• Asian Pacific Journal of Cancer Prevention
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• v.13 no.11
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• pp.5469-5475
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• 2012

Background and Objectives: Acute lymphoblastic leukemia (ALL) is a complex genetic disease involving many fusion oncogenes (FO) having prognostic significance. The frequency of various FO can vary in different ethnic groups, with important implications for prognosis, drug selection and treatment outcome. Method: We studied fusion oncogenes in 101 pediatric ALL patients using interphase FISH and RT-PCR, and their associations with clinical features and treatment outcome. Results: Five most common fusion genes i.e. BCR-ABL t (22; 9), TCF3-PBX1 (t 1; 19), ETV6-RUNX1 (t 12; 21), MLL-AF4 (t 4; 11) and SIL-TAL1 (del 1p32) were found in 89/101 (88.1%) patients. Frequency of BCR-ABL was 44.5% (45/101). BCR-ABL positive patients had a significantly lower survival ($43.7{\pm}4.24$ weeks) and higher white cell count as compared to others, except patients with MLL-AF4. The highest relapse-free survival was documented with ETV6-RUNX1 (14.2 months) followed closely by those cases in which no gene was detected (13.100). RFS with BCR-ABL, MLL-AF4, TCF3-PBX1 and SIL-TAL1 was less than 10 months (8.0, 3.6, 5.5 and 8.1 months, respectively). Conclusions: This is the first study from Pakistan correlating molecular markers with disease biology and treatment outcome in pediatric ALL. It revealed the highest reported frequency of BCR-ABL FO in pediatric ALL, associated with poor overall survival. Our data indicate an immediate need for incorporation of tyrosine kinase inhibitors in the treatment of BCR-ABL+ pediatric ALL in this population and the development of facilities for stem cell transplantation.

• Proceedings of the Korea Information Processing Society Conference
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• 2012.04a
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• pp.1213-1214
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• 2012

Global variables can be read or modified by any part of the program, making it difficult to remember or reason about every possible use. Sometime it has tight couplings between some of other variables, and couplings between variables and functions. The main focus of this paper is to use call graph and the control flow analysis to design a model from where we generate the test cases for testing global variables.

• Honam Mathematical Journal
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• v.43 no.1
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• pp.141-151
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• 2021

The main object of the present paper is to introduce the generalized Laguerre matrix polynomials for two variables. We prove that these matrix polynomials are characterized by the generalized hypergeometric matrix function. An explicit representation, generating functions and some recurrence relations are obtained here. Moreover, these matrix polynomials appear as solution of a differential equation.

• International Journal of Knowledge Content Development & Technology
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• v.6 no.1
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• pp.105-116
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• 2016

Use of information technology in providing efficient library services is inevitable in today's information world. Its implementation causes many challenges for all the stake holders. This study is an attempt to identify challenges faced by university libraries of Pakistan in information technology adoption. To elucidate the research problem, a combination of quantitative and qualitative research methods was used. Valid returned questionnaires (N=52) and recorded interviews of 51 LIS professionals with experience in library automation were analyzed to draw the results. The study determined that 'lack of training opportunities for LIS professionals' and 'lack of IT skills among the majority of LIS professionals' are major challenges to the adaptation of IT. Similarities were found in the results of this study and some previous studies conducted at national and international levels.

• Kyungpook Mathematical Journal
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• v.47 no.4
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• pp.473-480
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• 2007

In this paper we define prime right ideals of semirings and prove that if every right ideal of a semiring R is prime then R is weakly regular. We also prove that if the set of right ideals of R is totally ordered then every right ideal of R is prime if and only if R is right weakly regular. Moreover in this paper we also define prime subsemimodule (generalizing the concept of prime right ideals) of an R-semimodule. We prove that if a subsemimodule K of an R-semimodule M is prime then $A_K(M)$ is also a prime ideal of R.

• Archives of Pharmacal Research
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• v.28 no.7
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• pp.761-764
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• 2005

Indigin, alkylated xanthene (1) and indigoferic acid (2) have been isolated from the chloroform soluble fraction of Indigofera oblongifolia, along with $\beta$-sitosterol (3) and 3-hydroxybenzoic acid (4), which are reported for the first time from this species. Their structures were determined through spectroscopic techniques. Both the new compounds 1 and 2 showed significant activity against enzyme lipoxygenase, while 2 further showed moderate inhibition against BChE.

