• 분석과학
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• 제33권6호
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• pp.252-261
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• 2020

Currently, the potentiometric titration and the high pressure liquid chromatography (HPLC) method were utilized in Korean Pharmacopoeia XII (KP XII) as well as other pharmacopoeias (USP, EP, BP) for determination of loperamide hydrochloride in raw materials and capsules, respectively. The research objective is to overcome the remaining drawbacks from current methods such as solubility of mobile phase (KP XII), less scientific approach (USP 43) or using paired-ion chromatography reagent which shows some limitations (BP2017 and other formulation monographs). The proposed method was optimized by Design of Experiment (DoE) tool to obtain the satisfied method for determination of loperamide hydrochloride. The optimal condition was performed on the common C18 column (150 mm × 4.6 mm; 5 ㎛) using isocratic elution with the mobile phase containing 40 mM of potassium phosphate monobasic (pH 3.0) and acetonitrile (56:44), at a flow rate of 0.7 mL/min. The optimized method was validated and met the requirements of the International Conference on Harmonization. The developed method was applied to determine loperamide hydrochloride in capsules and can be used to update the current monograph in KP XII.

• 분석과학
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• 제31권4호
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• pp.143-148
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• 2018

Currently, the Korean Pharmacopoeia (KP XI) recommends HPLC and potentiometric titration (which is less specific than HPLC) for the determination of triflusal content in capsules and raw materials, respectively. Additionally, the British Pharmacopoeia (BP 2017) and European Pharmacopoeia (EP 8.0), which include a monograph for triflusal in raw materials only, describe a titration method for the assay. The latest version of the United States Pharmacopoeia (USP 39) and Japanese Pharmacopoeia (JP 17) still have not published monographs for triflusal and its preparations. To improve the specificity and efficacy of the assay, we present an HPLC method to determine triflusal content in both raw materials and capsules. The proposed method was validated in accordance with the requirements of the International Conference on Harmonization. A good linear relationship was achieved for triflusal in the range of $200-1250{\mu}g/mL$ with a coefficient of determination of approximately 0.9996. The relative standard deviations (RSDs) of inter- and intraday precision were 0.73-1.12 % and 0.34-0.51 %, respectively. The recovery percentage of triflusal was in the range of 98.80-101.31 %. Because its system suitability, intermediate precision, and robustness were satisfactory, this method could be suitable for determining triflusal content in raw materials and capsules.

• 한국항행학회논문지
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• 제13권4호
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• pp.490-502
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• 2009

본 논문에서는 이종의 이동통신망을 이용하여 HSDPA(High Speed Downlink Packet Access)와 WiBro(Wide Broadband)를 결합한 무인항공기 탑재용 통신시스템 개발에 대하여 논하고자 한다. 현재 서비스 되고 있는 이동통신망을 무인항공기 통신시스템으로 사용하기 위해서는 이동통신망 사용 시 나타날 수 있는 몇 가지 문제점들을 해결하여야 한다. 해결과제로는 무인항공기의 활동 반경에 근거한 넓은 커버리지의 확보, 감시 정찰용 무인항공기를 위한 대용량의 화상데이터 전송, 네트워크 트래픽에 대한 안정적인 통신환경의 보장 등이 있으며 본 논문에서는 이러한 문제를 해결하기 위한 이종의 이동통신망을 이용한 통신시스템을 제안한다. 제안된 통신시스템은 HSDPA와 WiBro를 이용하여 구성되며, HSDPA를 사용함으로써 넓은 커버리지를 확보할 수 있고, WiBro및 다수의 모뎀을 사용함으로써 대용량의 데이터 전송을 할 수 있으며, 이종의 이동통신망을 함께 사용함으로서 안정적인 통신환경을 보장할 수 있다. 또한 이러한 효과는 시뮬레이션과 실험을 통해 확인할 수 있다.

