• Journal of Information Processing Systems
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• v.10 no.1
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• pp.1-22
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• 2014

Recent technological advances provide the opportunity to use large amounts of multimedia data from a multitude of sensors with different modalities (e.g., video, text) for the detection and characterization of criminal activity. Their integration can compensate for sensor and modality deficiencies by using data from other available sensors and modalities. However, building such an integrated system at the scale of neighborhood and cities is challenging due to the large amount of data to be considered and the need to ensure a short response time to potential criminal activity. In this paper, we present a system that enables multi-modal data collection at scale and automates the detection of events of interest for the surveillance and reconnaissance of criminal activity. The proposed system showcases novel analytical tools that fuse multimedia data streams to automatically detect and identify specific criminal events and activities. More specifically, the system detects and analyzes series of incidents (an incident is an occurrence or artifact relevant to a criminal activity extracted from a single media stream) in the spatiotemporal domain to extract events (actual instances of criminal events) while cross-referencing multimodal media streams and incidents in time and space to provide a comprehensive view to a human operator while avoiding information overload. We present several case studies that demonstrate how the proposed system can provide law enforcement personnel with forensic and real time tools to identify and track potential criminal activity.

• The Journal of the Korean bone and joint tumor society
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• v.1 no.2
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• pp.210-219
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• 1995

Many different factors which may affect the prognosis of the soft tissue sarcomas have been reported by many authors ; Generally, tumor size, histologic type, surgical margin, and multi modality therapy therapy as the prognostic factors were reported. The objectives of this retrospective study of soft tissue sarcomas are : 1) to define more clearly prognostic variables that have significant predictive value for disease-free and overall survival ; and 2) to evaluate tumor histologic grade based upon extent of tumor necrosis as a means of stratifying more aggressive soft tissue sarcomas(grade II & III) of the extremities. We treated 94 patients who had soft tissue sarcoma of the extremities and trunk from May 1984 to September 1994(average duration of follow-up was 5 years ranging from 2 months to 10 years) and evaluated the prognostic factors of the soft tissue sarcomas; age, sex, depth, size, location, histologic type and grade, stage, therapy modality, surgical margin, local recurrence and distant metastasis. The results were as follows. 1. The patients with poorer prognosis were over the age of fifty, whose mass was deeply located, size of the mass was over 10cm in diameter, grade III in histology, who had local recurrence, metastasis, and received only surgery. 2. Among these prognostic factors, the most significant prognostic factor was histologic grade base upon extent of tumor necrosis.

• Journal of Genetic Medicine
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• v.13 no.2
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• pp.59-64
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• 2016

Gaucher disease type 1 (GD1) is an inherited lysosomal storage disorder caused by deficiency of acid ${\beta}$-glucosidase. The diminished enzyme activity leads to the accumulation of substrates and results in multi-systemic manifestations including hepatosplenomegaly, anemia, thrombocytopenia, and bone diseases. Enzyme replacement therapy (ERT) by infusion of recombinant protein has been the standard treatment for over 20 years. Despite the successful long-term treatment with ERT, several unmet needs remain in the treatment of GD1 such as severe pulmonary and skeletal manifestations. Substrate reduction therapy (SRT) reduces the accumulation of substrates by inhibiting their biosynthesis. Eliglustat, a new oral SRT, was approved in United States and Europe as a first-line therapy for treating adult patients with GD1 who have compatible CYP2D6 metabolism phenotypes. Although eliglustat is not yet available in Korea, introduction and summary of this new treatment modality are provided in this paper by review of literatures. Despite the fact that there are only limited studies to draw resolute conclusions, the current data demonstrated that eliglustat is not inferior to ERT in terms of its clinical efficacy. The approval of eligustat enables eligible adult GD1 patients to have the option of oral therapy although it still needs further studies on long-term outcomes. The individual patient should be assessed carefully for the choice of treatment modality when eliglustat becomes available in Korea. Furthermore, the clinical guidelines for Korean patients with GD1 regarding the use of eliglustat needs to be developed in near future.

