• The korean journal of orthodontics
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• v.28 no.2 s.67
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• pp.285-295
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• 1998

In clinical orthodontics, it is significant to understand the stage of growth in a growing patient. In order to assess the skeletal maturity of the patients, the hand-wrist radiograph and the cervical vertebrae (Cervical Vertebrae Maturation Indicators : CVMI) was evaluated from the lateral cephalograph and the skeletal maturity determined from the hand-wrist X-ray (Skeletal Maurity Indicators : SMI) taken on the same day in the same patients, and its interrelationship examined to come up with the following results: 1. The skeletal maturity evaluated from the hand-wrist radiograph and the maturation of the cervical vertebrae from the lateral cephalograph showed a significant interrelationship with each other. 2. In the evaluation of the skeletal maturity using the SMI and CVMI, the CVMI 1 showed a siginificant correlation with SMI 1, 2, the CVMI 2 with SMI 3, 4, CVMI 3 with SMI 6, 7, CVMI 4 with SMI 7, 8, CVMI 5 with 9, 10 and CVMI 6 with SMI 11. 3. When the morphological changes in the 2nd and 3rd cervical vertebrae were separately observed, it was seldom that the concavity appeared in the lower border of the 2nd cervical vertebra and at the same time not appear in the 3rd cervical vertebra (CVMI 2 : 10.38%, CVMI 3 : 6.56%) 4. In each of the skeletal maturation stage evaluated from the hand-wrist and the cervical vertebra, the average age and its standard deviation in male and female patients appeared to have large differences among individuals. Skeletal maturation seemed to appear earlier for the girls than for the boys, and its termination 24 months faster for girls.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.12
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• pp.6191-6196
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• 2012

Aims and Background: Traditional chemotherapy strategies for human leukemia commonly use drugs based on cytotoxicity to eradicate cancer cells. One predicament is that substantial damage to normal tissues is likely to occur in the course of standard treatments. Obviously, it is urgent to explore therapies that can effectively eliminate malignant cells without affecting normal cells. Our previous studies indicated that ginsenoside $Rg_1$ ($Rg_1$), a major active pharmacological ingredient of ginseng, could delay normal hematopoietic stem cell senescence. However, whether $Rg_1$ can induce cancer cell senescence is still unclear. Methods: In the current study, human leukemia K562 cells were subjected to $Rg_1$ exposure. The optimal drug concentration and duration with K562 cells was obtained by MTT colorimetric test. Effects of $Rg_1$ on cell cycle were analyzed using flow cytometry and by SA-${\beta}$-Gal staining. Colony-forming ability was measured by colony-assay. Telomere lengths were assessed by Southern blotting and expression of senescence-associated proteins P21, P16 and RB by Western blotting. Ultrastructural morphology changes were observed by transmission electron microscopy. Results: K562 cells demonstrated a maximum proliferation inhibition rate with an $Rg_1$ concentration of $20{\mu}\;mol{\cdot}L^{-1}$ for 48h, the cells exhibiting dramatic morphological alterations including an enlarged and flat cellular morphology, larger mitochondria and increased number of lysosomes. Senescence associated-${\beta}$-galactosidase (SA-${\beta}$-Gal) activity was increased. K562 cells also had decreased ability for colony formation, and shortened telomere length as well as reduction of proliferating potential and arrestin $G_2$/M phase after $Rg_1$ interaction. The senescence associated proteins P21, P16 and RB were significantly up-regulated. Conclusion: Ginsenoside $Rg_1$ can induce a state of senescence in human leukemia K562 cells, which is associated with p21-Rb and p16-Rb pathways.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.8
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• pp.3645-3651
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• 2012

Conventional pap smear (CPS) examination has been the mainstay for early detection of cervical cancer. However, its widespread use has not been possible due to the inherent limitations, like presence of obscuring blood and inflammation, reducing its sensitivity considerably. Automated methods in use in developed countries may not be affordable in the developing countries due to paucity of resources. On the other hand, manual liquid based cytology (MLBC) is a technique that is cost effective and improves detection of precursor lesions and specimen adequacy. Therefore the aim of the study was to compare the utility of MLBC with that of CPS in cervical cancer screening. A prospective study of 100 cases through MLBC and CPS was conducted from October 2009 to July 2010, in a Medical College in India, by two independent pathologists and correlated with histopathology (22 cases). Morphological features as seen through MLBC and CPS were compared. Subsequently, all the cases were grouped based on cytological diagnosis according to two methods into 10 groups and a subjective comparison was made. In order to compare the validity of MLBC with CPS in case of major diagnoses, sensitivity and specificity of the two methods were estimated considering histological examination as the gold standard. Increased detection rate with MLBC was 150%. The concordance rate by LBC/histopathology v/s CPS/histopathology was also improved (86% vs 77%) The percentage agreement by the two methods was 68%. MLBC was more sensitive in diagnosis of LSIL and more specific in the diagnosis of inflammation. Thus, MLBC was found to be better than CPS in diagnosis of precursor lesions. It provided better morphology with increased detection of abnormalities and preservation of specimen for cell block and ancillary studies like immunocytochemistry and HPV detection. Therefore, it can be used as alternative strategy for cervical cancer prevention in limited resource settings.

