• Genomics & Informatics
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• v.21 no.2
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• pp.23.1-23.9
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• 2023

The mammalian sirtuin family, consisting of SIRT1-SIRT7, plays a vital role in various biological processes, including cancer, diabetes, neurodegeneration, cardiovascular disease, cellular metabolism, and cellular homeostasis maintenance. Due to their involvement in these biological processes, modulating sirtuin activity seems promising to impact immuneand aging-related diseases, as well as cancer pathways. However, more understanding is required regarding the safety and efficacy of sirtuin-targeted therapies due to the complex regulatory mechanisms that govern their activity, particularly in the context of multiple targets. In this study, the interaction landscape of the sirtuin family was analyzed using a systems biology approach. A sirtuin protein-protein interaction network was built using the Cytoscape platform and analyzed using the NetworkAnalyzer and stringApp plugins. The result revealed the sirtuin family's association with numerous proteins that play diverse roles, suggesting a complex interplay between sirtuins and other proteins. Based on network topological and functional analysis, SIRT1 was identified as the most prominent among sirtuin family members, demonstrating that 25 of its protein partners are involved in cancer, 22 in innate immune response, and 29 in aging, with some being linked to a combination of two or more pathways. This study lays the foundation for the development of novel therapies that can target sirtuins with precision and efficacy. By illustrating the various interactions among the proteins in the sirtuin family, we have revealed the multifaceted roles of SIRT1 and provided a framework for their possible roles to be precisely understood, manipulated, and translated into therapeutics in the future.

• Journal of Industrial Convergence
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• v.21 no.12
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• pp.37-43
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• 2023

In today's business landscape, collaboration and interoperability are crucial for organizational success and profitability. However, integrating operations across multiple organizations is challenging due to differing roles and policies in Identity and Access Management (IAM). User-centric identity (UCI) adopts a personalized approach to digital identity management, centering on the end-user for authentication and access control. It provides a decentralized system that ensures secure and customized access for each user. UCI aims to address complex security challenges by aligning access privileges with individual user requirements. This research delves into UCI's ability to streamline resource access amidst conflicting IAM roles and protocols across various organizations. The study presents a UCI-based multi-domain access control (MDAC) framework, which encompasses an ontology, a unified method for articulating access roles and policies across domains, and software services melding with UCI infrastructure. The goal is to enhance organizational resource management and decision-making by offering clear guidelines on access roles and policy management across diverse domains, ultimately boosting companies' return on investment.

• Journal of Distribution Science
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• v.11 no.6
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• pp.41-50
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• 2013

Purpose - Inducing consumers' behavioral intent to use an outlet shopping center is a critical issue for managers since it can be used as a guide for developing marketing strategies. Low prices could lead to a growth in retail purchases, but there might also be a positive relationship between prices and customer perceptions of product quality. The extent to which consumers use price as a predictor of quality may differ according to the availability of important alternative cues such as brand, store name, and identity salience triggered by the store. Consumers can obtain non-economic benefits from marketing exchanges that go beyond basic economic achievement. We argue that identity salience can play a crucial mediating role when consumers, acting as exchange partners, seek to obtain social benefits. This study shows that identity salience could mediate the relationship between identity salience-inducing factors such as multi-finality, prestige and role performance, and consumers' behavioral intent to use an outlet shopping center. Research design, data and methodology - The survey was conducted on college students enrolled in marketing classes. A total of 200 questionnaires were distributed, of which only 194 were returned. After five incomplete questionnaires were excluded, a final sample of 189 was used for empirical analysis. Using a covariance structural analysis in Amos17, we confirmed the fit of the research model and estimated its parameters by using the maximum likelihood method. Results - The results of the hypotheses testing are as follows. First, both identity salience and economic benefits have positive effects on the behavioral intent to use an outlet shopping center. Second, role performance, prestige, and multi-finality have positive effects on identity salience. Finally, the additive analysis of the direct effects of identity salience-inducing factors shows that the role performance, prestige, and multi-finality factors have no direct effects on the behavioral intent to use an outlet shopping center, suggesting that identity salience plays a positive mediating role. Conclusions - This study informs marketers that not only price but shoppers' identity salience directly affects their intent to visit an outlet shopping center. To strengthen shoppers' identity salience, marketers should find ways to help shoppers fulfill their multiple social roles, realize their multiple goals, and achieve prestige. In other words, outlet shopping centers must improve their personal service environment in order to enhance their employees' service quality and assist the execution of multi-finality by minimizing the perceived costs (e.g., travel time, effort) associated with shopping trips, thus making it easier for consumers to combine visits to multiple stores in outlet shopping centers and buy the items required for their consumption goals. Outlet shopping centers must also offer assortments with both breadth and depth in order to help consumers play the social roles their social networks have given them.

• Journal of Hydrogen and New Energy
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• v.20 no.4
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• pp.265-273
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• 2009

Proton Exchange Membrane Fuel Cell (PEMFC) has low operating temperature and high efficiency. And PEMFC consists of many components as bipolar plate, gas diffusion layer, membrane etc.. Flow-field in bipolar plate roles path for transporting reactants to membrane. Therefore a design of flow-field has an effect on PEMFC's performance. In this study, Computational Fluid Dynamics (CFD) simulations were performed for comparing mixed multiple serpentine (MMS) flow-field and multiple serpentine (MS) flow-field. And we studied an effect according to change mixing region design in MMS flow-field. Finally the applicability of results is verified by performing CFD simulation about fixed MMS flow-field which is combined good designs.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.34 no.8
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• pp.953-964
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• 2010

In this study, we proposed duty executions to confine a robot in a specific place with multiple robots. The proposed method involved the use of a role classifier for assigning labor roles, behavior selector for each robot, and a collaboration manager for handling complex situations. Further, we verified the validity of the proposed method by performing simulations to confine a robot in the specific location by using multiple robots.

