• 한국노년학
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• 제37권1호
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• pp.201-219
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• 2017

나이가 들면서 남은 인생이 제한적임을 느끼게 됨에 따라 부정정서 경험을 최소화하고 긍정정서 경험을 극대화하는 방향으로 정서조절하게 된다는 사회정서적 선택이론을 한국 성인을 대상으로 검증하였다. 긍정적인 정서의 부정적 측면과 부정적인 정서의 긍정적 측면이 존재함을 인정하는 동양의 변증법적 정서개념에서는 부정정서를 최소화하고 긍정정서를 극대화할 필요성이 크지 않을 수 있다. 따라서 변증법적 정서개념에 기초한 동양문화권의 한국 노인은 긍정정서를 극대화하고 부정정서를 최소화하기보다는 각성을 줄여서 편안한 상태를 유지하는 방향으로 정서 조절할 가능성이 있다. 166명의 청년, 중년, 노인을 대상으로 PANAS 척도를 사용하여 각성수준이 다양한 긍정, 부정 정서경험의 빈도를 평가하였으며, 정서경험 상황에서 정서를 약화/순응/극대화 하는 지에 대해 질문하였다. 노인이 청년보다 부정정서 뿐만 아니라 긍정정서도 덜 빈번하게 경험하였다. 또 정서문항을 각성수준에 따라 분류하여 분석한 결과, 청년들은 고각성 정서를 저각성 정서보다 더 자주 경험하였으나, 노인들은 고각성 정서를 덜 경험하였다. 또 노인은 청년보다 부정정서를 약화시킨다는 반응과 긍정정서를 약화시킨다는 반응을 더 많이 하였다. 이에 반해 긍정정서를 극대화한다는 반응은 청년이 가장 많았다. 이러한 결과는 한국 노인은 각성수준이 높은 긍정정서와 부정정서를 모두 약화시켜서 정서적 안정을 유지함을 시사한다.

• 대한불안의학회지
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• 제16권1호
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• pp.41-48
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• 2020

Objective : There have been limited scientific studies differentiating those who attempt suicide from those who think about suicide but do not attempt suicide. Altered event-related potential (ERP) performance, such as GoNogo ERP has been regarded as the neurocognitive processes associated with behavioral inhibition and poor impulse control. The purpose of this study was to investigate the association between Nogo ERP and suicide attempt. Methods : A total of 63 participants (33 participants with suicide ideation and 30 with suicide attempt) were recruited, and performed GoNogo tasks during the electroencephalogram measurement. Depression, anxiety, emotional regulation and impulsivity were evaluated by self-rating scales. The clinical measures and Nogo P3 component were compared between the groups. The correlational analyse was conducted to evaluate the relationship between the clinical characteristics and the Nogo P3 component. Results : Participants with suicide attempt significantly decreased the Nogo P3 amplitudes at the frontal-central electrode than participants with suicide ideation (p=0.004, FDR adjusted p=0.032). In the correlation analysis, the Nogo P3 amplitude at frontal-central electrode was correlated with the total score of the Barrett impulsivity scale (r=-0.383, p=0.002), attentional impulsivity (r=-0.365, p=0.003) and motor impulsivity (r=-0.389, p=0.002) subscales of the Barrett impulsivity scale. Conclusion : These findings suggest that the decreased Nogo P3 amplitude may be one of the candidates of biological marker for poor impulse control in those who attempt suicide.

• 대한불안의학회지
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• 제13권1호
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• pp.46-52
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• 2017

이 연구는 학교 기반, 교사 주도의 초등 인성교육 프로그램이 초등학생들의 인성 함양에 영향을 미쳤는지 분석했다. 분석 결과 프로그램에 참여한 학생들의 인성 수준은 통계적으로 유의미하게 향상되었다. 이는 프로그램이 초등학생 인성함양에 효과가 있었음을 시사한다. 하지만 학년에 따라 인성교육의 효과가 달라질 수 있음을 보였다.

• Biomolecules & Therapeutics
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• 제28권5호
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• pp.389-396
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• 2020

Valproic acid is a clinically used mood stabilizer and antiepileptic drug. Valproic acid has been suggested as a teratogen associated with the manifestation of neurodevelopmental disorders, such as fetal valproate syndrome and autism spectrum disorders, when taken during specific time window of pregnancy. Previous studies proposed that prenatal exposure to valproic acid induces abnormal proliferation and differentiation of neural progenitor cells, presumably by inhibiting histone deacetylase and releasing the condensed chromatin structure. Here, we found valproic acid up-regulates the transcription of T-type calcium channels by inhibiting histone deacetylase in neural progenitor cells. The pharmacological blockade of T-type calcium channels prevented the increased proliferation of neural progenitor cells induced by valproic acid. Differentiated neural cells from neural progenitor cells treated with valproic acid displayed increased levels of calcium influx in response to potassium chloride-induced depolarization. These results suggest that prenatal exposure to valproic acid up-regulates T-type calcium channels, which may contribute to increased proliferation of neural progenitor cells by inducing an abnormal calcium response and underlie the pathogenesis of neurodevelopmental disorders.

