• Molecules and Cells
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• v.42 no.4
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• pp.313-320
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• 2019

Intraepithelial lymphocytes (IELs) develop through the continuous interaction with intestinal antigens such as commensal microbiome and diet. However, their respective roles and mutual interactions in the development of IELs are largely unknown. Here, we showed that dietary antigens regulate the development of the majority of $CD8{\alpha}{\beta}$ IELs in the small intestine and the absence of commensal microbiota particularly during the weaning period, delay the development of IELs. When we tested specific dietary components, such as wheat or combined corn, soybean and yeast, they were dependent on commensal bacteria for the timely development of diet-induced $CD8{\alpha}{\beta}$ IELs. In addition, supplementation of intestinal antigens later in life was inefficient for the full induction of $CD8{\alpha}{\beta}$ IELs. Overall, our findings suggest that early exposure to commensal bacteria is important for the proper development of dietary antigen-dependent immune repertoire in the gut.

• Smart Media Journal
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• v.13 no.6
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• pp.62-71
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• 2024

This study applies topic modeling to uncover user experience and app issues expressed in users' online reviews of a fan community platform, Weverse on Google Play Store. It allows us to identify the features which need to be improved to enhance user experience or need to be maintained and leveraged to attract more users. Therefore, we collect 88,068 first-level English online reviews of Weverse on Google Play Store with Google-Play-Scraper tool. After the initial preprocessing step, a dataset of 31,861 online reviews is analyzed using Latent Dirichlet Allocation (LDA) topic modeling with Gensim library in Python. There are 5 topics explored in this study which highlight significant issues such as network connection error, delayed notification, and incorrect translation. Besides, the result revealed the app's effectiveness in fostering not only interaction between fans and artists but also fans' mutual relationships. Consequently, the business can strengthen user engagement and loyalty by addressing the identified drawbacks and leveraging the platform for user communication.

• BMB Reports
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• v.49 no.6
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• pp.325-330
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• 2016

T-complex protein 10A homolog 2 (TCP10L) was previously demonstrated to be a potential tumor suppressor in human hepatocellular carcinoma (HCC). However, little is known about the molecular mechanism. MAX dimerization protein 1 (MAD1) is a key transcription suppressor that is involved in regulating cell cycle progression and Myc-mediated cell transformation. In this study, we identified MAD1 as a novel TCP10L-interacting protein. The interaction depends on the leucine zipper domain of both TCP10L and MAD1. TCP10L, but not the interaction-deficient TCP10L mutant, synergizes with MAD1 in transcriptional repression, cell cycle G1 arrest and cell growth suppression. Mechanistic exploration further revealed that TCP10L is able to stabilize intracellular MAD1 protein level. Consistently, the MAD1-interaction-deficient TCP10L mutant exerts no effect on stabilizing the MAD1 protein. Taken together, our results strongly indicate that TCP10L stabilizes MAD1 protein level through direct interaction, and they cooperatively regulate cell cycle progression.

• Science of Emotion and Sensibility
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• v.10 no.2
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• pp.155-168
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• 2007

Social and psychological experiences in human-agent interactions are becoming more important than the task-oriented efficiency, as the influence of computer agents increases and human-agent interaction develops similarly with interpersonal interaction. Many previous studies aimed to increase social presence in human-agent interaction, in order to derive users' positive psychological experiences, by applying the factors of interpersonal communication to verbal and non-verbal communication of the agents. This study examined the effects of the exchanges of mutual self-disclosure, one of the most important communication acts in interpersonal communication, between users and interface agents. Users' attachment styles towards the perception of social presence, the evaluations toward the agents, user experiences, and the intentions for future interaction were also studied. The mediating role of social presence in dependent variables was, also, examined in this research. The results showed that exchanging self-disclosures with an agent increased the perceptions of social experience, friendly evaluations toward the agent, positive user experience, and the intentions for future interaction. Participants' attachment styles, also, affected the perceptions of the dependent variables. The effects of the exchanges of self-disclosure and participants' attachment styles were mediated by perceived social presence toward the agent. The findings of this study imply that the social and communicational aspects need to be considered in design of the agents seriously. The results also suggest that there may be differences in the psychological effects of agents on users according to the users' personality.

