References
- Shingleton AW (2010) The regulation of organ size in Drosophila: physiology, plasticity, patterning and physical force. Organogenesis 6, 76-87 https://doi.org/10.4161/org.6.2.10375
- Gokhale RH and Shingleton AW (2015) Size control: the developmental physiology of body and organ size regulation. Wiley Interdiscip Rev Dev Biol 4, 335-356 https://doi.org/10.1002/wdev.181
- Halder G and Johnson RL (2011) Hippo signaling: growth control and beyond. Development 138, 9-22 https://doi.org/10.1242/dev.045500
- Twitty VCS, Josep L (1931) The growth of eyes and limbs transplanted heteroplastically between two species of Amblystoma. J Exp Zool 59, 61-86 https://doi.org/10.1002/jez.1400590105
- Michalopoulos GK and DeFrances MC (1997) Liver regeneration. Science 276, 60-66 https://doi.org/10.1126/science.276.5309.60
- Metcalf D (1964) Restricted Growth Capacity of Multiple Spleen Grafts. Transplantation 2, 387-392 https://doi.org/10.1097/00007890-196405000-00008
- Metcalf D (1963) The Autonomous Behaviour of Normal Thymus Grafts. Aust J Exp Biol Med Sci 41, SUPPL437-447 https://doi.org/10.1038/icb.1963.64
- Hilman D and Gat U (2011) The evolutionary history of YAP and the hippo/YAP pathway. Mol Biol Evol 28, 2403-2417 https://doi.org/10.1093/molbev/msr065
- Sebe-Pedros A, Zheng Y, Ruiz-Trillo I and Pan D (2012) Premetazoan origin of the hippo signaling pathway. Cell Rep 1, 13-20 https://doi.org/10.1016/j.celrep.2011.11.004
- Huang J, Wu S, Barrera J, Matthews K and Pan D (2005) The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP. Cell 122, 421-434 https://doi.org/10.1016/j.cell.2005.06.007
- Meng Z, Moroishi T and Guan KL (2016) Mechanisms of Hippo pathway regulation. Genes Dev 30, 1-17 https://doi.org/10.1101/gad.274027.115
- Piccolo S, Dupont S and Cordenonsi M (2014) The biology of YAP/TAZ: hippo signaling and beyond. Physiol Rev 94, 1287-1312 https://doi.org/10.1152/physrev.00005.2014
- Zhao B, Li L, Tumaneng K, Wang CY and Guan KL (2010) A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF(beta-TRCP). Genes Dev 24, 72-85 https://doi.org/10.1101/gad.1843810
- Liu CY, Zha ZY, Zhou X et al (2010) The hippo tumor pathway promotes TAZ degradation by phosphorylating a phosphodegron and recruiting the SCF{beta}-TrCP E3 ligase. J Biol Chem 285, 37159-37169 https://doi.org/10.1074/jbc.M110.152942
- Huang W, Lv X, Liu C et al (2012) The N-terminal phosphodegron targets TAZ/WWTR1 protein for SCFbeta-TrCP-dependent degradation in response to phosphatidylinositol 3-kinase inhibition. J Biol Chem 287, 26245-26253 https://doi.org/10.1074/jbc.M112.382036
- Hansen CG, Moroishi T and Guan KL (2015) YAP and TAZ: a nexus for Hippo signaling and beyond. Trends Cell Biol 25, 499-513 https://doi.org/10.1016/j.tcb.2015.05.002
- Meng Z, Moroishi T, Mottier-Pavie V et al (2015) MAP4K family kinases act in parallel to MST1/2 to activate LATS1/2 in the Hippo pathway. Nat Commun 6, 8357 https://doi.org/10.1038/ncomms9357
- Kim Y, Kim W, Song Y et al (2017) Deubiquitinase YOD1 potentiates YAP/TAZ activities through enhancing ITCH stability. Proc Natl Acad Sci U S A 114, 4691-4696 https://doi.org/10.1073/pnas.1620306114
- Yin F, Yu J, Zheng Y, Chen Q, Zhang N and Pan D (2013) Spatial organization of Hippo signaling at the plasma membrane mediated by the tumor suppressor Merlin/NF2. Cell 154, 1342-1355 https://doi.org/10.1016/j.cell.2013.08.025
- Fulford A, Tapon N and Ribeiro PS (2017) Upstairs, downstairs: spatial regulation of Hippo signalling. Curr Opin Cell Biol 51, 22-32
- Chaulk SG, Lattanzi VJ, Hiemer SE, Fahlman RP and Varelas X (2014) The Hippo pathway effectors TAZ/YAP regulate dicer expression and microRNA biogenesis through Let-7. J Biol Chem 289, 1886-1891 https://doi.org/10.1074/jbc.C113.529362