• 생물치료정신의학
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• 제24권3호
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• pp.129-141
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• 2018

Suicide is a behavior that is intended to cause death by itself and requires medical treatment, resulting in suicidal attempt or completion. Suicide causes loss of life, damages the body, costs a lot of medical expenses, and causes families to fall into sorrow and suffering therefore this suicide is a huge loss to family and society. There have been attempts to reduce and prevent suicide by understanding the mechanism of suicide. The mechanism of suicide can be thought of as psychological mechanism and biological mechanism. In the past, if we considered the psychological and biological mechanisms separately, the development of neuroscience now connects and integrates these two. Psychological factors affect biological factors and biological temperaments also affect perception or thinking about the situation and increase psychological vulnerability. Distant factors in suicidal behavior-such as childhood adversity and family and genetic predisposition-increase the lifetime risk of suicide. They alter the response to stress and other processes through changes in gene expression and regulation of emotional and behavioral characteristics. Distant factors affect the biological system and consequently changes in these systems can increase the risk of suicide. In other words, the distal factor does not directly induce suicidal behavior but rather acts indirectly through developmental or mediating factors. These mediating factors are impulsive aggressive and anxious trait, and chronic use of substances. The mechanism of this disorder is the abnormality of the serotonin system and the abnormality of the lipid level. Proximal factors are associated with the onset of suicide events and include changes in the major neurotransmitter systems, inflammatory changes, and dysfunction of glial cells in the brain. A series of studies, including a variety of research methods and postmortem and in-vivo imaging studies, show the impairment of the serotonergic neurotransmitter system and hypothalamic-pituitary-adrenal axis stress response system for suicidal behavior. These disorders lead to suicidal behavior due to difficulty in cognitive control of mood, pessimism, reactive aggression, abnormality in problem solving abilities, excessive response to negative social signals, severe emotional distress, and cognitive dysregulation of suicidal ideation.

• 대한불안의학회지
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• 제15권1호
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• pp.35-44
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• 2019

Objective : The aim of this study was to investigate the individual and job related factors as risk factors for mental health of firefighters. Methods : The data of 202 fire-fighters was analyzed by using a multinomial logistic regression analysis. All participants completed self-reported questionnaires including demographics (sex, age, work duration), the Childhood Trauma Questionnaire, the Ways of Coping Checklist, the Colleague related traumatic events, the Korean occupational stress scale, the Korean Perceived Stress Scale-10, and the Beck Depression Inventory. Participants were divided into three groups according to the level of stress and depressive symptom scores: Low Stress-Low Depression (LS-LD), High Stress-Low Depression (HS-LD), and High Stress-High Depression (HS-HD). Results : A job related factor-organizational injustice-was a significant factor related to HS-LD, while individual factors such as active coping level and childhood trauma experience and a job related factor-difficult physical environment-were significantly associated with HS-HD. Conclusion : These results imply the need to take both individual and environmental approaches into account when managing the stress and depression of firefighters. More specifically, psycho-education to facilitate active coping strategy and adaptive emotional regulation at the individual level and the improvement of physical work environment of firefighters should be supported.

• 생물정신의학
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• 제30권1호
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• pp.17-23
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• 2023

Objectives This study aims to develop valid experimental models for depression through chronic reserpine exposure to zebrafish (Danio rerio). Methods The effect of chronic reserpine on zebrafish behavior in the novel tank was examined. Changes of gene expression on telencephalon were also investigated. Results Chronic reserpine (40 mg/L, 7 days) induced overt behavioral effects, but markedly reduced activity, resembling motor retardation in depression. In telencephalon of zebrafish, gene expression associated with monoamine oxidase and norepinephrine transporter was decreased. Expression of serotonin transporter gene was increased. Conclusions Our results show that the pharmacological model of depression in zebrafish can induce not only behavioral changes, but also monoamine changes in the homology of human mood regulation centers.

