• 한국동물학회:학술대회논문집
• /
• 한국동물학회 2000년도 한국생물과학협회 학술발표대회
• /
• pp.174.3-175
• /
• 2000

• 한국생명과학회:학술대회논문집
• /
• 한국생명과학회 2007년도 제48회 학술심포지움 및 추계국제학술대회
• /
• pp.48.2-48.2
• /
• 2007

See Full Text

• 한국생명과학회:학술대회논문집
• /
• 한국생명과학회 2007년도 제48회 학술심포지움 및 추계국제학술대회
• /
• pp.49.1-49.1
• /
• 2007

See Full Text

• Parasites, Hosts and Diseases
• /
• 제52권2호
• /
• pp.197-199
• /
• 2014

Diphyllobothrium latum and Diphyllobothrium nihonkaiense are the 2 reported main causes of human diphyllobothriasis in the Republic of Korea. However, the differentiation of these 2 species based on morphologic features alone is difficult. The authors used nucleotide sequencing of the mitochondrial cytochrome c oxidase subunit 1 (cox1) gene to diagnose Diphyllobothrium spp. Two patients visited the emergency room at Kyungpook National University Hospital on 3 April and 12 April 2013, respectively, with fragments of parasites found while defecating. The parasites were identified as Diphyllobothrium spp. based on morphologic characteristics, and subsequent cox1 gene sequencing showed 99.9% similarity (1,478/1,480 bp) with D. nihonkaiense. Our findings support the hypothesis that D. nihonkaiense is a dominant species in Korea.

• 한국CDE학회논문집
• /
• 제16권6호
• /
• pp.458-466
• /
• 2011

The morphology of a bone is closely associated with its biomechanical response. Thus, much research has been focused on analyzing the effects of variation of bone morphology with subject-specific models. Subject-specific models, which are generally achieved from 3D imaging devices like CT and MRI, incorporate more of the detailed information that makes a model unique. Hence, it may predict individual responses more accurately. Despite these powerful characteristics, specific models are not easily parameterized to the extent possible with statistical models because of their morphologic complexities. Thus, it is still proven challenging to analyze morphologic variations of subject-specific models across changes due to aging or disease. The aim of this article is to propose a generic and robust parametric morphing method for a subject-specific bone structure. We demonstrate this by using the proposed method on a model of a human proximal femur. Automatic segmentation algorithms are also presented to parameterize the specific model efficiently. A total of 48 femur models were evaluated for defining morphing vector fields. Also, several anatomical and mechanical functions of femur were considered as morphing constraints, and the NURBS interpolating technique was applied in the method to guarantee the generality of our morphed results.

• 대한세포병리학회지
• /
• 제9권2호
• /
• pp.139-146
• /
• 1998

The AutoPap 300 QC System is an automated device for the analysis and classification of conventional cervical cytology slides for quality control purpose. These studies evaluated the sensitivity of the AutoPap 300 QC System, and estimated morphologic features other than epithelial abnormality to identify a high quality control(QC) score with the AutoPap 300 QC System. The sensitivity of the AutoPap 300 QC System at 10% review rate for 210 cases of cervicovaginal cytology with low grade squamous intraepithelial lesion(LSIL) and higher grade lesion was assessed, and compared with a 10% random rescreening. The morphologic features, such as presence of endocervical component, dirty background, atrophy, abnormal ceil size, and celluiarity of single atypical cells were estimated in 45 cases of no review and 30 cases of QC review cases. The AutoPap 300 QC System identified 119(56.7%) out of 210 cases with LSIL and higher grade lesion at 10% review rate. It was more sensitive to squamous cell lesions$(50{\sim}62%)$ than to glandular lesions(10%). The dirty background and the scanty cellularity of single atypical cells were significantly related to low QC score. Conclusively, AutoPap 300 QC System is superior to human random rescreen for the identification of false negative smears. The upgrading of this device is required to enhance the defection of glandular lesion and certain Inadequate conditions of the slides.

