• Journal of Digital Convergence
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• v.17 no.2
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• pp.135-144
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• 2019

The importance of logistics of warehouse stores has increased as their prices are cheaper and more convenient than those of large supermarkets. However, few studies on integrated depot location selection of warehouse stores have been conducted. In this regard, this study aims to derive factors for integrated depot location selection and calculate weights and select the location priority of target candidates by introducing an analytic hierarchy process (AHP). The analysis results exhibited that the most important selection factor was the cost reduction in transportation and delivery (0.198) followed by distance reduction in transportation and delivery (0.168), and time reduction in transportation. This study quantified the reduction in cost and increase in efficiency if depots were integrated and operated thereby presenting more realistic foundational data to hands-on workers. For the future study, the analysis model will be needed to be advanced through additional investigation on the factors in the analysis.

• Journal of the Korean Society of Manufacturing Process Engineers
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• v.19 no.11
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• pp.42-48
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• 2020

The agricultural tractor is a multi-purpose vehicle, which is frequently used in the agricultural field. It must be highly reliable in terms of human safety. Design and analysis of agricultural tractors must be performed using actual agricultural workload to maintain high reliability. Additionally, the frequency with which various components and systems are used must also be taken into consideration. In this study, a tractor is built to measure its workload in the actual field. Further, the measured load was analyzed for various farming tasks. The range of ratios of consumed power to engine power was measured to be 42.6%-87.2%, 75.1%-97%, 26.5%-59.2% for a plow, rotary, and harvest tasks, respectively. The results were fed into a transmission simulation model to analyze the strength and life of the transmission components. We conclude that a more reliable product can be constructed by incorporating the transmission analyses using the actual load.

• Journal of the Korea Society of Computer and Information
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• v.27 no.4
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• pp.161-167
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• 2022

This study aims to analyze the relation between management efficiency and financial performance in public institutions. Based on 135 public institutions published in public business information system from 2017 to 2020, Data Envelopment Analysis(DEA) for estimating management efficiency was performed. This study analyzed the relationship between DEA and financial performance included ROA and ROS using multi-regression analysis. The results of this study are as follows; We find that there is significant positive relation between management efficiency and ROA. We also find this significant relation in model with ROS. This finding implies that management efficiency a factor that improve financial performance in public institutions. The results of this study can provide an important empirical evidence for evaluating the strategy of governance to improve financial performance by enhancing management efficiency.

• Nuclear Engineering and Technology
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• v.54 no.8
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• pp.3059-3072
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• 2022

A Jacobian-Free Newton Krylov Two-Nodal Coarse Mesh Finite Difference algorithm based on Nodal Expansion Method (NEM_TNCMFD_JFNK) is successfully developed and proposed to solve the three-dimensional (3D) and multi-group reactor physics models. In the NEM_TNCMFD_JFNK method, the efficient JFNK method with the Modified Incomplete LU (MILU) preconditioner is integrated and applied into the discrete systems of the NEM-based two-node CMFD method by constructing the residual functions of only the nodal average fluxes and the eigenvalue. All the nonlinear corrective nodal coupling coefficients are updated on the basis of two-nodal NEM formulation including the discontinuity factor in every few newton steps. All the expansion coefficients and interface currents of the two-node NEM need not be chosen as the solution variables to evaluate the residual functions of the NEM_TNCMFD_JFNK method, therefore, the NEM_TNCMFD_JFNK method can greatly reduce the number of solution variables and the computational cost compared with the JFNK based on the conventional NEM. Finally the NEM_TNCMFD_JFNK code is developed and then analyzed by simulating the representative PWR MOX/UO₂ core benchmark, the popular NEACRP 3D core benchmark and the complicated full-core pin-by-pin homogenous core model. Numerical solutions show that the proposed NEM_TNCMFD_JFNK method with the MILU preconditioner has the good numerical accuracy and can obtain higher computational efficiency than the NEM-based two-node CMFD algorithm with the power method in the outer iteration and the Krylov method using the MILU preconditioner in the inner iteration, which indicates the NEM_TNCMFD_JFNK method can serve as a potential and efficient numerical tool for reactor neutron diffusion analysis module in the JFNK-based multiphysics coupling application.