- Mori M, Triboulet R, Mohseni M et al (2014) Hippo signaling regulates microprocessor and links celldensity- dependent miRNA biogenesis to cancer. Cell 156, 893-906 https://doi.org/10.1016/j.cell.2013.12.043
- Sabine A, Bovay E, Demir CS et al (2015) FOXC2 and fluid shear stress stabilize postnatal lymphatic vasculature. J Clin Invest 125, 3861-3877 https://doi.org/10.1172/JCI80454
- Wang L, Luo JY, Li B et al (2016) Integrin-YAP/TAZ-JNK cascade mediates atheroprotective effect of unidirectional shear flow. Nature 540, 579-582 https://doi.org/10.1038/nature20602
- Liu B, Zheng Y, Yin F, Yu J, Silverman N and Pan D (2016) Toll Receptor-Mediated Hippo Signaling Controls Innate Immunity in Drosophila. Cell 164, 406-419 https://doi.org/10.1016/j.cell.2015.12.029
- Wang S, Xie F, Chu F et al (2017) YAP antagonizes innate antiviral immunity and is targeted for lysosomal degradation through IKKvarepsilon-mediated phosphorylation. Nat Immunol 18, 733-743 https://doi.org/10.1038/ni.3744
- Wilkinson DS, Jariwala JS, Anderson E et al (2015) Phosphorylation of LC3 by the Hippo kinases STK3/STK4 is essential for autophagy. Mol Cell 57, 55-68 https://doi.org/10.1016/j.molcel.2014.11.019
- Maejima Y, Kyoi S, Zhai P et al (2013) Mst1 inhibits autophagy by promoting the interaction between Beclin1 and Bcl-2. Nat Med 19, 1478-1488 https://doi.org/10.1038/nm.3322
- Zhang S, Chen Q, Liu Q et al (2017) Hippo Signaling Suppresses Cell Ploidy and Tumorigenesis through Skp2. Cancer Cell 31, 669-684 e7 https://doi.org/10.1016/j.ccell.2017.04.004
- Justice RW, Zilian O, Woods DF, Noll M and Bryant PJ (1995) The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation. Genes Dev 9, 534-546 https://doi.org/10.1101/gad.9.5.534
- Xu T, Wang W, Zhang S, Stewart RA and Yu W (1995) Identifying tumor suppressors in genetic mosaics: the Drosophila lats gene encodes a putative protein kinase. Development 121, 1053-1063
- St John MA, Tao W, Fei X et al (1999) Mice deficient of Lats1 develop soft-tissue sarcomas, ovarian tumours and pituitary dysfunction. Nat Genet 21, 182-186 https://doi.org/10.1038/5965
- Tao W, Zhang S, Turenchalk GS et al (1999) Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity. Nat Genet 21, 177-181 https://doi.org/10.1038/5960
- Tapon N, Harvey KF, Bell DW et al (2002) salvador Promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines. Cell 110, 467-478 https://doi.org/10.1016/S0092-8674(02)00824-3
- Kango-Singh M, Nolo R, Tao C et al (2002) Shar-pei mediates cell proliferation arrest during imaginal disc growth in Drosophila. Development 129, 5719-5730 https://doi.org/10.1242/dev.00168
- Harvey KF, Pfleger CM and Hariharan IK (2003) The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis. Cell 114, 457-467 https://doi.org/10.1016/S0092-8674(03)00557-9
- Udan RS, Kango-Singh M, Nolo R, Tao C and Halder G (2003) Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway. Nat Cell Biol 5, 914-920 https://doi.org/10.1038/ncb1050
- Pantalacci S, Tapon N and Leopold P (2003) The Salvador partner Hippo promotes apoptosis and cell-cycle exit in Drosophila. Nat Cell Biol 5, 921-927 https://doi.org/10.1038/ncb1051
- Jia J, Zhang W, Wang B, Trinko R and Jiang J (2003) The Drosophila Ste20 family kinase dMST functions as a tumor suppressor by restricting cell proliferation and promoting apoptosis. Genes Dev 17, 2514-2519 https://doi.org/10.1101/gad.1134003
- Wu S, Huang J, Dong J and Pan D (2003) hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts. Cell 114, 445-456 https://doi.org/10.1016/S0092-8674(03)00549-X
