• Title/Summary/Keyword: N-R Method

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Plasmodium vivax dhfr Mutations among Isolates from Malarious Areas of Iran

  • Zaman, Jalal;Shahbazi, Abbas;Asgharzadeh, Mohammad
    • Parasites, Hosts and Diseases
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    • v.49 no.2
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    • pp.125-131
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    • 2011
  • The use of sulfadoxine and pyrimethamine (SP) for treatment of vivax malaria is uncommon in most malarious areas, but Plasmodium vivax isolates are exposed to SP because of mixed infections with other Plasmodium species. As P. vivax is the most prevalent species of human malaria parasites in Iran, monitoring of resistance of the parasite against the drug is necessary. In the present study, 50 blood samples of symptomatic patients were collected from 4 separated geographical regions of south-east Iran. Point mutations at residues 57, 58, 61, and 117 were detected by the PCR-RFLP method. Polymorphism at positions 58R, 117N, and 117T of P. vivax dihydrofolate reductase (Pvdhfr) gene has been found in 12%, 34%, and 2% of isolates, respectively. Mutation at residues F57 and T61 was not detected. Five distinct haplotypes of the Pvdhfr gene were demonstrated. The 2 most prevalent haplotypes were F57S58T61S117 (62%) and F57S58T61N117 (24%). Haplotypes with 3 and 4 point mutations were not found. The present study suggested that P. vivax in Iran is under the pressure of SP and the sensitivity level of the parasite to SP is diminishing and this fact must be considered in development of malaria control programs.

Experimental and numerical research on ballistic performance of carbon steels and cold worked tool steels with and without Titanium Nitride (TiN) coating

  • Ergul, Erdi;Doruk, Emre;Pakdil, Murat
    • Steel and Composite Structures
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    • v.23 no.2
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    • pp.153-160
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    • 2017
  • It is extremely important to be aware of the ballistic performances of engineering materials in order to be able to choose the lightest armor providing full ballistic protection in civil and military applications. Therefore, ballistic tests are an important part of armor design process. In this study, ballistic performance of plates made of carbon steel and cold worked tool steel against 7.62 mm AP (armor-piercing) bullets was examined experimentally and numerically in accordance with NIJ standards. Samples in different sizes were prepared to demonstrate the effect of target thickness on ballistic performance. Some of these samples were coated with titanium nitride using physical vapor deposition (PVD) method. After examining all successful and unsuccessful samples at macro and micro levels, factors affecting ballistic performance were determined. Explicit non-linear analyses were made using Ls-Dyna software in order to confirm physical ballistic test results. It was observed that the ballistic features of steel plates used in simulations comply with actual physical test results.

Principles of the Automatic Book-Classification (도서분류자동화 원리유도에 관한 연구)

  • 심의순;이경호
    • Journal of Korean Library and Information Science Society
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    • v.11
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    • pp.175-209
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    • 1984
  • The purpose of this study is to build a general principle for the automatic book-classification which can be put to use in library operation, and to present a methodology of the automatic classification for the library. Since the enumerative classification scheme which exist as manual systems cannot be a n.0, pplied to the automation of classification, the principles of Colon Classification by S.R. Ranganathan is brought in and studied. The result of the study can be summarized as follows: (1) Automatic book-classification can be performed by the principles of faceted classification. (2) This study presents a general and an a n.0, pplication principles for the automatic book-classification. (3) File design for the automatic book-classification of a general classification is different from that of special classification, (4) The methodology is to classify the literature by inputting the title into a terminal. In addition, the expected Value from the Automatic Book-classification is as follows: (1) The prompt and accurate process of classification is possible. (2) Though a book is classified in any library it can have the same classification number. (3) The user can retrieve the classification code of a book for which he or she wants to search through the dialogue with the computer. (4) Since the concept coordination method is employed, even the representing of a multi-subject concept is made simple. (5) By performing automatic book-classification, the automation of library operation can be completed.