• Journal of Korea Water Resources Association
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• v.54 no.7
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• pp.509-522
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• 2021

In many countries, including Korea, it has been challenging to understand flood-related social dynamics due to urbanization and climate change. In this regard, socio-hydrology has been proposed to consider the interaction between hydrologic systems, land-use change, and human activities. However, there is a general lack of understanding of the interactions of socio-hydrologicsystems. This study examines the interactions between human activities and hydrologic systems from a sociological perspective using a dynamic system model. In other words, this study aims to present a conceptualization model that considers the mutual interaction of flood and community from a socio-hydrologic perspective. Depending on the construction cost of the levee for the Yangjae River, this study considered three scenarios to simulate the interaction of socio-hydrologic systems. Socio-hydrologic interactions can effectively reproduce the changes in the Yangjae River. Moreover, It is expected that the proposed model can be further used to understand possible hydrologic changes and interaction with social systems in the future as a decision-making tool in water resources management.

• Korean Institute of Interior Design Journal
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• v.20 no.6
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• pp.262-271
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• 2011

The purpose of this study was to classify types of family visitors' behaviors more concretely, which could be useful in planning of exhibition spaces in a science museum, with given priority to their behaviors according to interaction between them, and to understand characteristics of the behaviors. With this view, the scope of this study was restricted to subjects, who were family visitors of Gwacheon National Science Museum, consisting of parents and their one elementary school child per family unit. For understanding their behaviors, itinerary tracking and observation method of behavior were conducted. Moreover, for understanding substantial types and characteristics of family visitors' behaviors, multivariate analysis was applied. Accordingly, the results of the study are as follows. First, as a result of factor analysis, two main factors were derived. In other words, they were 'Durability of viewing' as the first and 'Interactivity between family members' as the second, which were shown valid in classification of the types of their behaviors. Second, according to the factors derived, the types of their behaviors were classified into in-depth cooperative viewing, selective independent viewing, interest concentration child-led viewing and consideration parent-led viewing. They were shown valid in topological localization and classification, as a result of analysis of the main factors. Third, in view of common characteristics of the types, it is judged that active orientation prior to regular viewing could encourage visitors coming to the museum for the first time to feel more friendly to unfamiliar exhibition environments, during the initial seek time, and to reduce visual supersaturation. Fourth, it is judged that distributed arrangement of exhibits, which result in continuous standby, could avoid confused visitor circulation by the estimated time required for viewing.

• The Transactions of the Korean Institute of Electrical Engineers C
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• v.51 no.3
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• pp.105-110
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• 2002

J-aggregates in the mutual mixing LB films of [6Me-DS]$_{1-x}$ [DO]$_{x}$,[DS]$_{1-x}$ [DO]$_{x}$ and [DSe]$_{1-x}$ [DO]$_{x}$ have been studied by optical absorption, fluorescence and surface pressure-area isotherms. In [6Me-DS]$_{1-x}$ [DO]$_{x}$ films, sharp J-band absorption and fluorescence of [6Me-DS] are linearly shifted to the longer wavelength for the replacement of [6Me-DS] by [DO]. According to the x, a smooth shift of the limited area has been cleared. In the [DS]-[DO] system, the J-band is enhanced at 1:1 composition and strong fluorescence is also observed. Also, the presence of phase separation was suggested in the [DSe]-[DO] system, because the absorption spectra were decomposed into [DSe] and [DO] spectra. On the other hand, in the pressure-area isothermal study, reduction in the molecular occupying area of monolayers has been clarified. This could be ascribed to the enhancement of molecular ordering in J-aggregates. These facts are also believed to reflect the most closely packed arrangement of chromophores in the merocyanine dye monolayers. Thus, it was confirmed that the interaction between mixed dye molecules and the CdC1$_2$+KHCO$_3$subphases affected the J-aggregates of the LB films. Also. it is thought that the J-aggregates are formed non-dimensionally in LB films, such as solution synthesized [DX:DO] assemblies on mixing.s on mixing.

