• Journal of the Korean Institute of Landscape Architecture
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• v.41 no.5
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• pp.38-45
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• 2013

Buffer green space in the residential area is a mechanism for improving the residential environment and also significant for residential life satisfaction and its various social roles. Accordingly, this study aimed to discover the effect of the buffer green space, which was established to minimize environmental influences of the residential environment, on residential life satisfaction. For this purpose, a survey was conducted on residents in Myeongji Residential Area where the buffer green space was installed, to examine the factors of the buffer green space and to analyze its causal relation with residential life satisfaction. The SPSS(statistical package for social science) 21 program was used for analysis and factorial analysis, correlation analysis and multiple regression analysis were executed. As a result, the roles of the buffer green space in Myeong-ji Residential Area included residential comfort, disaster protection, green space usability and environmental ecological property. In the overall accrued factorial contribution rate, residential comfort was very high with 40.54% out of total 62.48%. In addition, the residential comfort and green area usability had a higher correlation with residential life satisfaction. However, the significant level of disaster protection and environmental ecological property were 0.725 and 0.898, respectively, which were not significant as a preference factor in multiple regression analysis. Accordingly, the buffer green space for improving residential comfort and green space usability was confirmed to enhance residential life satisfaction.

• The Research Journal of the Costume Culture
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• v.24 no.5
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• pp.588-599
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• 2016

The primary aim of this study was to analyze the fashion trend of wearing T-shirts with slogans at home and abroad and to consider the social influence of these shirts on fashion. The research method was based on the documentary method and the existing literature, and the study range was limited to the period from the middle of the 20th century to the present. Slogan T-shirts played important roles because they make the wearers highly visible wherever they go. T-shirts with slogans not only intentionally expressed the wearers' views on multiple social issues but they also made those issues more visible, thereby encouraging society to deal with them. The T-shirts also helped to form a social consensus regarding the issues. For this reason we referred to slogan T-shirts as 'the social fashion' in this research. Regarding the results, the research found that T-shirts with slogans were a social fashion that conveyed real political slogans and thus influenced people's political beliefs. Second, they politicized the issues in public interests with the public perspective. Third, the purpose of slogan T-shirts was to help people express their personality publicly and thereby bond with other people who held similar sympathies. Furthermore, the T-shirts conveyed multiple meanings in each message.

• Korean Journal of Poultry Science
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• v.42 no.1
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• pp.27-32
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• 2015

In this study, we used two breeds of chicken to identify genomic regions corresponding to necrotic enteritis (NE) resistance. We scanned the genomes of a resistant and susceptible line of Fayoumi and White Leghorn chickens (20 birds/line) using a chicken 60 K Illumina SNP panel. A total of 235 loci with divergently fixed alleles were identified across the genome in both breeds; particularly, several clusters of multiple loci with fixed alleles were found in five narrow regions. Moreover, consensus 15-SNP haplotypes that were shared by the resistant lines of both breeds were identified on chromosomes 3, 7 and 9. Genes responsible for NE resistance were identified in chicken lines selected for resistance and susceptibility. Annotation of the regions spanning clustered divergently fixed regions revealed a set of interesting candidate genes such as phosphoinositide-3-kinase, regulatory subunit 5, p101 (PIK3R5) and inositol 1,4,5-trisphosphate receptor 1 (ITPR1), which participate in immune response. Consensus haplotypes were found in regions containing possibly relevant genes, such as myostatin and myosin, which play important roles in muscle development. Thus, genome scans of divergent selection in multiple chicken lines and breeds can be used to identify genomic regions associated with NE resistance.

• BMB Reports
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• v.32 no.5
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• pp.468-473
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• 1999

Nuclear Factor 1 (NF1) proteins are a family of transcriptional factors consisting of four different types: NF1-A, -B, -C, and -X. Some NF1 transcription factors contain a heptasequence motif, SPTSPSY, which is found as a repeat sequence in the carboxy terminal domain (CTD) of the largest subunit of RNA polymerase II. A similar heptasequence, SPTSPTY, is contained in rat liver NF1-A at a position between residues 469 and 475. In order to investigate the roles of the individual amino acids of the heptasequence of rat liver NF1-A in transcriptional activation, we systematically substituted single and multiple amino acid residues with alanine residue(s) and evaluated the transcriptional activities of the mutated NF1-A. Substitution of a single amino acid reduced transcriptional activity by 10 to 30%, except for the proline residue at position 473, whose substitution with alanine did not affect transcriptional activity. However, changes of all four serine and threonine residues to alanine or of the tyrosine residue along with the serine residue at position 469 to alanine reduced the activity to almost background levels. Our results indicate that multiple serine and threonine residues, rather than a single residue, may be involved in the modulation of the transcriptional activities of the factor. Involvement of the tyrosine residue is also implicated.