• Korean Journal of Ichthyology
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• v.28 no.2
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• pp.116-120
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• 2016

A specimen of Cocotropus masudai (41.2 mm in standard length), belonging to the family Aploactinidae, was firstly collected from the eastern coastal waters of Jejudo Island, Korea by using a fish trap in July 2011. This species is characterized by having the following morphological traits: XII, 9 dorsal fin rays; I, 8 anal fin rays; 12 pectoral fin rays; I, 3 pelvic fin rays; five preopecular spines; five sensory pores present on lower jaw and isthmus tip beyond fifth sensory pore. This species is similar to C. izuensis except for the number of preopercular spines (five in C. izuensis vs. four in C. masudai) and the anterior position of the isthmus (well beyond the fifth lower jaw sensory pore vs. the tip mostly reaching to the pore). In Korea, C. masudai can be easily distinguished from the Erisphex pottii in having the dorsal fin with nine soft rays (vs. 10~14 for Erisphex pottii), anal fin with seven soft rays (vs. 10~13) and pelvic fin with three soft rays (vs. two). We propose new Korean names, "Dot-chi-sok" and "Dot-chi" for the genus and species, respectively.

• Journal of Wetlands Research
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• v.13 no.1
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• pp.79-94
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• 2011

As demonstrated in study for non-submerged groynes, the flow field is predominantly two-dimensional, with mainly horizontal eddies. The eddies shed form the tips of the groynes and migrate in the flow direction. These eddies have horizontal dimensions in the order of tens of meters and time-scales in the order of minutes. In the standard flow simulations, these motions are usually not resolved, due to a too coarse grid, too large time steps and, more importantly, the use of inadequate turbulence modelling. using for example a k-${\varepsilon}$ model, it is necessary to introduce substantial modifications. Therefore simulation resolved in this study, were carried out using the DELFT-3D-MOR programme, which is part of the DELFT3D software package of WL/Delft Hydraulics and In this study, apply a two-dimensional depth-averaged model, taking an horizontal large eddy simulation(HLES). The bed morphology computed when using HLES, as well as the associated time-scale, is similar to what has been obseved in a field case. When using a mean-flow model with-out HELS, the bed morphology is less realistic and the morphological time-scale is much larger. This slow development is the result of neglecting(or averaging). the strong velocity fluctuations associated with the time-varying eddy formation.

• Mycobiology
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• v.47 no.4
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• pp.449-456
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• 2019

Invasive fungal infections caused by Cyberlindnera fabianii have recently increased. However, biochemical kits such as API 20 C AUX and Vitek-2C have misidentified this species as other Candida spp. such as C. pelliculosa or C. utilis due to no information of Cy. fabianii in yeast database. During our 2016-2017 surveys, eleven isolates of Cy. fabianii were obtained in International St. Mary's Hospital in Korea. Here, we describe its morphological and molecular characteristics and tested its antifungal susceptibility against nine antifungal agents. The sequences of the ITS region and the D1/D2 region of LSU revealed 100% identity with the sequences of Cy. fabianii. In comparison with the results from MALDI-TOF mass spectrometry, we found that Cy. fabianii can be distinguished from other species. In antifungal susceptibility test, voriconazole and echinocandins exhibited good antifungal activities against the majority of Cy. fabianii isolates despite the absence of standard criteria.

• Journal of Korea Water Resources Association
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• v.51 no.4
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• pp.335-346
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• 2018