• 한국심리학회지:학교
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• 제8권3호
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• pp.379-403
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• 2011

본 연구는 재한 중국인 유학생들의 문화적응과정에서 그들의 사용하는 대처전략과 스스로 지각하는 변화양상에 대해 알아보았다. 한국에 거주하고 있는 56명의 중국유학생들이 연구에 참여하고, 개념도(concept mapping)를 이용하여 자료를 분석하였다. 그 결과 중국인 유학생들은 '언어적 유능감 향상'과 '사회적 네트워크 활용'을 중요한 대처전략으로 생각하며, '문화적 자기', '개인적 자기'의 변화를 포함하여 광범위한 측면에서의 변화를 인식하고 있음을 확인하였다. 대처전략과 변화양상에 대한 인식은 체류기간에 따라 차이를 보였는데, 장기 체류한 중국인 유학생들은 단기 유학생과는 달리 '기분조절'을 대처전략으로 삼았다. 또한, 단기 유학생들이 긍정적 변화양상을 우세하게 보고하는 반면,장기 유학생들은 긍정적 변화보다는 부정적 변화를 더 인식하는 것으로 나타났다. 이 연구 결과는 추후 대학 관계자들이 체류기간에 따라 다른 경험을 하게 되는 중국 유학생을 이해하고 민감하게 대응할 필요가 있음을 시사한다.

• 한국산림과학회지
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• 제106권2호
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• pp.196-203
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• 2017

임업 중에서 시장과 정부의 규제가 충돌하는 대표적인 산업을 토석산업이라 할 수 있다. 특히, 경제적 측면과 환경, 경관, 재해측면을 동시에 고려하기 어려워 적정한 규제 및 규제개혁의 검토를 통해 관련 법 조항의 개정이 필요한 실정이다. 본 연구는 전국 54개소의 토석채취지를 대상으로 산지관리법에 명시된 환경 및 경관피해, 재해저감 실태에 대한 이행상태를 조사함으로써 토석채취자 및 관련 종사자의 준법정신을 확인하고, 차후 종사자를 대상으로 한 교육, 법률 개정에 있어 기초자료로 제공하고자 실시하였다. 산지관리법과 하위 법령의 총 22개 항목에 대하여 이행상태를 분석한 결과, 환경피해 저감 관련 법 조항은 이행상태가 대체로 양호한 것으로 나타났으나, 경관피해 저감 관련 법 조항은 대부분의 토석채취지에서 해당사항이 없는 것으로 나타났다. 이것은 산림경관을 중요시하는 사회적 분위기에 따라 토석채취로 발생하는 경관피해를 최소화하고자 한 결과로 판단된다. 아울러 재해방지를 위한 침사지 설치 이행상태는 양호한 것으로 나타났으나, 침사지와 연계된 방류수의 배출기준(수질오염방지)의 정립 및 제시를 통해 효율성을 높일 필요가 있을 것으로 판단된다. 따라서 본 연구결과와 차후 진전된 연구를 통해 다양한 법률이 적용되는 토석산업에 대해서는 보다 명확한 내용과 근거를 기반으로 현실성 있는 규제와 산업의 발전을 위한 정책이 수립되어야 할 것이다.

• 대한불안의학회지
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• 제16권2호
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• pp.49-56
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• 2020

Objective : The present study aims to investigate differences in anger-related features in patients with somatic symptom disorder (SSD) compared to healthy controls, and to examine whether anger trait and anger regulation strategy are associated with clinical characteristics in patients with SSD. In addition, we examined the relationship between childhood adversity and SSD. Methods : 26 patients with SSD and 28 healthy controls were included. Anger-related features were assessed with State-Trait Anger Expression Inventory (STAXI). Clinical somatic symptoms were assessed using the somatization subscale of the Symptom Checklist-90-Revised and the Somatosensory Amplification Scale. Childhood adversity was assessed by the Childhood Traumatic Events Scale. Multivariate analysis of covariance was performed. Results : Disease status of SSD had a significant overall effect on anger-related features (Wilks λ=0.725, F(5, 44)=3.332, p=0.012). Patients with SSD showed a significantly high Trait-Anger (p=0.017) and they had a high score in both Anger-Out (p=0.013) and Anger-In (p=0.001) of anger expression styles. In particular, a directed inward style of anger expression was significantly associated with somatization symptom severity (p=0.003). Regarding childhood adversity, more childhood extreme illness was experienced by the SSD group than the control group (p=0.012). Within the SSD group, childhood extreme illness was associated with higher Trait-Anger (p=0.027) and Anger-Out (p=0.001). Conclusion : The present findings suggest that trait anger, anger expression styles, and childhood adversity of extreme illness may be involved in SSD. Further studies are needed to explore the role of anger-related features and its relationship with childhood adversity in the pathophysiology of SSD.