• Title/Summary/Keyword: Mulberry Leaf Extract

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Antioxidant Activity and in vitro for Anticancer Effects of Manufactured Fermented Mulberry Leaf Tea (뽕잎발효차 제조에 따른 항산화 및 in vitro 항암활성)

  • Bae, Man-Jong;Ye, Eun-Ju
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.39 no.6
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    • pp.796-804
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    • 2010
  • This study was conducted to compare and analyze the qualitative property of MLT (mulberry leaf tea) and FMLT (fermented mulberry leaf tea) based on the antioxidant, anticancer activities of various extracts. When the antioxidant activity of MLT and FMLT extracts was evaluated, the electron donating activity was found to increase proportionally as the concentration of each extract increased. In addition, the extract of FMLT showed a higher electron donating activity than that of MLT. Furthermore, the ethanol extracts showed the highest electron donating ability. When the SOD activity was evaluated, it was also found to increase proportionally with the concentration of each extract. Furthermore, the SOD activity of the ethanol extract group was the highest, whereas the SOD like activities of both MLT and FMLT were similar. When nitrite decomposition was evaluated for each pH, the highest value was observed at pH 1.2. Finally, the nitrite deleting ability was the highest for the ethanol extracts. When each extract of MLT and FMLT was analyzed in vitro for anticancer effects, they were found to decrease the number of cancer cells proportionally as the concentration of extract increased for both HeLa cells and MCF-7 cells. Furthermore, FMLT was found to exert a greater inhibition of cancer cells than MLT. Among the extract groups, the ethanol extract induced the greatest inhibition of the development of cancer cells, and these effects were greater against MCF-7 cells than HeLa cells.

The Effect of Mulberry Leaf Extract on Blood biochemical parameters in White Rats Exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (상엽 물추출물이 다이옥신 유도 독성에 대한 흰쥐의 혈액 생화학지표에 미치는 영향)

  • Lee, Yoon-Bok;Bae, Soo-Jeong;Lee, Da-Kyung;Park, Swung-Jae;Park, Ji-Won;Kim, Byung-Weon;Whang, Seok-Yeon
    • Journal of Digital Convergence
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    • v.11 no.1
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    • pp.299-308
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    • 2013
  • We investigated the effect of mulberry leaf extract (MLE) on blood biochemical parameters of white rats induced TCDD toxicity. Data were analyzed by One-way ANOVA and Post-Hoc Test. The numbers of leukocyte and platelet decreased by TCDD were increased dramatically after treated MLE (p<0.01). The concentration of calcium and magnesium decreased by TT were increased by MLE and shown a statistical significance (p<0.01) but the concentration of phosphorus increased by TT was decreased by MLE. In the test of parameters related to renal function, only the concentration of uric acid in the MLE group was decreased than it in TT group and shown a statistical significance (p<0.01). Also the concentration of blood glucose and the activity of amylase and lipase increased by TT were decreased after treated MLE and shown a statistical significance (p<0.01), and MLE had an control effect for elevating blood glucose. In the test of parameters related to liver function, the acticity of AST, ALT and ALP increased by TT was decreased after treated MLE and shown a statistical significance (p<0.01), and MLE had an improving effect for liver function. In the case of total cholesterol (T,cho), triglyceride( TG), LDL-cholesterol (LDL-C) and HDL-cholesterol (HDL-C) related to lipid metabolism, the amount of T,cho, TG, LDL-C increased by TT were decreased after treated MLE and shown a statistical significance (p<0.01), and MLE had an ability of anti-hyperlipidemia. From these results, we concluded that MLE could mollified TCDD toxicity in white rats exposed to TCDD.