A vast amount of riverine spatial dataset have recently become available, which include hydrodynamic and morphological survey data by advanced instrumentations such as ADCP (Acoustic Doppler Current Profiler), transect measurements obtained through building various river basic plans, riverine environmental and ecological data, optical images using UAVs, river facilities like multi-purposed weir and hydrophilic sectors. In this regard, a standardized data model has been subsequently required in order to efficiently store, manage, and share riverine spatial dataset. Given that riverine spatial dataset such as river facility, transect measurement, time-varying observed data should be synthetically managed along specified river network, conventional data model showed a tendency to maintain them individually in a form of separate layer corresponding to each theme, which can miss their spatial relationship, thereby resulting in inefficiency to derive synthetic information. Moreover, the data model had to be significantly modified to ingest newly produced data and hampered efficient searches for specific conditions. To avoid such drawbacks for layer-based data model, this research proposed a relational data model in conjunction with river network which could be a backbone to relate additional spatial dataset such as flowline, river facility, transect measurement and surveyed dataset. The new data model contains flexibility to minimize changes of its structure when it deals with any multi-dimensional river data, and assigned reach code for multiple river segments delineated from a river. To realize the newly developed data model, Seom river was applied, where geographic informations related with national and local rivers are available.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.57 no.12
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• pp.2351-2357
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• 2008

Noninvasive radial artery pulse wave has been widely used not only for the pulse wave analysis(PWA) itself but also for assessment of arterial stiffness with estimated aortic pulse wave from peripheral pulse wave. However, it has been found that the deformation of pulse shape can be caused readily by changing measuring position, indentation pressure, and so on. So, in this study, we have developed a system which can measure radial pulse wave and skin displacement simultaneously while the indentation body goes down to occlude subject's radial artery. This system can be divided into a measuring apparatus part, an indentation control hardware part, a data acquisition part and a control and computation part. And, the measuring apparatus consists of an arm-rest, a step motor, an indentation body, a laser displacement sensor(LK-G30, Keyence Co.) and pulse wave sensor. Under load-free condition and radial artery loaded condition, the evaluation of developed system has been performed. From these results, we can conclude: 1) The developed system can control the indentation body quantitatively and the adopted laser displacement sensor shows linear output characteristic even with skin as a reflector. 2) This system can measure the pulse wave and the displacement of indentation body, that is, skin displacement simultaneously at each specific level of indentation body. 3) This system can provide the number of motor steps used to get down the indentation body, the measured skin displacement, the calculated indentation pressure, the calculated pulse pressure and the pulse waveform as well as the information generated by combining these with each others. 4) This system can reveal the relationship between the morphological changes of pulse wave and the estimated displacement of radial artery wall by indentation. Consequently, the developed system can furnish more abundant information on radial artery than previous diagnosis systems based on tonometric measurement. In further study, we expect to setup the standard measuring process and to concrete the algorithm for the estimation of radial artery's diameter and of displacement of radial artery's wall. Furthermore, with well designed clinical studies, we hope to turn out the usefulness of developed system in the field of cardiovascular system evaluation.

• Journal of the korean academy of Pediatric Dentistry
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• v.46 no.4
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• pp.343-352
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• 2019

Abnormal orofacial functions such as lip incompetency in the period of growth and development can cause morphological anomalies of the craniofacial complex. Therefore, it is crucial to make an early diagnosis based on the evaluation of the myofunctional conditions, and to make appropriate treatment plans. The objectives of this study were to quantitatively evaluate the standard lip closing force (LCF) of each age in the elementary school children, and to evaluate the relationships between LCF and affecting factors. The sample consisted of 765 children who were 7 - 12 years old in Jeonju city. Clinical examination about occlusal conditions and lip competency, and LCF measurement were performed by a single examiner. LCF was measured three times for each children with the LCF measuring device. The LCF was correlated positively with age in both sexes. The distribution of LCF groups was correlated significantly with Angle's classes and lip competency (p = 0.016, 0.004). The proportion of children with high LCFs was greater in the "competent lip" group, whereas the proportion of those with low LCFs was greater in the "incompetent lip" group.

• Korean Journal of Food Science and Technology
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• v.20 no.2
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• pp.218-224
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• 1988

For the optimization of thermal processing conditions in soymilk process, 4 strains of thermoresistant flat-sour bacteria were isolated from soymilk. The isolates were aerobic spore-forming rods, and grew at $-65^{\circ}C$. Based on the morphological and physiological properties, all of the isolated strains were identified as Bacillus stearothermophilus. The heat resistance of spores of 3 isolates and Bacillus stearothermophillus ATCC 12980 as a reference was determined in soymilk(pH 7.0) and pH 7.0 buffer solution. For each of the spores studied, linear regression equations with standard error were presented for the thermal destruction at 110, 115, 121, and $125^{\circ}C$. It was not obvious that the components of soy milk increased the heat resistance of spores. Between the strains studied, variability was noted in the D values at the different temperature, and no one strain was consistently the most heat resistant at all the given temperatures. The average D value for the 4 strains was 77.27, 20.20, 2.76 and 1.39 min at 110, 115, 121 and $125^{\circ}C$, respectively, and the average z value was $8.36^{\circ}C$.