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Storage of Pollen Biofactory for in vitro Growth and rProtein Synthesis (기내배양과 재조합 단백질 생산을 위한 화분 Biofactory의 저장기술의 개발)

  • 박희성;고재철
    • KSBB Journal
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    • v.19 no.3
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    • pp.174-177
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    • 2004
  • A method of collection and long-term storage of viable lily (Lilium longiflorum) pollen grains were developed for their in vitro growth and transformation in consistency. Petroleum ether, n-heptane, cyclohexane and benzene, as pollen collection medium, were determined less toxic to pollen growth in vitro than others tested. Pollen grains, however, lost their growth activity if stored in these solvents more than a week, So, a serial performance, that is, pollen grain collection in these solvents, air-drying and immediate transfer to low temperature condition was determined desirable for keeping the viability much longer. Pollen grains from this storage showed a successful transformation in vitro with a cDNA encoding tissue plasminogen activator (TPA) protein using Agrobacterium via vacuum infiltration according to western blotting analysis.

A Study on the Evaluation of Motorcycle Jacket with Built-in Airbag (에어백 장착 모터사이클 쟈켓의 성능 실험방법 연구)

  • Do Wol-Hee;Choi Hei-Sun
    • Journal of the Korean Society of Clothing and Textiles
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    • v.29 no.6
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    • pp.837-846
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    • 2005
  • The purpose of this study is to suggest a standard of guidance for testing the performance and safety of motorcycle jacket with built-in airbag. The method of testing were as follows: The effects of the motorcycle jacket with built-in airbag are experimentaly investigated according to neck injury of FMVSS 208. The experiment consists of the crash simulation test by shield and the impact test. The head and neck injuries are evaluated based on industrial standards. Also, the displacements of the head and neck and chest are observed by film analysis. Using the results of the crash simulation test, neck injury$(N_ij)$ is discussed and the peak chest deflection of the results of the impact test, chest injury is pursued. Neck injury$(N_ij)$ of the result of the crash test show that the chance of a serious wound is $18\%$ if rider wear the R&D motorcycle jacket with built-in airbag(Type A). Chest injury is expected by peak chest deflection of the result of the impact test. The result of the peak chest deflection show that the reduction effect in chest injury of Type A motorcycle jacket is $10.3\%$.

Crystal Growth of Cd4GeS6 and Cd4GeS6:Co2+Single Crystals ($Cd_{4}GeS_{6}$$Cd_{4}GeS_{6}:Co^{2+}$ 단결정의 성장)

  • Kim, D.T.;Kim, H.G.;Kim, N.O.
    • Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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    • 2004.11b
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    • pp.1-6
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    • 2004
  • In this paper author describe the undoped and $Co^{2+}$ (0.5mole%)doped $Cd_4GeS_6$ single crystals were grown by the chemical transporting reaction(CTR) method using high purity(6N) Cd, $GeS_2$, S elements. It was found from the analysis of X-ray diffraction that the undoped and $Co^{2+}$(0.5mole%) doped $Cd_{4}GeS_{6}$ compounds have a monoclinic structure in space grop Cc. The optical energy band gap was direct band gap and temperature dependence of optical energy gap was fitted well to Varshni equation. Impurity optical absorption peaks due to the doped cobalt in the $Cd_4GeS_6:Co^{2+}$ single crystal were observed at 3593cm-1, 5048cm-1, 5901cm-1, 7322cm-1, 12834cm-1, 13250cm-1, 14250cm-1,and 14975cm-1 at 11.3K.

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Condensing Performance Evaluation in Smooth and Micro-Fin Tubes for Natural Mixture Refrigerant (Propane/Butane) (프로판/부탄 혼합자연냉매의 평활관과 마이크로핀관 내의 응축성능평가)

  • Lee Sang-Mu;Lee Joo-Dong;Park Byung-Duck
    • Korean Journal of Air-Conditioning and Refrigeration Engineering
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    • v.17 no.9
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    • pp.816-823
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    • 2005
  • This paper deals with the heat exchange performance prediction of a counter flow type double-tube condenser for natural refrigerant mixtures composed of Propane/n-Butane or Propane/i-Butane in a smooth tube and a micro-fin tube. The local characteristics of heat transfer, mass transfer and pressure drop are calculated using a prediction method developed by the authors. The total pressure drop and the overall heat transfer coefficient are also evaluated on various heat exchange conditions. The calculated results of the natural refrigerant mixtures are compared with HCFC22. In conclusion, natural refrigerant mixtures composed of Propane/n-Butane or Propane/i-Butane are appropriate candidates for alternative refrigerant from the viewpoint of heat transfer characteristics.

