• 대한지역사회작업치료학회지
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• 제6권2호
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• pp.1-10
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• 2016

목적 : 본 연구는 다감각 자극훈련이 노인의 인지기능 및 균형능력에 미치는 영향을 알아보고자 하였다. 연구방법 : 본 연구는 지역사회에 거주하는 65세 이상 노인 10명을 대상으로 다감각 자극훈련을 주 1회 60분씩 12주 동안 진행하였다. 다감각 자극훈련은 신체도식, 대근육, 촉각자극 영역을 포함한 총 12가지 주제에 맞는 활동으로 구성된 프로그램이다. 결과측정은 한국형-간이정신상태평가(Mini-Mental State Examination-Korean, MMSE-K)와 버그균형검사(Berg Balance Scale, BBS)를 사용하여 대상자의 사전사후 인지기능과 균형 능력을 평가하였고, 중재 이후 프로그램 만족도를 조사하였다. 측정 결과는 윌콕슨 순위 검정(Wilcoxon matched-pair signed rank test)을 사용하여 인지기능과 균형능력의 중재 전후로 차이를 비교하여 분석하였다. 결과 : 다감각 자극훈련 중재 이후 대상자들은 인지기능과 균형능력에서 유의한 향상을 보였다(p<.05). 또한 중재 이후 대상자 모두 프로그램에 대한 긍정적인 만족도를 보였다. 결론 : 지역사회 노인을 대상으로 한 다감각 자극훈련은 노인의 인지기능과 균형능력의 향상에 긍정적인 영향을 미쳤으며, 중재 이후 만족도에도 긍정적인 결과를 보였다. 다감각 자극훈련은 고령화 시대에 노인들에게 만족감을 줄 수 있는 그룹치료활동으로 효과적인 사용을 위한 추가적인 연구가 더 필요할 것으로 생각된다.

• Journal of Genetic Medicine
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• 제13권2호
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• pp.59-64
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• 2016

Gaucher disease type 1 (GD1) is an inherited lysosomal storage disorder caused by deficiency of acid ${\beta}$-glucosidase. The diminished enzyme activity leads to the accumulation of substrates and results in multi-systemic manifestations including hepatosplenomegaly, anemia, thrombocytopenia, and bone diseases. Enzyme replacement therapy (ERT) by infusion of recombinant protein has been the standard treatment for over 20 years. Despite the successful long-term treatment with ERT, several unmet needs remain in the treatment of GD1 such as severe pulmonary and skeletal manifestations. Substrate reduction therapy (SRT) reduces the accumulation of substrates by inhibiting their biosynthesis. Eliglustat, a new oral SRT, was approved in United States and Europe as a first-line therapy for treating adult patients with GD1 who have compatible CYP2D6 metabolism phenotypes. Although eliglustat is not yet available in Korea, introduction and summary of this new treatment modality are provided in this paper by review of literatures. Despite the fact that there are only limited studies to draw resolute conclusions, the current data demonstrated that eliglustat is not inferior to ERT in terms of its clinical efficacy. The approval of eligustat enables eligible adult GD1 patients to have the option of oral therapy although it still needs further studies on long-term outcomes. The individual patient should be assessed carefully for the choice of treatment modality when eliglustat becomes available in Korea. Furthermore, the clinical guidelines for Korean patients with GD1 regarding the use of eliglustat needs to be developed in near future.

• 대한통합의학회지
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• 제1권1호
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• pp.77-85
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• 2013

Purpose : The purpose of this study was to investigate the fieldwork satisfaction of Dept. of Health-related students, and to ascertain a change of perception on deciding on a course after fieldwork, and on a desired field and facility. Methods : Structured questionnaires were distributed to student of Dept. of Health-related(Occupational therapy, Physical therapy, Dental hygiene) from March 2 to April 30 of 2011. The questionnaires of 150 respondents were analyzed through frequency analyses, cross- and multi-reply analyses using SPSS ver. 12.0. Results : In fieldwork satisfaction, highly satisfied items were diversity of therapeutic equipment and tools, regular education, and recognition of the importance of fieldwork. The awareness of their decisions on employment and desired field changed positively for 52.7% students and negatively for 13.3%. Conclusion : Based on the results of this study, we identified that the awareness of one's decision on employment and desired field changes through fieldwork.