• 한국산학기술학회논문지
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• 제21권8호
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• pp.475-484
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• 2020

이 논문은 TV광고의 일반인 모델 인식에 관하여, 기능적인 양적 분석의 과거 행태로부터 탈피하여, 심층적이고 효과적으로 접근할 수 있는 주관성연구인 실증적인 Q방법론으로 연구되었다. 또한 이 분석에서는 기존 논의에서 연역적인 가설을 도출하는 종래의 연구 방법과는 달리, 사람들의 주관적 이미지에 의한 새로운 가설발견의 목적이 있다. 구체적으로 Q요인분석이란 통계방법을 사용하며, R방법의 변수를 요인화가 아닌 사람을 요인화하는 것이다. 이 연구에서는 TV광고의 일반인 모델에 대해 젊은 층의 수용행태 분석을 알아보는 것이다. 분석결과는 총 4가지의 유형{제 1유형[(N=7) : 광고 공감대형(Advertising Consensus Type)], 제 2유형[(N=7) : 광고 부정형(Advertising Negative Type)], 제 3유형[(N=5) : 광고 구매력 감소형(Advertising Purchasing Reduction Type)], 제 4유형[(N=1) : 광고 설득 지향형(Advertising Persuasion Orientation Type)]}으로 분류되었으며, 전반적으로 매우 차별적인 유형들로 발견되었다. 결론적으로, 이 연구는 TV광고의 일반인 모델인식에 대한 주로 젊은 응답자들의 주관적 수용 행태를 검토하였다. 또한 분석의 내용들은 관련 이슈와 아젠다 연구를 위한 발전적인 제안(개선)을 제시하는데 유의미한 논의를 제시하는 것이다.

• 약학회지
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• 제57권3호
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• pp.226-233
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• 2013

Although the dissolution test can serve as an effective tool for quality control and predictor of in vivo performance, there are a number of drugs with no established dissolution specification in Korean Pharmaceutical Codex (KPC). So, with each reference and test drugs, the dissolution test method and an analytical procedure by HPLC were developed and validated to establish dissolution specification for acebrophylline capsules and bromhexine hydrochloride tablets. The dissolution condition was determined based on the "Guidelines on Specifications of Dissolution tests for Oral dosage forms" of Ministry of Food and Drug Safety (MFDS). The analytical method of HPLC was validated in specificity, linearity, precision and accuracy. Final dissolution test was performed with commercially available samples of 3 lots to establish specification. In addition, no difference was observed by the inter-laboratory evaluation. Dissolution specifications and conditions will be used for revising the monograph of acebrophylline capsules and bromhexine hydrochloride tablets in next supplement of KPC.

• 한국컴퓨터정보학회논문지
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• 제11권6호
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• pp.175-184
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• 2006

컴퓨터 포렌식은 정보통신 기술의 순기능을 보호하고 역기능에 대한 증거를 추출하여 법정에 제출하는 과정을 다루게 된다. 컴퓨터 수사 현장에서 디지털증거의 무결성이 훼손된다면, 결정적인 증거가 기각당하거나 재판의 증거로서 채택되지 않는다. 본 논문에서는 이 문제점을 해결하는 방안으로 포렌식 자료의 무결성 확보를 위한 디스크 포렌식의 연계방안, 시스템 포렌식의 연계방안, 네트워크 포렌식의 연계방안, 모바일 포렌식의 연계방안, 데이터베이스 폰렌식의 연계방안을 연구한다. 제안된 연계방안으로 무결성이 입증되면, 수사 결과물들이 범죄 수사현장과 재판의 중요 증거 자료로 채택하게 될 것이다. 또한 실제 컴퓨터 포렌식 수사 현장에서의 디지털증거의 연계방안의 현장 수사의 문제점의 사례와 대안을 제시함으로서, 컴퓨터 디지털 포렌식의 발전과 정보보호의 현장 연구에 기여하게 될 것이다.

• 한국한의학연구원논문집
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• 제18권1호
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• pp.25-34
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• 2012

Objective : This study was carried out with focus on written by Joh, Taek-seung (曺澤承) and Joh, Byeong-who(曺秉矦) in the relation of father and son in 1933. This book is a medical book including rare data, which has never been reported to academic circles all this while. Method : First, this study looked into the authors of this book and its history of publication. Further, this study analyzed the composition and contents of this book. Lastly, this study summed up the meaning of this book from the standpoint of medical history. Result : The authors were Confucian doctors who were active in the latter era of the Joseon Dynasty and also in the period of Japanese colonial rule. They lived in Haenam district of Jeonlanam-do, and cured its neighboring local residents while studying. They published the book of by putting together their own medical experiences. The authors suggested their remedial prescription according to gender and age whereas Zhang Zhongjing(張仲景) suggested the remedial prescription according to Six-Meridian Pattern Identification & Syndrome Differentiation(六經辨證). In addition, the authors of gave weight to the relationship with internal damage. Additionally, the authors not only thought much of the relationship between internal damage and external damage but also thought of the weakness and strength of the healthy qi, and the new and the old of a disease as an important clue to medical treatment. It seems that such contents was influenced by (東醫寶鑑). Conclusion : shows the results of the research on which was spontaneously conducted in Joseon.

