• Journal of Nutrition and Health
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• 제31권9호
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• pp.1394-1403
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• 1998

The study was designed to observe the effect of dietary calcium and fats on plasma cholesterol level, hepatic microsomal fluidity and HMG-CoA reductase activity as well as the excretion of fecal bile acids and neutral sterols in 1, 2-dimethylhydrazine(DMH)-treated rats. Male Sprague Dawley rats, at 7 weeks of age, were divided into 2 groups, 0.3% and 1.0% Ca levels and each group again subdivided into 2 groups of corn oil and perilla oil. Each rat was intramuscularly infused with DMH for 6 weeks to give total dose of 180mg/kg body weight and also fed experimental diet containing 15%(w/w) different fit and Ca(0.3% or 1.0%) for 20 weeks. High dietary calcium(1.0%) did not significantly influence on plasma cholesterol as well as hepatic microsomal fluidity and HMG CoA reductase activity, but significantly reduced the excretion of total bile acid per gram of faces and increased the excretion of total neutral sterol. However, high dietary Ca reduced the excretion of secondary bile acid(deoxycholic and lithocholic acids) which was known as promoter for colon cancer. Perilla oil rich in n-3 ${\alpha}$-linolenic acid significantly decreased plasma cholesterol by increasing hepatic microsomal fluidity compared with corn oil, but did not influence on HMG CoA reductase activity. Perilla oil did not influence on fecal excretion of total and primary bile acids, but reduced the excretion of secondary bile acids. Therefore, it could be recommended to consume more fish product and food rich in calcium and use more perilla oil in meal preparation to prevent from coronary hear disease and colon cancer especially when high fit diet has been practiced. (Korean Nutrition 31(9) : 1394-1403, 1998)

• Journal of Microbiology and Biotechnology
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• 제26권7호
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• pp.1198-1205
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• 2016

Lactic acid bacteria (LAB) have beneficial effects on intestinal health and skin diseases. Lipoteichoic acid (LTA), a cell wall component of gram-positive bacteria, is known to induce the production of several cytokines such as TNF-α, IL-1β, and IL-8 and affect the intestinal microflora, anti-aging, sepsis, and cholesterol level. In this study, Weissella cibaria was isolated from Indian dairy products, and we examined its immune-enhancing effects. Live and heat-killed W. cibaria did not induce the secretion of immune-related cytokines, whereas LTA isolated from W. cibaria (cLTA) significantly increased the secretion of TNF-α, IL-1β, and IL-6 in a dose-dependent manner. cLTA increased the phosphorylation of nuclear factor kappa-light-chain-enhancer of activated B cells, p38 mitogen-activated protein kinases, and c-Jun N-terminal kinases in THP-1 cells. The secretion of TNF-α and IL-6 was also increased in the cLTA-treated mouse splenocytes. These results suggest that cLTA, but not W. cibaria whole cells, has immune-boosting potential and can be used to treat immunosuppression diseases.

• 한국정보과학회논문지:소프트웨어및응용
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• 제35권11호
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• pp.681-691
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• 2008

본 논문은 통계 기반 한국어 화행분류를 위하여 필요한 각 자질이 분류 성능에 미치는 영향과 성능 향상에 기여하는 자질 조합을 비교 평가한다. 지지벡터기계 학습 방법을 이용하여 구현한 화행 분류시스템을 통해 실험한 결과, n-gram 자질 중 품사 바이그램은 유용하지 않으며 형태소-품사 쌍과 다른 자질들을 결합했을 때 성능이 향상됨을 알 수 있었다. 또한, 자질 선택 기법을 사용한 자질 비율에 따른 실험을 통해서 매우 적은 자질만으로도 화행 분류에 있어 어느 정도 안정된 성능을 낼 수 있었다. 아울러, 실험 결과의 분석을 통해 한국어에서 마지막 어절이 문장 전체의 화행분류에 중요한 역할을 하며, 한국어의 특징인 자유 어순이나 주어의 빈번한 생략 등이 화행 분류 실험의 성능에 영향을 미친다는 사실도 알 수 있었다.