- Lai ZC, Wei X, Shimizu T et al (2005) Control of cell proliferation and apoptosis by mob as tumor suppressor, mats. Cell 120, 675-685 https://doi.org/10.1016/j.cell.2004.12.036
- Wei X, Shimizu T and Lai ZC (2007) Mob as tumor suppressor is activated by Hippo kinase for growth inhibition in Drosophila. EMBO J 26, 1772-1781 https://doi.org/10.1038/sj.emboj.7601630
- Zhao B, Wei X, Li W et al (2007) Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control. Genes Dev 21, 2747-2761 https://doi.org/10.1101/gad.1602907
- Zhang N, Bai H, David KK et al (2010) The Merlin/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammals. Dev Cell 19, 27-38 https://doi.org/10.1016/j.devcel.2010.06.015
- Overholtzer M, Zhang J, Smolen GA et al (2006) Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon. Proc Natl Acad Sci U S A 103, 12405-12410 https://doi.org/10.1073/pnas.0605579103
- Harvey KF, Zhang X and Thomas DM (2013) The Hippo pathway and human cancer. Nat Rev Cancer 13, 246-257 https://doi.org/10.1038/nrc3458
- Johnson R and Halder G (2014) The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment. Nat Rev Drug Discov 13, 63-79 https://doi.org/10.1038/nrd4161
- Moroishi T, Hansen CG and Guan KL (2015) The emerging roles of YAP and TAZ in cancer. Nat Rev Cancer 15, 73-79 https://doi.org/10.1038/nrc3876
- Sudol M (1994) Yes-associated protein (YAP65) is a proline-rich phosphoprotein that binds to the SH3 domain of the Yes proto-oncogene product. Oncogene 9, 2145-2152
- Komuro A, Nagai M, Navin NE and Sudol M (2003) WW domain-containing protein YAP associates with ErbB-4 and acts as a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus. J Biol Chem 278, 33334-33341 https://doi.org/10.1074/jbc.M305597200
- Ferrigno O, Lallemand F, Verrecchia F et al (2002) Yes-associated protein (YAP65) interacts with Smad7 and potentiates its inhibitory activity against TGF-beta/Smad signaling. Oncogene 21, 4879-4884 https://doi.org/10.1038/sj.onc.1205623
- Strano S, Munarriz E, Rossi M et al (2001) Physical interaction with Yes-associated protein enhances p73 transcriptional activity. J Biol Chem 276, 15164-15173 https://doi.org/10.1074/jbc.M010484200
- Zaidi SK, Sullivan AJ, Medina R et al (2004) Tyrosine phosphorylation controls Runx2-mediated subnuclear targeting of YAP to repress transcription. EMBO J 23, 790-799 https://doi.org/10.1038/sj.emboj.7600073
- Vassilev A, Kaneko KJ, Shu H, Zhao Y and DePamphilis ML (2001) TEAD/TEF transcription factors utilize the activation domain of YAP65, a Src/Yes-associated protein localized in the cytoplasm. Genes Dev 15, 1229-1241 https://doi.org/10.1101/gad.888601
- Yagi R, Chen LF, Shigesada K, Murakami Y and Ito Y (1999) A WW domain-containing yes-associated protein (YAP) is a novel transcriptional co-activator. EMBO J 18, 2551-2562 https://doi.org/10.1093/emboj/18.9.2551
- Espanel X and Sudol M (2001) Yes-associated protein and p53-binding protein-2 interact through their WW and SH3 domains. J Biol Chem 276, 14514-14523 https://doi.org/10.1074/jbc.M008568200
- Ota M and Sasaki H (2008) Mammalian Tead proteins regulate cell proliferation and contact inhibition as transcriptional mediators of Hippo signaling. Development 135, 4059-4069 https://doi.org/10.1242/dev.027151
- Wu S, Liu Y, Zheng Y, Dong J and Pan D (2008) The TEAD/TEF family protein Scalloped mediates transcriptional output of the Hippo growth-regulatory pathway. Dev Cell 14, 388-398 https://doi.org/10.1016/j.devcel.2008.01.007
- Zhang L, Ren F, Zhang Q, Chen Y, Wang B and Jiang J (2008) The TEAD/TEF family of transcription factor Scalloped mediates Hippo signaling in organ size control. Dev Cell 14, 377-387 https://doi.org/10.1016/j.devcel.2008.01.006
