• 대한전기학회논문지:전기물성ㆍ응용부문C
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• 제51권2호
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• pp.80-84
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• 2002

This paper presents some of the results of current research on 400kN Suspension Insulator Design. In this paper, authors carried out 2-dimensional field calculation in order to analyse dielectric characteristics of the insulator unit and 3-dimensional field calculation in order to analyse dielectric characteristics of the insulator strings. And the results of puncture tests of insulators were compared with the required field intensity of the insulator As results, it was found that electric field on the insulator unit is severest between two triple junctions, dielectric characteristics of insulator strings are much influenced by the surrounding configuration and the manufactured insulators have good results of puncture tests.

• Asian Pacific Journal of Cancer Prevention
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• 제16권8호
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• pp.3229-3232
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• 2015

Background: Triple-negative breast cancer (TNBC) is known to be associated with aggressive biologic features and a poor clinical outcome. Therefore, early detection of TNBC without missed diagnosis is a requirement to improve prognosis. Preoperative ultrasound features of TNBC may potentially assist in early diagnosis as characteristics of disease. Purpose: To retrospectively evaluate the sonographic features of TNBC compared to ER (+) cancers which include HER(-) and HER2 (+), and HER2 (+) cancers which are ER (-). Materials and Methods: From June 2012 through June 2014, sonographic features of 321 surgically confirmed ER (+) cancers (n=214), HER2 (+) cancers (n=66), and TNBC (n=41) were retrospectively reviewed by two ultrasound specialists in consensus. The preoperative ultrasound and clinicopathological features were compared between the three subtypes. In addition, all cases were analyzed using morphologic criteria of the ACR BI-RADS lexicon. Results: Ultrasonographically, TNBC presented as microlobulated nodules without microcalcification (p=0.034). A lower incidence of ductal carcinoma in situ (p<0.001), invasive tumor size that is>2 cm (p=0.011) and BI-RADS category 4 (p<0.001) were significantly associated with TNBC. With regard to morphologic features of 41 TNBC cases, ultrasonographically were most likely to be masses with irregular (70.7%) microlobulated shape (48.8%), be circumscribed (17.1%) or have indistinct margins (17.1%) and parallel orientation (68.9%). Especially TNBC microlobulated mass margins were more more frequent than with ER (+) (2.0%) and HER2 (+) (4.8%) cancers. Conclusions: TNBC have specific characteristic in sonograms. Ultrasonography may be useful to avoid missed diagnosis and false-negative cases of TNBC.

• Asian Pacific Journal of Cancer Prevention
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• 제14권6호
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• pp.3711-3717
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• 2013

Background: To assess the efficacy and tolerability of Cisplatin plus Gemcitabine combination in patients with brain metastases (BM) from breast cancer (BC). Materials and Methods: Eighteen BC patients with BM who were treated with Cisplatin plus Gemcitabine regimen between 2003-2011 were evaluated. Results: A median of 6 cycles of this regimen were received, in fifteen patients (83.3%) as first-line chemotherapy, in 2 as second-line and in 1 as third-line after diagnosis of BM. Dose reduction was performed in 11 (61.1%) patients; major reasons were neutropenia and leukopenia. Grade III neutropenia and Grade II trombocytopenia rates were 33.3% and 16.7% respectively. Overall response rate (ORR; complete+partial response rate) was 33.4% (n=6) for the entire study population; triple negative patients achieved an 66.6% ORR while hormone receptor (HR) positive patients had 25% and HER2 positive patients 12.5%. Median progression-free survival was 5.6 months (2.4-8.8 months, 95%CI) and longer in patients with triple negative breast cancer (TNBC) (median 7.4 months, 95%CI, 2.4-12.3 months) than the patients with other subtypes (median 5 months for HER2 positive and 3.6 months for HR positive patients). Median PFS of the patients with TNBC who received this regimen as first-line was 9.2 months (5.2-13.2 months, 95%CI). Conclusions: Cisplatin plus Gemcitabine may be a treatment option for patients with BM from breast cancer. Longer PFS and higher response rates are results that support the usage of this regimen especially for the triple negative subtype. However, further prospective and randomized trials are clearly required to provide more exact information.

• 전자공학회논문지D
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• 제34D권7호
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• pp.30-36
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• 1997

Bump bonded piezoesistive silicon accelerometer was fabricated by the porous silicon micromachining and th eprocess technique of integrated circuit. The output voltage of the accelerometer fabricated on (111)-oreiented Si substrates with n/n$^{+}$n triple layers showed good linear characteristic of less than 1%. The measured sensitivity and the resonant frequency was about 743 .mu.V/g and 2.04 kHz, respectively. And the transverse sensitivity of 5.2% was measured from the accelerometer. Also, to investigate an influence on the output characteristics of the sensor due to bump bonding, the values of the piezoresistors were measured through thermal-cycling test in the temperature variation form -50 to 120.deg. C. Then, there was 0.014% resistance changes about 3.61 k.ohm., so sthe output charcteristics of the sensor was less affected by bump bonding.g.

