• YAKHAK HOEJI
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• v.45 no.1
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• pp.78-84
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• 2001

Heme oxygenase is a rate-limiting enzyme in heme catabolism that cleaves heme to form biliverdin, iron, and carbon monoxide. Heme oxygenase-1 is expressed in many types of cells and tissues and is highly induced in response to oxidative stress. Carbon monoxide, one of the products of heme oxygenase, can stimulate soluble guanylate cyclase and dilate the vascular smooth muscle. So, the induction of heme oxygenase by lipopolysaccharide (LPS)-induced oxydative stress and the effect of the resultant carbon monoxide on aortic contractility were examined in this study. Zinc protoporphyrine IX (ZnPP), a inhibitor of heme oxygenase, elicited weak contraction of thoracic aortic ring, and this effect was more potent in aorta of LPS-treated rats than control and was blocked by methylene blue. The hyperreactivity to ZnPP in LPS-treated group was blocked by co-treatment with aminoguanidine. In the aortic ring of LPS-treated rats, ZnPP didn't change the vasoreactivity to phenylephrine or acetylcholine. ZnPP elicited hyper-tensive effect in concious rats, and pretreatment with LPS did not affect this effect. Prazosin significantly diminished the hypertensive effect of ZnPP. These results indicate that LPS induced heme oxygenase in aotra, and the resultant carbon monoxide diminished the aortic reactivity to vasoconstrictor.

• Proceedings of the Ginseng society Conference
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• 1998.06a
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• pp.182-189
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• 1998

Administration of ginsenosides, a mixture of saponin extracted from Panax ginseng, decreased blood pressure in rat. Previous studies have shown that ginsenosides caused endothelium-dependent relaxation, which was associated with the formation of cyclic GMP, suggested that ginsenosides caused release of nitric oxide (NO) from the vascular endothelium. The aim of the present study was to characterize the endothelium-independent relaxation to ginsenosides in the isolated rat aorta. Ginsenosides caused a concentration-dependent relaxation of rat aortic rings without endothelium constricted with 25 mM KCI but affected only minimally those constricted with 60 mM KCI. Ginsenoside Rg3 (Rg3) was a more potent vasorelaxing agonist than total ginsenoside mixture and also the ginsenoside PPT and PPD groups. Relaxation to ginsenosides were markedly reduced by TEA, but not by glibenclamide. Rg3 significantly inhibited Cal'-induced concentration-contraction curves and the "50a2'influx in aortic rings incubated in 25 mM KCI whereas those responses were not affected in 60 mM KCI. Rg3 caused efflux of $"Rb in aortic rings that was inhibited by tetraethy- lammonium (TEA), an inhibitor of Ca"-dependent K'channels, but not by glibenclamide, an inhibitor of AfP-dependent K'channels. These findings indicate that ginsenosides may induce vasorelaxation via activation of Ca2'-dependent K'channels resulting in hyperpolarization of the vas- cular smooth muscle with subsequent inhibition of the opening of voltage-dependent Caf'channels. These effects could contribute to explain the red ginseng-associated vasodilation and the beneficial effect on the cardiovascular system.

• Bulletin of the Korean Institute for Industrial Safety
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• v.3 no.1
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• pp.11-17
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• 2003

In recent years, work-related musculoskeletal disorders (WMSDs) are one of major issues in occupational safety and health in Korea, since the number of injured workers has rapidly increased and the related regulation was amended to improve the work conditions. Main risk factors of WMSDs in Korean industries include manual handling of heavy weight loads, awkward postures, repetitive tasks, prolonged static muscle contraction, and so on. in this article, some ergonomics case studies for identifying the risk factors of WMSDs and far their prevention were introduced. They include a biomechanical analysis for the heavy-weight handling task in a machine-repair shop, physiological evaluation of backpack-carrying tasks in a beverage delivery job, and a set of psychophysical studies to evaluate static-postural load. These studies showed that there are several different ergonomic approaches to identifying and evaluating risk factors of WMSDs and to eliminating them or reducing their levels, and that it is important to select proper methods and apply them in improving the work conditions according to the characteristics of the task. In addition, it needs to develop practical and effective ergonomic tools to prevent WMSDs and to provide these tools to the safety managers in the field so that they can improve the tasks by themselves.

