• Title/Summary/Keyword: NIO

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Preparation of Solid Dispersions of a Poorly Water-soluble Drug Using Supercritical Fluid (초임계 유체를 이용한 난용성 약물의 고체분산체 제조)

  • Kim, Seok-Yun;Lee, Jung-Min;Jung, In-Il;Lim, Gio-Bin;Ryu, Jong-Hoon
    • KSBB Journal
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    • v.24 no.6
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    • pp.533-540
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    • 2009
  • In this work, 5'-nitroindirubinoxime (5'-NIO) has been prepared as solid dispersions using a supercritical aerosol solvent extraction system (ASES) process in order to enhance its water solubility and dissolution rate. Solid dispersions of 5'-NIO and poly(vinyl pyrrolidone) (PVP) were prepared in various weight percent ratios. Three-component solid dispersions consisting of 5'-NIO, PVP, and poloxamer 188 (P188) were also prepared to study the influence of P188 level on their morphology, crystallinity, and dissolution behavior. All samples were prepared at $35^{\circ}C$ and 180 bar using supercritical carbon dioxide. The particle morphology and size of the two-component solid dispersions were found to be nearly spherical and much smaller (100-200 nm) compared with the original 5'-NIO. The morphology of three-component solid dispersions became more agglomerated as the level of P188 increased. The crystallinity of the original 5'-NIO was not observed in the solid dispersions prepared by the ASES process. Faster dissolution rates were observed for the three-componet solid dispersions because the arrangement of ethylene oxide and propylene oxide blocks of the poloxamer 188 enabled the formation of micelles in an aqueous phase.

General Web Cache Implementation Using NIO (NIO를 이용한 범용 웹 캐시 구현)

  • Lee, Chul-Hui;Shin, Yong-Hyeon
    • Journal of Advanced Navigation Technology
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    • v.20 no.1
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    • pp.79-85
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    • 2016
  • Network traffic is increased rapidly, due to mobile and social network, such as smartphones and facebook, in recent web environment. In this paper, we improved web response time of existing system using direct buffer of NIO and DMA. This solved the disadvantage of JAVA, such as CPU performance reduction due to the blocking of I/O, garbage collection of buffer. Key values circulated many data due to priority change put on a hash map operated easily and apply a priority modification algorithm. Large response data is separated and stored at a fast direct buffer and improved performance. This paper showed that the proposed method using NIO was much improved performance, in many test situations of cache hit and cache miss.

Assessment of the Nature and Severity of Pain Using SF-MPQ for Cancer Patients at the National Institute of Oncology in Rabat in 2015

  • Nabila, Rouahi;Zineb, OuazzaniTouhami;Hasna, Ahyayauch;Nisrin, El Mlili;A, Filali-Maltouf;Zakaria, Belkhadir
    • Asian Pacific Journal of Cancer Prevention
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    • v.17 no.8
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    • pp.3997-4001
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    • 2016
  • Background: Cancer is a worldwide health problem and pain is among the most common and unpleasant effects affecting well-being of cancer patients. Accurate description of pain can help physicians to improve its management. Many English tools have been developed to assess pain. Onkly a limited number of these are applied in Arab countries. Our aim was to assess the quality, the nature and the severity of pain using the short McGill Pain Questionnaire (SF-MPQ) on cancer patients in the National Institute of Oncology (NIO) in Rabat, Morocco. Materials and Methods: The tool used is the SF-MPQ inspired from the Arabic version of the MPQ. The subjects were cancer patients (N=182) attending the NIO, from 24th October 2015 to 8th January 2016, aging ${\geq}18$ years old, experiencing pain and coming to have or to update their pain medication. Results: The rate of participation was 96.3%. Eight patients had difficulties to express their pain using descriptors, but could use the Visual Analogue Scale (VAS) and the body diagram. The most frequent sensory descriptors were 'Throbbing', 'Shooting', 'Hot-Burning'. The most used affective descriptor was 'Tiring-Exhausting'. The mean VAS was 6.6 (2.4). The mean score of all items was 11.9 (7.8). The patients were suffering from severe pain. The internal consistency of the form was s acceptable. Conclusions: The findings indicate that most of the patients attending the pain center of the NIO could use the descriptors of the SF-MPQ to describe their pain. They indicate the usefulness of the SF-MPQ to assess the nature and the severity of pain in cancer patients. This tool should be tested in other Moroccan and Arabic contexts associated with other tools in clinical trials.

Analysis on the Characteristics of Climate about Korean Summer Season 1998

  • Cha, Eun-Jeong;Choi, Young-Jean;Oh, Jai-Ho
    • International Union of Geodesy and Geophysics Korean Journal of Geophysical Research
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    • v.26 no.1
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    • pp.31-41
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    • 1998
  • The climatic characteristics of summer in 1998 are analyzed with the weather observational data and the upper air observational data. The temperature of that period is lower than that of normal years and the precipitation is larger. Due to the heavy rainfall which started at July 31, rain pured down compared to normal years and the maximum precipitation recorded at the many observational stations, particularly in Seoul, Kyunggi-Do region and mountanious districts like Taegwallyong, Mt. Sokri and Mt. Chiri. The patterns of general circulations in 1982/98 and 1997/98 are compared each other and are analyzed. The anomaly patterns of stream functions on winter in two El Nio years are simialr. The counterclockwise circulation occurred near the date line and the clockwise circulation was appeared near the Hwanam region and Alaska. These patterns are opposite to those of La Nia year, 1988/89. And the anomaly patterns of 500hPa geopotential height in summer are similar, too. The low temperature and much rain were dominated in summer of 1997/98. These phenomena is similar to the existing results of research, that temperature is low and precipitation is large in summer of El Nio years.

