• Applied Microscopy
• /
• 제25권4호
• /
• pp.26-51
• /
• 1995

The present study was designed to examine effect of long term weight-training on aging atrophy in the rat skeletal muscle. Male rats of 8, 15, and 24 month old were used. Each age groups included control and weight-training for 5 months by using body press apparatus. The histo- and cytochemical, ultrastructural and stereological changes in aging skeletal muscles of the rat were observed in the present study. During the training period the body weight and muscular weight in all groups except the rectus femoris and the gastrocnemius in young age groups remained constant, but muscular weights were increased in the rectus femoris and the gastrocnemius muscles in young age groups. In trained rat, the volume density of muscle fiber type IIA and IIB were increased, but those of type IIC was decreased. Type I remained constant in 8 and 15 month old age groups, but reduced in the tibialis anterior and the gastrocnemius muscles in the 24 month old groups. Some histotological and ultrastructural changes associated with age were found: numerical increase of cytiplasmic vacuoles, lysosomes, lipofuscins, and irregularity of myofibrils. At 24 month old groups some unusual formation of contraction band and muscle splitting were observed. After weight-training, ultrastructural degenerative changes occured in the type I muscle fiber, such as splitting of muscle fiber, disorganization of myofilaments, swelling of mitochondria, accumulation of many lipid droplets, appearance of many lysosomes and residual bodies and necrotic fibers, in the old age groups. But, in the type II muscle fibers hypertrophy of muscle fiber appeared without any noticible damage as the type I. The activities of $Mg^{++}$ -ATPase decreased with age and this enzyme activities in the trained rat were significantly decreased with age. Activities of the acid phosphatase were increased with age and significantly in the trained rat. In stereological analysis, volume density of the myofibrils and the tubular system were increased, on the other hand there mitochondrial capacity was decreased. These experimental results suggested that old rats are not susceptible to be affected by weight-training as young rats, and that physical capacity of the rats must be considered when old rats are exercised for training.

• 생명과학회지
• /
• 제27권11호
• /
• pp.1340-1348
• /
• 2017

Sanguinarine은 다양한 목적으로 사용되고 있는 Sanguinaria canadensis L.의 뿌리에서 유래된 benzophenanthridine alkaloid 계열 물질중의 하나이다. 그동안 sanguinarine의 다양한 약리학적인 효능이 알려져 왔고, 항암활성에 대한 연구도 여러 암세포들을 대상으로 수행되어 왔다. 그러나 sanguinarine에 의한 암세포의 apoptosis 유도에 대한 현상은 여전히 많은 부분에서 연구의 대상으로 남아 있다. 본 연구는 Hep3B 인체 간암세포를 대상으로 sanguinarine의 항암활성에 대한 추가적인 자료를 제시하기 위하여 수행되었다. 본 논문의 결과에 의하면, sanguinarine은 처리 농도 의존적으로 Hep3B 세포의 증식을 억제하였으며, 이는 apoptosis 유도와 연관성이 있었다. Sanguinarine은 두 가지 apoptosis 경로인 extrinsic 및 intrinsic 경로의 개시 initiator caspase인 caspase-8 및 caspase-9 뿐만 아니라 대표적인 effector caspase인 caspase-3의 활성을 증가시켰고, caspase-3의 기질인 PARP의 분절을 유발하였다. 아울러 sanguinarine은 DR-related 유전자들의 발현을 부분적으로 증가시켰으며, Bcl-2 family에 속하는 pro-apoptotic Bax의 발현을 증가시킨 반면, anti-apoptotic Bcl-2의 발현은 억제시켰다. 또한 sanguinarine은 Bid의 truncation을 촉진하였고, MMP의 소실에 따른 cytochrome c를 미토콘드리아에서 세포질로의 이동을 증가시켰다. 그리고 sanguinarine에 의한 apoptosis 유도 및 세포 증식율 억제 현상이 caspase의 활성을 인위적으로 억제하였을 경우, 모두 사라졌다. 따라서 sanguinarine에 의하여 유도하는 Hep3B 세포의 apoptosis 유발에는 caspase 의존적으로 extrinsic 및 intrinsic 경로가 모두 관여하고 있음을 알 수 있었다.