• The Korean Journal of Physiology and Pharmacology
• /
• 제16권4호
• /
• pp.243-247
• /
• 2012

Recent studies suggest that immunization with autologous dendritic cells (DCs) results in protective immunity and rejection of established tumors in various human malignancies. The purpose of this study is to determine whether DCs are generated from peripheral blood mononuclear cells (PBMNs) by using cytokines such as F1t-3 ligand (FL), granulocyte macrophage-colony stimulating factor (GM-CSF), IL-4, and TNF-${\alpha}$, and whether cytotoxic T cells activated against the thyroid cancer tissues by the DCs. Peripheral blood was obtained from 2 patients with thyroid cancer. DCs were established from PBMNs by culturing in the presence of FL, GM-CSF, IL-4, and TNF-${\alpha}$ for 14 days. At day 14, the differentiated DCs was analyzed morphologically. The immunophenotypic features of DCs such as CDla, CD83, and CD86 were analyzed by immunofluorelescence microscopy. At day 18, DCs and T cells were incubated with thyroid cancer tissues or normal thyroid tissues for additional 4 days, respectively. DCs generated from the PBMNs showed the typical morphology of DCs. Activated cytotoxic T lymphocytes (CTLs) were observed also. DCs and the CTLs were attached to the cancer tissues on scanning electron microscope. The DCs activated the CTLs, which able to specifically attack the thyroid cancer. This study provides morphologic evidence that the coculture of T cells/cancer tissues activated the T cells and differentiated CTLs. The CTLs tightly adhered to cancer tissues and lysed cancer tissues vigorously. Therefore DCs could be used as potential vaccines in the immunotherapy.

• 한국산학기술학회논문지
• /
• 제12권1호
• /
• pp.507-512
• /
• 2011

최근 하천의 유동 및 하상 자료를 광범위한 영역에서 신속하게 계측할 수 있는 전자기파 기반의 수리계측기기들이 등장하여 하천의 특성을 이해하는 방식을 전통적인 수치모델링을 통한 방식으로부터 자료만을 활용하는 방식으로 전환되고 있다. 본 논문은 최신 관측기기로 초음파유속계(ADCP), 이미지 유속계(LSPIV), 복수빔 음파수심계(MBES), 공중 전파수심계(ABL) 의 관측 방식과 적용 사례를 보여준다. 그리고 관측된 2차원 혹은 3차원의 유동 및 하상 자료를 GIS에 기반하여 상호 연계하고 저장하여 하천의 시공간적인 변화를 추적할 수 있게 하는 하천정보화시스템의 구축방안을 제시한다.

• 한방안이비인후피부과학회지
• /
• 제28권1호
• /
• pp.53-67
• /
• 2015

Objective: The aim of this study was to investigate the wound healing effect of herbal ointment, Gamijaungo, on the burn-induced model. Reports about Gamijaungo on the wound healing effect by local application in mice model or human study have published in the several domestic or internationally, but most are anecdotal and lack solid scientific evidence. Method: We observed the morphologic and histologic changes in the burn-induced mice model. we counted white blood cell and platelet changes. we confirmed VEGF, PI3K and pAkt protein expression by Western blot analysis. Result: In this study, we observed that Gamijaungo showed strong wound healing effects in the morphologic and histologic changes in the burn-induced mice model. Also we found that the significant changes of white blood cell and platelet changes by the treatment of Gamijaungo. In molecular mechanism, we got the strong positive effect by Gamijaungo treatment on angiogenesis, a key process in the formation of the granulation tissue during wound healing. Conclusion: These findings suggest the potential use of Gamijaungo as a therapeutic in thermal burn-induced skin injuries.

• 한국수자원학회논문집
• /
• 제30권1호
• /
• pp.75-82
• /
• 1997

소하천 수계인 원주천의 지형학적 특성은 Hortoh-Strahler의 하천 차수법칙에 따라 일정한 규칙을 갖고 발달하였다. 이미 인접 유역에의 적용을 통해 검정과 검증이 이루어진 강우-유출모형인 NWS-PC 모형에 의해 모의발생한 일유량과 Manningtlr의 적용결과로 원주교 지점에서의 수리특성을 분석하였다. 산정된 원주천의 형태학적 특성계수에 의한 단위유량도의 첨두유량 및 이의 발생시간을 분석하였다. 비록 이같은 연구가 초기단계이기는 하나, 이 결과는 원주천을 포함한 미계측 유역의 유출해석에 중요한 수단인 지형학적 순간단위 유량도 해석의 자료로 제공될 것이다. 아울러 지속적인 현장관측에 의한 수위-유량곡선의 보완과 수문곡선의 작성을 통해 원주천 유역의 수문·수리학적 특성의 규명이 이루어져야 한다.