• 한국국방경영분석학회지
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• 제23권2호
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• pp.85-102
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• 1997

There have been several research efforts to support interoperability among multiple databases. In integrating multiple databases, we must resolve schema conflicts due to the heterogeneity in databases. To resolve these conflicts, not only meta-data for database schemas but also general knowledge expressing the real world meanings associated with the database schemas are required. This paper presents a uniform representation method for relational schema and general knowledge base that is composed, among other things, of concept hierarchy and thematic roles in relationship, using the knowledge representation language Lk. This representation method has a flexible descriptive power which facilitates concepts to be expressed at different levels of granularity and can describe knowledge expressed in Lk are used for input of the next step, such as conflict resolution and query processing of multiple database.

• Journal of Ginseng Research
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• 제45권3호
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• pp.371-379
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• 2021

Mitochondrial dysfunction contributes to the pathogenesis and prognosis of many common disorders, including neurodegeneration, stroke, myocardial infarction, tumor, and metabolic diseases. Ginsenosides, the major bioactive constituents of Panax ginseng (P. ginseng), have been reported to play beneficial roles in the molecular pathophysiology of these diseases by targeting mitochondrial dysfunction. In this review, we first introduce the types of ginsenosides and basic mitochondrial functions. Then, recent findings are summarized on different ginsenosides targeting mitochondria and their key signaling pathways for the treatment of multiple diseases, including neurological disorders, cancer, heart disease, hyperglycemia, and inflammation are summarized. This review may explain the common targets of ginsenosides against multiple diseases and provide new insights into the underlying mechanisms, facilitating research on the clinical application of P. ginseng.

• 지역사회간호학회지
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• 제21권4호
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• pp.398-408
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• 2010

Purpose: The purpose of this study was to describe and understand elementary school health teachers' role perception in their own perspectives. Methods: Data were collected from three focus groups composed of five participants for each group. Each focus group had an interview for two and a half hours on the average. The main question was "What is your perception on the roles of health teachers in elementary schools?" Qualitative data from transcribed notes and field notes were analyzed using qualitative content analysis. Results: Five main roles were identified from the participants. The participants perceived themselves as 'an expert of health education in school and community', 'a health service provider for school members', 'a health guardian for school members, the coordinator of healthcare related works in school, and the leader of school health. Conclusion: The participants have multiple role identities, which are very important for health management of school members. And the roles such as an expert of health education and a leader for school health are recently emphasized. The findings of this study can provide useful information to design orientation programs for newly appointed health teachers and continuing education programs for enhancing role performance of health teachers in elementary schools.

• Molecules and Cells
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• 제39권1호
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• pp.60-64
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• 2016

Inflammation is a pathophysiological response to infection or tissue damage during which high levels of reactive oxygen and nitrogen species are produced by phagocytes to kill microorganisms. Reactive oxygen and nitrogen species serve also in the complex regulation of inflammatory processes. Recently, it has been proposed that peroxiredoxins may play key roles in innate immunity and inflammation. Indeed, peroxiredoxins are evolutionarily conserved peroxidases able to reduce, with high rate constants, hydrogen peroxide, alkyl hydroperoxides and peroxynitrite which are generated during inflammation. In this minireview, we point out different possible roles of peroxiredoxins during inflammatory processes such as cytoprotective enzymes against oxidative stress, modulators of redox signaling, and extracellular pathogen- or damage-associated molecular patterns. A better understanding of peroxiredoxin functions in inflammation could lead to the discovery of new therapeutic targets.

• Journal of Microbiology and Biotechnology
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• 제29권9호
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• pp.1335-1340
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• 2019

Probiotics, including bacteria and yeast, are live microorganisms that have demonstrated beneficial effects on human health. Recently, probiotic bacteria are constantly being studied and their applications are also being considered in promising adjuvant treatments for various intestinal diseases. Clinical trials and in vivo experiments have extended our current understanding of the important roles that probiotics play in human gut microbiomeassociated diseases. It has been documented through many clinical trials that probiotics could shape the intestinal microbiota leading to potential control of multiple bowel diseases and promotion of overall wellness. In this review, we focused on the relationship between probiotics and the human gut microbiota and its roles in gut microbiome-associated diseases. Here, we also discuss future directions and research areas that need further elucidation in order to better understand the roles of probiotics in the treatment of intestinal diseases.