- Zhao B, Ye X, Yu J et al (2008) TEAD mediates YAP-dependent gene induction and growth control. Genes Dev 22, 1962-1971 https://doi.org/10.1101/gad.1664408
- Schlegelmilch K, Mohseni M, Kirak O et al (2011) Yap1 acts downstream of alpha-catenin to control epidermal proliferation. Cell 144, 782-795 https://doi.org/10.1016/j.cell.2011.02.031
- von Gise A, Lin Z, Schlegelmilch K et al (2012) YAP1, the nuclear target of Hippo signaling, stimulates heart growth through cardiomyocyte proliferation but not hypertrophy. Proc Natl Acad Sci U S A 109, 2394-2399 https://doi.org/10.1073/pnas.1116136109
- Zhang W, Gao Y, Li P et al (2014) VGLL4 functions as a new tumor suppressor in lung cancer by negatively regulating the YAP-TEAD transcriptional complex. Cell Res 24, 331-343 https://doi.org/10.1038/cr.2014.10
- Koontz LM, Liu-Chittenden Y, Yin F et al (2013) The Hippo effector Yorkie controls normal tissue growth by antagonizing scalloped-mediated default repression. Dev Cell 25, 388-401 https://doi.org/10.1016/j.devcel.2013.04.021
- Hamaratoglu F, Willecke M, Kango-Singh M et al (2006) The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis. Nat Cell Biol 8, 27-36 https://doi.org/10.1038/ncb1339
- Willecke M, Hamaratoglu F, Kango-Singh M et al (2006) The fat cadherin acts through the hippo tumorsuppressor pathway to regulate tissue size. Curr Biol 16, 2090-2100 https://doi.org/10.1016/j.cub.2006.09.005
- Silva E, Tsatskis Y, Gardano L, Tapon N and McNeill H (2006) The tumor-suppressor gene fat controls tissue growth upstream of expanded in the hippo signaling pathway. Curr Biol 16, 2081-2089 https://doi.org/10.1016/j.cub.2006.09.004
- Cho E, Feng Y, Rauskolb C, Maitra S, Fehon R and Irvine KD (2006) Delineation of a Fat tumor suppressor pathway. Nat Genet 38, 1142-1150 https://doi.org/10.1038/ng1887
- Poon CL, Lin JI, Zhang X and Harvey KF (2011) The sterile 20-like kinase Tao-1 controls tissue growth by regulating the Salvador-Warts-Hippo pathway. Dev Cell 21, 896-906 https://doi.org/10.1016/j.devcel.2011.09.012
- Boggiano JC, Vanderzalm PJ and Fehon RG (2011) Tao-1 phosphorylates Hippo/MST kinases to regulate the Hippo-Salvador-Warts tumor suppressor pathway. Dev Cell 21, 888-895 https://doi.org/10.1016/j.devcel.2011.08.028
- Chung HL, Augustine GJ and Choi KW (2016) Drosophila Schip1 Links Expanded and Tao-1 to Regulate Hippo Signaling. Dev Cell 36, 511-524 https://doi.org/10.1016/j.devcel.2016.02.004
- Yu J, Zheng Y, Dong J, Klusza S, Deng WM and Pan D (2010) Kibra functions as a tumor suppressor protein that regulates Hippo signaling in conjunction with Merlin and Expanded. Dev Cell 18, 288-299 https://doi.org/10.1016/j.devcel.2009.12.012
- Genevet A, Wehr MC, Brain R, Thompson BJ and Tapon N (2010) Kibra is a regulator of the Salvador/Warts/Hippo signaling network. Dev Cell 18, 300-308 https://doi.org/10.1016/j.devcel.2009.12.011
- Baumgartner R, Poernbacher I, Buser N, Hafen E and Stocker H (2010) The WW domain protein Kibra acts upstream of Hippo in Drosophila. Dev Cell 18, 309-316 https://doi.org/10.1016/j.devcel.2009.12.013
- Su T, Ludwig MZ, Xu J and Fehon RG (2017) Kibra and Merlin Activate the Hippo Pathway Spatially Distinct from and Independent of Expanded. Dev Cell 40, 478-490 e473 https://doi.org/10.1016/j.devcel.2017.02.004
- Thompson BJ, Pichaud F and Roper K (2013) Sticking together the Crumbs - an unexpected function for an old friend. Nat Rev Mol Cell Biol 14, 307-314