Anti-obesity Effects of Mulberry Leaf and Yacon Extract in Obese Rats

  • Lim, Yong;Oh, Ji Hye;Park, Un Kyu;Huh, Man Kyu;Hwang, Seock-Yeon
    • Biomedical Science Letters
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    • v.26 no.2
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    • pp.75-84
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    • 2020
  • We evaluated the effect of anti-obesitic activity of MYE (mulberry leaf + Yacon tuber) extracted from Morus alba as muberry leaf and Smallanthus sonchifolia as yacon. 1%, 3%, or 5% of MYE were treated to Sprague-Dawley rats exposed to a high-fat diet. MYE treated rats were suppressed weight during four weeks, and they lost weight significantly after six weeks. Common blood chemistry panels related to liver function revealed significant improvement in the MYE-treated groups. The expression of leptin as indicators for obesity was decreased in perirenal fat. Such results indicate that MYE could be a promising candidate for the improvement of obesity. In addition, MYE effected on deceased glucose metabolism, reducing the activities of glucose-6-phosphate dehydrogenase (G-6-PDH) and glucokinase related to glycogen synthesis. The fatty liver was observed in high-fat diet-treated rats, resulting from increased number of adipose cells and Ito cells. However, this pathologic change was significantly improved by administration of MYE. MYE have significant effects on antioxdative function and glycometabolism against high fat diet. Thereby, it seems that MYE prevent fatty liver by high-fat diet. Thus it is suggested that MYE would be worth being developed as an biofunctional food to prevent undesirable effects caused by obesity.

Effect of Natural Extracts on Oral Care Probiotics Weissella cibaria CMU and Periodontal Pathogens

  • Yeu, Ji-Eun;Kim, Hyun-Jin;Kang, Mi-Sun
    • International Journal of Oral Biology
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    • v.43 no.4
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    • pp.193-200
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    • 2018
  • The purpose of this study is to determine if natural extracts could be used as an additive in oral health food made with Weissella cibaria CMU (oraCMU). Natural extracts of green tea, mulberry leaf, licorice, and propolis, which are reported to have antimicrobial activities, were selected and used in this study. The minimum inhibitory concentrations (MIC) of extracts on periodontal pathogens such as Fusobacterium nucleatum and Porphyromonas gingivalis and their synergy effects with oraCMU by the fractional inhibitory concentrations methods were measured. From the results obtained, all the extracts showed no effect on the growth of oraCMU. Green tea extract showed the best antibacterial activity with MIC of 1.8 mg/ml against both F. nucleatum and P. gingivalis. In addition, green tea extract had a synergistic effect with oraCMU against F. nucleatum. Therefore, these results suggested that green tea extract is available as an additive in oral health food made with oraCMU.

Anti-diabetic effect of mulberry leaf extract fermented with Lactobacillus plantarum (Lactobacillus plantarum으로 발효한 뽕잎 추출물의 항당뇨 효과)

  • Choi, Jisu;Lee, Sulhee;Park, Young-Seo
    • Korean Journal of Food Science and Technology
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    • v.52 no.2
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    • pp.191-199
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    • 2020
  • The purpose of this study was to isolate novel lactic acid bacteria to ferment mulberry leaf extract (MLE) and to investigate its anti-diabetic effect. Lactobacillus plantarum SG-053 isolated from gatkimchi was selected to ferment MLE because it exhibited high α-glucosidase inhibitory activity (96.8%) and enhanced the content of 1-deoxynojirimycin (DNJ), an anti-diabetic substance, in fermented MLE up-to 2.2 times. MLE fermented with L. plantarum SG-053 (FMLE) showed growth promoting activity against L6 myotubes and increased the gene expressions of IRS-1, PI3K p85α, and GLUT-4 up-to 1.4, 2.2, and 1.4 times, respectively, and 2-deoxyglucose uptake up-to 40.7%. In rat skeletal muscle tissue, the expressions of PI3K p85α and GLUT-4 increased by 6.4 and 2.1 times, respectively. These results suggest that L. plantarum SG-053 could enhance the DNJ content of MLE by fermentation and that FMLE is effective in ameliorating insulin resistance via activation of the insulin signaling pathway.