• Asian Pacific Journal of Cancer Prevention
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• 제15권19호
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• pp.8019-8026
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• 2014

The promyelocytic leukemia (PML) gene is a gene known to be a tumor suppressor, although recent data suggest that it has a dual function in tumorigenesis. It was initially discovered in acute promyelocytic leukemia (APL) in which a t(15; 17) chromosomal translocation fused it to the retinoic acid receptor alpha ($RAR{\alpha}$). It has been shown to be involved in various types of cancer. It has at least 6 nuclear isoforms and a cytoplasmic type with different characteristics. Its multiple functions in growth inhibition, apoptosis induction, replicative senescence, inhibition of oncogenic transformation, and suppression of migration and angiogenesis have made it a therapeutic target for cancer therapy. However, its dual role in the process of tumorigenesis has made this field challenging. In this review, we discuss PML structure, functions and expression in tumors.

• BMB Reports
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• 제51권11호
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• pp.557-562
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• 2018

Reactive oxygen species (ROS) are major sources of cellular oxidative stress. Specifically, cancer cells harbor genetic alterations that promote a continuous and elevated production of ROS. While such oxidative stress conditions could be harmful to normal cells, they facilitate cancer cell growth in multiple ways by causing DNA damage and genomic instability, and ultimately by reprogramming cancer cell metabolism. This review provides up to date findings regarding the roles of ROS generation induced by diverse biological molecules and chemicals in representative women's cancer. Specifically, we describe the cellular signaling pathways that regulate direct or indirect interactions between ROS homeostasis and metabolism within female genital cancer cells.

• 가정과삶의질연구
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• 제35권1호
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• pp.59-69
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• 2017

The purpose of the study was to investigate the roles of child group home directors and their experiences with children. The study utilised the interpretive science paradigm and individual in-depth interviews for data collection. The qualitative theme analysis method explored the experiences of child group home directors. The participants, seven group home directors in the metropolitan area of Seoul, explained their multiple roles such as protector, nurturer, discipliner, mediator, and supporter of children while recognizing dysfunctions of children's family of origin. Participants claimed that the specialization of the child group home and the professionalism of its staffs were needed in order to improve the quality of child welfare. The results of this study might contribute to practical suggestions for group home professionals.

• BMB Reports
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• 제50권10호
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• pp.487-495
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• 2017

Mammalian inner ear comprises of six sensory organs; cochlea, utricle, saccule, and three semicircular canals. The cochlea contains sensory epithelium known as the organ of Corti which senses sound through mechanosensory hair cells. Mammalian inner ear undergoes series of morphogenesis during development beginning thickening of ectoderm nearby hindbrain. These events require tight regulation of multiple signaling cascades including FGF, Wnt, Notch and Bmp signaling. In this review, we will discuss the role of newly emerging signaling, FGF signaling, for its roles required for cochlear development.

• Journal of Information Technology Applications and Management
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• 제10권1호
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• pp.35-46
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• 2003

This study focuses on the effect of Social Scaffolding of virtual community on its growth and thrift. The research model proposed in this study is that communities, which have goof social scaffolding, tend to grow and thrive. Social Scaffolding refers to those aspects of a site Purpose, Places, Profiles, leaders, Roles, Rules, Cyclic Events, integrating with the real world, and Subgroups. The data were collected from 100 virtual communities in Daum Communications and analyzed in this study. Multiple regression is used to analyze the relationship of variables. The result is following ; purpose, loaders, rules, integrating with the real world support the effects of social scaffolding of virtual community on its growth and thrift, but profiles, roles, cyclic events do not. The result of this study implies the importance of social scaffolding of virtual community for re-searches, and developers.