• Nuclear Engineering and Technology
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• v.54 no.2
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• pp.523-531
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• 2022

In order to study the sensitivity and the uncertainty of the Moroccan research reactor TRIGA Mark II, a model of this reactor has been developed in our ERSN laboratory for use with the N-Particle MCNP Monte Carlo transport codes (version 6). In this article, the sensitivities of the effective multiplication factor of this reactor are evaluated using the ENDF/B-VII.0, ENDF/B-VII.1 and JENDL-4.0 libraries and in 44 energy groups, for the cross sections of the fuel (U-235 and U-238) and the moderator (H-1 and O-16). However, the quantification of the uncertainty of the nuclear data is performed using the nuclear code NJOY99 for the generation and processing of covariance matrices. On the one hand, the highest uncertainty deviations, calculated using the ENDFB-VII.1 and JENDL4.0 evaluations, are 2275, 386 and 330 pcm respectively for the reactions U₂₃₅(n, f), $ U_{235}(n\bar{\nu})$ and H₁(n, γ). On the other hand, these differences are very small for the neutron reactions of O-16 and U-238. Regarding the neutron spectra, in CT-mid plane, they are very close for the three evaluations (ENDF/B-VII.0, ENDF/B-VII.1 and JENDL-4.0). These spectra present two peaks (thermal and fission) around the energies 0.05 eV and 1 MeV.

• Journal of Korean Neurosurgical Society
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• v.66 no.5
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• pp.525-535
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• 2023

Objective : We performed an expanded multi-ethnic meta-analysis to identify associations between inflammation-related loci with intracranial aneurysm (IA) susceptibility. This meta-analysis possesses increased statistical power as it is based on the most data ever evaluated. Methods : We searched and reviewed relevant literature through electronic search engines up to August 2022. Overall estimates were calculated under the fixed- or random-effect models using pooled odds ratio (OR) and 95% confidence intervals (CIs). Subgroup analyses were performed according to ethnicity. Results : Our meta-analysis enrolled 15 studies and involved 3070 patients and 5528 controls including European, Asian, Hispanic, and mixed ethnic populations. Of 17 inflammation-related variants, the rs1800796 locus (interleukin [IL]-6) showed the most significant genome-wide association with IA in East-Asian populations, including 1276 IA patients and 1322 controls (OR, 0.65; 95% CI, 0.56-0.75; p=3.24#x00D7;10^-9) under a fixed-effect model. However, this association was not observed in the European population (OR, 1.09; 95% CI, 0.80-1.47; p=0.5929). Three other variants, rs16944 (IL-1β), rs2195940 (IL-12B), and rs1800629 (tumor necrosis factor-α) showed a statistically nominal association with IA in both the overall, as well as East-Asian populations (0.01<p<0.05). Conclusion : Our updated meta-analysis with increased statistical power highlights that rs1800796 which maps on the IL-6 gene is associated with IA, and in particular confers a protective effect against occurrence of IA in the East-Asian population.

• Geomechanics and Engineering
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• v.32 no.2
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• pp.159-177
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• 2023

In the present work, a simple and refined shear deformation theory is used to analyze the effect of visco-elastic foundation on the buckling response of exponentially-gradient sandwich plates under various boundary conditions. The proposed theory includes indeterminate integral variables kinematic with only four generalized parameters, in which no shear correction factor is used. The visco-Pasternak's foundation is taken into account by adding the influence of damping to the usual foundation model which characterized by the linear Winkler's modulus and Pasternak's foundation modulus. The four governing equations for FGM sandwich plates are derived by employing principle of virtual work. To solve the buckling problem, Galerkin's approach is utilized for FGM sandwich plates for various boundary conditions. The analytical solutions for critical buckling loads of several types of powerly graded sandwich plates resting on visco-Pasternak foundations under various boundary conditions are presented. Some numerical results are presented to indicate the effects of inhomogeneity parameter, elastic foundation type, and damping coefficient of the foundation, on the critical buckling loads.