• 대한인간공학회지
• /
• 제25권2호
• /
• pp.1-10
• /
• 2006

In spite of the rapid increase of computer use in our everyday life, not much effort is undertaken to take measures to prevent Musculoskeletal Disorders(MSDs). In this paper, we suggest a movable armrest which would lower the exposure to the MSDs, especially on the vicinity of arm. The aim of this study is to determine whether there are differences in wrist angle variations, forearm muscular loads, comfort and normal performance between the invented movable armrest and a conventional armrest when using a computer mouse. Eight experienced VDU workers performed a standardized simple task set which consists of 15 detailed tasks with each armrest. The wrist angle variations in the right arm were registered by electrogoniometer and the muscle activities in the shoulder, deltoid and two extensors in the forearm were also registered by electromyograph. The subjects rated perceived comfort while performing the tasks with each armrest. Working with the invented armrest, compared to general, gave significantly decreased wrist angle variations at most of the detailed tasks of both biaxial movements. Moreover, as the distance of targets increased, the difference of muscle activities in two different situations trend to be increasing. At the same time, in work with invented armrest, the subjects rated more comfort and they showed decreased normal performances in 8 detailed tasks which were mainly caused by macro moving time.

• 한국정밀공학회지
• /
• 제34권2호
• /
• pp.115-123
• /
• 2017

This paper presents the design and the control performance of a novel dynamic compliant-arm support with parallel elastic actuators that was developed to assist with the daily living activities of those whose arms are compromised by muscular disease or the aging process. The parallel elastic-arm support consists of a compliant mechanism with combined passive and active components for human interaction and to reach the user's desired positions. The achievement of these tasks requires impedance control, which can change the virtual stiffness, damping coefficients, and equilibrium points of the system; however, the desired-position tracking by the impedance control is limited when the end-effector weight varies according to the equipping of diverse objects. A prompt algorithm regarding weight calibration and friction compensation is adopted to overcome this problem. A result comparison shows that, by accurately assessing the desired workspace, the proposed algorithm is more effective for the accomplishment of the desired activities.

• 동의생리병리학회지
• /
• 제19권3호
• /
• pp.596-599
• /
• 2005

Human health is affected by not only physical conditions but also mental and social well-being. Changes of human emotions show up as gestures, facial expressions and sweating. Human emotions are affected by such automatic nerve system functions as blood pressure, blood circulation speed, heart beats, pupillary reflex, fluid transfusion, muscular contraction and digestive organs, all of which influence the holistic diseases. The Oriental Medicine sees from a perspective of unity of divinity and men that human life activities are united in terms of their physical and mental functions. From such a perspective, human Five Organs are linked with Five Mental(五神) and Seven Emotions(七情), while they are affected by each other, influencing the life activities both directly and indirectly. Based on Confucianism, Sa-Sang Theory argues that human emotions can be categorized into four energy states and therefore, that human diseases and physiological conditions there of may be determined differently depending on the Four Energies(四氣). There seems to be some common points between Sa-Sang Theory and the conventional Oriental Medicine in that human emotions affect individuals' health conditions, so there seems to be much room for mutual complementation.

• Physical Therapy Rehabilitation Science
• /
• 제10권3호
• /
• pp.367-373
• /
• 2021

Objective: Short foot exercise(SFE) is frequently used to increase the medial longitudinal arch of the foot, as well as the intrinsic foot muscles. This studyinvestigated the effects of SFE onmuscular activity and the onset of contraction of the quadriceps femoris muscle during squats in healthypeople. It also aimed to compare and analyze the results with those of the general squat method and propose a more efficient squat method. Design: Cross-sectional study. Methods: This study compared 20 adults (male=10, female=10) who statisfied the inclusion criteria for the muscle activity and onset of the muscle contraction of the quadriceps femoris using surface EMG under two conditions: general squats and SFE squats. Results: Separate analyses and comparisons of the outcomes of the SFE squat and the general squat, showed a significant increase in the muscle activities of the rectus femoris and vastus medial muscles in both males and females (p<0.05). The onset of muscle contraction was significantly delayed for the vastus lateralis relative to that for the vastus medialis (p<0.05). However, it delayed significantly in females, but not in males. Conclusions: The SFE squats induced selective muscular activities of the rectus femoris and vastus medialis muscels and affected the onset of contraction of the vastus medialis and lateralis muscles.

