• The Korean Journal of Physiology and Pharmacology
• /
• v.17 no.1
• /
• pp.89-97
• /
• 2013

Developing an animal model for a specific disease is very important in the understanding of the underlying mechanism of the disease and allows testing of newly developed new drugs before human application. However, which of the plethora of experimental animal species to use in model development can be perplexing. Administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a very well known method to induce the symptoms of Parkinson's disease in mice. But, there is very limited information about the different sensitivities to MPTP among mouse strains. Here, we tested three different mouse strains (C57BL/6, Balb-C, and ICR) as a Parkinsonian model by repeated MPTP injections. In addition to behavioral analysis, endogenous levels of dopamine and tetrahydrobiopterin in mice brain regions, such as striatum, substantia nigra, and hippocampus were directly quantified by liquid chromatography-tandem mass spectrometry. Repeated administrations of MPTP significantly affected the moving distances and rearing frequencies in all three mouse strains. The endogenous dopamine concentrations and expression levels of tyrosine hydroxylase were significantly decreased after the repeated injections, but tetrahydrobiopterin did not change in analyzed brain regions. However, susceptibilities of the mice to MPTP were differed based on the degree of behavioral change, dopamine concentration in brain regions, and expression levels of tyrosine hydroxylase, with C57BL/6 and Balb-C mice being more sensitive to the dopaminergic neuronal toxicity of MPTP than ICR mice.

• Journal of KIISE:Software and Applications
• /
• v.37 no.1
• /
• pp.39-50
• /
• 2010

Interactive broadcasting service using wired/wireless Internet return channel has strong ripple effect. It allows the audiences to participate actively to the program they are watching, and communicating. This paper develops an authoring tool that makes an object-formed interactive advertisement from extracted areas of the advertising object the user specified in TV programs. In the authoring tool, the advertisement producer specifies the target object subjectively and the selected object keeps moving here and there repeatedly. Therefore, it is hard to make an object-formed interactive advertisement with existing tools. This paper suggests sketch-based interface technique for extracting advertising objects, and also provide evaluation functions to correct any sketch error. This paper also converts the area of object into MPEG-4 BIFS codes for authoring the object-formed interactive advertisement.

• Journal of Korean Association for Spatial Structures
• /
• v.6 no.3 s.21
• /
• pp.59-67
• /
• 2006

A conventional passive TMD is only effective when it is tuned properly. In many practical applications, inevitable off-tuning of a TMD occurs because the mass in a building floor could change by moving furnishings, people gathering, etc. when TMDs are offtuned, TMDs their effectiveness is sharply reduced. Moreover, the off-tuned nTMDs can excessively amplify the vibration levels of the primary structures. This paper discusses the application of a new class of MR damper, for the reduction of floor vibrations due to machine and human movements. The STMD introduced uses a MR damper called to semi-active damper to achieve reduction in the floor vibration. Here, the STMD and the groundhook algorithm are applied to a single degree of freedom system representative of building floors. The performance or the STMD is compared to that or the equivalent passive TMD. In addition, the effects of off-tuning due to variations in the mass of the floor system. Comparison of the results demonstrates the efficiency and robustness or STMD with respect to equivalent TMD.

• Journal of the Korean School Mathematics Society
• /
• v.5 no.2
• /
• pp.71-82
• /
• 2002

This study purported to develop the learning materials for the optional activities of mathematics, apply them to the students, and examine the effect on the learner's interest and attitude to mathematics. In order to conduct this study, the learning materials for the mathematics optional activities were developed according to the units of grade 8-Ga and the developed learning materials of the mathematics optional activities were inputted in two classes for 18 units after the second grade middle school students in Daejeon area received the questionnaire regarding the learning attitude and the interest in the mathematics. After that, the questionnaire regarding the learning attitude and the interest in the mathematics and the examination regarding the response to the application of the learning materials for mathematics optional activities were conducted and did t-test. The results of the study as follows : First The learning materials applied exciting games for mathematics optional activities aroused interest in mathematics and made the learners have confidence in mathematics learning. Second, There was affirmative change in the interest and attitude to the mathematics learning with the application of the mathematics optional learning materials. Third The leaning materials of the mathematics optional activities made the learners think mathematical questions connected with the real life and try various ways to solve the questions. Here are some suggestions to study the development of the learning materials such as story, game, quiz and craft. First it is necessary to develop the learning materials applied the games or the real life matters connected with mathematics for all grade middle school students and use them in the mathematics optional activities. Second, many students feel a great interest in animation. moving picture, sound graphic, etc. If the multimedia learning materials included the real life matters or the games are developed, the learners will feel more interest in mathematics. Third, the systematic and economical support is continuously needed in order that teachers are given much time to study and the opportunity to attend the training course for the understanding of the optional activities and the development of the various learning materials.

• Informatization Policy
• /
• v.23 no.2
• /
• pp.35-53
• /
• 2016

This paper attempts to present critical issues of the information society and an alternative research addressing the challenges of ensuring that ICT is applied in ways that are enabling and responsive to social contexts in which people live their lives. Drawing the question of why insights arising from the mainstream vision are rarely useful in policies, the study highlights some developmental paradigms linked to ICT. It explores how ICT is seen as a means to development, and elaborates on the limitations of how current issues are related to the quality of life. The results indicate that ICT reduces quality of life while economic growth entails the opposite. The research framework here involves some meaningful components of cultural residues: independence, risk-taking, government responsibility by mapping how the level of ICT is distributed in the topology of values around the world. Moving to the next phase, ICT policy design and implementation need to be set up practically in a broad perspective that can be pursued by those concerned with social and technological innovation.