• PNF and Movement
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• v.6 no.1
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• pp.27-32
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• 2008

Purpose : The purpose of this study is to review of effect of the PNF application for improvement of the basic physical fitness in the elderly. Methods : By using internet, we research the PubMed, Science Direct, KISS, DBpia and the article on the effect of PNF. We selected the article between 1970 and 2007. Key words were PNF, Exercise, Elderly. Results : PNF refers to any of several post-isometric relaxation stretching techniques in which a muscle group is passively stretched, then contracts isometrically against resistance while in the stretched position, and then is passively stretched again through the resulting increased range of motion. Most PNF techniques employ isometric agonist contraction/relaxation where the stretched muscles are contracted isometrically and then relaxed. The most common PNF techniques are CR, HR, CRAC, HR-AC, AC. PNF exercise effected on the muscular strength and flexibility and balance and ROM in the elderly. Conclusion : PNF is a safety and effective exercise to improve the muscular strength and flexibility and balance and ROM in the elderly. Therefore, we suggest that PNF need to generalize for the elderly.

• Journal of the Ergonomics Society of Korea
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• v.28 no.4
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• pp.17-23
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• 2009

The purpose of this study was to assess activation and contribution of muscles of the elderly according to increased loading during the arm flexion extension resistance exercise. Surface electromyographic signals were acquired from biceps brachii, triceps brachii, deltoid posterior, pectoralis major and latissimmus dorsi to determine the difference of the activation of specific muscles between the elderly and young. Five elderly and five young males with no musculoskeletal disease volunteered for the study. Electromyographic activities in the muscles were measured during resistance exercise and normalized to the maximum EMG activity recorded in the maximal voluntary static contraction (MVC). Against the increased loading during arm flexion/extension resistance exercises, the young uses muscles evenly but the elderly uses one specific muscle frequently. Contribution of triceps brachii during extension and deltoid posterior during flexion was principal in the elderly.

• Physical Therapy Korea
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• v.4 no.1
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• pp.70-77
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• 1997

An A-B-A-C single subject research design was used to assess the effectiveness of transcutaneous electrical nerve stimulation(TENS) and inhibitive techniques on spasticity in a 10-year-old girl with cerebral palsy. Stimulation electrodes were placed over the sural nerve of the right leg. The standard method of cutaneous stimulation, TENS with impulse frequency of 100 Hz, was applied. Inhibitive techniques including stretch, antagonist contraction, and weight bearing were used. The tonus of the leg muscle was measured by means of a surface-EMG biofeedback unit. Visual analysis of data indicate that the child showed clinically significant reduction of spasticity in passive ankle movement following 30 minutes of TENS and inhibitive techniques application, respectively. The effect of TENS on spasticity inhibition was similar to that of inhibitive techniques. This result suggests that for this child with cerebral palsy, the application of TENS to the sural nerve may induce short-term post-stimulation inhibitory effects on the spasticity of cerebral palsy. Replication of this study with a more complex single-subject design involving more subjects is recommended to confirm this result.

• Proceedings of the Korea Society of Environmental Biology Conference
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• 2003.11a
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• pp.86-91
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• 2003

In this study, in order to examine whether salt and heat shock stress would alter or not contraction and relaxation of isolated rat aorta. Under anesthesia with sodium pentobarbital(50 mg Kg$^{-1}$ i.p.), male Sprague Dawley rats weighing 300-330 g were subjected to 0, heat shock combined salt stress, where as the sham group was left at modified Krebs-bicarbonate solution. To measure contractile response of vascular ring preparation isolated from rat was determined in organ bath and was recorded on physiograph connected to isometric transducer. And the strip was checked for expression of heat shock protein(Hsps) by means of western blotting. The combination group of heat and 50 mM NaCl group increased vascular contractility, and the heat and 150 mM NaCl group decreased vascular contractility for 5 hours, and then recovered for 8 hours compared to that of control. Expressin of Hsp 70 of vascular muscle of rat aorta more increased by combination of heat and NaCl treatment than those of single treatment of heat or NaCl treatment, and vascular Hsp 70 showed a little decrease at 8 hours compared at 5 hours. These result indicate that mixed environmental stress either increased or decreased in vascular contractility by combination of heat and NaCl concentration.