- Chen CL, Gajewski KM, Hamaratoglu F et al (2010) The apical-basal cell polarity determinant Crumbs regulates Hippo signaling in Drosophila. Proc Natl Acad Sci U S A 107, 15810-15815 https://doi.org/10.1073/pnas.1004060107
- Ling C, Zheng Y, Yin F et al (2010) The apical transmembrane protein Crumbs functions as a tumor suppressor that regulates Hippo signaling by binding to Expanded. Proc Natl Acad Sci U S A 107, 10532-10537 https://doi.org/10.1073/pnas.1004279107
- Grzeschik NA, Parsons LM, Allott ML, Harvey KF and Richardson HE (2010) Lgl, aPKC, and Crumbs regulate the Salvador/Warts/Hippo pathway through two distinct mechanisms. Curr Biol 20, 573-581 https://doi.org/10.1016/j.cub.2010.01.055
- Varelas X, Samavarchi-Tehrani P, Narimatsu M et al (2010) The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-beta- SMAD pathway. Dev Cell 19, 831-844 https://doi.org/10.1016/j.devcel.2010.11.012
- Hirano S, Kimoto N, Shimoyama Y, Hirohashi S and Takeichi M (1992) Identification of a neural alphacatenin as a key regulator of cadherin function and multicellular organization. Cell 70, 293-301 https://doi.org/10.1016/0092-8674(92)90103-J
- Herrenknecht K, Ozawa M, Eckerskorn C, Lottspeich F, Lenter M and Kemler R (1991) The uvomorulin-anchorage protein alpha catenin is a vinculin homologue. Proc Natl Acad Sci U S A 88, 9156-9160 https://doi.org/10.1073/pnas.88.20.9156
- Silvis MR, Kreger BT, Lien WH et al (2011) alpha-catenin is a tumor suppressor that controls cell accumulation by regulating the localization and activity of the transcriptional coactivator Yap1. Sci Signal 4, ra33
- Wei SY, Escudero LM, Yu F et al (2005) Echinoid is a component of adherens junctions that cooperates with DE-Cadherin to mediate cell adhesion. Dev Cell 8, 493-504 https://doi.org/10.1016/j.devcel.2005.03.015
- Yue T, Tian A and Jiang J (2012) The cell adhesion molecule echinoid functions as a tumor suppressor and upstream regulator of the Hippo signaling pathway. Dev Cell 22, 255-267 https://doi.org/10.1016/j.devcel.2011.12.011
- Nishioka N, Inoue K, Adachi K et al (2009) The Hippo signaling pathway components Lats and Yap pattern Tead4 activity to distinguish mouse trophectoderm from inner cell mass. Dev Cell 16, 398-410 https://doi.org/10.1016/j.devcel.2009.02.003
- Wang W, Huang J, Wang X et al (2012) PTPN14 is required for the density-dependent control of YAP1. Genes Dev 26, 1959-1971 https://doi.org/10.1101/gad.192955.112
- Liu X, Yang N, Figel SA et al (2013) PTPN14 interacts with and negatively regulates the oncogenic function of YAP. Oncogene 32, 1266-1273 https://doi.org/10.1038/onc.2012.147
- Michaloglou C, Lehmann W, Martin T et al (2013) The tyrosine phosphatase PTPN14 is a negative regulator of YAP activity. PLoS One 8, e61916 https://doi.org/10.1371/journal.pone.0061916
- Moon S, Kim W, Kim S et al (2017) Phosphorylation by NLK inhibits YAP-14-3-3-interactions and induces its nuclear localization. EMBO Rep 18, 61-71 https://doi.org/10.15252/embr.201642683
- Dupont S, Morsut L, Aragona M et al (2011) Role of YAP/TAZ in mechanotransduction. Nature 474, 179-183 https://doi.org/10.1038/nature10137
- Halder G, Dupont S and Piccolo S (2012) Transduction of mechanical and cytoskeletal cues by YAP and TAZ. Nat Rev Mol Cell Biol 13, 591-600 https://doi.org/10.1038/nrm3416
- Panciera T, Azzolin L, Cordenonsi M and Piccolo S (2017) Mechanobiology of YAP and TAZ in physiology and disease. Nat Rev Mol Cell Biol 12, 758-770
- Zhao B, Li L, Wang L, Wang CY, Yu J and Guan KL (2012) Cell detachment activates the Hippo pathway via cytoskeleton reorganization to induce anoikis. Genes Dev 26, 54-68 https://doi.org/10.1101/gad.173435.111
