical investigations due to increased risk of presence of bladder tumors. This study aimed to evaluate the efficacy of RisikoCheck(C) questionnaire together with NMP-22(R) (BladderChek(R)) as a point-of-care urine test in predicting the presence of bladder tumors in patients presenting with microscopic hematuria as the sole finding. In this multi-institutional prospective evaluation of 303 consecutive patients without a history of urothelial carcinoma (UC), RisikoCheck(C) risk group assessment, urinary tract imaging and cystourethroscopy as well as urine cytology and Nuclear Matrix Protein-22 (NMP-22 BladderChek) testing were performed where available. The sensitivity, specificity, negative predictive value (NPV), and positive predictive values (PPV) for the risk adapted approach were calculated. All patients underwent cystoscopy, and tumors were detected in 18 (5.9%). Urine cytology and NMP-22 was positive for malignancy in 9 (3.2%) and 12 (7.5%) of patients, respectively. A total of 43 (14%) patients were in the high risk group according to the RisikoCheck(C) questionnaire. The sensitivity and specificity of the questionnaire in detecting a bladder tumor was 61.5 % and 84.0 % in the high risk group. In patients with either a positive NMP-22 test or high risk category RisikoCheck(C), 23.6% had bladder tumors with a corresponding sensitivity of 54.2% and specificity of 88.6%. If both tests were negative only 3.3% of the patients had bladder tumors. The results of our study suggest that the efficacy of diagnostic evaluation of patients with microscopic hematuria may be further enhanced by combining RisikoCheck(C) questionnaire with NMP-22.

• 멤브레인
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• 제15권1호
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• pp.22-33
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• 2005

비대칭 폴리비닐리덴플루오라이드(PVDF) 막을 상전환법으로 제조하였다. 도포용액은 PVDF를 용매인 N-ethyl-2-pyrrolidone (NMP)와 비용매인 1,4-dioxane, diethyleneglycol dimethyl ether (DGDE), acetone, (equation omitted)-butyrolactone(GBL)의 혼합용매에 녹여서 제조한다. 여러 첨가제가 도포용액 특성, 투과특성과 막 구조에 미치는 영향을 조사하였다. 응고제인 물과 1,4-dioxane, DGDE, acetone과의 상용성이 NMP보다 낮아서 기공크기가 작아진다. 첨가제의 양을 조절하여 기공크기를 변화시켰다. 혼합용매(수계 및 비수계)가 막의 투과성능에 미치는 영향을 살펴보았다. 용액점도뿐만 아니라 표면장력도 용매 투과특성에 영향을 끼침을 알 수 있었다.

• 멤브레인
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• 제22권3호
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• pp.178-190
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• 2012

침지법 상전이 공정 방법으로 polysulfone (PSF) 분리막을 제조하였다. PSF/NMP/PVP/phosphoric acid의 캐스팅 용액과 물 침전조를 이용하여 분리막을 제조하였다. 증기 유도 상전이법과 비용매 유도 상전이법을 연속하여 적용함으로서 캐스팅 용액에 첨가된 인산의 영향이 분리막의 구조 및 투과량에 미치는 영향을 살펴보았다. 미량의 인산의 첨가로도 평균 기공의 크기, 공극률, 수투과량의 증가를 볼 수 있었다. 또한 분리막의 구조가 치밀한 스펀지 형태의 구조에서 비대칭성이 향상된 구조로 변화함을 확인할 수 있었다. PSF/NMP/PVP/phosphoric acid/BE를 함유한 캐스팅 용액을 준비한 후 동일한 조건으로 증기 유도 상전이법과 비용매 유도 상전이법을 연속하여 적용하여 분리막을 제조하였다. BE의 첨가는 평균 기공의 크기를 거의 0.1 ${\mu}m$ 정도 향상시키는 효과를 가져왔으며 수 투과 유량 또한 10~12 $L/cm^2{\cdot}min{\cdot}bar$ 향상시키는 결과를 나타내었다.

• 접착 및 계면
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• 제4권4호
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• pp.22-27
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• 2003

탄소나노튜브(CNT)의 분산성을 개선하기 위하여 $HNO_3$와 $H_2SO_4$를 사용하여 표면을 개질하였고, 적외선 분광법(FT-IR)과 산-염기 적정법을 통하여 CNT의 표면에 카르복실산이 도입된 것을 확인하였다. CNT의 분산성을 확인하기 위하여 초음파를 이용하여 톨루엔, 디메틸포름아마이드 (DMF) 및 N-메틸피롤리돈(NMP) 등의 유기용매에 개질 전(rCNT) 및 개질 후(mCNT)를 각각 분산시키고, 실시간 광학현미경(real-time video microscope)으로 분산거동을 관찰하였다. rCNT에 비해 mCNT가 극성이 큰 DMF 및 NMP 용매에 분산이 잘 되었으며 비극성인 톨루엔에는 분산성이 나쁨을 알 수 있었다. 또한, DMF에 CNT를 분산시킨 후, 폴리메틸메타크릴레이트(PMMA)를 용해시키고 이를 필름으로 제조한 후 주사전자현미경(SEM)을 통하여 분산형태를 관찰한 결과 mCNT의 분산성이 우수하였다.

