• Journal of Physiology & Pathology in Korean Medicine
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• v.30 no.6
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• pp.385-396
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• 2016

It is a fact that the existing pharmacological research method is difficult to explain the effect and mechanism of action of herbal formula of Korean medicine. We are now very pleased with the development of modern science and the development of a methodology for studying herbal formula characterized by network targets and multi-component therapeutics over the human body. In this review, systems pharmacology or network pharmacology is demonstrated how these are applied to explain the effectiveness of herbal medicine. The post-genomic era provides a unique opportunity for the two fields to understand and benefit from each other. In particular, recent research trends, research methodology, useful databases and results of research on herbal formula are introduced. China already has a policy of scientific development of traditional chinese medicine (TCM) and the development of Chinese medicine industry with a focus on herbal formula research at national level, and in Korea, it is urgent to support and nurture the methodology appropriate to the characteristics of the herbal formula in order to study the safety and efficacy of Korean medicine.

• Nuclear Engineering and Technology
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• v.52 no.10
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• pp.2238-2249
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• 2020

In a seismic PSA, dependency among seismic failures of components has not been explicitly modeled in the fault tree or event tree. This dependency is separately identified and assigned with numbers that range from zero to unity that reflect the level of the mutual correlation among seismic failures. Because of complexity and difficulty in calculating combination probabilities of correlated seismic failures in complex seismic event tree and fault tree, there has been a great need of development to explicitly model seismic correlation in terms of seismic common cause failures (CCFs). If seismic correlations are converted into seismic CCFs, it is possible to calculate an accurate value of a top event probability or frequency of a complex seismic fault tree by using the same procedure as for internal, fire, and flooding PSA. This study first proposes a methodology to explicitly model seismic dependency by converting correlated seismic failures into seismic CCFs. As a result, this methodology will allow systems analysts to quantify seismic risk as what they have done with the CCF method in internal, fire, and flooding PSA.

• Structural Engineering and Mechanics
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• v.82 no.5
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• pp.667-678
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• 2022

Moment-resisting frames (MRFs) are among the most conventional steel structures for mid-rise buildings in many earthquake-prone cities. Here, a simplified performance-based methodology is proposed for the seismic collapse capacity assessment of these buildings. This method employs a novel multi-mode pushover analysis to determine the engineering demand parameters (EDPs) of the regular steel MRFs up to the collapse prevention (CP) performance level. The modal combination coefficients used in the proposed pushover analysis, are obtained from two metaheuristic optimization algorithms and a fitting procedure. The design variables for the optimization process are the inter-story drift ratio profiles resulting from the multi-mode pushover analyses, and the objective values are the outcomes of the incremental dynamic analysis (IDA). Here, the collapse capacity of the structures is assessed in three to five steps, using a modified IDA procedure. A series of regular mid-rise steel MRFs are selected and analyzed to calculate the modal combination coefficients and to validate the proposed approach. The new methodology is verified against the current existing approaches. This comparison shows that the suggested method more accurately evaluates the EDPs and the collapse capacity of the regular MRFs in a robust and easy to implement way.

• The Transactions of the Korean Institute of Power Electronics
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• v.23 no.4
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• pp.247-255
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• 2018

This paper proposes a transformer design of a direct cell-to-cell active cell balancing circuit with a multi-winding transformer for battery management system (BMS) applications. The coupling coefficient of the multi-winding transformer and the output capacitance of MOSFETs significantly affect the balancing current transfer efficiency of the cell balancing operation. During the operation, the multi-winding transformer stores the energy charged in a specific source cell and subsequently transfers this energy to the target cell. However, the leakage inductance of the multi-winding transformer and the output capacitance of the MOSFET induce an abnormal energy transfer to the non-target cells, thereby degrading the transfer efficiency of the balancing current in each cell balancing operation. The impacts of the balancing current transfer efficiency deterioration are analyzed and a transformer design methodology that considers the coupling coefficient is proposed to enhance the transfer efficiency of the balancing current. The efficiency improvements resulting from the selection of an appropriate coupling coefficient are verified by conducting a simulation and experiment with a 1 W prototype cell balancing circuit.

• Journal of the Korea Society for Simulation
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• v.20 no.1
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• pp.39-49
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• 2011

Nowaday, Many equipments like TabletPC, Digital kiosk, ATM using touch-panel service instead of keyboard or button, to support intuitively input for user. Furthermore these days touch-panels recognize up to 5 contact points using recent technology. On this study, I Introduce password input/store methodology on multi-touch environment. On past, User must input password 1 character by 1 character, like [1, 2, 3, 4]. but, on multi-touch environment user can input more than one character at the same time, like [(1,3), 2, (3,4), (1,2,3)]. In result, users can use password more intensely. This study is utilized post security technology study on multi-touch environment.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.40 no.2
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• pp.78-91
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• 2017