• 정보과학회 논문지
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• 제43권6호
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• pp.653-661
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• 2016

기존의 패턴기반 트리플 생성 시스템은 distant supervision의 가정으로 인해 오류 패턴을 생성하여 트리플 생성 시스템의 성능을 저하시키는 문제점이 있다. 이 문제점을 해결하기 위해 본 논문에서는 패턴과 프로퍼티 사이의 의미 유사도 기반의 패턴 신뢰도를 측정하여 오류 패턴을 제거하는 방법을 제안한다. 의미 유사도 측정은 비지도 학습 방법인 워드임베딩과 워드넷 기반의 어휘 의미 유사도 측정 방법을 결합하여 사용한다. 또한 한국어 패턴과 영어 프로퍼티 사이의 언어 및 어휘 불일치 문제를 해결하기 위해 정준 상관 분석과 사전 기반의 번역을 사용한다. 실험 결과에 따르면 제안한 의미 유사도 기반의 패턴 신뢰도 측정 방법이 기존의 방법보다 10% 높은 정확률의 트리플 집합을 생성하여, 트리플 생성 성능 향상을 증명하였다.

• Molecules and Cells
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• 제46권6호
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• pp.387-398
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• 2023

Microtubule acetylation has been proposed as a marker of highly heterogeneous and aggressive triple-negative breast cancer (TNBC). The novel microtubule acetylation inhibitors GM-90257 and GM-90631 (GM compounds) cause TNBC cancer cell death but the underlying mechanisms are currently unknown. In this study, we demonstrated that GM compounds function as anti-TNBC agents through activation of the JNK/AP-1 pathway. RNA-seq and biochemical analyses of GM compound-treated cells revealed that c-Jun N-terminal kinase (JNK) and members of its downstream signaling pathway are potential targets for GM compounds. Mechanistically, JNK activation by GM compounds induced an increase in c-Jun phosphorylation and c-Fos protein levels, thereby activating the activator protein-1 (AP-1) transcription factor. Notably, direct suppression of JNK with a pharmacological inhibitor alleviated Bcl2 reduction and cell death caused by GM compounds. TNBC cell death and mitotic arrest were induced by GM compounds through AP-1 activation in vitro. These results were reproduced in vivo, validating the significance of microtubule acetylation/JNK/AP-1 axis activation in the anti-cancer activity of GM compounds. Moreover, GM compounds significantly attenuated tumor growth, metastasis, and cancer-related death in mice, demonstrating strong potential as therapeutic agents for TNBC.

• 천문학회지
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• 제29권spc1호
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• pp.93-94
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• 1996

The Galaxy and the Large and Small Magellanic Clouds (LMC and SMC respectively) form a triple system of mutually interacting galaxies. We have carried out a set of N-body simulations on the gravitational interaction of the SMC with the Galaxy and the LMC in order to model prominent features such as the Magellanic Stream, the inter-Cloud Bridge, and the large depth of the SMC which are thought to be products of the tidal interactions among the members of this system.

• 한국산업정보학회:학술대회논문집
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• 한국산업정보학회 1998년도 춘계공동학술대회 발표논문집 IMF시대의정보화 추진전략
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• pp.229-233
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• 1998

이 논문에서 우리는 분산환경의 결함허용 응용소프트웨어 개발을 위한 명세방법을 제안한다. 즉, 시스템의 오류시에도 복구 가능한 논리전달을 위한 명세언어를 제공하는데 분산환경에 적합한 package개념과 객체에 기반하여 시스템을 이끈다. 이 명세방법을 이용하면 triple modular redundancy 나 voted-process pairs 등이 쉽게 명세 가능하다. 특히 , 본 논문은 DARTS 설계방법의 모듈객체와의 접목을 통하여 자연스럽게 실시간 설계로 유도한다.

• 동굴
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• 제5호
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• pp.66-69
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• 1997

The island of S.Miguel is part of the Azores, an archipelago composed of nine volcanic islands situated between the european and american continents. Aligned in a general WNW -ESE trend, between latitudes 37$^{\circ}$ -40$^{\circ}$ N and longitude 25$^{\circ}$ -31$^{\circ}$ W, the Azores islands show a very special geotectonic setting, at the triple junction of the Eurasian, African and North American lithospheric plates.(omitted)

• Journal of applied mathematics & informatics
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• 제37권1_2호
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• pp.37-52
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• 2019

In this paper we introduce a new concept for Riesz almost lacunary ${\chi}^3$ sequence spaces strong P - convergent to zero with respect to an Orlicz function and examine some properties of the resulting sequence spaces. We introduce and study statistical convergence of Riesz almost lacunary ${\chi}^3$ sequence spaces and some inclusion theorems are discussed.