• Molecules and Cells
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• 제25권4호
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• pp.531-537
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• 2008

Abnormal activation of nuclear factor kappa B ($NF-{\kappa}B$) probably plays an important role in the pathogenesis of Duchenne's muscular dystrophy (DMD). In this report, we evaluated the efficacy of curcumin, a potent $NF-{\kappa}B$ inhibitor, in mdx mice, a mouse model of DMD. We found that it improved sarcolemmic integrity and enhanced muscle strength after intraperitoneal (i.p.) injection. Histological analysis revealed that the structural defects of myofibrils were reduced, and biochemical analysis showed that creatine kinase (CK) activity was decreased. We also found that levels of tumor necrosis factor alpha ($TNF-\alpha$), interleukin-1 beta ($IL-1\beta$) and inducible nitric oxide synthase (iNOS) in the mdx mice were decreased by curcumin administration. EMSA analysis showed that $NF-{\kappa}B$ activity was also inhibited. We thus conclude that curcumin is effective in the therapy of muscular dystrophy in mdx mice, and that the mechanism may involve inhibition of $NF-{\kappa}B$ activity. Since curcumin is a non-toxic compound derived from plants, we propose that it may be useful for DMD therapy.

• Archives of Pharmacal Research
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• 제2권2호
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• pp.121-125
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• 1979

Piperine showed a central nervous system depressant activity which was characterized by the antagonistic effect against chemoshock seizure as well as potent muscular incoordination in mice.

• 한국정밀공학회지
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• 제29권9호
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• pp.1026-1034
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• 2012

The purpose of this study was to verify the validation of effect on improvement of muscle strength unbalance according to exercise load deviation during rowing exercise. We performed evaluation of muscular activity and joint torque before the test. We recruited twenty subjects who one side's muscle strength is bigger in more 20% than other side. Subjects divided two groups. One is dominant left side and the other was dominant right side. Subjects performed rowing exercise in electric load deviation rowing equipment (Robo.gym, Humonic Co., Ltd., Daegu, Korea). Exercise performed four sets a day including 25 times a set, and three days a week. Measurements consist of evaluation of muscular activity and joint torque. Exercise load deviation adapted that different value of muscle strength in both arms multiplied 1RM% and added 1RM 50%. The results in adapted load deviation showed that the differences of maximal peak torque in 22.75% were getting increase significantly during exercise in 5.72%. This interpreted that rowing exercise with loading deviation types could provide muscle strength and muscular endurance exercise in same time for balance. Our study found out that loading deviation could provide muscle strength and muscular endurance exercise for improving muscle unbalance.

• 수산해양교육연구
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• 제26권3호
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• pp.525-534
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• 2014

This study has examined the effect of after-school physical activity on body composition and health related fitness of middle school students. The duration of after-school physical activity training program of this study is 12 weeks, the training time in 1 hours warming-up 10 minutes, the skill training 45 minutes and cool down did in 5 minutes. Exercise frequency is 5 time per week. Height basketball class, soccer class, subject class showed statistically meaningful increase between group variance showed statistically meaningful. Weight basketball class, soccer class, showed statistically meaningful decrease. Muscle mass basketball class showed statistically meaningful increase, soccer class showed statistically meaningful decrease. Cardiopulmonary basketball class, soccer class, showed statistically meaningful decrease. Explosive muscular strength basketball class, soccer class, showed statistically meaningful decrease. subject class showed statistically meaningful increase, between group variance showed statistically meaningful. Flexibility basketball class showed statistically meaningful increase, soccer class. Muscular strength basketball class, soccer class, subject class showed not statistically meaningful different.

• Biomolecules & Therapeutics
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• 제7권4호
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• pp.335-341
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• 1999

Antidiabetic activity and mechanism of Supungsungihyan(SPSGH) were examined in db/db mice, which is a spontaneously hyperglycemic, hyperinsulinemic and obese animal model. SPSGH and acarbose were administered orally for 4 weeks. Fasting and non-fasting serum glucose, glycated hemoglobin and trig-lyceride of SPSGH treated group were all reduced when compared with those of db/db control group. At 12th week after birth, SPSGH increased an insulin secretion although statistic significance was not seen. Total activities of sucrose, maltase and lactase in SPSGH treated group were not significantly different from those in db/db control. On the other hand, sucrase and maltase activities in acarbose treated groups were increased. Effect of SPSGH on mRNA expression of glucose transporter(GLUT-4) was also examined by RT-PCR and in vitro transcription with co-amplification of rat $\beta$-actin gene as an internal standard. Muscular GLUT-4 mRNA expression in SPSGH treated group was increased significantly. These results may suggest that SPSGH lowered blood glucose ascribing to upregulation of muscular GLUT-4 mRNA expression.

• 한국운동역학회지
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• 제17권4호
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• pp.107-113
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• 2007

The purpose of this study were to investigate the effects of knee brace on the knee muscular neuro-biomechanical variables during the rebound in female highschool basketball players. Twelve high school female ($17.9{\pm}0.8years$) basketball players rebound jumped for maximal vertical height to sufficiently stress the anterior cruciate ligament with and without knee brace. Kinematic data were collected to estimate the knee flexion, abduction angles and jump height. The EMG data from the biceps femoris and rectus femoris was used to estimate the ratio of quadriceps muscle activity. Female athletes with knee brace showed more reduced the knee abduction angle and the ratio of quadriceps muscle activity at foot contact phase than without knee brace. In conclusion, Female athletes with brace reduced knee anterior cruciate ligament loads.