• 한국동물위생학회지
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• 제32권3호
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• pp.265-273
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• 2009

A cross-sectional survey was undertaken to identify risk factors and clinical signs associated with parasitic helminth infections of cattle in Mymensignh district of Bangladesh. A nonrandom convenience sampling method was used to select 138 animals from 40 farmers/herds. The eggs per gram of faeces (epg) for nematodes and trematodes were determined by McMaster and Stoll's methods respectively. Animal-level and herd-level data were recorded by means of a questionnaire. Multi-collinearity amongst explanatory variables were assessed using $2{\times}2{\times}\;X^2$ test and one variable in a pair was dropped if $P{\leq}0.05$ formultiple logistic regression models. Association study between outcome and explanatory variables was conducted using classification tree, random forests and multiple logistic regression. A positive epg was considered as infected. Analyses were performed using $STATA^{(R)}$, version 8.0/Intercooled and $R^{(R)}$, Version 2.3.0. Seventy eight percent of the cattle were found to be infected with at least one type of helminth. Twenty four pairs of combinations of explanatory variables showed significant associations. Male animals (OR=3.3, P=.006, 95% CI=1.4, 7.7) were associated with significantly increased prevalence of nematode infection. Female cattle of the study area are mostly cross-breed, kept indoor, fed relatively good diet and not used for draught purpose. Males are used for draught purpose thereby more exposed to nematode infective stage and provided with relatively poor diet. So stressed male cattle may become more susceptible to nematode infection. All of the three statistical techniques selected gender and lumen motility as most important variables in association with nematode infection in cattle. The result of this survey can only be extrapolated to the periurban cattle population of traditional management system.

• 한국토양비료학회지
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• 제49권2호
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• pp.125-131
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• 2016

The biodegradable film application can escape from plastic environmental pollution. This experiments studied the effect of biodegradable mulch film on the soil microbial community using fatty acid methyl ester method in soybean production field. The soil $NO_3$-N content in polyethylene mulch film (PE) soil was significantly higher than biodegradable mulch film soil (p < 0.05). The soil microbial community of Gram negative bacteria showed significantly higher in biodegradable mulch film soil than PE mulch film soil (p < 0.05). In addition, biodegradable mulch film soil had significantly low ratio of cy17:0 to $16:1{\omega}7c$ and cy19:0 to $18:1{\omega}7c$ compared with those of PE mulch film soil (p < 0.05), indicating that microbial stress decreased. The ratio of cy17:0 to $16:1{\omega}7c$ and cy19:0 to $18:1{\omega}7c$ should be considered as a potential responsible factor for the obvious differentiation that was observed between the biodegradable mulch film soil and PE mulch film soil in a upland field. The results of this experimentation show the potential of using biodegradable mulch film in place of PE.

• 디지털융복합연구
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• 제12권6호
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• pp.655-667
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• 2014

본 연구는 질병과 관련한 온라인 포럼에서 추출한 언어 데이터를 통해 제 2형 당뇨병 환자의 질병에 대한 담론을 양적으로 분석하였다. 또한 환자 언어행위의 양적분석을 통해 환자들의 주요 관심사와 심리적 특징의 일반화가 가능한지에 대해 실증적으로 검증하였다. 분석방법으로는 기존의 인터뷰에 기반한 정성적 연구방법론과 달리 환자들의 담론 표본 전체를 파싱 (parsing)과 POS 태깅을 통해 언어학적으로 형태소 분류를 하였다. 주요 어휘빈도 추출과 N-gram을 통한 최빈도 구문구조 분석을 병행하여, 질병과 관련한 이슈의 주요 범주와 심리상태에 관한 언어적인 특징을 살펴보았다. 연구 결과 환자들의 자발적 대화는 주로 다이어트, 운동, 증상, 약물치료, 심리상태의 5가지 범주로 나타나고 있음을 확인하였고, 최빈도 구문구조 분석을 통해 질병치료와 식생활습관 개선 전반에 대한 부정적인 견해가 두드러진 것을 확인하였다. 결과적으로 의료진의 정확한 정보 전달과 전문가의 조언, 정서적 지원 등이 당뇨환자에 대한 심리적 상태에 중요한 만큼 심리치료 서비스이 개선이 필요할 것으로 보인다. 이런한 결과는 기존의 의료제도 안에서의 환자의 관심사와 심리적 특징이 온라인 상에서도 적절하게 투영되고 있음을 시사한다.

• 대한의생명과학회지
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• 제26권3호
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• pp.244-248
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• 2020

Skin and soft tissue infections caused by methicillin-resistant Staphylococcus aureus (MRSA) can occur especially in community populations such as military training camps. We investigated antimicrobial resistance patterns and molecular epidemiological characteristics of MRSA isolated from nasal swabs in healthy army trainees. From January 2018 to March 2018, one MRSA strain was isolated from nasal swab and hand of healthy army trainees. mecA gene detection, SCCmec and mec complex typing were performed to analyze the antimicrobial resistance patterns and molecular epidemiological characteristics of MRSA isolates. As a result, SCCmec and mec complex type of MRSA isolate from military trainees was not-typeable (n=1). In conclusion, not-typeable subtype of MRSA isolate from military trainees need to be confirmed by continuous follow-up study to determine whether there is a different genotype or a new subtype of genotype present in the Republic of Korea.

