• Title/Summary/Keyword: Multistep

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Study on mechanism of multistep hepatotumorigenesis in rat : Bio-indices on hepatic tumorigenesis (간암의 다단계 발생기전에 관한 연구: 종양형성 과정에서의 생체지표)

  • Kang, Chung-boo;Kim, Chi-kyeong;Song, Seung-hee;Ha, Woo-song
    • Korean Journal of Veterinary Research
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    • v.41 no.4
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    • pp.583-589
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    • 2001
  • To estalish bio-indices for detection of the development of multistep hepatotumorigenesis, rats were fed water containing 0.01% diethylnitrosamine (DEN) ad libitum for 13-14 weeks. Hepatocellular carcinoma was developed by treatment with DEN, DEN only was able to induce hepatic tumors in rats without any other cocarcinogen. Compared to control group, liver cytosol protein concentration in all treated grous was significantly decreased (p<0.05). From week to week, $20{\alpha}$-hydroxysteroid dehydrogenase ($20{\alpha}$-HSD) activity was increased and the highest activity was observed on the 12th week (p<0.05). In addition, the urine biopterin concentration was also significantly increased compared to control groups (p<0.05) in a time course manner. These results indicated that $20{\alpha}$-HSD activity, urine biopterin and liver cytosol protein concentration might be very useful maker to hepatic tumorigenesis.

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Complete Decomposition of Chlorinated-Organic Compounds(PCB, 4-DCBz) with Improved Supercritical Water Oxidation Method (개량된 초임계수 산화법에 의한 염소계 유기물(PCB, 4-DCBz)의 완전분해반응)

  • Lee Sang-Hwan;Park Ki-Chul;Park Yoon-Yul;Yang Jong-Gyu;Kim Jung-Sung;Hiroshi Tomiyasu
    • Journal of Environmental Science International
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    • v.14 no.5
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    • pp.513-520
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    • 2005
  • For the destruction of toxic chlorinated organic compounds, this study proposes improved supercritical water oxidation method (multistep oxidation) using sodium nitrate as an oxidizer. This method solves the problems involved in the existing supercritical water oxidation method. Multistep oxidation means that $NaNO_3$ is oxidized to $N_2\;via\;NaNO_2$ and NO. Toxic and hard to destroy organic substances like para-dichlorobenzen(4-DCBz), polychlorinate biphenyl(PCB) ware oxidized to non toxic substances in a condition, in which rapid pressure and temperature rise is restrained as much as possible. 4-dichlorobenzene(4-DCBz) and Polychlorinate biphenyl(PCB) in condition$(450^{\circ}C,\;p_w=0.25g/cm^3,\;30min)$ Was discomposed perfectly.

Parameter Estimation of a Small-Scale Unmanned Helicopter by Automated Flight Test Method (자동화 비행시험기법에 의한 소형 무인헬리콥터의 파라메터 추정)

  • Bang, Keuk-Hee;Kim, Nak-Wan;Hong, Chang-Ho;Suk, Jin-Young
    • Journal of Institute of Control, Robotics and Systems
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    • v.14 no.9
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    • pp.916-924
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    • 2008
  • In this paper dynamic modeling parameters were estimated using a frequency domain estimation method. A systematic flight test method was employed using preprogrammed multistep excitation of the swashplate control input. In addition when one axis is excited, the autopilot is engaged in the other axis, thereby obtaining high-quality flight data. A dynamic model was derived for a small scale unmanned helicopter (CNUHELI-020, developed by Chungnam National University) equipped with a Bell-Hiller stabilizer bar. Six degree of freedom equations of motion were derived using the total forces and moments acting on the small scale helicopter. The dynamics of the main rotor is simplified by the first order tip-path plane, and the aerodynamic effects of fuselage, tail rotor, engine, and horizontal/vertical stabilizer were considered. Trim analysis and linearized model were used as a basic model for the parameter estimation. Doublet and multistep inputs are used to excite dynamic motions of the helicopter. The system and input matrices were estimated in the frequency domain using the equation error method in order to match the data of flight test with those of the dynamic modeling. The dynamic modeling and the flight test show similar time responses, which validates the consequence of analytic modeling and the procedures of parameter estimation.

Blind Direct Decision Feedback Equalization using Prediction Error Filters (예측 오류 필터를 이용한 블라인드 결정 궤환 등화기 추정 기법)

  • 유화선;홍대식
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.28 no.3C
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    • pp.279-285
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    • 2003
  • In this paper we propose a blind decision feedback equalizer (DFE) that is characterized by the fact that it does not require channel estimation. Because the output of the optimized multistep prediction error filter (PEF) can be represented as a product of the channel partial impulse response and the transmitted sequence, a backward multistep PEF can be used as the blind DFE feedforward filter (FFF). The corresponding feedback filter (FBF) is obtained from the symbol -rate partial channel impulse response. The proposed algorithm has several advantages over existing blind channel estimation techniques, including stable performance without the necessity of exact channel order estimation.