- Kim NG and Gumbiner BM (2015) Adhesion to fibronectin regulates Hippo signaling via the FAK-Src-PI3K pathway. J Cell Biol 210, 503-515 https://doi.org/10.1083/jcb.201501025
- Elosegui-Artola A, Andreu I, Beedle AEM et al (2017) Force Triggers YAP Nuclear Entry by Regulating Transport across Nuclear Pores. Cell 171, 1397-1410 https://doi.org/10.1016/j.cell.2017.10.008
- Mo JS (2017) The role of extracellular biophysical cues in modulating the Hippo-YAP pathway. BMB Rep 50, 71-78 https://doi.org/10.5483/BMBRep.2017.50.2.199
- Wang Z, Wu Y, Wang H et al (2014) Interplay of mevalonate and Hippo pathways regulates RHAMM transcription via YAP to modulate breast cancer cell motility. Proc Natl Acad Sci U S A 111, E89-98 https://doi.org/10.1073/pnas.1319190110
- Sorrentino G, Ruggeri N, Specchia V et al (2014) Metabolic control of YAP and TAZ by the mevalonate pathway. Nat Cell Biol 16, 357-366 https://doi.org/10.1038/ncb2936
- Mo JS, Meng Z, Kim YC et al (2015) Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway. Nat Cell Biol 17, 500-510 https://doi.org/10.1038/ncb3111
- Wang W, Xiao ZD, Li X et al (2015) AMPK modulates Hippo pathway activity to regulate energy homeostasis. Nat Cell Biol 17, 490-499 https://doi.org/10.1038/ncb3113
- Zhang X, Qiao Y, Wu Q et al (2017) The essential role of YAP O-GlcNAcylation in high-glucose-stimulated liver tumorigenesis. Nat Commun 8, 15280 https://doi.org/10.1038/ncomms15280
- Peng C, Zhu Y, Zhang W et al (2017) Regulation of the Hippo-YAP Pathway by Glucose Sensor O-GlcNAcylation. Mol Cell 68, 591-604 e595 https://doi.org/10.1016/j.molcel.2017.10.010
- Ma B, Chen Y, Chen L et al (2015) Hypoxia regulates Hippo signalling through the SIAH2 ubiquitin E3 ligase. Nat Cell Biol 17, 95-103
- Ma X, Zhang H, Xue X and Shah YM (2017) Hypoxia-inducible factor 2alpha (HIF-2alpha) promotes colon cancer growth by potentiating Yes-associated protein 1 (YAP1) activity. J Biol Chem 292, 17046-17056 https://doi.org/10.1074/jbc.M117.805655
- Xiang L, Gilkes DM, Hu H et al (2014) Hypoxiainducible factor 1 mediates TAZ expression and nuclear localization to induce the breast cancer stem cell phenotype. Oncotarget 5, 12509-12527
- Ma B, Cheng H, Gao R et al (2016) Zyxin-Siah2-Lats2 axis mediates cooperation between Hippo and TGF-beta signalling pathways. Nat Commun 7, 11123 https://doi.org/10.1038/ncomms11123
- Hong AW, Meng Z, Yuan HX et al (2017) Osmotic stress-induced phosphorylation by NLK at Ser128 activates YAP. EMBO Rep 18, 72-86 https://doi.org/10.15252/embr.201642681
- Lin KC, Moroishi T, Meng Z et al (2017) Regulation of Hippo pathway transcription factor TEAD by p38 MAPK-induced cytoplasmic translocation. Nat Cell Biol 19, 996-1002 https://doi.org/10.1038/ncb3581
- Taylor LK, Wang HC and Erikson RL (1996) Newly identified stress-responsive protein kinases, Krs-1 and Krs-2. Proc Natl Acad Sci U S A 93, 10099-10104 https://doi.org/10.1073/pnas.93.19.10099
- Lehtinen MK, Yuan Z, Boag PR et al (2006) A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span. Cell 125, 987-1001 https://doi.org/10.1016/j.cell.2006.03.046
- Shao D, Zhai P, Del Re DP et al (2014) A functional interaction between Hippo-YAP signalling and FoxO1 mediates the oxidative stress response. Nat Commun 5, 3315
- Nusse R and Clevers H (2017) Wnt/beta-Catenin Signaling, Disease, and Emerging Therapeutic Modalities. Cell 169, 985-999 https://doi.org/10.1016/j.cell.2017.05.016
- Kim W, Kim M and Jho EH (2013) Wnt/beta-catenin signalling: from plasma membrane to nucleus. Biochem J 450, 9-21 https://doi.org/10.1042/BJ20121284
- Varelas X, Miller BW, Sopko R et al (2010) The Hippo pathway regulates Wnt/beta-catenin signaling. Dev Cell 18, 579-591 https://doi.org/10.1016/j.devcel.2010.03.007