Bioactive Cyclopentenone Derivatives from Marine Isolates of Fungi

  • Feng, Zhile;Leutou, Alain S.;Yang, Guohua;Nenkep, Viviane N.;Siwe, Xavier N.;Choi, Hong-Dae;Kang, Jung-Sook;Son, Byeng-Wha
    • Bulletin of the Korean Chemical Society
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    • v.30 no.10
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    • pp.2345-2350
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    • 2009
  • As part of an effort to discover bioactive natural products from marine sources, we investigated the bioactive secondary metabolites from two marine isolates of the fungi, Trichoderma viride and Rhizopus stolonifer. Three cyclopentenones, myrothenones A (1) and B (2) and trichodenone A (3), were isolated from T. viride and two cyclopentenones, 2-bromomyrothenone B (4) and botrytinone (5), were isolated from R. stolonifer. The molecular structures and absolute stereochemistries of the cyclopentenones were determined from chemical and physicochemical evidence, including quantum chemistry calculations, X-ray analysis, and the circular dichroism (CD) exciton chirality method. Myrothenone A (1) displays tyrosinase inhibitory activity, with an I$C_{50}$ value of 6.6 ${\mu}M$, and is therefore more active than the positive control, kojic acid.

Numerical Calculation of Transformation Plasticity Using a FE Analysis Coupled with n Phase Field Model (상장모델과 유한요소법의 연계해석을 통한 변태소성 전산모사)

  • Cho, Y.G.;Kim, J.Y.;Cha, P.R.;Lee, J.K.;Han, H.N.
    • Proceedings of the Korean Society for Technology of Plasticity Conference
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    • 2009.05a
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    • pp.318-321
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    • 2009
  • Transformation plasticity is that when a phase transformation of ferrous or non-ferrous alloys progresses even under an extremely small applied stress compared with a yield stress of the material, a permanent deformation occurs. One of widely accepted description for the transformation was proposed by Greenwood and Johnson [1]. Their description is based on an assumption that a weaker phase of an ideal plastic material could deform plastically to accommodate the externally applied stress and the internal stress caused by the volumetric change accompanying the phase transformation. In this study, an implicit finite element model was developed to simulate the deformation behavior of a low carbon steel during phase transformation. The finite element model was coupled with a phase field model, which could simulate the kinetics for ferrite to austenite transformation of the steel. The thermo-elasto-plastic constitutive equation for each phase was adopted to confirm the weaker phase yielding, which was proposed by Greenwood and Johnson [1]. From the simulation, the origin of the transformation plasticity was quantitatively discussed comparing with the other descriptions of it.

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Development of Friction Surface Modification System and Evaluation to the Effect of Process Parameter (마찰 표면개질 시스템 개발 및 공정인자의 영향 평가)

  • Chun, Chang-Keun;Chang, Woong-Seong;Noh, Joong-Suk;Joung, Tae-Whee;Joh, Joong-Seon
    • Journal of Welding and Joining
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    • v.24 no.1
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    • pp.43-49
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    • 2006
  • This paper describes the friction surface modification which has been successfully developed with the friction stir welding recently There are several problems including just position control and backlash in conventional friction surface modification system. Therefore it has been developed the friction surface modification system which has been controlled precisely both position and force by driving hydraulic cylinder in this paper. The mechtrode rotation speed(N) and feeding speed(Vz), travel speed(Vx,y) are of critical importance for the width and thickness of the coating in friction surfacing process. But there is no theoretical method of determining interrelations between process parameters affect the coating width and thickness. As a result of DOE(design of experiment) with developed system, the coating thickness and width seemed to decrease according to increase the mechtrode rotation speed(N) and traveling speed(Vx,y), to decrease feeding speed(Vz) apparently. However as the result of regression analysis the main effect was only the mechtrode rotation speed in the coating thickness.