• Journal of Physiology & Pathology in Korean Medicine
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• v.24 no.2
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• pp.278-283
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• 2010

Inducible nitric oxide synthase (iNOS) are important inflammation enzyme and severe up-nitric oxide (NO) production by this enzyme has been intricate with pathogenesis of atopy dermatitis. The present study was designed in order to determine whether Lonicera japonica could inhibit atopy dermatitis through modulation of iNOS by NF-${\kappa}B$ suppression. We found that IKK mRNA and iNOS mRNA expression in RAW 264.7 macrophages stimulated with lipopolysaccharide dose-dependantly decreased by Lonicera japonica (0.4 - 1.0 mg/$m{\ell}$) and NO production decreased. The distribution of NF-${\kappa}B$ p65 and iNOS positive reacted cell in NC/Nga mice with atopy dermatitis were decreased by Lonicera japonica (45 mg/kg/day) and apoptosis were increased. These data likely indicate that Lonicera japonica may act as inflammatory regulator for atopy dermatitis through iNOS modulation by NF-${\kappa}B$B suppression and may be possible to develop useful agent for chemoprevention of NO intricate inflammatory diseases.

• Korean Journal of Computational Design and Engineering
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• v.8 no.2
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• pp.115-121
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• 2003

A new Layered Manufacturing(LM) system, named PaperMill, is developed applying micro milling technology. A micro endmill(127 11m in diameter) is introduced as the cutter of build material. The selected build material for this system is an adhesive-coated paper roll which provides advantages such as good bonding between layers, machinability, and low material cost. A 3-axis CNC controller and three step-motors are used for the movement of X-Y-Z table of the system. For simplicity of the control of mechanism, the control system for feeding the paper roll is uncoupled from CNC controller. Two code converters are developed for the toolpath generation of the new LM system. The NC converter generates a set of NC codes for PaperMill using commercial CAM software while the SML converter generates an NC code from Quickslice's SML format. The NC codes generated from the converters consist of a series of profile data and trigger code for paper feeding. Two sample gears were fabricated to prove the concept of the system, which shown that the dimensional errors of the fabricated gears is under 3.4 percent.

• Journal of Physiology & Pathology in Korean Medicine
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• v.20 no.4
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• pp.1036-1043
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• 2006

The present study was conducted to investigate the effect of Gamisamul-tang (GSMT) on atopic dermatitis (AD). AD was induced in NC/Nga mutant mice by DNCB treatment. GSMT administration reduced levels of skin severity scores. Serum levels of IgE, IgG, IgM, and inflammatory cytokines including IL-4, IL-4 and 1L-13 were significantly decreased by GSMT treatment. Levels of mRNA's encoding IL-4, IL-6, IL-13, $TNF-{\alpha}$, and $interferon-{\gamma}$ in the dermal tissue and draining lymph node (DLN) by real time RT-PCR analysis showed decrease by GSMT testament. Moreover, the number of CD4+ and CD8+ cells was significantly decreased in the spleen and DLN tissues. Histological examination showed that infiltration levels of immune cells in ear, skin, and DLN of AD-induced NC/Nga mice were much improved by GSMT treatment. The present data suggest that GSMT may play an important role in recovering AD symptoms by regulating immune reactivity.

• Proceedings of the Korean Society of Machine Tool Engineers Conference
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• 1997.10a
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• pp.207-212
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• 1997

The purpose of this study is the development of CAM system which can cut and measure any shape by machining center and coordinate measuring machine. The overall goal of the CAM system is to achieve the CNC machining, from digitizing through to final cutting. The hardware of the system comprises PC and machining center, CMM. There are three steps in the CNC machining, (1) workpiece measuring on the CMM, (2) geometric modeling by the CAD system, (3) NC commands generation by the tool path compensated for tool nose radius. It is developed a software package, with which can conduct a micro CAM system in the PC without economical burden.

• Journal of the Korean Society for Precision Engineering
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• v.32 no.4
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• pp.329-337
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• 2015

In this paper, a simulation based estimation method of energy consumption of the spindle and feed drives for the NC machine tool during the cutting process is proposed. To predict energy consumption of the feed drive system, position, velocity, acceleration and jerk of the table are analyzed based on NC data and then the power and energy are calculated considering friction force and mass of the stages. Energy consumption of the spindle is estimated based on models from acceleration motion of rotating parts, friction torque and power loss of motors. Moreover, simulation models of cutting power and energy for the material removal along the NC tool paths are proposed.

• Journal of the Korean Society of Manufacturing Technology Engineers
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• v.7 no.4
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• pp.79-88
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• 1998

This study deals with the development of CAM system which can machine and measure any shape of mold and die by machining center and coordinate measureing machine . The overall goal of the CAM system is to achieve the mold and die machining , from digitizing through to final cutting. The hardware of the system comprises PC and machining center. CMM. There are three steps in the mold and die machining. (1) measuring of physical model by the CMM, (2) geometric modeling by the CAD system, (3) generation of NC code by the tool path compensated for tool radius. It is developed a software package, with which can conduct a micro CAM system in the PC without economical burden.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2003.06a
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• pp.869-872
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• 2003

This paper presents a geometric machining simulation algorithm to enhance the reliability and user-friendliness of a comprehensive computer aided process planning (CAPP) system by verifying generated NC data. In order to represent the complex machining geometry with high accuracy, the proposed algorithm is developed based on a boundary representative (B-rep) solid modelling kernel. Solid models are used to represent the part geometry. tool swept volume and material removal volume by Boolean unite and subtract operations. By integrating a machining simulation procedure into the CAPP system, the systematic analysis of the tool path can be implemented synthetically. To demonstrate and check the validity of suggested system, a simple example of simulation is represented and the result is discussed.

• Journal of the Korean Society for Precision Engineering
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• v.19 no.12
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• pp.86-92
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• 2002

This paper presents a new model of NC verification in NC milling using z-map. The model can describe the motion of machine tool like a real machine effectively. The model uses x, y, and z directional feed rate as well as cutting data for modeling Z-map of workpiece. The model verifies the over-cut, the under-cut and the surface topography using NC codes and cutting conditions. To investigate the performance of the model, simulation study was carried out. As the results, the model gave the geometry accuracy of workpiece, the surface topography, and the chip loads.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2003.06a
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• pp.367-372
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• 2003

This paper shows about the machine simulation embodiment when it happened NC equipment and between workpiece and interference collision at 5 axises processing of aircraft parts. And this research has been chosen because of the highest equipment interference occurrence rate at aircraft parts processing of 5 axises horizontal machine. It can verify simulation and machining process through correlation about their dynamic relations. interference, collision as embodied virtual manufacturing system of machining tool, workpiece, and holder etc. that is necessary element in shape of machine tool and function and processing in imagination ball. Also. it verified about interference and collision between NC equipment parts and workpiece, for applied machine simulation to NC Data of actuality aircraft parts of BULKHEAD and FRAME.

• 제어로봇시스템학회:학술대회논문집
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• 1992.10b
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• pp.22-28
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• 1992

The need for intelligent systems that can operate in an unstructured, dynamic environment has created a growing demand for the use of multiple, distributed sensors. While most research in multisensor fusion has revolved around applications in object recognition-including military applications for automatic target recognition-developments in microsensor technology are encouraging more research in affordable, highly-redundant sensor networks. Three trends that are described at length are the increasing use of microsensors, the techniques that are used in the handling of partial or uncertain data, and the application of neural network techniques for sensor fusion.