Characteristic and Application Under the Sericulture of Subtropical Zones Mulberry Adapted Itself to the Field Cultivation (노지재배(露地栽培)에 적응(適應)한 아열대산(亞熱帶産) 뽕나무의 특성(特性)과 양잠(養蠶)에서의 응용(應用))

  • Seok Young-Seek;Park Sang-Jo;An Sin-Hun;Han Sang-Mi;Yeo Joo-Hong;Han Myung-Sae
    • Journal of Sericultural and Entomological Science
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    • v.47 no.2
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    • pp.68-77
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    • 2005
  • A characteristic of subtropical zones region MK-T2 compares with an gaeryangppong, and the 9-10 schedule the times when a leaf blooms to are fast, and ratio that a branch edge by the colds becomes lean showed 5.7%, and a growth of the new branch which went out delivers 67.2 cm, mulberry loaves of the new branch which went out, and 18.6, a form of a leaf is the 1.10 that length of a leaf grew more a bit than width of a leaf up. Thickness of a leaf is $228.2{\mu}m$, and an area is more similar than gaeryangppong as $225.6cm^2$. in plant taxonomy, the hair whom the style exists short with 0.7 mm, and go to the pistil head inside so as to be rare is distributed, and belong to Dolichostylae Pubescentes. The new branch cutting which executed without remedy processes was independent of a thickness of a case branch, and the form and 100% root was said, and an gaeryangppong compared with the fact that 10% root went out of 15 mm ideal, and was excellent very, and looked, a root went out a root the soil and water, all showed a characteristic to go out at central of a branch bases at 45% ratio. Length was 24.6 mm, and were water rate 78.8%, and mulberry of MK-T2 was carrying together sweetness and acidity to pH 4.7 while, besides, arrival was 19.21 Brix%. A larva period and pupa ratio, cocoon thickness ratio are almost similar to gaeryangppong, or weight of one cocoon, cocoon thickness, 20,002 cocoon quantity shows some results to drop, and be soft of a leaf, and feed value certifications are comparatively top-ranking. As a result of having analyzed amino acid of the 3rd day of 5th silkworm larva which bred to MK-T2, a collation absorbing an gaeryangppong went, and looked, but compared with a collation in case of tests to eat MK-T2, and looked, and the lie collations were not detected a difference at Leu, but MK-T2 tests were detected mutual almost similar amino acid creation. medical efficacy of the 3rd day of 5th silkworm larva ethanol extract which bred to MK-T2 and black results, histologic a case did not appear at HE dyeing about the kidney organization which extracted form the rats which ate a silkworm ethanol extract and dyeing all chemical organization immunity, and one step protein revelation became lower with almost unidentified levels.

Inhibition of endoplasmic reticulum stress in high-fat-diet-induced obese C57BL/6 mice: Efficacy of a novel extract from mulberry (Morus alba) leaves fermented with Cordyceps militaris

  • Lee, Mi Rim;Bae, Su Ji;Kim, Ji Eun;Song, Bo Ram;Choi, Jun Young;Park, Jin Ju;Park, Ji Won;Kang, Mi Ju;Choi, Hyeon Jun;Choi, Young Whan;Kim, Kyung Mi;Hwang, Dae Youn
    • Laboraroty Animal Research
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    • v.34 no.4
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    • pp.288-294
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    • 2018
  • A few clues about correlation between endoplasmic reticulum (ER) stress and mulberry (Morus alba) leaves were investigated in only the experimental autoimmune myocarditis and streptozotocin-induced diabetes. To investigate whether a novel extract of mulberry leaves fermented with Cordyceps militaris (EMfC) could suppress ER in fatty liver, alterations in the key parameters for ER stress response were measured in high fat diet (HFD)-induced obese C57L/6 mice treated with EMfC for 12 weeks. The area of adipocytes in the liver section were significantly decreased in the HFD+EMfC treated group as compared to the HFD+Vehicle treated group, while their level was higher in HFD+Vehicle treated group than No treated group. The level of the eukaryotic initiation factor 2 alpha ($eIF2{\alpha}$) and inositol-requiring enzyme 1 beta ($IRE1{\alpha}$) phosphorylation and CCAAT-enhancer-binding protein homologous protein (CHOP) expression were remarkably enhanced in the HFD+Vehicle treated group. However, their levels were restored in the HFD+EMfC treated group, although some differences were detected in the decrease rate. Similar recovery was observed on the ER stress-induced apoptosis. The level of Caspase-3, Bcl-2 and Bax were decreased in the HFD+EMfC and HFD+orlistat (OT) treated group compared to the HFD+Vehicle treated group. The results of the present study therefore provide first evidence that EMfC with the anti-obesity effects can be suppressed ER stress and ER stress-induced apoptosis in the hepatic steatosis of HFD-induced obesity model.