• Journal of Acupuncture Research
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• v.21 no.4
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• pp.177-196
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• 2004

Objective : Rheumatoid arthritis is an autoimmune disease that pathogenesis is not fully understood and one of the most intractable musculoskeletal diseases. The concern in the immunopathogenesis of rheumatoid arthritis has been increased since 1980's and many immunotherapeutic agents including disease-modifying antirheumatic drugs (DMARDs) were developed and became the mainstay of treatment of rheumatoid arthritis. However, the cure of the disease has hardly been achieved. In oriental medicine, rheumatoid arthritis is related to Bi-Zheng(痺證), that presents pain, swelling, andlor loss of joint function as major clinical manifestations, and also known to be deeply involved in suppression of immune function related to weakness of Jung-Ki(正氣). The herbal medicine, empirically used, could be a potential resource of development of new immunotherapeutic agents for rheumatoid arthritis. Methods : We developed a search strategy using terms to include "rheumatoid arthritis and herbal medicine" combined with "Chinese medicine" and/or "Oriental medicine". The search was focused on experimental studies of herbal medicine (January 1999 to May 2004), which is known to have effects on immune function of patients with rheumatoid arthritis. Computerized search used Internet databases including KISS and RISS4U (Korea), CNKI (China), MOMJ (Main Oriental Medicine Journal, Japan), and PubMed. The articles were selected from journals of universities or major research institutes. Results : The literature search for experimental studies on effects of herbal medicine on immunity of rheumatoid arthritis retrieved a total of 21 articles (Korea; 8, China ; 12, Japan ; 1). Of 21 articles, 10 were related to single-drug formula, 2 to drug interaction, and 9 to multi-drug formula. Single-drug formula was mainly used for aqua-acupuncture and researches on active components. Studies of drug interaction emphasized harmony of Ki-Hyul(氣血) and balance of Han-Yeul(寒熱). Multi-drug regimen was mainly found among formulas for Bo-Ki-Hyul(補氣血) and Bo-Sin(補腎). Conclusion : Studies on rheumatoid arthritis were performed both in vitro and in vivo in vitro study, LPS-stimulated splenocytes and synoviocytes were treated with herbal medicine, resulting in proliferation and activation of immune cells and suppression of cytokine activities in vivo study CIA animal model demonstrated that herbal medicine decreased antibody production and improved function of immune cells. In cellular and molecular study herbal medicine showed profound effects on the level of mRNA expression of certain cytokines related to immune function. This study revealed that herbal medicine has significant immune modulatory action and could be used for recovery of immune dysfunction of rheumatoid arthritis patients.

• The Journal of the Acoustical Society of Korea
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• v.32 no.4
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• pp.308-316
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• 2013

A set of experiments (Shallow Water 2006, SW06) was carried out in shallow water near the New Jersey shelf break in summer 2006. Significant fluctuations in direct and surface reflected arrivals were observed from the chirp data (1100~2900 Hz) measured on a vertical line array. This paper presents a geoacoustic inverssion technique for short-range acoustic data with fluctuating arrivals and inversion results of experimental data. In order to reduce effects of random sea surface on the inversion, the acoustic energy back-propagated from the array to the source through direct and bottom-reflected paths is defined as the objective function. A multi-step inversion scheme is applied to the data using VFSR (Very Fast Simulated Reannealing) optimization technique. The inversion results show a source depth oscillation period equal to the measured ocean surface wave period. The inverted bottom sound speed is 1645 m/s and is similar to that estimated by other work at the same site.

• Science of Emotion and Sensibility
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• v.13 no.3
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• pp.551-558
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• 2010

Pain is very complex and multi-level experience that should be objective or subjective. Acupuncture is a traditional method to heal the pain and have been based on meridian theory. There have been many clinical evidences showing the pain-relieving effect of acupuncture but science-based understanding of it was poor. Furthermore in daily life, we feel huge gap between the source of pain and pain control by acupuncture stimulation. However, the underlying connection between pain control and acupuncture stimulation has been reported in many recent reports. In this paper, we briefly introduce the brain imaging techniques (functional magnetic resonance images, positron emission tomography, electroencephalograph, and magnetoencephalography) and review researches in pain and acupuncture. Through this, the brain areas that activated by pain and acupuncture will be verified, and compared each other regarding their specificity and similarity. In addition, detailed understanding of brain function which is related to pain and acupuncture analgesia through brain imaging techniques will be discussed.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.38 no.3
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• pp.309-314
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• 2014

The structural layout of mechanical and civil structures is commonly obtained using conventional methods. For example, the shape of structures such as electric transmission towers and offshore substructures can be generated systematically. However, with rapid advancements in computer graphic technology, advanced structural analyses and optimum design technologies have been implemented. In this study, the structural shape of a jacket substructure for an offshore wind turbine is investigated using a topology optimization technique. The structure is subjected to multiple loads that are intended to simulate the loading conditions during actual operation. The optimization objective function is defined as one that ensures compliance of the structure under the given boundary conditions. Optimization is carried out with constraints on the natural frequency in addition to the volume constraint. The result of a first step model provides quick insights into the optimum layout for the second step structure. Subsequently, a 3D model in the form of the frustum of a quadrilateral pyramid is developed through topology optimization.