• The Plant Pathology Journal
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• v.35 no.1
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• pp.51-62
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• 2019

A great variable response was observed when PP-3 and PP-J encumbered with 116 populations of root knot nematode (RKN) at two different temperatures ($25{\pm}2^{\circ}C$ and $30{\pm}2^{\circ}C$) and concentrations ($10^4$ and $10^5$ spores/ml). The PCR reaction amplified intergenic region between cytochrome oxidase subunit II gene (COII) and large subunit of rRNA gene (lrRNA) of the mitochondrial genome of different RKN species. The primer C2F3 and 1108 identified M. incognita with the highest frequency (52.6%) followed by M. javanica (36.8%) and M. arenaria (10.5%). The sizes of PCR products were 1.7 kb for M. incognita and M. javanica populations while populations of M. arenaria produced 1.1 kb fragment. The digestion with Hinf I yielded three different fragment length patterns on 1.5 % agarose gel. From current research it is concluded that intra-Meloidogyne genetic variability exist in RKN populations which have better encumbrance with P. penetrans.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.12 no.10
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• pp.5120-5142
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• 2018

Social media enables customers to share their views, opinions and experiences as product reviews. These product reviews facilitate customers in buying quality products. Due to the significance of online reviews, fake reviews, commonly known as spam reviews are generated to mislead the potential customers in decision-making. To cater this issue, review spam detection has become an active research area. Existing studies carried out for review spam detection have exploited feature engineering approach; however limited number of features are considered. This paper proposes a Feature-Centric Model for Review Spam Detection (FMRSD) to detect spam reviews. The proposed model examines a wide range of feature sets including ratings, sentiments, content, and users. The experimentation reveals that the proposed technique outperforms the baseline and provides better results.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.9
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• pp.4581-4585
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• 2012

Fms-like tyrosine kinase 3 (FLT3) performs a vital role in the pathogenesis of hematopoietic malignancies. Therefore in recent times, the focus of several studies was on use of FLT3 as a prognostic marker. The present study investigated the molecular characterization and incidence of FLT3 mutations in acute leukemia patients in Pakistan. A total of 55 patients were studied, of which 25 were suffering from acute lymphoblastic leukemia (ALL) and 30 were suffering from acute myeloid leukemia (AML). The polymerase chain reaction demonstrated FLT3/ITD mutations in 1 (4%) of 25 ALL patients, a male with the L2 subtype. In AML cases the rate was 4 (13.3%) of 30, three males and one female. The AML-M4 subtype was found in three and the AML M2 subtype in the other. In the AML cases, a statistically significant (p=0.009) relationship was found between WBC (109/L) and FLT3/ITD positivity. However, no significant relationship was found with other clinical parameters (p>0.05). In acute myeloid leukemia (AML) $FLT3/ITD^+$ mutation was more prevalent in elderly patients 31-40 age groups, 21-30 and 51-60 age groups respectively. In acute lymphoblastic leukemia (ALL) statistically no significant relationship was found between clinical features and FLT3/ITD positivity (p>0.05). However, in acute lymphoblastic leukemia (ALL) $FLT3/ITD^+$ mutation was more commonly found in age groups of 21-30.

• Advances in environmental research
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• v.3 no.1
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• pp.1-9
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• 2014

Effect of automobile polluted soil with five soil concentration (0 (Control), 25, 50, 75 and 100%) was observed on early seedling growth performance and biomass production of Neem (Azadirachta indica A. Juss). The treatment of 75% automobile polluted soil significantly (p < 0.05) decreased the seedling length (18.60 cm) of A. indica. The automobile polluted soil treatment with the concentration of 50% slightly increased the root length as compared to control. The automobile polluted soil treatment with the concentration of 25, 50, 75 and 100% negatively affected shoot length of A. indica as compared to control. The treatment of all concentration of automobile polluted soil progressively decreased the total leaf area A. indica as compared to control soil treatment. The automobile polluted soils also showed negative effects on biomass production of A. indica. The automobile polluted soil treatment at 25% concentration significantly (p < 0.05) affected shoot, leaves and seedling dry weight of A. indica as compared to control soil treatment. The order of relationship between production of A. indica's seedling dry weight and automobile polluted soil treatment was observed as root > shoot > leaves > total seedling.