• Proceedings of the KIEE Conference
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• 2004.11c
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• pp.459-461
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• 2004

This paper presents an implementation of real-time speaker localization using audio-visual information. Four channels of microphone signals are processed to detect vertical as well as horizontal speaker positions. At first short-time average magnitude difference function(AMDF) signals are used to determine whether the microphone signals are human voices or not. And then the orientation and distance information of the sound sources can be obtained through interaural time difference and interaual level differences. Finally visual information by a camera helps get finer tuning of the speaker orientation. Experimental results of the real-time localization system show that the performance improves to 99.6% compared to the rate of 88.8% when only the audio information is used.

• Journal of Dental Rehabilitation and Applied Science
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• v.21 no.2
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• pp.191-204
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• 2005

Traditionally, the implant treatment require load-free healing period of at least 3 months in the mandible and 6 months in the maxilla. But this long healing period provides patients with the discomfort and economical trouble. Many experiments has been attempted for the outcome of such disadvantage, so recently the immediate loaded implant is getting popularity. Several literature has been published for clinical success of immediate loaded implant. The studies for the success rate of immediate loaded implant in multi-way has been reporting, nevertheless, we don't have yet a probable success. Various studies have been practiced that the advantages and disadvantages associated with immediate loaded implant, and factors that may influence the success of immediate implant, including patient selection, type of bone quality, required implant length, structure of the implant, surgical skill, need for achieving primary stability, control of occlusal force, peri-implant bone activity. The objective of this study is to review the literature related to immediate loading of implants and to discuss factors that may influence this treatment modality, based on scientific evidence.

• Clinical and Experimental Pediatrics
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• v.53 no.6
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• pp.688-693
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• 2010

An increase in the number of preterm infants and a decrease in the gestational age at birth have resulted in an increase in the number of patients with significant bronchopulmonary dysplasia (BPD) and secondary pulmonary hypertension (PH). PH contributes significantly to the high morbidity and mortality in the BPD patients. Therefore, regular monitoring for PH by using echocardiography and B-type natriuretic peptide (BNP) or N-terminal-proBNP must be conducted in the BPD patients with greater than moderate degree to prevent PH and to ensure early treatment if PH is present. In the BPD patients with significant PH, multi-modality treatment, including treatment for correcting an underlying disease, oxygen supply, use of diverse selective pulmonary vasodilators (inhaled nitric oxide, inhaled prostacyclins, sildenafil, and endothelin-receptor antagonist) and other methods, is mandatory.

• Nuclear Medicine and Molecular Imaging
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• v.42 no.sup1
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• pp.157-161
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• 2008

Malignant pleural mesothelioma (MPM) has a poor prognosis and a strong association with exposure to asbestos. Although there are not generally accepted guidelines for treatment of MPM, recent reports suggest that multi modality therapy combining chemotherapy, radiotherapy, and surgery can improve the survival of patients with MPM. Therefore exact staging is required to decide the best treatment option. However, it is well known that there are many difficulties in determining precise preoperative stage, predicting prognosis, and monitoring response to therapy with conventional imaging modalities such as CT and MRI in MPM. Recently PET with $^{18}F-FDG$ comes into the spotlight as an important staging method. There is increasing evidence that PET is superior to other conventional imaging modalities in diagnosis and staging of MPM. Particularly PET/CT improves the diagnostic and staging accuracy over PET or CT alone in MPM because it provides anatomic imaging data as well as functional information. PET and PET/CT are also useful for monitoring response to therapy and SUV is reported as a prognostic factor in MPM.