• The Journal of Korean Physical Therapy
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• 제27권6호
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• pp.434-438
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• 2015

Purpose: The purpose of this study was to determine the effects of calcaneal taping on peak plantar pressure of rearfoot and forefoot while walking. Methods: Fifteen healthy subjects with normal feet participated in this study. Inclusion criteria were as follows: (1) no disturbance of gait and foot pain, (2) normal range of motion of ankle joint, (3) no foot deformity. Pedoscan was used for recording of plantar pressure data during walking. The participants walked along a 12-m walkway before and after application of calcaneal taping. The plantar pressure gait was measured 3 times under barefoot and calcaneal taping conditions randomly at a speed practiced with the metronome during gait. The peak plantar pressure data were calculated for medial and lateral areas of the rearfoot and forefoot. The paired t-test was used to determine significant differences in peak plantar pressure of rearfoot and forefoot before and after application of calcaneal taping. A p-value less than 0.05 was accepted as significant. Results: The calcaneal taping resulted in statistically significant decreases in peak plantar pressure of the rearfoot (medial side: p=0.03; lateral side: p=0.01). However, there were no significant changes in peak plantar pressure of the forefoot (medial side: p=0.45; lateral side: p=0.40). Conclusion: The calcaneal taping is recommended to reduce plantar pressure of the rearfoot in weight-bearing activities in subjects with plantar heel pain caused by atrophy of the fat pad.

• Asian-Australasian Journal of Animal Sciences
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• 제14권9호
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• pp.1331-1341
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• 2001

Dairy cows are prone to fatty liver during the time of periparturient. Despite of the extensive studies, etiology and solutions for fatty liver are still not well known.The liver synthesizes triglycerides (TG) using precursors from bloodstream and secretes TG in form of very low density lipoprotein (VLDL) into bloodstream for the utilization by peripheral tissues. When the amount of TG synthesis exceeds the amount of secretion in VLDL-TG, TG accumulation within the liver occurs. Hepatic VLDL assembly and secretion involve multi-biochemical events.The availabilities of apolipoprotein B (apoB), E (apoE), microsomal triglyceride transfer protein (MTP) and soluble low density lipoprotein (LDL) receptor are now believed to be some of the main regulators for hepatic VLDL assembly and secretion. Studies in transgenic animals show that overexpression of these proteins stimulates VLDL production and secretion, which provides a possibility for alleviating bovine fatty liver by gene therapy. However, many problems remain to be solved to attain this goal. This review focuses on the molecular mechanisms of hepatic VLDL assembly and secretion, and the possibilities and problems of applying the knowledges to solve bovine fatty liver by gene therapy.

• Nuclear Medicine and Molecular Imaging
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• 제41권4호
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• pp.265-271
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• 2007

Radionuclide therapy has been an important field in nuclear medicine. In radionuclide therapy, relevant evaluation of Internally absorbed dose is essential for the achievement of efficient and sufficient treatment of incurable disease, and can be accomplish by means of accurate measurement of radioactivity in body and its changes with time. Recently, the advances of nuclear medicine imaging and multi modality imaging processing techniques can provide change of more accurate and easier measurement of the measures commented above, in cooperation of conventional imaging based approaches. in this review, basic concept for internal dosimetry using nuclear medicine imaging is summarized with several check points which should be considered In real practice.

• 한국전문물리치료학회지
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• 제14권3호
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• pp.1-8
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• 2007

The purpose of this study was to determine whether aromatherapy massages with manual lymph drainage (MLD) are significantly more effective than sham massages with MLD in reducing edematous limb volume in lymphedema. This study was performed on 46 patients who had developed unilateral upper or lower lymphedema. Twenty-three patients served as the experimental group and were treated with complex decongestive physiotherapy (CDP) applications including aroma massages with MLD, multi layered compression bandages, remedial exercises and skin care. Twenty-three patients in the control group were treated with CDP applications including sham massages with MLD, bandages, exercises and skin care. Patients undergo a therapy program once a day; 5 days a week for 2 weeks. Percentage excess volume (PEV) and body mass index (BMI) were recorded before and after treatment. PEV and BMI were significantly decreased before and after treatment in the experimental as well as in the control groups (p<.05). However, the percentage excess volume and BMI were not significantly improved after treatment between the two groups (p>.05). This study there suggests that aroma massages is not effective in the edema of patients with lymphedema.