• KIEAE Journal
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• 제14권1호
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• pp.67-74
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• 2014

There have distinctly been no the installation criteria and maintenance management of BIPV systems, although the BIPV market is consistently going on increasing. In addition, consideration of the BIPV generation quantity which has been installed at several diverse places is currently almost behind within region in Korea. Therefore, the main aim of this study is to evaluate the BIPV generation and to be base data of reducing rate depending on regional installation angles using PVpro which was verified by measured data. Various conditions were an angle of inclination and azimuth under six major cities: Seoul, Daejeon, Daegu, Busan, Gwangju, Jeju-si for the BIPV system generation analysis. As the results, Seoul showed the lowest BIPV generation: 1,054kWh/kWp.year, and Jeju-si have 5percent more generation: 1,108.0kWh/kWp.year than Seoul on horizontal plane. Gwangju and Daejeon turned out to have similar generation of result, and Busan showed the highest generation: 1,193.5kWh/kWp.year, which was increased by over 13percent from Seoul on horizontal plane. Another result, decreasing rate of BIPV generation depending on regional included angle indicate that the best position was located on azimuth: $0^{\circ}$(The south side) following the horizontal position(an angle of inclination: $30^{\circ}$). And the direction on a south vertical position(azimuth: $0^{\circ}$, an angle of inclination: $90^{\circ}$) then turned out reducing rate about 40percent compared with the best one. Therefore, these results would be used to identify the installation angle of the BIPV module as an appropriate position.

• 정보관리학회지
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• 제20권4호통권50호
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• pp.1-21
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• 2003

본 연구는 국내 과학기술분야 인용정보의 형태 및 출판경과시간에 따른 인용비율과 인용 나이를 분석하여 과학기술문헌의 수명을 측정하고, 국내 연구자들의 국내외 정보원의 의존도를 밝히는데 그 목적이 있다. 이를 위하여 국내 과학기술분야 가운데 대표적인 영역인 기계, 건축, 화학, 전기전자분야에 대한 학술잡지 198건의 논문기사에 인용된 2,619건의 문헌을 대상으로 정보 인용형태의 차이와 특성을 비교 분석하였다. 그 결과 학술잡지, 도서, 회의자료, 연구보고서의 순서로 많이 인용되고 있었으며, 정보의 해외의존도는 화학분야가 가장 높았다. 인용문헌의 나이분석에서 국내문헌의 약 70%이상이 출판된 지 5년 이내의 문헌이었고, 전체로는 약60% 이상이 출판된 지 10년 이내의 정보원으로 나타났다. 또한 문헌의 반감기는 기계 6.50년, 건축 5.45년, 화학 9.65년, 전기전자 5.60년으로 측정되었다.

• Journal of Preventive Medicine and Public Health
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• 제48권1호
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• pp.1-9
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• 2015

The purpose of the present review is to give an overview of the association between alcohol intake and the risk of developing cancer. Two large-scale expert reports; the World Cancer Research Fund (WCRF)/American Institute of Cancer Research (AICR) report from 2007, including its continuous update project, and the International Agency for Research of Cancer (IARC) monograph from 2012 have extensively reviewed this association in the last decade. We summarize and compare their findings, as well as relate these to the public health impact, with a particular focus on region-specific drinking patterns and disease tendencies. Our findings show that alcohol intake is strongly linked to the risk of developing cancers of the oral cavity, pharynx, larynx, oesophagus, colorectum (in men), and female breast. The two expert reports diverge on the evidence for an association with liver cancer and colorectal cancer in women, which the IARC grades as convincing, but the WCRF/AICR as probable. Despite these discrepancies, there does, however, not seem to be any doubt, that the Population Attributable Fraction of alcohol in relation to cancer is large. As alcohol intake varies largely worldwide, so does, however, also the Population Attributable Fractions, ranging from 10% in Europe to almost 0% in countries where alcohol use is banned. Given the World Health Organization's prediction, that alcohol intake is increasing, especially in low- and middle-income countries, and steadily high in high-income countries, the need for preventive efforts to curb the number of alcohol-related cancers seems growing, as well as the need for taking a region- and gender-specific approach in both future campaigns as well as future research. The review acknowledges the potential beneficial effects of small doses of alcohol in relation to ischaemic heart disease, but a discussion of this lies without the scope of the present study.