• Food Science and Biotechnology
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• 제18권3호
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• pp.694-699
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• 2009

A multiplex polymerase chain reaction (PCR) method was developed for the detection of 4 events of genetically modified (GM) soybean. The event-specific primers were designed from 4 events of GM soybean (RRS, A2704-12, DP356043-5, and MON89788). The lectin was used as an endogenous reference gene of soybean in the PCR detection. The primer pair YjLec-4-F/R producing 100 bp amplicon was used to amplify the lectin gene and no amplified product was observed in any of the 9 different plants used as templates. This multiplex PCR method allowed for the detection of event-specific targets in a genomic DNA mixture of up to 1% GM soybean mixture containing RRS, A2704-12, DP356043-5, and MON89788. In this study, 20 soybean products obtained from commercial food markets were analyzed by the multiplex PCR. As a result, 6 samples contained RRS. These results indicate that this multiplex PCR method could be a useful tool for monitoring GM soybean.

• Korean Journal of Otorhinolaryngology-Head and Neck Surgery
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• 제61권12호
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• pp.637-643
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• 2018

Radioimmunotherapy (RIT) is a therapy that takes advantage of the "cross-fire" effect of emitted radiation by radionuclides conjugated to tumor-directed monoclonal antibodies (mAb) (including those fragments) or peptides. While RIT has been successfully employed for the treatment of lymphoma, mostly with radiolabeled antibodies against CD20 [$^{90}yttrium$ ($^{90}Y$)-ibritumomab tiuxetan; $Zevalin^{(R)}$ and $^{131}iodine$ ($^{131}I)-tositumomab$; $Bexxar^{(R)}$], its use in solid tumors is more challenging, so far. Immuno-PET, a tool for tracking and quantification of mAbs with PET in vivo, is an exciting novel option to improve diagnostic imaging and guide mAb-based therapy. RIT in solid tumors including head and neck cancer may be an alternative treatment with advances in various biological, chemical, and treatment procedures, and it may help to reduce unnecessary exposure and enhance the therapeutic efficacy. Also, immuno-PET based on RIT might play an important role in cancer staging, in patients or targets selection of targeted therapeutics and in monitoring the response of targeted therapeutics as precision medicine. In this review, fundamentals of RIT/immune-PET and current knowledge of the preclinical/clinical trials in RIT for solid tumor including head and neck cancer are reviewed.

• International Journal of Computer Science & Network Security
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• 제22권10호
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• pp.333-339
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• 2022

The purpose of the article is to identify priority trends of technological innovations and strategic opportunities for using the smart potential to the benefit of the Russian industrial production development in the context of digital transformation. The article substantiates the demand for technological process automation at industrial enterprises in Russia and considers the possibilities of using artificial intelligence and the implementation of smart manufacturing in the industry. The article reveals the priorities of the leading Russian industrial companies in the field of digitalization, namely, an expansion of the use of cloud technologies, predictive analysis, IaaS services (virtual data storage and processing centers), supervisory control, and data acquisition (SCADA), etc. The authors give the characteristics of the monitoring of the smart manufacturing systems development indicators in the Russian Federation, conducted by Rosstat since 2020; presents projected data on the assessment of the required resources in relation to the instruments of state support for the development of smart manufacturing technologies for the period until 2024. The article determines targets for the development of smart technologies within the framework of the Federal Project "Digital Technologies".

• Mass Spectrometry Letters
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• 제13권4호
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• pp.158-165
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• 2022

Many therapeutic class drugs such as beta-blocker, corticosteroids, NSAIDs, etc are prohibited substances in the horse racing industry. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) technology makes it possible to isolate drugs from interference, enables various drug analyses in complex biological samples due to its sensitive sensitivity, and has been successfully applied to doping control. In this paper, we describe a rapid and sensitive method based on solid-phase extraction (SPE) using solid phase cartridge and LC-MS/MS to screen for different class's 35 drug targets in equine plasma. Plasma samples were pretreated by SPE with the NEXUS cartridge consisted non-polar carbon resin and minimum buffer solvent. Chromatographic separation of the analytes was performed on ACQUITY HSS C18 column (2.1 × 150 mm, 1.8 ㎛). The elution gradient was conducted with 5 mM ammonium formate (pH 3.0) in distilled water and 0.1% formic acid in acetonitrile at a flow rate of 0.25 mL/min. The selected reaction monitoring (SRM) mode was used for drug screening with multiple transitions in the positive ionization mode. The specificity, limit of detection, recovery, and stability was evaluated for validation. The method was found to be sensitive and reproducible for drug screening. The method was applied to plasma sample analysis for the proficiency test from the Association of Racing Chemist.