- Imajo M, Miyatake K, Iimura A, Miyamoto A and Nishida E (2012) A molecular mechanism that links Hippo signalling to the inhibition of Wnt/beta-catenin signalling. EMBO J 31, 1109-1122 https://doi.org/10.1038/emboj.2011.487
- Barry ER, Morikawa T, Butler BL et al (2013) Restriction of intestinal stem cell expansion and the regenerative response by YAP. Nature 493, 106-110
- Tsutsumi R, Masoudi M, Takahashi A et al (2013) YAP and TAZ, Hippo signaling targets, act as a rheostat for nuclear SHP2 function. Dev Cell 26, 658-665 https://doi.org/10.1016/j.devcel.2013.08.013
- Heallen T, Zhang M, Wang J et al (2011) Hippo pathway inhibits Wnt signaling to restrain cardiomyocyte proliferation and heart size. Science 332, 458-461 https://doi.org/10.1126/science.1199010
- Kim W, Khan SK, Gvozdenovic-Jeremic J et al (2017) Hippo signaling interactions with Wnt/beta-catenin and Notch signaling repress liver tumorigenesis. J Clin Invest 127, 137-152
- Fitamant J, Kottakis F, Benhamouche S et al (2015) YAP Inhibition Restores Hepatocyte Differentiation in Advanced HCC, Leading to Tumor Regression. Cell Rep 10, 1692-1707 https://doi.org/10.1016/j.celrep.2015.02.027
- Azzolin L, Zanconato F, Bresolin S et al (2012) Role of TAZ as mediator of Wnt signaling. Cell 151, 1443-1456 https://doi.org/10.1016/j.cell.2012.11.027
- Azzolin L, Panciera T, Soligo S et al (2014) YAP/TAZ incorporation in the beta-catenin destruction complex orchestrates the Wnt response. Cell 158, 157-170 https://doi.org/10.1016/j.cell.2014.06.013
- Cai J, Maitra A, Anders RA, Taketo MM and Pan D (2015) beta-Catenin destruction complex-independent regulation of Hippo-YAP signaling by APC in intestinal tumorigenesis. Genes Dev 29, 1493-1506 https://doi.org/10.1101/gad.264515.115
- Yu FX, Zhao B, Panupinthu N et al (2012) Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling. Cell 150, 780-791 https://doi.org/10.1016/j.cell.2012.06.037
- Miller E, Yang J, DeRan M et al (2012) Identification of serum-derived sphingosine-1-phosphate as a small molecule regulator of YAP. Chem Biol 19, 955-962 https://doi.org/10.1016/j.chembiol.2012.07.005
- Park HW, Kim YC, Yu B et al (2015) Alternative Wnt Signaling Activates YAP/TAZ. Cell 162, 780-794 https://doi.org/10.1016/j.cell.2015.07.013
- Struhl G, Fitzgerald K and Greenwald I (1993) Intrinsic activity of the Lin-12 and Notch intracellular domains in vivo. Cell 74, 331-345 https://doi.org/10.1016/0092-8674(93)90424-O
- Schroeter EH, Kisslinger JA and Kopan R (1998) Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain. Nature 393, 382-386 https://doi.org/10.1038/30756
- Bray SJ (2016) Notch signalling in context. Nat Rev Mol Cell Biol 17, 722-735 https://doi.org/10.1038/nrm.2016.94
- Meignin C, Alvarez-Garcia I, Davis I and Palacios IM (2007) The salvador-warts-hippo pathway is required for epithelial proliferation and axis specification in Drosophila. Curr Biol 17, 1871-1878 https://doi.org/10.1016/j.cub.2007.09.062
- Polesello C and Tapon N (2007) Salvador-warts-hippo signaling promotes Drosophila posterior follicle cell maturation downstream of notch. Curr Biol 17, 1864-1870 https://doi.org/10.1016/j.cub.2007.09.049
- Camargo FD, Gokhale S, Johnnidis JB et al (2007) YAP1 increases organ size and expands undifferentiated progenitor cells. Curr Biol 17, 2054-2060 https://doi.org/10.1016/j.cub.2007.10.039
- Zhou D, Zhang Y, Wu H et al (2011) Mst1 and Mst2 protein kinases restrain intestinal stem cell proliferation and colonic tumorigenesis by inhibition of Yes-associated protein (Yap) overabundance. Proc Natl Acad Sci U S A 108, E1312-1320 https://doi.org/10.1073/pnas.1110428108