• Composites Research
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• 제35권1호
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• pp.18-22
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• 2022

복합재료의 제조에 있어서 분산은 매우 중요한 요소 중 하나이다. 복합재료의 제조 시 matrix 용재에 강화재를 보다 잘 분산하기 위하여 용매를 사용하는데 용매에 따라 분산도가 달라지기 때문에 어떠한 용매가 분산에 용이할지에 대한 연구가 필요하다. 본 연구에서는 다양한 솔벤트 용매(DMF, NMP, Ethylene glycol, Acetone, DI water)에 대해 나노 필러인 산화 그래핀(Graphene oxide)의 용매에 따른 GO의 분산거동과 용해도 분석을 통해 분산에 유리한 용매를 파악하고자 하였다. 그 결과 UV-Vis spectroscopy 흡광도 측정을 통해 DMF와 Ethylene glycol이 가장 좋은 분산성을 가짐을 알 수 있는 반면 DI water는 가장 낮은 분산성을 보임을 알 수 있었다. 또한 표면장력과 시간에 따른 분산 육안 관측을 통해 DI water, Ethylene glycol, NMP, DMF, Acetone 순으로 분산성이 우수한 것을 알 수 있었는데 이는 Hansen solubility parameter 값과 일치하는 경향임을 확인할 수 있었다.

• Environmental Engineering Research
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• 제22권3호
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• pp.245-254
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• 2017

This study investigates methyl orange (MO) degradation by an ultrasonically dispersed nano-metallic particle (NMP) assisted advanced Fenton process. The NMPs were synthesized from the leachate of automobile-shredder residue. X-ray photoelectron spectroscopy and Fourier-transform infrared spectroscopy were performed for the prepared NMPs. Various parameters, such as the effects of the NMP dosage, the pH value of the solution, the initial concentration of MO, and the amount of $H_2O_2$ on the degradation efficiency of MO were studied. The MO degradation efficiency could be increased by approximately 100% by increasing the dosages of the NMPs and $H_2O_2$ to certain limits, after which in both cases the degradation efficiency was reduced when an excess amount was added. The MO degradation efficiency was found to be 100% at pH 2.0 and 2.5 with the 10 mg/L of initial concentration of the MO. The degradation of MO by ultrasonically dispersed NMPs was appropriate with the pseudo-first-order kinetics.

• Carbon letters
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• 제10권1호
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• pp.19-22
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• 2009

In this work, the hydrogen storage behaviors of carbon nanotubes (CNTs)/metal-organic frameworks-5 (MOF-5) hybrid composites (CNTs/MOF-5) were studied. Hydrothermal synthesis of MOF-5 was conducted by conventional convection heating using 1-methyl-2-pyrrolidone (NMP) as a solvent. Morphological characteristics and average size of the CNTs/MOF-5 were also obtained using a scanning electron microscopy (SEM). The pore structure and specific surface area of the CNTs/MOF-5 were analyzed by N2/77 K adsorption isotherms. The capacity of hydrogen storage of the CNTs/MOF-5 was investigated at 298 K/100 bar. As a result, the CNTs/MOF-5 had crystalline structures which were formed by hybrid synthesis process. It was noted that the CNTs/MOF-5 can be potentially encouraging materials for hydrogen adsorption and storage applications at room temperature.

• 한국막학회:학술대회논문집
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• 한국막학회 1998년도 춘계 총회 및 학술발표회
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• pp.22-24
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• 1998

1. INTRODUCTION : The phase inversion method is widely used to prepare a variety of polymeric membranes ranging from micro-filtration to gas separation. The final morphology obtained by immersion precipitation strongly reflects the thermodynamics and kinetics of the system involved. The equilibrium thermodynamics of the ternary system of polymer/solvent/ nonsolvent is still very important to understand and predict membrane structure. Polysulfone (PSf) and polyethersulfone (PES) are important polymers as membrane materials due to the chemical resistance, mechanical strength, thermal stability and transport properies. There are several reports on the experimental phase diagrams in ternary mixtures of PSf/solvent/nonsolvent, and PES/solvent/nonsolvent. It would be interesting to investigate the solution thermodynamics containing these two polymers since PES is slightly less hyclrophobic than PSf.

• 한국건강관리협회지
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• 제2권3호
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• pp.73-96
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• 2004

Along with a development of medical technology, a variety of tests, such as laboratory tests, x-ray and endoscopies are being used in health screening tests. As the tests determine the quality of health screening, test items and methods should be carefully selected. This study was to get hold of the test items of major health screening programs in Korea Most of the health screening programmes focused upon detection of risk factors and diagnosis of life - style related diseases (diabetes, hypertension, cardiovascular diseases, hypercholesterolemia, overweight, drinking, smoking, cerebrovascular diseases, osteoporosis) ,cancers (stomach, cervix, lung, breast, liver, colon, prostate, ovary, pancreas, thyroid, esophagus) , infectious diseases (hepatitis, tuberculosis, sexually-transmitted diseases, parasites) , chronic obstructive respiratory diseases, chronic renal diseases (bacteriuria hematuria, proteinuria) , anemia, glaucoma, hearing loss, Alzheimer disease, stress, early psychiatric diseases. The health screening tests were basic physical examination, basic laboratory tests (CBC, urinalysis, liver function tests, lipid tests, glucose, HbAlc, uric acid, electrolytes, serological tests (HBsAg, HBs-Ab, HCV-Ab, HIV-Ab, VDRL) EKG, x-ray (chest PA, CT) , endoscopy (gastroscopy, colonoscopy) , sonography(abdomen, thyroid, pelvis, breast) ,cytology (cervix) , bone density, tumor markets (NMP22, alpha-FP, CEA, CA-19-9, CA12S, PSA) and eye tests. Advanced technologies, like CT, PET, MRI, MRT/Angio, molecular testings) were widely used in hospital health screening programmes .In summary, a variety of tests were utilized in health screening in Korea. Those tests were utilized by stages or according to sex and age in most of health screening programmes, however a few program used tests to excess disregarding health screening subjects.