• Biomolecules & Therapeutics
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• v.25 no.1
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• pp.80-90
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• 2017

Initial discovery on sphingosine 1-phosphate (S1P) as an intracellular second messenger was faced unexpectedly with roles of S1P as a first messenger, which subsequently resulted in cloning of its G protein-coupled receptors, $S1P_{1-5}$. The molecular identification of S1P receptors opened up a new avenue for pathophysiological research on this lipid mediator. Cellular and molecular in vitro studies and in vivo studies on gene deficient mice have elucidated cellular signaling pathways and the pathophysiological meanings of S1P receptors. Another unexpected finding that fingolimod (FTY720) modulates S1P receptors accelerated drug discovery in this field. Fingolimod was approved as a first-in-class, orally active drug for relapsing multiple sclerosis in 2010, and its applications in other disease conditions are currently under clinical trials. In addition, more selective S1P receptor modulators with better pharmacokinetic profiles and fewer side effects are under development. Some of them are being clinically tested in the contexts of multiple sclerosis and other autoimmune and inflammatory disorders, such as, psoriasis, Crohn's disease, ulcerative colitis, polymyositis, dermatomyositis, liver failure, renal failure, acute stroke, and transplant rejection. In this review, the authors discuss the state of the art regarding the status of drug discovery efforts targeting S1P receptors and place emphasis on potential clinical applications.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.36 no.9
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• pp.859-866
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• 2008

A guidance scheme for controlling the relative geometry of multiple flight vehicle formation flying is proposed. Each flight vehicle in the formation takes the roles of leader and follower simultaneously except for the formation leader. In this scheme, the flight commands for a leader are shared by all the followers and this leaders to a synchronized flight of all flight vehicles comprising the formation. Lyapunov stability theorem is used to obtain the guidance law. High fidelity nonlinear simulation results are presented to show the effectiveness of the proposed guidance law using a reconnaissance and surveillance mission example.

• Journal of Microbiology and Biotechnology
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• v.29 no.11
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• pp.1852-1859
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• 2019

Chikungunya virus (CHIKV) is a single-stranded positive-sense RNA virus, belonging to the genus Alphavirus of the Togaviridae family. It causes multiple symptoms, including headache, fever, severe joint and muscle pain, and arthralgia. Since CHIKV was first isolated in Tanzania in 1952, there have been multiple outbreaks of chikungunya fever. However, its pathogenesis and mechanisms of viral immune evasion have been poorly understood. In addition, the exact roles of individual CHIKV genes on the host innate immune response remain largely unknown. To investigate if CHIKV-encoded genes modulate the type I interferon (IFN) response, each and every CHIKV gene was screened for its effects on the induction of the IFN-β promoter. Here we report that CHIKV nsP2, E2 and E1 strongly suppressed activation of the IFN-β promoter induced by the MDA5/RIG-I receptor signaling pathway, suggesting that nsP2, E2, and E1 are the major antagonists against induction of IFN-β. Delineation of underlying mechanisms of CHIKV-mediated inhibition of the IFN-β pathway may help develop virus-specific therapeutics and vaccines.

• The Journal of Korean Society for School & Community Health Education
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• v.13 no.2
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• pp.1-15
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• 2012

Objectives: This is an explanatory correlational study to identify the relationship among knowledge, attitudes about cancer, self efficacy and health behavior for cancer prevention in school-age children. Methods: Data were collected from 488 students in grades 5 or 6 who understood the purpose of the study and agreed to participate. Data were analyzed by descriptive statistics, t-test, Pearson's correlation coefficient, and multiple regression using SPSS 18.0. Results: There were significant differences in health behavior for cancer prevention between upper 25% and lower 25% group of attitudes about cancer and self efficacy. Result from the multiple regression analysis revealed difference in the related factors and in the magnitude of the relationship evaluated by the standardized beta coefficients. Significant factors, listed by the magnitude of beta coefficients, were self efficacy, attitudes about cancer, perceived health status. These variables accounted for 30.5% of health behavior for cancer prevention. Conclusions: Based on results of the present study, systemic health education about cancer prevention for school-age children is suggested. Further research is necessary in order to draw consensus on roles of the related factors of health behavior for cancer prevention.