• The Korean Journal of Physiology and Pharmacology
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• v.5 no.1
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• pp.47-53
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• 2001

Drinking excessive alcohol has been recognized as a risk factor for hypertension. However, the mechanism by which alcohol intake causes hypertension still remains elusive. We tested the hypothesis that ethanol itself acts as a stress factor on vasculature and indirectly modulates vascular contractility. After end of exposure to 1, 2.5 and 5% ethanol for 45 min, rat aortic strips were subjected to contractile responses, immunoblot for Hsp70 and the measurement of levels of myosin light chain phosphorylation. Exposure to 5% ethanol not only augmented contractions to KCl or phenylephrine, but also increased expression of Hsp70 and the levels of myosin light chain phosphorylation. There were no significant differences in contractions produced by $1\;{\mu}mol/L$ phorbol 12,13-dibutyrate, a protein kinase C activator, whether the tissues were exposed to 5% ethanol or not. This is the first report to show that even short exposure to ethanol has a delayed effect to increase vascular smooth muscle contractility through a modulation of thick filament regulation. It may be a mechanism by which ingestion of alcohol induces hypertension.

• Archives of Plastic Surgery
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• v.45 no.3
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• pp.214-221
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• 2018

Clarification is needed regarding the definitions and classification of groove and hollowness of the infraorbital region depending on the cause, anatomical characteristics, and appearance. Grooves in the infraorbital region can be classified as nasojugal grooves (or folds), tear trough deformities, and palpebromalar grooves; these can be differentiated based on anatomical characteristics. They are caused by the herniation of intraorbital fat, atrophy of the skin and subcutaneous fat, contraction of the orbital part of the orbicularis oculi muscle or squinting, and malar bone resorption. Safe and successful treatment requires an optimal choice of filler and treatment method. The choice between a cannula and needle depends on various factors; a needle is better for injections into a subdermal area in a relatively safe plane, while a cannula is recommended for avoiding vascular compromise when injecting filler into a deep fat layer and releasing fibrotic ligamentous structures. The injection of a soft-tissue filler into the subcutaneous fat tissue is recommended for treating mild indentations around the orbital rim and nasojugal region. Reducing the tethering effect of ligamentous structures by undermining using a cannula prior to the filler injection is recommended for treating relatively deep and fine indentations. The treatment of mild prolapse of the intraorbital septal fat or broad flattening of the infraorbital region can be improved by restoring the volume deficiency using a relatively firm filler.

• Fashion & Textile Research Journal
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• v.21 no.2
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• pp.209-219
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• 2019

This study analyzed and compared wearer mobility for different types of clothing that also included the potential to develop firefighter station uniforms using range of motion (ROM) and electromyography (EMG). This study focused on a comparison of wearer mobility affected by different materials and shapes of the station uniforms worn under firefighter turnout gear. Japanese standard uniform (UNI), stretch-wear (ST), and compression-wear (CP) were used as station uniforms for the experiment. This study analyzed wearer movements and quantified ROM and EMG. In addition, the subjective evaluation of wearer mobility and comfort were assessed for comparisons. Nine healthy male students participated in the experiment. Wearer mobility was analyzed using ROM and EMG data obtained by measuring five motions; in addition, subjective evaluations were also obtained. As compared with the standard station uniform, ROM increased 6.8 % and 7.2 % due to stretch-wear and compression-wear. The benefits of wearing stretch material or compression material to improve muscle performance (such as reduced percent of maximum voluntary contraction) were not proven. Differences between materials and designs influenced subjective wearer comfort. In particular, the wearing of compression materials was shown best in terms of wearer comfort that may also allow greater wearer mobility.