- Yimlamai D, Christodoulou C, Galli GG et al (2014) Hippo pathway activity influences liver cell fate. Cell 157, 1324-1338 https://doi.org/10.1016/j.cell.2014.03.060
- Manderfield LJ, Aghajanian H, Engleka KA et al (2015) Hippo signaling is required for Notch-dependent smooth muscle differentiation of neural crest. Development 142, 2962-2971 https://doi.org/10.1242/dev.125807
- Rayon T, Menchero S, Nieto A et al (2014) Notch and hippo converge on Cdx2 to specify the trophectoderm lineage in the mouse blastocyst. Dev Cell 30, 410-422 https://doi.org/10.1016/j.devcel.2014.06.019
- Tschaharganeh DF, Chen X, Latzko P et al (2013) Yes-associated protein up-regulates Jagged-1 and activates the Notch pathway in human hepatocellular carcinoma. Gastroenterology 144, 1530-1542 e1512 https://doi.org/10.1053/j.gastro.2013.02.009
- Massague J (2012) TGFbeta signalling in context. Nat Rev Mol Cell Biol 13, 616-630 https://doi.org/10.1038/nrm3434
- Luo K (2017) Signaling Cross Talk between TGF-beta/Smad and Other Signaling Pathways. Cold Spring Harb Perspect Biol 9, a022137 https://doi.org/10.1101/cshperspect.a022137
- Ayyaz A, Attisano L and Wrana JL (2017) Recent advances in understanding contextual TGFbeta signaling. F1000Res 6, 749 https://doi.org/10.12688/f1000research.11295.1
- Attisano L and Wrana JL (2013) Signal integration in TGF-beta, WNT, and Hippo pathways. F1000Prime Rep 5, 17
- Varelas X, Sakuma R, Samavarchi-Tehrani P et al (2008) TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal. Nat Cell Biol 10, 837-848 https://doi.org/10.1038/ncb1748
- Nallet-Staub F, Yin X, Gilbert C et al (2015) Cell density sensing alters TGF-beta signaling in a cell-type-specific manner, independent from Hippo pathway activation. Dev Cell 32, 640-651 https://doi.org/10.1016/j.devcel.2015.01.011
- Mahoney JE, Mori M, Szymaniak AD, Varelas X and Cardoso WV (2014) The hippo pathway effector Yap controls patterning and differentiation of airway epithelial progenitors. Dev Cell 30, 137-150 https://doi.org/10.1016/j.devcel.2014.06.003
- Zhao R, Fallon TR, Saladi SV et al (2014) Yap tunes airway epithelial size and architecture by regulating the identity, maintenance, and self-renewal of stem cells. Dev Cell 30, 151-165 https://doi.org/10.1016/j.devcel.2014.06.004
- Lee DH, Park JO, Kim TS et al (2016) LATS-YAP/TAZ controls lineage specification by regulating TGFbeta signaling and Hnf4alpha expression during liver development. Nat Commun 7, 11961 https://doi.org/10.1038/ncomms11961
- Lai D and Yang X (2013) BMP4 is a novel transcriptional target and mediator of mammary cell migration downstream of the Hippo pathway component TAZ. Cell Signal 25, 1720-1728 https://doi.org/10.1016/j.cellsig.2013.05.002
- Nishio M, Sugimachi K, Goto H et al (2016) Dysregulated YAP1/TAZ and TGF-beta signaling mediate hepatocarcinogenesis in Mob1a/1b-deficient mice. Proc Natl Acad Sci U S A 113, E71-80 https://doi.org/10.1073/pnas.1517188113
- Pefani DE, Pankova D, Abraham AG et al (2016) TGF-beta Targets the Hippo Pathway Scaffold RASSF1A to Facilitate YAP/SMAD2 Nuclear Translocation. Mol Cell 63, 156-166 https://doi.org/10.1016/j.molcel.2016.05.012
- Stroschein SL, Wang W, Zhou S, Zhou Q and Luo K (1999) Negative feedback regulation of TGF-beta signaling by the SnoN oncoprotein. Science 286, 771-774 https://doi.org/10.1126/science.286.5440.771
- Zhu Q, Le Scolan E, Jahchan N, Ji X, Xu A and Luo K (2016) SnoN Antagonizes the Hippo Kinase Complex to Promote TAZ Signaling during Breast Carcinogenesis. Dev Cell 37, 399-412 https://doi.org/10.1016/j.devcel.2016.05.002
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