• 한국정보디스플레이학회:학술대회논문집
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• 2007.08a
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• pp.980-981
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• 2007

Liquid crystal (LC) devices can be operated as amplitude modulators and phase modulators. They usually require two polarizers; therefore the optical efficiency is limited. We introduce two general principles of polarization-free liquid crystal devices and also show several LC devices by applying the principles.

• Journal of Information Display
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• v.3 no.3
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• pp.24-29
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• 2002

Liquid Crystal Spatial Light Modulators (LC-SLMs) provide many interesting applications in laser optics and opto-el ectronic systems, in addition to displays. Among them, three topics developed at Thales Research & Technology are reviewed: wavefront correction for laser beam control, microwave processing in radar systems and holography for TN-LCDs viewing angle compensation.

• Proceedings of the Optical Society of Korea Conference
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• 1989.02a
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• pp.165-168
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• 1989

A finite-element method is developed to calculate the impedance of arbitrarily shaped electrodes on traveling-wave modulators. This method employs the divergence theorem to obtain the total charge on an electrode from the node potential values. By using this method, the impedance of multi strip-line electrodes on anisotropic inhomogeneous dielectric media was analysed and the effect of non-zero electrode thickness was calculated.

• The Korean Journal of Physiology and Pharmacology
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• v.5 no.5
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• pp.433-441
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• 2001

The ATP-sensitive potassium $(K_{ATP})$) channel is a member of inward rectifier potassium channel (Kir) that is inhibited by intracellular ATP and functions in close relation to sulfonylurea receptors (SUR). Although the molecular mechanism and physiological function of $K_{ATP}$ channels are well understood, the expression pattern during development or treatment with the channel modulators such as glybenclamide is little known. In this work, we determined mRNA levels of a $K_{ATP}$ channel (Kir6.2) and a sulfonylurea receptor (SUR2) in rat tissues by RNase protection assay. Levels of Kir6.2 and SUR2 mRNA in the rat brain and skeletal muscle were higher in adult $(90{\sim}120\;days)$ than in neonate $(2{\sim}8\;days),$ whereas those in the heart were not much different between neonate $(2{\sim}8\;days)$ and adult $(90{\sim}120\;days).$ In addition, none of $K_{ATP}$ channel modulators (opener, pinacidil and nicorandil; blocker, glybenclamide) affected the Kir6.2 mRNA levels in the heart, brain and skeletal muscle. The results indicate that the expression of Kir and SUR genes can vary age-dependently, but the expression of Kir is not dependent on the long-term treatment of channel modulators. The effect of the channel modulators on mRNA level of SUR is remained to be studied further.

• Toxicological Research
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• v.27 no.2
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• pp.85-93
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• 2011

Selective estrogen receptor modulators (SERMs) are synthetic molecules which bind to estrogen receptors (ER) and can modulate its transcriptional capabilities in different ways in diverse estrogen target tissues. Tamoxifen, the prototypical SERM, is extensively used for targeted therapy of ER positive breast cancers. Unfortunately, the use of tamoxifen is associated with acquired resistance and some undesirable side effects. This study investigated the availability of the conventional SERMs on the TAM-resistance breast cancer cells. SERMs showed more effectiveness in MCF-7 cells than tamoxifen resistant cells, except toremifene and ospemifene. Especially, toremifene was more efficacious in tamoxifen resistant cells than MCF-7. Ospemifene had similar cytotoxic activity on the two types of breast cancers. The other SERMs used in this experiment didn't inhibit efficiently the proliferation of tamoxifen resistant cells. These results support the possibility to usage of toremifene on tamoxifen resistant cancer. The effectiveness by toremifene on tamoxifen resistant cells might be different pathways from the apoptosis and the autophagy. Further study should be needed to elucidate the underlying mechanism of effect of toremifene on tamoxifen resistant cancer.

• The Korean Journal of Applied Statistics
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• v.6 no.2
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• pp.383-391
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• 1993

Interaction between anti-cancer agents and various modulators of multidrug resistance in producing their joint effects are of fundamental interest in the chemtherapeutic treatment of cancer. We generate a dose-response curve for each combination of several anti-cancer agents and modulators based on an in-vitro experiment on each of several human cancer cell lines. We employ a log-linear model developed by Wahrendorf et al (1981) and Piegorsch et al (1988) to detect synergism among several compounds. We show two examples of the data analysis and their results. We believe that these results encourage further experiment in-vivo studies.

• Bulletin of Food Technology
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• v.22 no.4
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• pp.700-709
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• 2009

• Bioindustry News
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• v.12 no.3
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• pp.45-49
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• 1999

• Proceedings of the Optical Society of Korea Conference
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• 1997.08a
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• pp.43-43
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• 1997

• Journal of Mechanical Science and Technology
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• v.20 no.4
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• pp.554-560
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• 2006

This paper describes the demonstration of successful fabrication and initial characterization of micromachined pressure sensors and micromachined jets (microjets) fabricated for use in macro flow control and other applications. In this work, the microfabrication technology was investigated to create a micromachined fluidic control system with a goal of application in practical fluids problems, such as UAV (Unmanned Aerial Vehicle)-scale aerodynamic control. Approaches of this work include: (1) the development of suitable micromachined synthetic jets (microjets) as actuators, which obviate the need to physically extend micromachined structures into an external flow; and (2) a non-silicon alternative micromachining fabrication technology based on metallic substrates and lamination (in addition to traditional MEMS technologies) which will allow the realization of larger scale, more robust structures and larger array active areas for fluidic systems. As an initial study, an array of MEMS pressure sensors and an array of MEMS modulators for orifice-based control of microjets have been fabricated, and characterized. Both pressure sensors and modulators have been built using stainless steel as a substrate and a combination of lamination and traditional micromachining processes as fabrication technologies.