• Journal of the Korean Society for Nondestructive Testing
• /
• v.24 no.6
• /
• pp.566-572
• /
• 2004

It is necessary to measure the direct current with a non-contact methodology for the liquid or gas phase, as welt as the conducting metals. This paper described a theoretical consideration and experimental verification for a non-contact quantitative direct current measurement system using the Faraday effect and magnetic flux leakage. The leakage of magnetic flux occurs around a gap when a ferromagnetic core including the discontinuous gap is magnetized. Two large anisotropic domains in a magneto-optical film are occurred by the vertical component of leaked magnetic flux and the domain walls are paralleled to the center of the gap. Here, the symmetrical arrangement of domains are deflected when a vertical magnetic field is applied to the magneto-optical film. The domain wall of the magneto-optical film are relocated when a measuring current passes through the ferromagnetic core. Therefore, a direct current passing through the core can be determined quantitatively by the measurement of moving distance of the domain wall.

• Journal of KIISE:Software and Applications
• /
• v.34 no.1
• /
• pp.52-58
• /
• 2007

In this paper we propose a new robust method to extract accurate human silhouettes indoors with active stereo camera. A prime application is for gesture recognition of mobile robots. The segmentation of distant moving objects includes many problems such as low resolution, shadows, poor stereo matching information and instabilities of the object and background color distributions. There are many object segmentation methods based on color or stereo information but they alone are prone to failure. Here efficient color, stereo and image segmentation methods are fused to infer object and background areas of high confidence. Then the inferred areas are incorporated in graph cut to make human silhouette extraction robust and accurate. Some experimental results are presented with image sequences taken using pan-tilt stereo camera. Our proposed algorithms are evaluated with respect to ground truth data and proved to outperform some methods based on either color/stereo or color/contrast alone.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
• /
• 2002.11a
• /
• pp.596-602
• /
• 2002

An easy elevator for learning originated is opened to compare the existed learning equipment, and it had a high studying efficient that the sequence control circuit can opens and closes with the wire. The structure of equipment to be controlled from the first floor to the fifth floors is demonstrated a constructive apparatus by a lamp atc to express the function of the open-close of the door according to the cage moving with a mechanical actuation of the forward-reverse breaker and the motor of load and a mechanical actuation of hand-operation control components of push-button S/W and L/S and relay etc. These components let connects each other in order to control of the elevator function with the auto program and the designed sequence control circuit. Consequent1y the process of these functions of 1~5steps could operates the cage with an auto program of the elevator and the sequence control circuit. The sequence control circuit is controlled by the step of forward and reverse to follow as that the sensor function of the L/S1~L/S5 let posit with the control switchs of S/W1~S/W5 of PLC testing panel and switchs of S/W1~S/W5 installed on the transparent acryl plate of the frame. In here, improved apparatus is a hand-auto operation combined learning equipment to study the principle and a technique of the originated sequence control circuit and the auto program of PLC.

• Proceedings of the Korean Nuclear Society Conference
• /
• 1995.05a
• /
• pp.707-712
• /
• 1995

Grain boundary diffusion plays significant role in the fission gas release, which is one of the crucial processes dominating nuclear fuel performance. Gaseous fission products such as Xe and Kr generated inside fuel pellet have to diffuse in the lattice and in the grain boundary before they reach open space in the fuel rod. In the mean time, the grains in the fuel pellet grow and shrink according to grain growth kinetics, especially at elevated temperature at which nuclear reactors are operating. Thus the boundary movement ascribed to the grain growth greatly influences the fission gas release rate by lengthening or shortening the lattice diffusion distance, which is the rate limiting step. Sweeping fission gases by the moving boundary contributes to the increment of the fission gas release as well. Lattice and grain boundary diffusion processes in the fission gas release can be studied by 'tracer diffusion' technique, by which grain boundary diffusion can be estimated and used directly for low burn-up fission gas release analysis. However, even for tracer diffusion analysis, taking both the intragranular grain growth and the diffusion processes simultaneously into consideration is not easy. Only a few models accounting for the both processes are available and mostly handle them numerically. Numerical solutions are limited in the practical use. Here in this paper, an approximate analytical solution of the lattice and stationary grain boundary diffusion in a polycrystalline solid is developed for the tracer diffusion techniques. This short closed-form solution is compared to available exact and numerical solutions and turns out to be acceptably accurate. It can be applied to the theoretical modeling and the experimental analysis, especially PIE (post irradiation examination), of low burn up fission. gas release.

• Journal of the Society of Naval Architects of Korea
• /
• v.30 no.2
• /
• pp.43-53
• /
• 1993

There exist two difficulties in the nonlinear wave-body problems. First is the abrupt behavior near the intersection point between the body and the free surface, and second is the far field treatment. In this paper, the far field treatment is considered. The main idea is the Taylor series expansion of free-surface geometry and the application of F.F.T. algorithm. The numerical step is as follows. The velocity potential is expressed by the Green's theorem. and the solution is obtained by iteration method. In the iteration stage, the expressions by the Green's theorem are transformed to the convolution forts with the expansion of free surface by the wave slope. Here F.F.T. is applied, so the computing time can be of O(Nlog N) where N is the number of unknowns. The numerical analysis is carried out and the results are compared with other results in linear floating body problem and nonlinear moving pressure patch problem, and good agreements are obtained. Finally nonlinear floating body radiation problem is carried out with computing time of O(Nlog N).