In this study, we conducted a comparative study on user's perception and behavior on public system service (PSS) using institutionalism theory and MGA (multi-group analysis) methodology. In particular, this study focuses on how institutional isomorphism is applied to public system services and how MGA can be implemented correctly in a variance based SEM (structural equation model) such as PLS (partial least square). A data set of 496 effective responses was collected from pubic system users and an empirical research was conducted using three segmented models categorized by public proximity theory (public firms = 113, government contractors = 210, private contractors = 173). For rigorous group comparisons, each model was estimated by the same indicators and approaches. PLS-SEM was used in testing research hypotheses, followed by parametric and non-parametric PLS-MGA procedures in testing categorical moderation effects. This study applied novel procedures for testing composite measurement invariance prior to multi-group comparisons. The following main results and implications are drawn : 1) Partial measurement invariance was established. Multi-group analysis can be done by decomposed models although data can not be pooled for one integrated model. 2) Multi-group analysis using various approaches showed that proximity to public sphere moderated some hypothesized paths from quality dimensions to user satisfaction, which means that categorical moderating effects were partially supported. 3) Careful attention should be given to the selection of statistical test methods and the interpretation of the results of multi-group analysis, taking into account the different outcomes of the PLS-MGA test methods and the low statistical power of the moderating effect. It is necessary to use various methods such as comparing the difference in the path coefficient significance and the significance of the path coefficient difference between the groups. 4) Substantial differences in the perceptions and behaviors of PSS users existed according to proximity to public sphere, including the significance of path coefficients, mediation and categorical moderation effects. 5) The paper also provides detailed analysis and implication from a new institutional perspective. This study using a novel and appropriate methodology for performing group comparisons would be useful for researchers interested in comparative studies employing institutionalism theory and PLS-SEM multi-group analysis technique.

• Proceedings of the Korea Society for Simulation Conference
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• 2001.10a
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• pp.44-49
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• 2001

This paper is concerned with development of a multi-attribute structured decision model. In this study, we used AHP(analytic hierarchy process) and fuzzy set ranking methodology to overcome the multi-attributes structured decision problems ; such as multi-objective, multi-criterion, and multi-attributes. We proposed a 2-step approach : 1) individual evaluation and 2) integration of individual evaluations. In the first step, we define the performance factors and construct ana]isis structure, and in the second step performance evaluation by individual evaluators, and in second step, the results of individual evaluations are integrate. Also we developed a systematic and practical computer program to solve the problems according to the proposed methods. The proposed approach was known to be effective through a set of sample problems.

• Proceedings of the Korean Society for Technology of Plasticity Conference
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• 1999.03b
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• pp.213-217
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• 1999

An expert system is developed for rational and efficient design of multi-component injection molding which is a fairly new manufacturing technique to produce plastic parts by injecting two or more materials sequentially using multiple injection units in a single machine into a single rotary mold. The knowledge base used in the present design system is primarily composed of two parts ; knowledge from domain expert and knowledge from CAE analysis. The present expert system has hour main modules ; general design guidelines for injection molding specific guidelines for multi-component injection molding redesign guidelines from the result of the CAE analysis and finally troubleshooting for multi-component injection molding. To show the validity of the present design methodology two shop floor design problems were tested ; design and fabrication of timing belt cover and power window's assist knob by using multi-component injection molding.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.30 no.8 s.251
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• pp.741-748
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• 2006

This paper numerically investigates the effects of pass arrangement on the flow distribution characteristics and the performance of a multi-pass multi-branch heat exchanger. Four cases of pass arrangement (2, 4, 6, 8 pass) are chosen to select a proper pass arrangement. A JF factor is used as an evaluation characteristic value to consider the heat transfer and the pressure drop. The present results indicate that 4-pass heat exchanger shows the best performance, and the design parameters in 4-pass heat exchanger are optimized. The design parameters are the locations of the inlet, outlet and separator, and are optimized using a response surface methodology. The JF factor of the optimum model is increased by about 9.3%, compared to that of the reference model (2-pass heat exchanger).

• Proceedings of the Korean Society for Quality Management Conference
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• 1998.11a
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• pp.680-695
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• 1998

The objective of this study is to optimize the responses of the creep feed ceramic grinding process simultaneously by an off-1ine multicriteria optimization methodology. The responses considered as objectives are material removal rate, flexural strength, normal grinding force, workpiece surface roughness and grinder power. Alumina material was ground by the creep feed grinding mode using superabrasive grinding wheels. The process variables optimized for the above objectives include grinding wheel specification, such as bond type, mesh size, and grit concentration, and grinding process parameters, such as depth of cut and feed rate. A weighting method transforms the multi-objective problem into a single-objective programming format and then, by parametric variation of weights, the set of non-dominated optimum solutions are obtained. Finally, the multi-objective optimization methodology was tested by a sensitivity analysis to check the stability of the model.