• PNF and Movement
• /
• 제22권1호
• /
• pp.151-158
• /
• 2024

Purpose: The present study investigated how variations in diagonal exercises affect shoulder muscle activity, examining changes in neuromuscular activation during scapular and shoulder diagonal patterns of exercises. Furthermore, we explored whether the exercise phase affects muscle activation. Methods: Sixteen asymptomatic male participants were recruited. Four diagonal pattern exercises (scapular anterior elevation, posterior elevation, flexion-adduction-external rotation, flexion, abduction-external rotation), and two exercise phases (concentric and eccentric) were administered. Surface electromyography data were collected. Results: Upper trapezius activity was significantly higher during the concentric phase of scapular posterior elevation exercises compared with the others (p<0.05). The serratus anterior, anterior deltoid, and infraspinatus activities were significantly higher during shoulder diagonal pattern exercises compared with the scapular diagonal pattern exercises (p<0.05). Except for the lower trapezius, muscular activities during the concentric phase were significantly greater compared with the eccentric phase (p<0.05). Conclusion: The current study suggests that the diagonal pattern of exercise may contribute to selective strengthening of the shoulder complex muscles and that the form of exercise should be tailored to the subject. It also suggests that diagonal exercises with concentric contractions tend to be more beneficial than eccentric contractions for overall muscle recruitment, but the effects vary for specific diagonal patterns.

• PNF and Movement
• /
• 제19권1호
• /
• pp.147-152
• /
• 2021

Purpose: This study was conducted to investigate the functional differences of the two heads of the biceps brachii by measuring the functions in supination according to pronation by the angle of the flexion of the elbow joint, except for the activities of the elbow flexors. Methods: This study was conducted with 25 healthy men in their 20s. At a glenohumeral-joint 0˚ flexion posture, angles of flexion of the elbow joint of 0˚, 30˚, 60˚, 90˚, and 120˚ were randomly provided, and they were asked to perform supination and pronation with an elastic band. Using an eight-channel surface electromyogram, the muscle activities of the long and short heads of the biceps brachii were measured. The activities of the short and long heads according to the angle were analyzed using a one-way ANOVA, and as a post-test, LSD was employed. Results: The analysis of the impact of the resistance of the elastic band in supination on the differences in the muscle activities in the short and long heads suggests there was a significant difference between 0˚ and 30˚ (p < 0.05). Conclusion: In supination according to forearm pronation, the long head had greater action in the early flexion posture of the elbow joint, and it is judged that the ratio of the flexion of the elbow joint according to the actions of the biceps brachii was considered small.

• PNF and Movement
• /
• 제6권2호
• /
• pp.1-10
• /
• 2008

Purpose : The purpose of this study was to investigate the effect of aquatic exercise applied PNF patterns on body composition and balance performance in people who have had a stroke. Methods : Forteen candidates who have all experienced a stroke were participating in a community based rehabilitation program, have been included in this study. The program was conducted three times weekly, 1 hour per session, for 10 consecutive weeks. Subjects were tested with body composition and 5 items of Berg's balance test at pre-training and post-training. Total balance indexes in 3 conditions were measured by K.A.T. 3000. The aquatic exercise applied PNF patterns was consisted of PNF patterns and various aquatic activities. Results : After ten weekends of aquatic exercise training, there were not significant difference in body composition(p>.05) except of muscular weight of affected lower extremity(p<.05). But edema index increased more than pre-training (p<.05). Subjects showed significant difference in Berg's balance test results except of 2 items of Berg's balance test (p<.05). Total balance index score when subjects opened their eyes and didn't hold the handle was decreased less than pre-training(p<.05). Conclusion : The results of this study showed that intervention of this aquatic exercise program applied PNF patterns could increase edema index and muscular weight of affected lower extremity and improve the balance performance in people who have had a stroke.

• 국제물리치료학회지
• /
• 제2권1호
• /
• pp.214-221
• /
• 2011

The purpose of this study is to investigate and reveal the effects that the complex exercise training consisting of aerobic exercise and strength training(sit up, push up) that everyone can easily practice regardless of a time and a place in order to manage practically the physical strength of the aged affects the difference on their body composition and the change of physical fitness level. Looking into the change of body composition of an experimental group, the weight of 2.5kg was reduced after applying complex training for 12 weeks and the body fat mass of 2.65kg was reduced. Also, the abdominal fat of 0.13% was decreased and the muscle mass of 1.56kg was increased. For the change factors of physical fitness, cardiovascular endurance, muscular strength, muscular endurance, balance and flexibility excluding agility showed significant improvement after applying complex exercise training. The improvement of health fitness of the aged under this study was significantly effective to improve specified body functions which had been lowered by aging and insufficient physical activities. So, it is regarded that their health fitness is the important factor to improve the activity competence required for daily life and to lead healthy living by the improved activity competence. Henceforth, it needs to study more the complex composition of several sports, exercise intensity and the frequency based on the previous researches and studies. In addition, it needs to develop the complex exercise training in accordance with various characteristics such as a sex of the aged, an age, a physical fitness level, environment, a disease and the program in consideration of the efficacy and safety during training.