• Proceedings of the Korea Society for Simulation Conference
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• 2004.05a
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• pp.118-122
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• 2004

본 논문에서는 인체의 머리 부분을 촬영한 의료 영상에서 뇌 영역만을 분할하는 방법에 대해 제시하고자 한다. 뇌의 해부학적 구조 및 기능적 이상 부위를 파악할 경우에 영상 내에 함께 보여지는 두개골과 뇌척수액 등을 제외한 대뇌피질 영역을 분할하면 보다 효과적인 정보 분석 및 진단이 가능하게 된다. 본 시스템에서는 3단계 알고리즘을 제시한다. 첫 번째 단계에서는 영상 내에 존재하는 잡음을 제거하기 위한 필터링이고, 두 번째 단계에서는 필터링된 결과에 대한 영상분할을 수행하는 것이다 이 때 정확한 결과 도출을 위하여 사용자의 인터렉션이 들어가게 된다. 세번째 단계에서는 형태학적 방법을 이용하여 분할 결과를 보완한다. 본 연구를 위한 실험에는 자기 공명 촬영 영상(MRI: Magnetic Resonance Imaging), 단일 광전자 방출 단층 촬영영상(SPECT: Single Photon Emission Computed Tomography), 양전자 방출 단층 촬영영상(PET: Positron Emission Tomography) 등을 사용하였다. 본 시스템에서는 다양한 모달리티의 뇌 영상에서 대뇌피질 부분을 정확하게 영상 분할함으로써 뇌의 구조적 이상을 판단하기 위한 해부학적 정보 분석을 가능케 하고 있다. 뿐만 아니라 뇌 질환에 대한 정확한 진단 시뮬레이션도 가능하게 하고자 한다.

• Proceedings of the Korean Society for Cognitive Science Conference
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• 2010.05a
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• pp.66-71
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• 2010

본 논문에서는 멀티 모달리티가 인간의 기억 현상 중에서 특히 회상 현상에 도움이 될 것이 라는 아이디어를 인간 실험과 컴퓨터 시뮬레이션을 통해서 비교 확인한다. 우리는 순차적 멀티모달리티 정보가 기억회상 현상에 미치는 영향을 알아보기 위해서 확률 하이퍼그래프 메모리모델을 사용하여 컴퓨터 시뮬레이션을 수행하였으며, 시뮬레이션 결과를 동일한 데이터를 사용한 인간 실험 결과와 비교하였다. 본 실험에서는 TV 드라마의 비디오 데이터를 이용하여 이전시점의 사진과 문장 정보가 다음 시점의 문장 생성에 미치는 영향을 확인하였다. 본 실험의 목적은 이전 시점의 문장 정보와 문장/사진 정보를 활용하여 멀티 모달리티의 영향을 확인하는 것이며 다양한 시점의 정보를 활용하여 순차성이 회상에 갖는 영향을 확인하는 것이다. 이를 통해서 기억 회상 현상에 있어서 멀티 모달리티가 미치는 영향과 순차적 데이터가 미치는 영향을 보일 수 있었으며, 기계를 통해서 인간의 기억 회상 현상을 재현할 수 있는 시뮬레이션 모델을 구현 하는데 실마리를 제공하였다.

• BMB Reports
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• v.43 no.12
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• pp.773-780
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• 2010

Cancers are still difficult targets despite recent advances in cancer therapy. Due to the heterogeneity of cancer, a single-treatment modality is insufficient for the complete elimination of cancer cells. Therapeutic strategies from various aspects are needed. Gene therapy has been expected to bring a breakthrough to cancer therapy, but it has not yet been successful. Gene therapy also should be combined with other treatments to enhance multiple therapeutic pathways. In this view, gene delivery vector itself should be equipped with intrinsic anti-cancer activities. HVJ (hemagglutinating virus of Japan; Sendai virus) envelope vector (HVJ-E) was developed to deliver therapeutic molecules. HVJ-E itself possessed anti-tumor activities such as the generation of anti-tumor immunities and the induction of cancer-selective apoptosis. In addition to the intrinsic anti-tumor activities, therapeutic molecules incorporated into HVJ-E enabled to achieve multi-modal therapeutic strategies in cancer treatment. Tumor-targeting HVJ-E was also developed. Thus, HVJ-E will be a novel promising tool for cancer treatment.