MULTI-BLOCK BOUNDARY VALUE METHODS FOR ORDINARY DIFFERENTIAL AND DIFFERENTIAL ALGEBRAIC EQUATIONS

  • OGUNFEYITIMI, S.E.;IKHILE, M.N.O.
    • Journal of the Korean Society for Industrial and Applied Mathematics
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    • v.24 no.3
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    • pp.243-291
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    • 2020
  • In this paper, multi-block generalized backward differentiation methods for numerical solutions of ordinary differential and differential algebraic equations are introduced. This class of linear multi-block methods is implemented as multi-block boundary value methods (MB2 VMs). The root distribution of the stability polynomial of the new class of methods are determined using the Wiener-Hopf factorization of a matrix polynomial for the purpose of their correct implementation. Numerical tests, showing the potential of such methods for output of multi-block of solutions of the ordinary differential equations in the new approach are also reported herein. The methods which output multi-block of solutions of the ordinary differential equations on application, are unlike the conventional linear multistep methods which output a solution at a point or the conventional boundary value methods and multi-block methods which output only a block of solutions per step. The MB2 VMs introduced herein is a novel approach at developing very large scale integration methods (VLSIM) in the numerical solution of differential equations.

A comparative analysis of prediction and measurement for reinforcement effect of face bolts (수치해석 및 계측자료 분석을 통한 막장볼트의 보강효과에 관한 연구)

  • Seo, Kyoung-Won;Kim, Woong-Ku;Baek, Ki-Hyun;Kim, Jin-Woung
    • Journal of Korean Tunnelling and Underground Space Association
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    • v.12 no.5
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    • pp.359-368
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    • 2010
  • Unlike in Korea where steel pipe-reinforced multistep grouting is of commonly used methods for tunnel reinforcement, face bolt method is more widely used due to its better workability and lower construction cost in other countries. In this paper, the effects of both methods after tunnel failure were numerically analyzed and verified based on the oversea construction experiences. As a result it is concluded that the face bolt method may be effective to reinforcement especially when there are some fractured zones developed in the face of tunnel.

Applicability Analysis of an Improved Multistep Steel Pipe Grouting Method in Shallow Depth Railway Tunnels in Considering Safety and Constructability (저토피 철도터널구간의 안전 및 시공성을 고려한 개선된 강관다단 그라우팅 공법 적용성 분석)

  • Kim, Nakseok;Choi, Gisung;Kim, Seokhyun
    • KSCE Journal of Civil and Environmental Engineering Research
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    • v.40 no.1
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    • pp.97-103
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    • 2020
  • The newly improved multistep steel pipe grouting method was applied to an existing steel pipe-reinforced grouting method. It was applied in order to prevent a damage caused by ground failure from excessive grouting pressure in a tunnel construction. The tunnel goes under a highway and a ramp connected to a rest area on OO highway with 11.3~12.1 m depth cover and is a part of roadbed facility construction section ordered by OO public corporation. The improved grouting method provides pre-construction work condition assessment technique through new water injection limit test and grouting effect assessment technique by grouting type assessment. It also includes assessments on interval of joints, appropriate grouting pressure, and optimal operation time to be applied to current operations. Application of the grouting method allowed the smooth road management in shallow-depth grouting construction area located upper part of tunnel excavation. Moreover, the possibility of the application of the method not only to shallow-depth grouting construction but also to various steel pipe-reinforced grouting constructions was confirmed.

A STUDY OF GENERALIZED ADAMS-MOULTON METHOD FOR THE SATELLITE ORBIT DETERMINATION PROBLEM

  • Hong, Bum Il;Hahm, Nahmwoo
    • Korean Journal of Mathematics
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    • v.21 no.3
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    • pp.271-283
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    • 2013
  • In this paper, a generalized Adams-Moulton method that is a $m$-step method derived by using the Taylor's series is proposed to solve the satellite orbit determination problem. We show that our proposed method has produced much smaller error than the original Adams-Moulton method. Finally, the accuracy performance is demonstrated in the satellite orbit correction problem by giving a numerical example.

Development of finite element analysis model for multi-step excavation problem (시공단계를 고려할 수 있는 유한요소 해석 모델 개발)

  • Lee, Youn-Kyou
    • Tunnel and Underground Space
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    • v.6 no.4
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    • pp.326-334
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    • 1996
  • In underground construction the multi-step excavation sequence is commonly adopted for the convenience of the underground work. A numerical simulation method which is capable of analyzing the effects of excavation sequence on the stability of the opening is greatly needed. In this study a two dimensional finite element code was developed based on the effective numerical algorithm for the multistep excavation. The practical applicability of the model was verified for the simplified excavation sequences.

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