• Archives of Plastic Surgery
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• 제46권5호
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• pp.470-474
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• 2019

Congenital absent sternum is a rare birth defect that requires early intervention for optimal long-term outcomes. Descriptions of the repair of absent sternum are limited to case reports, and no preferred method for management has been described. Herein, we describe the use of porcine acellular dermal matrix to reconstruct the sternum of an infant with sternal infection following attempted repair using synthetic mesh. The patient was a full-term male with trisomy 21, agenesis of corpus callosum, ventricular septal defect, patent ductus arteriosus, right-sided aortic arch, and congenital absence of sternum with no sternal bars. Following removal of the infected synthetic mesh, negative pressure wound therapy with instillation was used to manage the open wound and provide direct antibiotic therapy. When blood C-reactive protein levels declined to ${\leq}2mg/L$, the sternum was reconstructed using porcine acellular dermal matrix. At 21 months postoperative, the patient demonstrated no respiratory issues. Physical examination and computed tomography imaging identified good approximation of the clavicular heads and sternal cleft and forward curvature of the ribs. This case illustrates the benefits of negative pressure wound therapy and acellular dermal matrix for the reconstruction of absent sternum in the context of infected sternal surgical site previously repaired with synthetic mesh.

• 한국전문물리치료학회지
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• 제30권1호
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• pp.8-14
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• 2023

Background: Excessive hamstring (HS) activation due to the weakness of the gluteus maximus (GM) causes pain in the hip joint. A single-leg deadlift is a hip extensor exercise, especially GM, that includes functional movements in daily life and complex multi-joint training. In single-leg deadlift, the muscle activity depends on the forward trunk lean angle, and it's necessary to study which muscles are used dominantly depending on the angle. Objects: The purpose of this study was to compare the effect on the muscle activity of the GM and HS during single-leg deadlift according to different forward trunk lean angles and the ratio of the GM vs HS (GM/HS). Methods: Twenty-one healthy female participants were recruited. The muscles activities of the GM, HS and the GM/HS ratio were measured through electromyography during single-leg deadlift according to three condition of forward trunk lean angles (30°, 60°, and 90°). Results: The GM and HS activities significantly differed among three conditions (p < 0.05). GM/HS ratio was significantly higher at 30° and 60° of forward trunk lean compared to 90°. Moreover, the GM activity was significantly higher at 60° of forward trunk lean than at 30° (p < 0.05). Conclusion: The single-leg deadlift at 60° of forward trunk lean is a proper GM muscle strengthening exercise.

• 산업융합연구
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• 제20권10호
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• pp.39-49
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• 2022

본 연구는 국외 경도인지장애 노인의 우울증상을 위한 비약물적 중재에 대한 특성과 효과를 분석하기 위해 무작위 대조군 실험연구에 대한 체계적 고찰을 시행하였다. 3개의 검색 데이터베이스를 사용하여 2011년 1월부터 2021년 7월까지 출간된 문헌을 분석하였다. 총 1,455편의 문헌이 검색되어 총 11편의 문헌을 최종 분석하였다. 문헌의 질 평가는 Risk of bias(RoB)를 사용하였다. 우울증상 평가도구는 Geriatric Depression Scale(GDS)이 가장 많이 사용되었다. 분석된 문헌에서 사용된 중재는 요가, 심리사회적 중재, 인지훈련, 건강교육, 다중요소 중재, 게임훈련, 유산소/심폐물리치료, 미술치료, 음악회상 활동, 기억특이성 훈련, 인지자극, 수면교육이 적용되었다. 그 중 요가, 다중요소 중재, 게임훈련이 우울증상 개선에 효과적이었다. 본 연구는 경도인지장애 노인의 우울증상에 대한 중재계획 및 실행에서 임상적 근거를 제시하였다.