• 보건행정학회지
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• 제29권4호
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• pp.469-481
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• 2019

Background: As South Korea is becoming an aged society very rapidly, the increase in osteoarthritis prevalence raises various public health issues in this country. This study aimed to explore the socio-demographic factors associated with osteoarthritis in the current Korean elderlies. Methods: Using the National Survey of Korean Elderly data (2014, 2017), we analyzed 20,326 elderlies (males, 8,248; females, 12,078) and conducted multivariate logistic regression analyses by sex. The dependent variable is whether a participant was diagnosed with osteoarthritis or not. Independent variables of interest is socio-demographic factors such as age, marital status, household type, residential area, household income, religion, the longest job, the number of close relatives, the number of close friends, and survey year. Control variables are various health behavioral factors and disease-related factors. Results: Prevalence of osteoarthritis was 19.2% in male elderlies and 47.0% in female elderlies. According to the results of the multivariate logistic regression adjusted for all studied control variables, the odds ratio (OR) for having osteoarthritis of under-elementary school graduates (their counterpart was college graduate group) was 1.81 (95% confidence interval [CI], 1.29-2.52) in males and 1.67 (95% CI, 1.12-2.47) in females. The OR of those having a job in agriculture & forestry fishery as their longest job (their counterpart was those who had never participated in labor force during their lifetime) was 5.07 (95% CI, 1.46-17.58) in males and 1.49 (95% CI, 1.27-1.74) in females. In males, the second-low quartile group in household yearly income (their counterpart was the highest quartile group) had the OR of 1.22 (95% CI, 0.98-1.53). In females, the OR of those having a religion of Buddhism (their counterpart was those having no religion) was 1.20 (95% CI, 1.07-1.35) and the OR of those who had no relatives (their counterpart was those having more than 3 close relatives) was 1.31 (95% CI, 1.10-1.56). Conclusion: This study found that in Korean elderlies, education, the longest job, household income, religion, and the number of close relatives are associated with their suffering from osteoarthritis. Further study and designing appropriate interventions are needed to alleviate current and future individual and socioeconomic burdens of osteoarthritis in an aged society like South Korea.

• Bulletin of the Korean Chemical Society
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• 제30권5호
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• pp.1121-1126
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• 2009

This paper describes a pattern recognition method of Magnoliae flos based on a gas chromatographic/mass spectrometric (GC/MS) analysis of the essential oil components. The botanical drug is mainly comprised of the four magnolia species (M. denudata, M. biondii, M. kobus, and M. liliflora) in Korea, although some other species are also being dealt with the drug. The GC/MS separation of the volatile components, which was extracted by the simultaneous distillation and extraction (SDE), was performed on a carbowax column (supelcowax 10; 30 m{\time}0.25 mm{\time}0.25{\mu}m$) using temperature programming. Variance in the retention times for all peaks of interests was within RSD 2% for repeated analyses (n = 9). Of the 74 essential oil components identified from the magnolia species, approximately 10 major components, which is $\alpha$-pinene, $\beta$-pinene, sabinene, myrcene, d-limonene, eucarlyptol (1,8-cineol), $\gamma$-terpinene, p-cymene, linalool, $\alpha$-terpineol, were commonly present in the four species. For statistical analysis, the original dataset was reduced to the 13 variables by Fisher criterion and factor analysis (FA). The essential oil patterns were processed by means of the multivariate statistical analysis including hierarchical cluster analysis (HCA), principal component analysis (PCA) and discriminant analysis (DA). All samples were divided into four groups with three principal components by PCA and according to the plant origins by HCA. Thirty-three samples (23 training sets and 10 test samples to be assessed) were correctly classified into the four groups predicted by PCA. This method would provide a practical strategy for assessing the authenticity or quality of the well-known herbal drug, Magnoliae flos.