• Biomolecules & Therapeutics
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• v.31 no.6
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• pp.661-673
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• 2023

Treatment of colorectal cancer (CRC) has always been challenged by the development of resistance. We investigated the antiproliferative activity of licochalcone H (LCH), a regioisomer of licochalcone C derived from the root of Glycyrrhiza inflata, in oxaliplatin (Ox)-sensitive and -resistant CRC cells. LCH significantly inhibited cell viability and colony growth in both Ox-sensitive and Ox-resistant CRC cells. We found that LCH decreased epidermal growth factor receptor (EGFR) and AKT kinase activities and related activating signaling proteins including pEGFR and pAKT. A computational docking model indicated that LCH may interact with EGFR, AKT1, and AKT2 at the ATP-binding sites. LCH induced ROS generation and increased the expression of the ER stress markers. LCH treatment of CRC cells induced depolarization of MMP. Multi-caspase activity was induced by LCH treatment and confirmed by Z-VAD-FMK treatment. LCH increased the number of sub-G1 cells and arrested the cell cycle at the G1 phase. Taken together LCH inhibits the growth of Ox-sensitive and Ox-resistant CRC cells by targeting EGFR and AKT, and inducing ROS generation and ER stress-mediated apoptosis. Therefore, LCH could be a potential therapeutic agent for improving not only Ox-sensitive but also Ox-resistant CRC treatment.

• Journal of the Korean Society for information Management
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• v.29 no.4
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• pp.143-163
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• 2012

The dominant model of acquiring scholarly contents at academic libraries is so called big deal where libraries subscribe to a bundle of hundreds, if not thousands of journals in a multi-year contract with fixed annual rate increase. The bid deal, started in the mid-1990s, offered a number of advantages for academic libraries and their users. However, escalating prices for these packages have become a serious issue casting doubts about the sustainability of the subscription-based model. At the moment, it appears there is no viable alternative other than pay-per-view method that is being tested at some libraries. Libraries' budget situation will remain a key factor that might change the situation. Open access started in the 2000s as a vehicle to eliminate barriers to publishing and distributing peer-reviewed scholarly journal articles. Open access publishing is witnessing two-digit growth annually. Open access articles now occupy close to 20% of two major citation databases: Scopus and Web of Science. Google Scholar service, debuted in late 2004, is now a popular tool for discovering and accessing scholarly articles from a vast selection of journals around the world. There is a call for taking Google Scholar seriously as a potential replacement of library databases amid concerns regarding the quality of journals indexed, limited search capabilities vis-$\grave{a}$-vis library databases, and monopoly of public goods. Escalating budget problems, rapid growth of open access publishing and the emergence of powerful free tool, such as Google Scholar, need to be taken seriously as these forces might bring disruptive changes to the existing subscription-based model of scholarly contents at academic libraries.

• Journal of Bio-Environment Control
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• v.15 no.4
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• pp.289-295
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• 2006

A computational fluid dynamics (CFD) numerical model has been developed to effectively study the ventilation efficiency of multi-span greenhouses with internal crops. As the first step of the study, the internal plants of the CFD model had to be designed as a porous media because of the complexity of its physical shapes. In this paper, the results of the wind tunnel tests were introduced to find the aerodynamic resistance of the plant canopy. The Seogun tomato was used for this study which made significant effects on thermal and mass exchanges with the adjacent air as well as internal airflow resistance. With the main factors of wind speed, static pressure, and density of plant canopy, the aerodynamic resistance factor was statically found. It was finally found to be 0.26 which will be used later as an input data of the CFD model. Moreover, the experimental procedure of how to find the aerodynamic resistance of various plants using, wind tunnel was established through this study.