• Journal of Korean Society of Steel Construction
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• v.16 no.1 s.68
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• pp.123-134
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• 2004

In this research, a multilevel decomposition technique to enhance the efficiency of the configuration optimization of truss structures was proposed. On the first level, the nonlinear programming problem was formulated considering cross-sectional areas as design variables, weight, or volume as objective function and behavior under multiloading condition as design constraint. Said nonlinear programming problem was transformed into a sequential linear programming problem. which was effective in calculation through the approximation of member forces using behavior space approach. Such approach has proven to be efficient in sensitivity analysis and different form existing shape optimization studies. The modified method of feasible direction (MMFD) was used for the optimization process. On the second level, by treating only shape design variables, the optimum problem was transformed into and unconstrained optimal design problem. A unidirectional search technique was used. As numerical examples, some truss structures were applied to illustrate the applicability. and validity of the formulated algorithm.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.26 no.5
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• pp.445-454
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• 2015

In this paper, we propose an optimal design method for a dual reflector antenna(DRA) using the Genetic algorithm. In order to reduce the computational burden during the optimal design, we exploit the iterative physical optics(IPO) to calculate the surface current distribution at each reflector antenna. To improve the accuracy, we consider the shadow effect by the structure and the coupling effect by the multi-reflection based on the iterative MFIE(Magnetic Field Integral Equation). To reduce the number of design variables and generate a smooth surface, we use the Bezier function with the control points, which become the design variables in this paper. We adopt the HPBW(Half Power Beam Width), the FNBW(First Null Beam Width), and the SLL(Side Lobe Level) as the objective or cost functions. To verify the results, we compare them with the those of the commercial tool.

• The Korean Journal of Food And Nutrition
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• v.26 no.2
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• pp.323-328
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• 2013

The objective of this study was to investigate the sensory quality attributes for the development of soy sauce containing an extract of the fruit of Hovenia dulcis Thunb (Hutgae), also known as liver function improvement and hangover removal. Aqueous extracts of Hutgae fruit and Hutgae fruit-soy sauce were used for determining the sensory evaluation. The intensity of the sweet smell and taste was predominated in the Hutgae fruit extract (p<0.05). Various seasoning items, such as apples, pears, dried figs, Korean bramble (Bokbunja), citron (Yuza) and sun-dried hot pepper (Taeyangcho), were used to determine the suitable type of seasoned soy sauce with the Hutgae fruit extract. In the sensory analysis, the highest overall preference (acceptance score 5) was obtained from the pear extract added to soy sauce with the Hutgae fruit. The overall preference of Yuza (score 4.9) and Taeyangcho (score 4.5) extracts also very well-matched the seasoning items for soy sauce with the Hutgae fruit extract. There was no difference among the extract mixtures of multi-seasoning items added to soy sauce with the Hutgae fruit extract. As more pear extract was added, a higher overall preference was obtained. On the other hand, as the more Yuza extract was added, the higher flavor intensity without the change of the overall preference was obtained. The overall preference of soy sauce with the pear- Yuza-Taeyangcho extract mixture was not different between with or without the Hutgae fruit extract. However, the overall preference (score 5.6) was significantly higher in the pear extract added to soy sauce with the Hutgae fruit extract compared with the pear extract added to soy sauce without the Hutgae fruit extract (score 4.8). These results suggest that soy sauce with the Hutgae fruit-pear extract mixture may be useful as a functional seasoning for various salad dressings.

• The Transactions of the Korea Information Processing Society
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• v.5 no.5
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• pp.1151-1161
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• 1998

In this paper, we are considering a heterogeneous processor system in which each processor may have different performance and reliability characteristics. In other to fully utilize this diversity of processing power it is advantageous to assign the program modules of a distributed program to the processors in such a way that the execution time of the entire program is minimized. This assignment of tasks to processors to maximize performance is commonly called load balancing, since the overloaded processors can perform their own processing with the performance degradation. For the task assignment problem, we propose a new objective function which formulates this imbalancing cost. Thus the task assignment problem is to be carried out so that each module is assigned to a processor whose capabilities are most appropriate for the module, and the total cost is minimized that sum of inter-processor communication cost and execution cost and imbalance cost of the assignment. To find optimal assignment is known to be NP-hard, and thus we proposed an efficient heuristic algorithm with time complexity $O(n^2m)$ in case of m task modules and n processors.

• Journal of Korea Society of Industrial Information Systems
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• v.24 no.6
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• pp.55-65
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• 2019

With the advent of the Fourth Industrial Revolution and changes in the educational environment, team-based assignments are increasing in university classes. Effective team formation in team-based class is an important issue that affects students' satisfaction and the effectiveness of education. However, previous studies mostly focused on post analysis on the results of team formation, which makes it difficult to use them in actual classes. In this paper, we present a mathematical model of how to create a balanced team that reflects students' abilities and other characteristics. Characteristic values for assignment may be scores, such as students' proficiency, binary values such as gender, and multi-values, such as grade or department. This problem is a type of equitable partitioning problem, which takes the form of 0-1 integer programming, and the objective function is linear or nonlinear, depending on how balance is achieved. The basic model or the extended model presented can be applied to the situation where teams are balanced in consideration of various factors in actual class.

• Journal of the Korean Institute of Intelligent Systems
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• v.15 no.3
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• pp.375-381
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• 2005

Usually genetic algorithms are used to design optimal system. However the performance of the algorithm is determined by the fitness function and the system environment. It is expected that a co-evolutionary algorithm, two populations are constantly interact and co-evolve, is one of the solution to overcome these problems. In this paper we propose three types of co-evolutionary algorithm to solve GA-Hard problem. The first model is a competitive co-evolutionary algorithm that solution and environment are competitively co-evolve. This model can prevent the solution from falling in local optima because the environment are also evolve according to the evolution of the solution. The second algorithm is schema co-evolutionary algorithm that has host population and parasite (schema) population. Schema population supply good schema to host population in this algorithm. The third is game model-based co-evolutionary algorithm that two populations are co-evolve through game. Each algorithm is applied to visual servoing, robot navigation, and multi-objective optimization problem to verify the effectiveness of the proposed algorithms.