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The Development of Ensemble Statistical Prediction Model for Changma Precipitation (장마 강수를 위한 앙상블 통계 예측 모델 개발)

  • Kim, Jin-Yong;Seo, Kyong-Hwan
    • Atmosphere
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    • v.24 no.4
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    • pp.533-540
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    • 2014
  • Statistical forecast models for the prediction of the summertime Changma precipitation have been developed in this study. As effective predictors for the Changma precipitation, the springtime sea surface temperature (SST) anomalies over the North Atlantic (NA1), the North Pacific (NPC) and the tropical Pacific Ocean (CNINO) has been suggested in Lee and Seo (2013). To further improve the performance of the statistical prediction scheme, we select other potential predictors and construct 2 additional statistical models. The selected predictors are the Northern Indian Ocean (NIO) and the Bering Sea (BS) SST anomalies, and the spring Eurasian snow cover anomaly (EUSC). Then, using the total three statistical prediction models, a simple ensemble-mean prediction is performed. The resulting correlation skill score reaches as high as ~0.90 for the last 21 years, which is ~16% increase in the skill compared to the prediction model by Lee and Seo (2013). The EUSC and BS predictors are related to a strengthening of the Okhotsk high, leading to an enhancement of the Changma front. The NIO predictor induces the cyclonic anomalies to the southwest of the Korean peninsula and southeasterly flows toward the peninsula, giving rise to an increase in the Changma precipitation.

Implementation of Morning-Call System based on the Multi-point Group Communication (다자간 그룹 통신 기반의 모닝콜 시스템 구현)

  • Ryu, Ho-Dong;Kim, Woo-In;Kim, Hee-Yong;Park, Ki-Hong;Lee, Yang Sun
    • Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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    • 2015.10a
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    • pp.954-957
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    • 2015
  • In this paper, the android platform based on the morning call system using multi-point group communication is proposed. Implemented multi-point group communication was applied by fusing a variety of techniques such as JAVA NIO, JSP, MySQL, DBMS Pool, GCM and JSON. Some experiments are conducted so as to verify the proposed method, and as a result, morning-call application based multi-point group communication is well performed.

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Intelligent Web Crawler for Supporting Big Data Analysis Services (빅데이터 분석 서비스 지원을 위한 지능형 웹 크롤러)

  • Seo, Dongmin;Jung, Hanmin
    • The Journal of the Korea Contents Association
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    • v.13 no.12
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    • pp.575-584
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    • 2013
  • Data types used for big-data analysis are very widely, such as news, blog, SNS, papers, patents, sensed data, and etc. Particularly, the utilization of web documents offering reliable data in real time is increasing gradually. And web crawlers that collect web documents automatically have grown in importance because big-data is being used in many different fields and web data are growing exponentially every year. However, existing web crawlers can't collect whole web documents in a web site because existing web crawlers collect web documents with only URLs included in web documents collected in some web sites. Also, existing web crawlers can collect web documents collected by other web crawlers already because information about web documents collected in each web crawler isn't efficiently managed between web crawlers. Therefore, this paper proposed a distributed web crawler. To resolve the problems of existing web crawler, the proposed web crawler collects web documents by RSS of each web site and Google search API. And the web crawler provides fast crawling performance by a client-server model based on RMI and NIO that minimize network traffic. Furthermore, the web crawler extracts core content from a web document by a keyword similarity comparison on tags included in a web documents. Finally, to verify the superiority of our web crawler, we compare our web crawler with existing web crawlers in various experiments.

A study on the piezoelectric characteristic of 0.02PYW-0.98PZT system piezoelectric ceramics dopped with NiO, $Cr_2O_3$ (NiO 및 $Cr_2O_3$를 첨가한 0.02PYW-0.98PZT계 세라믹의 압전특성에 관한 연구)

  • Kim, Jean-Shop;Kim, Hyun-Chul;Woon, Hyen-Sang;Bae, Seon-Gi
    • Proceedings of the KIEE Conference
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    • 1999.07d
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    • pp.1789-1791
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    • 1999
  • In consideration of piezoelectric characteristic and Temperature stability, 3-element system dopped with NiO, $Cr_2O_3$ well-known as Hardner and Stabilizer whose primary element is PZT was eximanated its structure, piezoelectric characteristics, dopping with Nio, $Cr_2O_3$. We think that piezoelectric Characteristic is developed, remenent polarization and $E_c$ can developed in specimens by dopping with NiO, $Cr_2O_3$ additive. also, electromechanical quality factor largely showed tendency of decrement. According to dopping NiO, $Cr_2O_3$ more.

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