• Title/Summary/Keyword: Multiple roles

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An Efficient Load Balancing Mechanism in Distributed Virtual Environments

  • Jang, Su-Min;Yoo, Jae-Soo
    • ETRI Journal
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    • v.30 no.4
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    • pp.618-620
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    • 2008
  • A distributed virtual environment (DVE) allows multiple geographically distributed objects to interact concurrently in a shared virtual space. Most DVE applications use a non-replicated server architecture, which dynamically partitions a virtual space. An important issue in this system is effective scalability as the number of users increases. However, it is hard to provide suitable load balancing because of the unpredictable movements of users and hot-spot locations. Therefore, we propose a mechanism for sharing roles and separating service regions. The proposed mechanism reduces unnecessary partitions of short duration and supports efficient load balancing.

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The history and regulatory mechanism of the Hippo pathway

  • Kim, Wantae;Jho, Eek-hoon
    • BMB Reports
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    • v.51 no.3
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    • pp.106-118
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    • 2018
  • How the organ size is adjusted to the proper size during development and how organs know that they reach the original size during regeneration remain long-standing questions. Based on studies using multiple model organisms and approaches for over 20 years, a consensus has been established that the Hippo pathway plays crucial roles in controlling organ size and maintaining tissue homeostasis. Given the significance of these processes, the dysregulation of the Hippo pathway has also implicated various diseases, such as tissue degeneration and cancer. By regulating the downstream transcriptional coactivators YAP and TAZ, the Hippo pathway coordinates cell proliferation and apoptosis in response to a variety of signals including cell contact inhibition, polarity, mechanical sensation and soluble factors. Since the core components and their functions of the Hippo pathway are evolutionarily conserved, this pathway serves as a global regulator of organ size control. Therefore, further investigation of the regulatory mechanisms will provide physiological insights to better understand tissue homeostasis. In this review, the historical developments and current understandings of the regulatory mechanism of Hippo signaling pathway are discussed.

Cell Cycle Alteration and Apoptosis Induced by Ceramide in IM-9 Cells (IM-9세포에 있어서 세라마이드에 의한 세포주기 변화와 아포프토시스)

  • 윤기호;최관수;김원호;최경희;김미영
    • YAKHAK HOEJI
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    • v.39 no.6
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    • pp.689-694
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    • 1995
  • Sphingolipids play important roles in cell regulation and signal transduction. Recently, a sphinogomyelin cycle has been described in which activation of neutral sphingomyelinase leads to the breakdown of sphingomyelin and the generation of ceramide. Ceramide, in turn, has emerged as a candidate intracellular mediator for the action of certain cell agonists and has multiple biologic actions. Ceramide is a potent suppressor of cell growth and an inducer of apoptosis. The present studies show that exposure of IM-9 cells to ceramide resulted in internucleosomal cleavage of DNA, yielding laddered patterns of oligonucleosomal fragments characteristic of apoptosis. DNA fragmentation induced by ceramide was also confirmed by diphenylamine assay. The effect of ceramide on cell cycle progression was also studied. The addition of ceramide increase G$_{1}$ phase distribution in cell cycle. Cell cycle-related cyclin D$_{1}$ gene expression was decreased in a time-dependent manner. These results suggest that apoptosis induced by ceramide is related to cell cycle associated with the alteration of cell cycle in IM-9 cells.

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Interleukin-32 in Inflammatory Autoimmune Diseases

  • Kim, Soohyun
    • IMMUNE NETWORK
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    • v.14 no.3
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    • pp.123-127
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    • 2014
  • Interleukin-32 (IL-32) is a cytokine inducing crucial inflammatory cytokines such as tumor necrosis factor-${\alpha}(TNF{\alpha})$ and IL-6 and its expression is elevated in various inflammatory autoimmune diseases, certain cancers, as well as viral infections. IL-32 gene was first cloned from activated T cells, however IL-32 expression was also found in other immune cells and non-immune cells. IL-32 gene was identified in most mammals except rodents. It is transcribed as multiple-spliced variants in the absence of a specific activity of each isoform. IL-32 has been studied mostly in clinical fields such as infection, autoimmune, cancer, vascular disease, and pulmonary diseases. It is difficult to investigate the precise role of IL-32 in vivo due to the absence of IL-32 gene in mouse. The lack of mouse IL-32 gene restricts in vivo studies and restrains further development of IL-32 research in clinical applications although IL-32 new cytokine getting a spotlight as an immune regulatory molecule processing important roles in autoimmune, infection, and cancer. In this review, we discuss the regulation and function of IL-32 in inflammatory bowel diseases and rheumatoid arthritis.

The Zinc Transport Systems and Their Regulation in Pathogenic Fungi

  • Jung, Won Hee
    • Mycobiology
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    • v.43 no.3
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    • pp.179-183
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    • 2015
  • Zinc is an essential micronutrient required for many enzymes that play essential roles in a cell. It was estimated that approximately 3% of the total cellular proteins are required for zinc for their functions. Zinc has long been considered as one of the key players in host-pathogen interactions. The host sequesters intracellular zinc by utilizing multiple cellular zinc importers and exporters as a means of nutritional immunity. To overcome extreme zinc limitation within the host environment, pathogenic microbes have successfully evolved a number of mechanisms to secure sufficient concentrations of zinc for their survival and pathogenesis. In this review, we briefly discuss the zinc uptake systems and their regulation in the model fungus Saccharomyces cerevisiae and in major human pathogenic fungi such as Aspergillus fumigatus, Candida albicans, and Cryptococcus gattii.