• 한국노년학
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• 제36권3호
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• pp.541-562
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• 2016

본 연구는 가교일자리에서의 근로가 베이비부머의 결혼만족도의 변화에 어떠한 영향을 미치며, 그 과정에서 일자리 특성의 변화가 매개역할을 하는가를 검증하였다. 구체적으로 본 연구는 '한국 베이비부머 패널 조사' 1-3차년도(2010-2014년) 자료를 활용하여 다변량 잠재성장모형의 분석을 실시하였다. 분석결과, 생애주된일자리에서 가교일자리로 이동하는 것은 근로소득의 변화율을 매개로 하여 결혼만족도의 변화율에 부적인 영향을 미치는 것으로 나타났다. 즉, 1-3차년도 사이에 가교일자리로 이동한 베이비부머의 근로소득이 현저히 감소하였고, 그로 인해 생애주된일자리를 유지한 자에 비하여 결혼만족도가 보다 완만하게 상승하는 효과가 있었다. 반면에, 가교일자리에서 근로를 지속하는 것은 직업몰입의 변화율을 매개로 하여 결혼만족도의 변화율에 정적인 영향을 미쳤다. 즉, 1차년도에 이미 가교일자리에서 일하고 있었으며 이후 가교일자리에서 계속 일한 경우에는 생애주된일자리를 유지한 경우에 비하여 직업몰입이 더 가파르게 상승하였고, 그로 인해 결혼만족도가 더 가파르게 높아졌다. 본 연구결과는 부부관계를 재정립하는 중년기에 생애주된일자리에서 가교일자리로 이동하는 것이 생애주된일자리를 유지하는 것에 비하여 결혼만족도의 상승을 저해하는 효과가 있으나, 그 효과가 지속되지는 않음을 시사한다. 또한 본 연구는 가교일자리에서의 근로가 결혼만족도의 변화에 영향을 미치는 메커니즘을 실증적으로 분석하였다는 의의를 갖는다. 후속연구에서는 가교일자리로의 이동 시의 소득감소가 결혼만족도의 변화에 미치는 부정적 효과를 완충할 수 있는 중재요인을 탐색하는 것이 필요하다.

• 보건행정학회지
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• 제34권1호
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• pp.87-93
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• 2024

연구배경: 최근 건강기능식품 섭취에 따른 의료비 절감효과에 대해 상이한 연구결과들이 제시되면서 논쟁이 불거졌다. 이에 따라 본 연구는 건강기능식품 섭취 여부가 의료비 지출에 미친 영향을 분석하고자 한다. 방법: 2019-2020년의 제2기 한국의료패널 자료에서 2년간 건강기능식품을 섭취한 군과 섭취하지 않은 군을 확인하고 이들의 일반적 특성 차이를 배제하고자 성향점수매칭기법을 통해 1:1 매칭 데이터를 추출하였으며 두 군의 연간 총 의료비를 비교하였다. 더불어 의료비 지출에 대한 건강기능식품 섭취 여부의 영향을 확인하기 위해 다변량 회귀분석(Proc Surveyreg)을 실시하였다. 결과: 건강기능식품 섭취군은 약 172만 원을, 미섭취군은 약 143만 원을 의료비로 지출하였다(p=0.0186). 다변량 회귀분석 결과, 섭취군이 미섭취군에 비해 약 26.15% 더 많은 의료비를 지출하는 것으로 확인되었다(p=0.0004). 결론: 건강기능식품 섭취가 의료비를 절감시킨다는 이전 연구들과 달리, 본 연구에서는 건강기능식품을 지속적으로 섭취하는 사람들이 의료서비스 지출이 더 큰 것으로 나타났다. 이는 건강기능식품 섭취가 질병 예방이나 의료비 절감의 관점보다는 건강에 관심 있는 사람들이 건강관리를 위해 취하는 행동임을 제시한 이전 연구들과 같은 맥락으로 해석될 수 있다. 그러나 의료패널 자료의 다양한 한계점으로 인해 주의 깊은 해석이 필요하다. 향후 개인수준의 코호트 자료를 활용한 인과성 규명이 필요하다.

• Journal of the Korean Wood Science and Technology
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• 제48권5호
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• pp.591-607
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• 2020

This study was aimed to investigate the changes of chemical composition of the volatile organic compounds (VOCs) emitted from red pine needles in the process of needle abscission or senescence. The VOCs in intact, senescent, and litter red pine needle samples were analyzed by headspace-solid phase microextraction gas chromatography-mass spectrometry (HS-SPME-GC/MS). And then, multivariate statistical interpretation of the processed data sets was conducted to investigate similarities and dissimilarities of the needle samples. Principal component analysis (PCA) and orthogonal partial least squares discriminant analysis (OPLS-DA) were used to investigate the dataset structure and discrimination between samples, respectively. From the data preview, the levels of major components of VOCs from needles were not significantly different between needle samples. By PCA investigation, the data reduction according to classification based on the chlorophyll a / chlorophyll b (Ca/Cb) ratio were found to be ideal for differentiating intact, senescent, and litter needles. The following OPLS-DA taking Ca/Cb ratio as y-variables showed that needle samples were well grouped on score plot and had the significant discriminant compounds, respectively. Several compounds had significantly correlated with Ca/Cb ratio in a bivariate correlation analysis. Notably, the litter needles had a higher content of oxidized compounds than the intact needles. In summary, we found that chemical compositions of VOCs between intact, senescent, and litter needles are different each other and several compounds reflect characteristic of needle.