• Structural Monitoring and Maintenance
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• 제10권3호
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• pp.243-260
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• 2023

Indonesia has had seismic codes for earthquake-resistant structures designs since 1970 and has been updated five times to the latest in 2019. In updating the Indonesian seismic codes, seismic hazard maps for design also update, and there are changes to the Peak Ground Acceleration (PGA). Indonesian seismic design uses the concept of building performance levels consisting of Immediate occupancy (IO), Life Safety (LS), and Collapse Prevention (CP). Related to this performance level, cases still found that buildings were damaged more than their performance targets after the earthquake. Based on the above issues, this study aims to analyze the performance of base isolation design on existing target buildings and analyze the seismic fragility for a case study in Indonesia. The target building is a prototype design 8-story medium-rise residential building using the reinforced concrete moment frame structure. Seismic fragility analysis uses Incremental Dynamic Analysis (IDA) with Nonlinear Time History Analysis (NLTHA) and eleven selected ground motions based on soil classification, magnitude, fault distance, and earthquake source mechanism. The comparison result of IDA shows a trend of significant performance improvement, with the same performance level target and risk category, the base isolation structure can be used at 1.46-3.20 times higher PGA than the fixed base structure. Then the fragility analysis results show that the fixed base structure has a safety margin of 30% and a base isolation structure of 62.5% from the PGA design. This result is useful for assessing existing buildings or considering a new building's performance.

• Journal of Forest and Environmental Science
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• 제39권4호
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• pp.254-260
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• 2023

A sensor system has been developed that uses an ultrasonic sensor to detect the downhill slope on the side of a forest road and prevents a vehicle-type forest machine from rolling down a mountainside. A specular reflection of ultrasonic wave might cause severe issues in measuring distances to targets. By investigating the installation angle of the sensor to minimize the negative effects of specular reflection, the installation angle of lateral monitoring ultrasonic sensor could be determined based on the width of road shoulder. Obstacles such as small rocks or piece of log in a forest road may cause the forest machine to be overturned while the machine riding over due to excessive its posture change. It was determined that the laser sensor could be a part of a sensor system capable of specifying the location and size of small obstacles. Not only this sensor system including ultrasonic and laser sensors can issue a warning of dangerous sections to drivers in forest forwarders currently in use, but also it can be used as a driving safety sensor in autonomous forest machine or remote-control forest machine in the future.

• 유통과학연구
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• 제22권4호
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• pp.59-68
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• 2024

Purpose: The function of internal audit is to help achieve company goals and targets by minimizing the impact of business risks. The distribution of internal audit activities in carrying out control and supervision covers all aspects or activities at all levels of management. The aim of the research is to determine the distribution of risk-based internal audit effectiveness assessments in companies. Data and Research Design Methodology: Researchers examined research trends regarding things that could influence the distribution of the effectiveness of the internal audit function from 2007 to 2023.This research used a systematic literature review (SLR) research method. This research used 23 papers sourced from the Scopus database. Results: The distribution of the effectiveness of audit services provided by internal auditors is more influenced by the personal characteristics of internal auditors and has little to do with the leadership of the chief internal auditor, technology, and risk management. Conclusion: The distribution of monitoring services provided by internal auditors covers all levels of departments or divisions of the organization. The assessment of internal audit effectiveness is more influenced by the auditor's personal attributes such as independence, competence, and management support.