• PNF and Movement
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• 제10권1호
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• pp.35-41
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• 2012

Purpose : This study was conducted to identify the effects of high heel shoes on surface electromyography(EMG) activities fo tibialis anterior(TA), soles(S), and gastrocnemius(G) in 12 healthy women. Methods : Subjects were composed of three group(sports shoes, 5cm heel height shoes, and 9cm heel height shoes). The muscle activity of the TA, G, S in the lower leg were measured using a surface EMG. Results : Results of one way repeated measures ANOVA of the after waling 30minutes standing task duration among the sport shoes, 5cm, and 9cm heel height conditions. The comparison of the muscular activities showed significant differences in the G muscles among the high heel shoes. Conclusion : Wearing high heel shoes for hours will bring inappropriate alignment of the lower limbs and cause postural changes or abnormal sensation and several other problems in the body, resulting in exposure to ankle sprain or fall injuries.

• 한국콘텐츠학회논문지
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• 제13권9호
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• pp.270-280
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• 2013

본 연구의 목적은 선천성 근육사경과 산모의 직업적 활동 간의 관련성을 알아보는 것이다. 2006년부터 2011년 4월까지 수원 "C" 병원 재활의학과를 내원한 선천성 근육사경아동의 산모 89명을 대상으로 실시하였다. 결과는 첫째, 연구대상자의 일반적 특성을 보면, 출산 평균연령은 30.09세, 교육수준은 대졸이상이 많았으며, 초산이 82.0%로 나타났으며, 자연분만, 제왕절개, 흡입분만 순이었고, 분만 시 둔위여부는 20.2%로 나타났으며, 첫째 아동이 사경인 경우가 82.0%로 나타났고, 둘째, 연구대상자의 직업적 특성에서 직장생활을 한 산모가 59.6%이고 전문가 및 관련종사자가 45.3%를 차지하였고, 직장생활을 임신 3기까지 한 산모가 75.5%로 나타났고, 주로 서서 일하는 자세보다 앉아서 일하는 자세로 앉아서 일하는 시간이 7시간 이상이 54.7%로 나타났으며, 하루 평균 근무시간은 8.75시간으로 나타났고, 셋째, 연구대상자의 직무스트레스는 하위 25%이하 수준으로 나타났으며, 하위 요인별 정도에선 관계갈등영역에서만 상위 50%이상으로 나타났다. 넷째, 연구대상자의 직무스트레스와 직업적 업무 특성간의 상관관계를 보면, 스트레스(100점 환산)와 직무스트레스의 직무요구, 관계갈등, 보상 부적절, 직장문화와 양의 상관관계가 높게 나타났으며, 직장문화와 보상 부적절간에도 양의 상관관계가 높게 나타났다. 직업적 업무 중 하루 평균 근무시간과 평균 일주일 근무시간과 양의 상관관계가 높게 나타났다.

• PNF and Movement
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• 제14권3호
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• pp.245-254
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• 2016

Purpose: This study investigates the influence of elastic resistance exercise using proprioceptive neuromuscular facilitation (PNF) on the daily activities of a patient with incomplete spinal cord injury. The result will be proposed as background data for effective intervention in a patient with incomplete spinal cord injury. Methods: The target subject was a patient with incomplete spinal cord injury to the cervical cord (C6). Elastic resistance exercise based on PNF was performed for 30 min daily, five times a week, for eight weeks. The ASIS motor scale was applied to test the muscular strength of the upper limb, and the spinal cord independence measure II (SCIM II) was used to evaluate the capacity of daily activity. Results: By applying elastic resistance exercise based on PNF, the muscular strength of the upper limb increased and the performance of daily activity improved. Conclusion: Because elastic resistance exercise based on PNF positively influences the ASIA motor scale and SCIM II of the patient with incomplete spinal cord injury. It can be used for training programs to improve the capacity of daily activity of the patient.

• 비파괴검사학회지
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• 제29권3호
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• pp.224-229
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• 2009

An experimental study was conducted to investigate the effects of turtle neck syndrome, so called, on muscular fatigue and muscle activity. Six subjects (males) participated and performed the prolonged casual computer work in the study. EMG signals from six muscles of the dominant neck-back region were acquired and recorded for 10 seconds at the beginning and the end of three hours computer work. EMG was recorded from six muscles by using a computerized data recording and analysis system. Power spectrum function of EMG was calculated off-line by means of a signal processing software package. Power spectrum functions were smoothed with a moving average filter of 21 points and normalized with respect to the maximal value achieved during the trials. Muscle activity and median frequencies of Sternocleidomastoid(SCM) in turtle neck posture was approximately 51%, which were less than those in normal neck posture. SCM also showed the biggest decrease in median frequency. Results will provide the insight into the neck-back injury mechanism of turtle neck patients. Furthermore, they will be helpful in developing rehabilitation programs for restoring patients' neck-back functions.