• The Journal of Korean Institute of Communications and Information Sciences
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• v.28 no.7B
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• pp.647-659
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• 2003

LPM(Longest Prefix Matching)searching in If address lookup is a major bottleneck of IP packet processing in the high speed router. In the conventional lookup table for the LPM searching in CAM(Content Addressable Memory) the complexity of fast update take 0(1). In this paper, we designed pipeline architecture for fast update of 0(1) cycle of lookup table and high throughput and low area complexity on LPM searching. Lookup-table architecture was designed by CAM(Content Addressable Memory)away that uses 1bit RAM(Random Access Memory)cell. It has three pipeline stages. Its LPM searching rate is affected by both the number of key field blocks in stage 1 and stage 2, and distribution of matching Point. The RTL(Register Transistor Level) design is carried out using Verilog-HDL. The functional verification is thoroughly done at the gate level using 0.35${\mu}{\textrm}{m}$ CMOS SEC standard cell library.

• The Korean Journal of Physiology and Pharmacology
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• v.24 no.6
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• pp.493-502
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• 2020

Apigenin, a naturally occurring flavonoid, is known to exhibit significant anticancer activity. This study was designed to determine the effects of apigenin on two malignant mesothelioma cell lines, MSTO-211H and H2452, and to explore the underlying mechanism(s). Apigenin significantly inhibited cell viability with a concomitant increase in intracellular reactive oxygen species (ROS) and caused the loss of mitochondrial membrane potential (ΔΨm), and ATP depletion, resulting in apoptosis and necroptosis in monolayer cell culture. Apigenin upregulated DNA damage response proteins, including the DNA double strand break marker phospho (p)-histone H2A.X. and caused a transition delay at the G₂/M phase of cell cycle. Western blot analysis showed that apigenin treatment upregulated protein levels of cleaved caspase-3, cleaved PARP, p-MLKL, and p-RIP3 along with an increased Bax/Bcl-2 ratio. ATP supplementation restored cell viability and levels of DNA damage-, apoptosisand necroptosis-related proteins that apigenin caused. In addition, N-acetylcysteine reduced ROS production and improved ΔΨm loss and cell death that were caused by apigenin. In a 3D spheroid culture model, ROS-dependent necroptosis was found to be a mechanism involved in the anti-cancer activity of apigenin against malignant mesothelioma cells. Taken together, our findings suggest that apigenin can induce ROS-dependent necroptotic cell death due to ATP depletion through mitochondrial dysfunction. This study provides us a possible mechanism underlying why apigenin could be used as a therapeutic candidate for treating malignant mesothelioma.

• KIISE Transactions on Computing Practices
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• v.21 no.10
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• pp.639-644
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• 2015

The capacity of flash-based storage such as Solid State Drive(SSD) and embedded Multi Media Card(eMMC) is ever-increasing because of the needs from the end-users. However, if a flash-based storage crashes, such as during power failure, the flash translation layer(FTL) is responsible for the crash recovery based on the entire flash memory. The recovery time increases as the capacity of the flash-based storages increases. We propose O1FTL with O(1) crash recovery time that is independent of the flash capacity. O1FTL adopts the working area technique suggested for the flash file system and evaluates the design on a real hardware platform. The results show that O1FTL achieves a crash recovery time that is independent of the capacity and the overhead, in terms of I/O performance, and achieves a low P/E cycle.

• Nuclear Engineering and Technology
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• v.27 no.4
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• pp.555-561
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• 1995

This paper examines the applicability of the modified Borresen's coarse-mesh method(MBSN) to the core power distribution monitoring program development for the Yonggwang nuclear power plant unit 3(YGN 3) which uses fixed incore detectors for monitoring core power distribution. In so doing the modified Borresen's coarse-mesh equations are solved with core internal boundary conditions provided by the fixed incore detectors and three-dimensional core power distributions are com puted for the first-cycle core of the YGN 3 PWR. The results are compared with predictions of the COLSS(Core Operating Limit Supervisory System) which is the axial power shape monitoring program of the YGN 3. It is shown that the modified Borresen's method can reproduce the core axial power shape more closely than the COLSS. Because of other advantages in computing speed and predictive capability, n conclude that the proposed MBSN has a promising practical application for core power distribution monitoring program development.

• Korean Journal of Materials Research
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• v.24 no.5
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• pp.243-248
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• 2014

Silicon-carbon composite was prepared by the magnesiothermic reduction of mesoporous silica and subsequent impregnation with a carbon precursor. This was applied for use as an anode material for high-performance lithium-ion batteries. Well-ordered mesoporous silica(SBA-15) was employed as a starting material for the mesoporous silicon, and sucrose was used as a carbon source. It was found that complete removal of by-products ($Mg_2Si$ and $Mg_2SiO_4$) formed by side reactions of silica and magnesium during the magnesiothermic reduction, was a crucial factor for successful formation of mesoporous silicon. Successful formation of the silicon-carbon composite was well confirmed by appropriate characterization tools (e.g., $N_2$ adsorption-desorption, small-angle X-ray scattering, X-ray diffraction, and thermogravimetric analyses). A lithium-ion battery was fabricated using the prepared silicon-carbon composite as the anode, and lithium foil as the counter-electrode. Electrochemical analysis revealed that the silicon-carbon composite showed better cycling stability than graphite, when used as the anode in the lithium-ion battery. This improvement could be due to the fact that carbon efficiently suppressed the change in volume of the silicon material caused by the charge-discharge cycle. This indicates that silicon-carbon composite, prepared via the magnesiothermic reduction and impregnation methods, could be an efficient anode material for lithium ion batteries.