• 한국가시화정보학회:학술대회논문집
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• 2007.11a
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• pp.134-137
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• 2007

The temporal evolution of wake behind a circular cylinder oscillating rotationally with a relatively high forcing frequency has been investigated experimentally using a dynamic PIV technique. Experiments were carried out with varying the frequency ratio $F_R\;(=f_f/f_n)$ in the range from 0.0 (stationary) to 1.6 at oscillation amplitude of ${\theta}_A=30^{\circ}$ and Reynolds number of $Re=4.14{\times}10^3$. Depending on the forcing condition ($F_R$), the flow was divided into three regimes; non-lock-on ($F_R=0.4$), transition ($F_R=0.8$, 1.6) and lock-on regimes ($F_R=1.0$) with markedly different flow structure in the near-wake region behind the cylinder. When the frequency ratio was less than 1.0 ($F_R{\le}1.0$), the rotational oscillatory motion of the cylinder decreased the length of the vortex formation region and enhanced the mutual interaction between large-scale vortices across the wake centerline. The entrainment of ambient fluid seemed to play an important role in controlling the near-wake flow and shear-layer instability. However, the flow characteristics changed markedly beyond the lock-on flow regime ($F_R=1.0$) due to high-frequency forcing. At $F_R=1.6$, the mutual interactions between the vortices shed from both sides of the cylinder were not so strong. Thereby, the flow entrainment and momentum transfer into the wake center region were reduced. In addition, the size of the large-scale vortices decreased since the lateral extent of the wake was suppressed.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.7 no.4
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• pp.9-20
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• 2012

The purpose of this research is to confirm how the determinant factors for shopping mall selection (proximity, parking facility, benefits, mutual interaction effects, physical environment, surroundings) affect attractiveness (image and appraisal) of the traditional markets and revisit intention and suggest strategic methods for revitalization of the traditional markets. Results of this research are drawn from a survey of customers who visit any of the twenty-two traditional markets in the Seoul area at least twice a week. Moreover, the theory is verified through the structural equation model analysis using the SPSS win 18.0 and AMOS 18 version statistics package. From the determinant factors of visiting traditional markets, parking facility, physical environment, and the surroundings were significant in image attractiveness; benefits, mutual interaction effects, and physical environment showed significant effects on appraisal attractiveness. Additionally, image attractiveness was not significantly influential in retention proneness while appraisal attractiveness was a key factor in deciding whether or not to revisit. Therefore, improvement in image is important but appraisal aspects like product reliability that customers can personally assess, are more essential for revitalization of traditional markets.

• Journal of Intelligence and Information Systems
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• v.16 no.3
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• pp.37-54
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• 2010

The information system that preserves and presents information collections, records, processes, retrievals, is applied in various fields recently and is supporting man's many activities. Conventional information systems are based on the reactive interaction model. Such reactive systems respond to only specific instructions, i.e. the defined commands, from the user. To go beyond the reactive interaction, it is necessary that the interactive dynamic interaction based information system which understands human's action and intention autonomously and then provides sensible information adapted to the user. Therefore, we propose a Gaze Mirroring-based intelligent information system for making user's latent interest using the internal state estimation methods based on the interactive dynamic interaction. Then, the proposed Gaze Mirroring method is that an anthropomorphic agent(avatar) actively established the joint attention with the user by imitating user's eye-gaze behavior. We verify that the Gaze Mirroring can elicit the user's behavior reflecting the latent interestand contribute to improving the accuracy of interest estimation. We also have confidence that the Gaze Mirroring promotes the self-awareness of interest. Such a Gaze Mirroring-based intelligent information system also provides suitable information to user by making user's latent interest using the internal state estimation.