• Journal of Korean Academy of Nursing
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• v.29 no.6
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• pp.1336-1354
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• 1999

Researchers have rarely explored menopausal experience in the context of the totality of women's lives, subsequently making the picture of menopause incomplete, discrete and fragmented. Respecting the totality of women's lives, this study addressed how a vulnerable group of women-low income Korean immigrant women-experience menopause within a context of multiple transitions. This is a cross-sectional study using methodological triangulation. A sample of 119 first-generation Korean immigrant women aged 40 to 60 years, who were in low-income jobs, was recruited using convenience sampling methods. From the total sample, 21 peri-or post-menopausal women were recruited for in-depth interviews following the collection of the survey data. Questionnaires, short interviews, and in- depth interviews were used to collect data. The quantitative data were analyzed using descriptive and inferential statistics. Thematic analysis was used to interpret interview data. The findings indicate that menopause was given the lowest priority amidst women's multiple and demanding roles within a gendered multiple transitional (immigration, work and menopause) context. The lack of language clarity to describe women's experience, cultural background, inadequate knowledge, and lack of social supports made menopause hidden, invisible, and inaudible. Conclusions and implications for nursing practice are guided by the goal of understanding women's experiences and meanings of menopause and supporting women through reflecting these experiences into their health care.

• Biomolecules & Therapeutics
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• v.30 no.1
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• pp.98-116
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• 2022

The small GTPase RhoA has been studied extensively for its role in actin dynamics. In this study, multiple bioinformatics tools were applied cooperatively to the microarray dataset GSE64714 to explore previously unidentified functions of RhoA. Comparative gene expression analysis revealed 545 differentially expressed genes in RhoA-null cells versus controls. Gene set enrichment analysis (GSEA) was conducted with three gene set collections: (1) the hallmark, (2) the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway, and (3) the Gene Ontology Biological Process. GSEA results showed that RhoA is related strongly to diverse pathways: cell cycle/growth, DNA repair, metabolism, keratinization, response to fungus, and vesicular transport. These functions were verified by heatmap analysis, KEGG pathway diagramming, and direct acyclic graphing. The use of multiple gene set collections restricted the leakage of information extracted. However, gene sets from individual collections are heterogenous in gene element composition, number, and the contextual meaning embraced in names. Indeed, there was a limit to deriving functions with high accuracy and reliability simply from gene set names. The comparison of multiple gene set collections showed that although the gene sets had similar names, the gene elements were extremely heterogeneous. Thus, the type of collection chosen and the analytical context influence the interpretation of GSEA results. Nonetheless, the analyses of multiple collections made it possible to derive robust and consistent function identifications. This study confirmed several well-described roles of RhoA and revealed less explored functions, suggesting future research directions.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.17 no.1
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• pp.280-294
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• 2023

Unmanned aerial vehicles (UAVs) and millimeter-wave frequencies play key roles in supporting 5G wireless communication systems. They expand the field of wireless communication by increasing the data capacities of communication systems and supporting high data rates. However, short wavelengths, owing to the high millimeter-wave frequencies can cause problems, such as signal attenuation and path loss. To address these limitations, research on high directional beamforming technologies continue to garner interest. Furthermore, owing to the mobility of the UAVs, it is essential to track the beam angle accurately to obtain full beamforming gain. This study presents a beam tracking method based on the unscented Kalman filter using hybrid beamforming. The simulation results reveal that the proposed beam tracking scheme improves the overall performance in terms of the mean-squared error and spectral efficiency. In addition, by expanding analog beamforming to hybrid beamforming, the proposed algorithm can be used even in multi-user and multi-stream environments to increase data capacity, thereby increasing utilization in new-radio multiple-input multiple-output orthogonal frequency-division multiplexing systems.

• Proceedings of the Korean Society for Bioinformatics Conference
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• 2005.09a
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• pp.113-117
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• 2005

In comparative genome analyses, synteny blocks play important roles for finding ortholog genes, reconstructing phylogenetic tree and predicting genome rearrangement events. In this paper, we propose a novel method to search biologically plausible synteny blocks not only from the viewpoint of finding highly preserved regions but also from the viewpoint of analyzing genome rearrangements. We have applied the method to our experiments on four fungal organisms, and succeeded to obtain some biologically interesting results.

• Journal of Microbiology and Biotechnology
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• v.18 no.9
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• pp.1485-1491
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• 2008

Tylosin biosynthesis is controlled in cascade fashion by multiple transcriptional regulators, acting positively or negatively, in conjunction with a signalling ligand that acts as a classical inducer. The roles of regulatory gene products have been characterized by a combination of gene expression analysis and fermentation studies, using engineered strains of S. fradiae in which specific genes were inactivated or overexpressed. Among various novel features of the regulatory model, involvement of the signalling ligand is not essential for tylosin biosynthesis.