• 한국환경농학회지
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• 제40권3호
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• pp.211-218
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• 2021

BACKGROUND: Fine particulate matter (PM_2.5) is produced by chemical reactions between various precursors. PM_2.5 has been found to create greater human risk than particulate matter (PM₁₀), with diameters that are generally 10 micrometers and smaller. Ammonia (NH₃) and nitrogen oxides (NOx) are the sources of secondary generation of PM_2.5. These substances generate PM_2.5 through some chemical reactions in the atmosphere. Through chemical reactions in the atmosphere, NH₃ generates PM_2.5. It is the causative agent of PM_2.5. In 2017 the annual ammonia emission recorded from the agricultural sector was 244,335 tons, which accounted for about 79.3% of the total ammonia emission in Korea in that year. To address this issue, the agricultural sector announced the inclusion of reducing fine particulate matter and ammonia emissions by 30% in its targets for the year 2022. This may be achieved through analyses of its emission characteristics by monitoring the PM_2.5 and NH₃. METHODS AND RESULTS: In this study, the PM_2.5 concentration was measured real-time (every 1 hour) by using beta radiation from the particle dust measuring device (Spirant BAM). NH₃ concentration was analyzed real-time by Cavity Ring-Down Spectroscopy (CRDS). The concentrations of ozone (O₃) and nitrogen dioxide (NO₂) were continuously measured and analyzed for the masses collected on filter papers by ultraviolet photometry and chemiluminescence. CONCLUSION: This study established air pollutant monitoring system in agricultural areas to analyze the NH₃ emission characteristics. The amount of PM_2.5 and NH₃ emission in agriculture was measured. Scientific evidence in agricultural areas was obtained by identifying the emission concentration and characteristics per season (monthly) and per hour.

• 한국산업보건학회지
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• 제18권4호
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• pp.310-317
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• 2008

The objective of the survey is to define and judge exposure profiles semi-qualitative data in high risk processes using styrene. The survey was conducted on 98 factories out of 229 factories based on data from periodic working environment monitoring for styrene. Styrene is widely utilized as a raw material for PS and co-polymers such as ABS, SAN, SBR, SBL, unsaturated polyester resins(UPR) and others. An approximate breakdown of styrene's markets in Korea is PS 30%, expandable PS 17%, ABS 33%, SAN 5%, SBL 4%, SBR 3%, UPR 1% and other 7%. Although UPR accounts for 1% of total amount of styrene, workers dealing with it are exposed to very high concentrations up to 64 ppm. Especially styrene is widely used in the laminating process of fiberglass reinforced plastics(FRP) manufacturing industry. The Applications using styrene are largely classified into two sections which are applied to styrene monomer(SM) and UPR. SM is utilized for a raw material of resins, surfactant and adhesive. UPR is employed for FRP and non-FRP. For SM control targets are mixing colors and packing in the gelcoat resins manufacturing industry(MI), for UPR control targets out of works using UPR are 1) laminating in the MI of plastics, automobile parts and boats, 2) mixing and packing in the SMC/BMC MI, 3) molding and cutting in the other specific plastics MI, 4) mixing and coating in artificial marble product MI, 5) dipping in the electric motors & transformers MI, 6) molding in the button MI, 7) painting in the musical instrument MI. Findings from the study have given the information for the high risk processes and working practices so that occupational health professionals could focus on targeted workplaces to prevent occupational diseases. It is also useful to develop a control strategies and specific controls for high risk processes and facilities using styrene.

• 토지주택연구
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• 제3권3호
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• pp.225-240
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• 2012

본 연구의 목적은 해외 6개국의 주거실태조사를 비교 분석함으로써 국내 주거실태조사의 발전 방안을 논의하였다. 분석 대상 국가는 국가 차원에서 2만 가구 이상의 대규모 조사를 시행하고 자료 수집의 용이성을 감안하여 미국, 영국, 프랑스, 네덜란드, 호주, 일본으로 선정하였다. 비교 분석 항목은 조사 연혁, 목적, 대상, 시행주체, 조사 항목, 자료수집 방법, 조사결과 활용 부분이다. 비교 분석 결과, 각 국가는 자국의 주택재고 특성 및 정책목적에 따라 주거실태조사를 정기적으로 시행하고 있었으며, 그 결과는 주로 정책대상계층 선정 및 적정 임대료 기준 등과 같은 정책 기준선 마련, 주거지원을 위한 예산 수립의 근거로 활용되고 있었다. 2006년부터 현재까지 3차례 시행된 국내 주거실태조사는 이러한 해외의 선험적 사례를 참고로 하여, 향후 조사 내용의 체계화와 표준화, 주택재고 상태의 변화를 모니터링할 수 있는 판단기준과 방법론, 정책대상계층을 규명하는 기준, 그리고 데이터 공개 및 피드백 장치를 마련하여 그 정책적 활용성을 더욱 높여 나가야 할 것이다.