• Journal of Korea Trade
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• 제23권5호
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• pp.129-144
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• 2019

Purpose - Recent empirical studies have reached mixed results on the effects of financial liberalization and currency crises. We argue that this relationship is likely to depend both on whether controls are primarily on the degrees of financial liberalization and on the stability of the government. Using the disaggregated data on financial liberalization recently developed by Abiad et al (2010) for a sample of 30 emerging countries over the period 1995-2015, we attempt to investigate the political economy determinants of currency crises. Design/methodology - Our empirical model considers the relationship between financial liberalization and currency crises for emerging market economies. This study employs the existing theoretical framework to identify the disaggregate level for financial liberalization across countries. Using a multivariate logit model, this study attempts to estimate the interrelationship among financial liberalization, government stability and currency crises complemented by a case study of South Korea. Findings - Our main findings can be summarized as follows: we find strong support for the proposition that more liberalized financial institutions are positively associated with the probability of currency crises especially under less stable governments, but reduce the risks of currency crises especially for more stable governments. We also examine the role of financial systems with the case of South Korea after Asian financial crises and the results are further supported and consistent with the empirical findings. Originality/value - Existing studies focus on the economic factors across countries. This paper instead attempts to evaluate the effects of financial liberalization and currency crises by incorporating political considerations with newly developed dataset on financial liberalization, which are essential to the understanding of the causes of currency crises.

• Genomics & Informatics
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• 제20권3호
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• pp.27.1-27.13
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• 2022

Oral squamous cell carcinoma (OSCC) is the most prevalent head and neck malignancy, with frequent cervical lymph-node metastasis, leading to a poor prognosis in OSCC patients. The present study aimed to identify potential markers, including microRNAs (miRNAs) and genes, significantly involved in the etiology of early-stage OSCC. Additionally, the main OSCC's dysregulated Gene Ontology annotations and significant signaling pathways were identified. The dataset GSE45238 underwent multivariate statistical analysis in order to distinguish primary OSCC tissues from healthy oral epithelium. Differentially expressed miRNAs (DEMs) with the criteria of p-value < 0.001 and |Log2 fold change| > 1.585 were identified in the two groups, and subsequently, validated targets of DEMs were identified. A protein interaction map was constructed, hub genes were identified, significant modules within the network were illustrated, and significant pathways and biological processes associated with the clusters were demonstrated. Using the GEPI2 database, the hub genes' predictive function was assessed. Compared to the healthy controls, main OSCC had a total of 23 DEMs. In patients with head and neck squamous cell carcinoma (HNSCC), upregulation of CALM1, CYCS, THBS1, MYC, GATA6, and SPRED3 was strongly associated with a poor prognosis. In HNSCC patients, overexpression of PIK3R3, GIGYF1, and BCL2L11 was substantially correlated with a good prognosis. Besides, "proteoglycans in cancer" was the most significant pathway enriched in the primary OSCC. The present study results revealed more possible mechanisms mediating primary OSCC and may be useful in the prognosis of the patients with early-stage OSCC.

• Genomics & Informatics
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• 제21권1호
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• pp.8.1-8.19
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• 2023

Cancer of the stomach is the second most frequent cancer-related death worldwide. The survival rate of patients with gastric cancer (GC) remains fragile. There is a requirement to discover biomarkers for prognosis approaches. Helicobacter pylori in the stomach is closely associated with the progression of GC. We identified the genes associated with poor/favorable prognosis in H. pylori-induced GC. Multivariate statistical analysis was applied on the Gene Expression Omnibus (GEO) dataset GSE54397 to identify differentially expressed miRNAs (DEMs) in gastric tissues with H. pylori-induced cancer compared with the H. pylori-positive with non-cancerous tissue. A protein interaction map (PIM) was built and subjected to DEMs targets. The enriched pathways and biological processes within the PIM were identified based on substantial clusters. Thereafter, the most critical genes in the PIM were illustrated, and their prognostic impact in GC was investigated. Considering p-value less than 0.01 and |Log2 fold change| as >1, five microRNAs demonstrated significant changes among the two groups. Gene functional analysis revealed that the ubiquitination system, neddylation pathway, and ciliary process are primarily involved in H. pylori-induced GC. Survival analysis illustrated that the overexpression of DOCK4, GNAS, CTGF, TGF-b1, ESR1, SELE, TIMP3, SMARCE1, and TXNIP was associated with poor prognosis, while increased MRPS5 expression was related to a favorable prognosis in GC patients. DOCK4, GNAS, CTGF, TGF-b1, ESR1, SELE, TIMP3, SMARCE1, TXNIP, and MRPS5 may be considered prognostic biomarkers for H. pylori-induced GC. However, experimental validation is necessary in the future.