• 대한예방한의학회지
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• 제4권1호
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• pp.144-151
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• 2000

This study was carried out to evaluate cytotoxic effects of Houttuynia cordata Thunberg extracts on murine leukemia tumor cell lines. Disruptions in cell organelles were determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazol iumbromide (MMT) assay. The comparison of $IC_{50}$ values of Houttuynia cordata Thunberg extracts on $L1210,\;P388D_1$ and Vero cell lines showed that the methanol extract of Houttuynia cordata Thunberg indicated the most antitumor activity in the MTT assay. In order to develop a antimicrobial agent, dried Houttuynia cordata Thunberg was extracted with several solvents, and then antimicrobial activity was investigated. The minimal inhibitory concentration (MIC) of the extracted substance against microorganisms were also examined. Antimicrobial activity of amocla and ketoconazole as references was compared to those of other solvent extracts such as $H_2O$, n-hexane, chloroform, ethyl acetate ethanol and methanol. The antimicrobial activity of all extracts from the sample had growth inhibition activity against gram-negative bacteria, yam-positive bacteria and fungi $(MIC,\;>\;200\;{\mu} g/ml)$. These results suggest that the methanol soluble extract of Houttuynia cordata Thunberg may be a valuable choice for the studies on the treaeent of murine leukemia tumor cell lines and antimicrobial agents.

• 한국음향학회:학술대회논문집
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• 한국음향학회 1999년도 학술발표대회 논문집 제18권 1호
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• pp.82-85
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• 1999

본 연구에서는 연속음성인식 시스템의 성능 향상을 위하여 음성의 채록환경 및 데이터량 등을 고려한 효과적인 언어모델 작성방법을 제안하고, 이를 항공편 예약시스템에 적용하여 성능 평가 실험을 실시한 결과 $91.6\%$의 인식률을 얻어 제안한 방법의 유효성을 확인하였다. 이를 위하여 소량의 200문장의 항공편 예약 텍스트 데이터를 이용하여 좀더 강건한 단어발생 확률을 가지도록 하기 위해 일반적으로 대어휘 연속음성인식에서 많이 이용되고 있는 단어 N-gram 언어모델을 도입하고 이를 다양한 발성환경을 고려하여 1,154문장으로 확장한 후 동일 문장'을 반복 학습하여 언어모델을 작성하였다. 인식에 있어서는 오인식과 문법적 오류를 최소화하기 위하여 forward - backward pass 방법의 stack decoding알고리즘을 이용하였다. 인식실험 결과, 평가용 3인의 200문장을 각 반복학습 회수에 따라 학습한 각 언어모델에 대해 평가한 결과, forward pass의 경우 평균 $84.1\%$, backward pass의 경우 평균 $91.6\%$의 문장 인식률을 얻었다. 또한, 반복학습 회수가 증가함에 따라 backward pass의 인시률의 변화는 없었으나, forward pass의 경우, 인식률이 반복회수에 따라 증가하다가 일정값에 수렴함을 알 수 있었고, 언어모델의 복잡도에서도 반복회수가 증가함에 따라 서서히 줄어들며 수렴함을 알 수 있었다. 이상의 결과로부터 소량의 텍스트 데이터를 이용한 제한된 태스크에서 언어모델을 작성할 때 반복학습 방법이 유효함을 확인할 수 있다.

• 한국임상약학회지
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• 제30권3호
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• pp.196-205
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• 2020

Background: The indication of denosumab for osteoporosis was expanded from second-line to first-line therapy in 2019. The aim of this study was to evaluate the efficacy of denosumab as both first- and second-line therapy in postmenopausal women with osteoporosis and osteopenia with risk factors by using the Fracture Risk Assessment Tool (FRAX). Methods: We conducted a medication use evaluation of denosumab in 98 patients who had been treated three or more times for osteoporosis or osteopenia at Chungnam National University Hospital from July 1^st, 2017 to January 31^st, 2020. Risk factors were identified using quantitative N-gram analyses of FRAX estimations. Patient information, including menopause status and results of bone mineral density tests (T-score), was obtained from electronic medical records. Results: Age, body mass index (BMI), prior medication use, and T-score were identified as risk factors and were included as variables in the evaluation of denosumab use. Since no significant differences were detected between groups, denosumab is likely effective regardless of age or BMI. In addition, no significant difference was detected in T-scores following denosumab treatment, between groups who took bisphosphonates and selective estrogen receptor modulators (SERMs) with denosumab as first-line therapy for postmenopausal osteoporosis. Denosumab may, therefore, be effective as second-line therapy. Conclusion: Efficacy of denosumab was evaluated in postmenopausal women with osteoporosis. Denosumab may be used as first- and second-line therapy regardless of age, BMI, and prior use of bisphosphonates and SERMs.