• Research in Community and Public Health Nursing
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• v.9 no.1
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• pp.223-231
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• 1998

결혼한 여성의 우울과 관련된 주 요인의 하나는 그들의 다양한 역할이 정신적인 건강에 부정적인 영향을 심리적으로 미친다고 발표되어 있다. 그럼에도 불구하고 한국 이민 주부에 대한 이러한 영역에서의 연구가 매우 부족한 실정이다. 중서부의 주요 도시인 시키고의 도심지에 위치한 11곳의 한국인 교회에서 편의 표출 방법으로 다음과 같은 기준에 맞는 대상자를 선택하였다. 나이는 25-55세 사이, 결혼하여 남편과 함께 살고 있으며, 매주 20시간 이상씩 일하고 있는 여성 등의 기준을 충족시키는 응답자의 수는 282명이었다 대상자들에게는 5가지의 설문 즉 인구통계학적, 우울에 대한 역학 연구, 성 역할 지향성의 지수, 역할 분담 및 대처 전략 등에 관한 질문이었다. 중다회귀분석 (Multiple Regression Analysis)에서 통계학적으로 유의한 관계를 보인 것은 다음과 같았다. 주부의 자녀가 적을수록 우울의 수준은 높았고, 가족의 수입이 많을수록 우울의 수준은 낮았으며, 주부가 일하는 것이 경제적 필요를 충족시키기 위함이라고 스스로 지각(주부들은 일하는 역할이 합법적으로 판단되어지기를 원했고 또 지각했는데 이와 대조하여 일의 역할을 비합법적으로 지각하는 것)할수록 우울의 수준은 더 높았다. 비록 일하는 것이 저녁 늦게 자고 아침 일찍 일어남을 의미할지라도 모든 가사를 완수하기 위하여 열심히 일한다고 하면 할수록 우울의 수준은 더 높았다. 주부가 일의 역할을 합법적으로 지각하면 할수록 남편과 다른 가족의 구성원들에게 도움을 요청하거나 도움을 받는 것을 원하지 않았으며, 일을 더 열심히 하기 위해 대처전략과 우선순위(주부가 일을 전혀 완수 할 수 없을지라도 가정의 어떤 일이 중요하고 어느 것이 두 번째로 중요한지를 결정하는)를 더 잘 설정하고 더 잘 수용하는 것 같았다. 식품 등을 쇼핑하는데에 많은 시간을 소모할수록 우울의 수준은 더 높았다. 이 자료는 스트레스와 대처이론을 지지하고 있다.

• IMMUNE NETWORK
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• v.14 no.2
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• pp.67-72
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• 2014

The herpes virus entry mediator (HVEM) is a member of the tumor necrosis factor receptor superfamily (TNFRSF), and therefore it is also known as TNFRSF14 or CD270 (1,2). In recent years, we have focused on understanding HVEM function in the mucosa of the intestine, particularly on the role of HVEM in colitis pathogenesis, host defense and regulation of the microbiota (2-4). HVEM is an unusual TNF receptor because of its high expression levels in the gut epithelium, its capacity to bind ligands that are not members of the TNF super family, including immunoglobulin (Ig) superfamily members BTLA and CD160, and its bi-directional functionality, acting as a signaling receptor or as a ligand for the receptor BTLA. Clinically, Hvem recently was reported as an inflammatory bowel disease (IBD) risk gene as a result of genome wide association studies (5,6). This suggests HVEM could have a regulatory role influencing the regulation of epithelial barrier, host defense and the microbiota. Consistent with this, using mouse models, we have revealed how HVEM is involved in colitis pathogenesis, mucosal host defense and epithelial immunity (3,7). Although further studies are needed, our results provide the fundamental basis for understanding why Hvem is an IBD risk gene, and they confirm that HVEM is a mucosal gatekeeper with multiple regulatory functions in the mucosa.