• 한국지리정보학회지
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• 제14권4호
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• pp.128-136
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• 2011

새만금 방조제 건설 및 토지 개발사업에 따른 해양환경변화 모니터링 및 예측을 위하여 2002년부터 실시간 또는 정기 해양관측 및 수치모델 시뮬레이션을 수행하고 있다. 새만금 해양환경자료는 크게 해양기상, 해양물리/해수유동, 해양수질, 해양생태계, 해저 지형/지질 분야로 분류되며, 각 분야별 관측 및 예측을 통해 지속적으로 생산되는 자료는 10여년에 걸쳐 축적되고 있다. 수집된 해양환경자료는 대용량의 다차원 다변수 시 공간적 분포 특성을 갖는 이질적 자료이기 때문에 이러한 특성을 고려하여 효과적으로 자료의 수집 처리 관리 제공이 가능한 정보시스템 개발은 필수적이다. 이에 본 논문에서는 지리정보시스템과 연계된 웹 기반 새만금 해양환경정보시스템 구축을 통하여 분야별로 축적된 새만금 해양환경정보를 통합적으로 수집 관리하며, 직관적이고 효율적인 웹 사용자 인터페이스 구성과 statistical graphs 및 thematic cartography를 적용한 자료의 과학적 가시화를 통해 방대하고 복잡한 자료의 효과적인 조회 및 분석이 가능하다. 나아가 지오프로세싱을 통한 공간분석을 통해 장기간에 걸친 변화 양상에 대한 정량적 분석을 통하여 새만금의 친환경적 개발을 위한 과학적 근거 제시 및 의사결정 지원을 위한 도구로 활용되고 있다. 또한 원활한 웹 기반 정보 서비스를 위해 다중 맵 캐쉬, 다중 레이어, 공간 데이터베이스 구축 등도 병행되었다.

• 대한치과교정학회지
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• 제39권2호
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• pp.112-119
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• 2009

본 연구는 다변량 기법을 도입하여 치아 크기의 다양성을 고려하면서 정확성이 높은 혼합치 열기 분석법을 개발하기 위해 시행되었다. 견치 및 소구치 크기를 예측하는 데 이용된 변수는 상악 중절치, 상악 제1대구치, 하악 중절치, 하악 측절치 및 하악 제1대구치로서 총 5개 치아 크기 변수가 이용되었다. 우선 정상교합자 연구 표본 307명을 5개 치아 변수를 이용하여 k-means 군집 분석으로 치아 크기에 따라 나눈 후 판별식을 이용, 치아 크기가 큰 그룹과 작은 그룹으로 분류하였다. 이후 견치와 소구치 크기의 합을 예측하기 위하여 남녀별, 상하악별, 치아 크기 그룹별로 다중선형 분석을 이용하여 회귀식을 구했다. 검증 표본에는 504명의 부정교합자가 이용되었으며, 이들에 대하여 정상교합자로부터 도출된 판별식을 이용하여 2그룹으로 할당한 후 정상교합자로부터 도출된 회귀식을 이용하여 상악과 하악의 견치 및 소구치 크기 합을 예측하였다. 오차 분석 결과 정상교합자는 최대 0.71, 부정교합자 검증표본은 최대 0.82 mm의 residual standard deviation 값을 보였다. 부정교합 분류별, 치아 크기 패턴별로 예측 오차의 유의한 차이는 없었다. 1 mm 및 2 mm 이상의 예측 오차를 보인 빈도는 각각 17.3%와 1.8%였다. 본 연구 결과 도출된 혼합치열기 분석법은 기존의 연구들과 비교하여 그 정확성이 높은 것으로 고찰되었다. 다만, 임상 적용 시 복잡한 계산 과정으로 인하여 전산화 환경에서 더욱 유용할 것으로 생각된다.