• Molecules and Cells
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• v.21 no.1
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• pp.112-120
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• 2006

It has been suggested that defective interfering (DI) RNA contributes to the persistence of Japanese encephalitis virus (JEV). In this study, we characterized molecular and biological aspects of the DI RNA and its relation to viral persistence. We identified a homologous DI virus intimately associated with JEV persistence in Vero cells. The production of DI RNA during undiluted serial passages of JEV coincided with the appearance of cells refractory to acute infection with JEV. We also established a Vero cell clone with a persistent JEV infection in which the DI RNA coreplicated efficiently at the expense of helper virus. The infectious virus yield of the clone fluctuated during its growth depending upon the amount of DI RNA accumulated in the previous replication cycle. Identification of the corresponding negative-sense RNA of the DI RNA indicated that the DI RNA functioned as a replication unit. Most of the DI RNA molecules retained their open reading frames despite a large deletion, encompassing most of the prM, the entire E, and the 5' half of the NS1 gene. Taken together, these observations suggest that the generation of homologous DI RNA during successive JEV acute infections in Vero cells probably participates actively in persistent JEV infection.

• Journal of Korea Multimedia Society
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• v.18 no.1
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• pp.25-34
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• 2015

Recently, in distribution market, demand for electronic shelf label system is increasing gradually to provide the accurate price immediately and detailed product information to consumers and reduce operation costs. Most of electronic shelf label system companies develop the full-graphic display device to display a wide variety of product information as well as the exact price. Our system had introduced Go-Back-N retransmission method in the early. However, we encountered performance problems that it delayed updating of the electronic shelf label system and exhausted the battery life time. Proposed adaptive image retransmission technique based on the selective scheme is that tags of electronic shelf label system recognize idle time of transmission cycle and require partial image retransmission to sever by itself. As a result, it can acquire much more opportunities of partial image retransmission within the same period and increase reception rate of full image for each tags. The experimental result shows that adaptive image retransmission technique's reception rate of full image for each tags is approximately 4% higher than existing previous works. And total battery life time increases 30 hours because tag reduce wake-up time as it receive only lost data instead of whole data.

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 2008.03a
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• pp.109-114
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• 2008

This paper presents the development status of a subscale precooled turbojet engine "S-engine" for the hypersonic cruiser and space place. S-engine employs the precooled-cycle using liquid hydrogen as fuel and coolant. It has $23cm{\times}23cm$ of rectangular cross section, 2.6 m of the overall length and about 100 kg of the target weight employing composite materials for a variable-geometry rectangular air-intake and nozzle. The design thrust and specific impulse at sea-level-static(SLS) are 1.2 kN and 2,000 sec respectively. After the system design and component tests, a prototype engine made of metal was manufactured and provided for the system firing test using gaseous hydrogen in March 2007. The core engine performance could be verified in this test. The second firing test using liquid hydrogen was conducted in October 2007. The engine, fuel supplying system and control system for the next flight test were used in this test. We verified the engine start-up sequence, compressor-turbine matching and performance of system and components. A flight test of S-engine is to be conducted by the Balloon-based Operation Vehicle(BOV) at Taiki town in Hokkaido in October 2008. The vehicle is about 5 m in length, 0.55 m in diameter and 500 kg in weight. The vehicle is dropped from an altitude of 40 km by a high-altitude observation balloon. After 40 second free-fall, the vehicle pulls up and S-engine operates for 60 seconds up to Mach 2. High altitude tests of the engine components corresponding to the BOV flight condition are also conducted.

• Journal of the Korea Society of Computer and Information
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• v.19 no.11
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• pp.33-41
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• 2014

In this paper, we implemented a system to measure respiration rate with nonrestraint sensors comfortable for people to do their everyday life. The proposed system consists of a pad covered with a Piezoelectric sensor, a respiration measuring device able to send the signal data after amplifying and filtering the source signals to the viewer, a viewer providing sensor data visualization and implementing the respiration measuring algorithm. The algorithm is based on a breathing cycle with the local peak points extracted from threshold on sensor data. Respiration measurements on 3 subjects were performed by changing moving averages and thresholds. The proposed system showed less than 5% error rate when proper moving averages are N=50~60 and a range of thresholds is 800~1300. The system will contribute to preventing suffocation during sleep for infants and the elderly living alone.

• Nuclear Engineering and Technology
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• v.47 no.7
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• pp.875-883
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• 2015

The use of subcritical aqueous homogenous reactors driven by accelerators presents an attractive alternative for producing $^{99}Mo$. In this method, the medical isotope production system itself is used to extract $^{99}Mo$ or other radioisotopes so that there is no need to irradiate common targets. In addition, it can operate at much lower power compared to a traditional reactor to produce the same amount of $^{99}Mo$ by irradiating targets. In this study, the neutronic performance and $^{99}Mo$, $^{89}Sr$, and $^{131}I$ production capacity of a subcritical aqueous homogenous reactor fueled with low-enriched uranyl nitrate was evaluated using the MCNPX code. A proton accelerator with a maximum 30-MeV accelerating power was used to run the subcritical core. The computational results indicate a good potential for the modeled system to produce the radioisotopes under completely safe conditions because of the high negative reactivity coefficients of the modeled core. The results show that application of an optimized beam window material can increase the fission power of the aqueous nitrate fuel up to 80%. This accelerator-based procedure using low enriched uranium nitrate fuel to produce radioisotopes presents a potentially competitive alternative in comparison with the reactor-based or other accelerator-based methods. This system produces ~1,500 Ci/wk (~325 6-day Ci) of $^{99}Mo$ at the end of a cycle.