Mother-Child Relationship in Female-headed Single Parent Families (여성 한부모가족의 모-자녀관계)

  • 조성연
    • Journal of Families and Better Life
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    • v.22 no.1
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    • pp.153-167
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    • 2004
  • The purpose of this study was to investigate the difficulties, conflicts, and communications between female-headed single parents and their children, their child rearing methods and attitude, and the political suggestions for the welfare in those families. The in-depth interviews were conducted for 7 women in Gyonggi-Do and Chungnam-Do on March 3-27, 2003. The interviewees were selected for the mothers whose children were enrolled either elementary schools or middle schools. The contents of interviews were receded to be analyzed by qualitative method. The results were as follows; first, female-headed single parent families were in low economic status with unstable employment condition. Secondly, women in that families were confronted with psychological problems because of their multiple roles and low income. Third, although they had a controlled child rearing method, they used much reinforcement and praise. Thirdly, they were in need of the aids for the basic life such as housings and their children's private institute expenses. Finally, they required the repealing of an existing birthright system.

Unique Feature of Horticulture in Asia and Its Global Impact

  • Lee, Jung-Myung
    • Horticultural Science & Technology
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    • v.18 no.1
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    • pp.39-50
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    • 2000
  • Asia has 60% of the world population and only about 34.5% of the world arable land. However, Asians traditionally consume very large amount of horticultural produce and depend heavily on vegetables for the sources of horticultural food crop. The vegetable production in Asia is highly intensive and multiple and successive cropping are routinely practiced. Concomitant with the rapid economic growth in many east Asian countries, the demands for high-quality horticultural crop have been drastically increased among many Asians and their interest in high-quality products, outstanding cultivars, machinery and equipment, production technology has been sharply increased in recent years. It is therefore believed that establishing and maintaining closer and regular relations among scientists and societies could provide an excellent momentum for promotion of horticulture on a global basis and both the ISHS and the ASHS could play decisive roles for this kind of promotion.

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The Roles of Menopausal-specific Quality of Life on Breast Cancer Screening Beliefs in Menopausal and Postmenopausal Women

  • Cheng, Winnie Lai-Sheung
    • Journal of Menopausal Medicine
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    • v.24 no.3
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    • pp.188-195
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    • 2018
  • Objectives: This study investigated the association between menopausal-specific quality of life (MENQOL) and breast cancer screening beliefs among Hong Kong Chinese menopausal and postmenopausal women. Methods: A cross-sectional study was employed to collect data. The questionnaire was distributed to a convenience sample of 218 women aged above 45. The outcome variables were breast cancer screening beliefs and breast examination. Multiple regression analyses were conducted to test the effect of 4 domains in MENQOL (vasomotor, psycho-social, physical, and sexual symptom) and the health behaviors on the 2 outcome variables. Results: This study found that the overall MENQOL scores (in particular psycho-social, and physical aspects) were significantly associated with positive attitudes toward health check-ups and better knowledge and perceptions in breast cancer. Regular exercise was also significantly related to breast examination. Conclusions: MENQOL (especially psycho-social and physical domain) and regular exercise are important factors associated with breast cancer screening beliefs. The results of this study illuminate health care professionals to develop primary health care strategies to improve the quality of life of mid-life women.

Technological and Personal Factors of Determining the Acceptance of Wrist-Worn Smart Devices

  • Kim, Sun Jin;Cho, Jaehee
    • Asian Journal for Public Opinion Research
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    • v.7 no.3
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    • pp.143-168
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    • 2019
  • With much attention being paid to the rapid growth of wrist-worn smart devices, this study aimed to examine the micro-processes that determine an individual's adoption of smart bands and smartwatches. Primarily relying on the theoretical background of the extended technology acceptance model (TAM II), this study explored relationships between three groups of predictors-social, personal, and device-oriented-and the three main components of the original TAM: perceived usefulness (PU), perceived ease of use (PEOU), and behavioral intention (BI). Results from the path analysis indicated multiple factors played significant roles in increasing the PU, PEOU, and BI of wristworn smart devices: subjective norms, social image, self-efficacy, perceived service diversity, and perceived reasonable cost. The main findings from this research contribute to significantly improving the understanding of the main factors leading people to adopt wrist-worn smart devices.

Media Use and Political Participation in China: Taking Three National Large-N Surveys as Examples

  • Miao, Hongna
    • Asian Journal for Public Opinion Research
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    • v.7 no.1
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    • pp.1-22
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    • 2019
  • In the age of continuous media change and the coexistence of multiple forms of media, the relationship between the public's media use and political participation is an urgent area of study. This paper makes use of large national sample surveys from 2002, 2011, and 2015, summarizes the change of the public's media use by descriptive statistics analysis, and finds that while the Internet has become an important communication channel, the use of Internet for political information and political participation is still overestimated. Compared to the weak impact of different media channels for political information on political participation, the frequency of media exposure and Internet use play a significant role in political participation. Because of the negative effect of the frequency of Internet use on political participation, the democratization function of the Internet needs to be treated with caution. This paper describes media use and its roles in contemporary China, analyzes the impact of media use on political participation, and extends the cross-cultural application of the theory of political communication.