• Tunnel and Underground Space
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• v.9 no.1
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• pp.20-26
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• 1999

The completion of the Bakun Diversion Tunnel is subsequently to the Main Dam construction. Therefore, the completion date is very important for the Bakun Hydroelectric Project. Generally, the tunnel lining work as a finishing phase of the tunnelling project occupies a important portion as well as an excavation and a support work of the tunnels in respect to the construction cost and period. Internal section of Bakun Diversion Tunnel is designed circular shape to reduce the roughness of the water flow with 12 meters in diameter of total length 4314.6 meters of 3 tunnels. The lining thickness is varied between 500 mm and 700 mm depending on the structural condition. From the original Tender design of the Bakun tunnels, the required quantity of steel bars was 5,985 ton designed by Reinforced Concrete (RC) through the entire tunnel linings. During the detail design stage by the consideration of the rock conditions and various load conditions, we could suggest five kinds of RC lining type including plain concrete lining type. Through the detail design modification, we could reduce the required amount of steel bars to 2,178 ton, as a half of original Bill of Quantity. Finally, this design modification give us the time and cost saving effect to catch up the construction progress in time.

• Journal of Digital Convergence
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• v.13 no.9
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• pp.489-495
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• 2015

Image availability evaluated by the degree of agreement and sensitive using the process improve visualization according to the Algorithm modification in Image Post-Processing. Reliability measured by the Breast Imaging Reporting and Data System. 172 patients visit same period divided by BI-RADS, category five stages, and contents of breast parenchyma into Calcification, Nodule and Mass. Evaluated the TE/PV image reliability, visualization sensitive, agreement of diagnosis. Convergence analysis was an in various fields. According to the result of this research, PV has higher sensitive and accuracy about lesions than TE visual and there is a difference insensitive by contents of breast parenchyma. Therefore, practical use of Algorithm Modification(Tissue Equalization: TE, Premium View: PV) is expected to improve more accurate, useful diagnosis, which has not been easy until now.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.23 no.10
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• pp.670-677
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• 2011

Direct numerical simulation are performed in order to investigate the effect of the circular cylinder shape on the forced convection around a circular cylinder at the Reynolds number of 300 and Prandtl number of 0.71. Three-dimensional characteristics of fluid flow and heat transfer around the smooth, wavy and torsional cylinders are investigated. A wavy cylinder has the sinusoidal variation in the cross sectional area along the spanwise direction with the wave length of ${\pi}/3$ and wavy amplitude of 0.1. A torsional cylinder has the twisted elliptic cross section with a torsional period of ${\pi}/2$ and an axis ratio of 1.35 corresponding to the major axis of 1.15 and the minor axis of 0.85. The value of time-and surface-averaged drag coefficient for the smooth cylinder is similar to that for the wavy cylinder, but larger than that for the torsional cylinder. The time and surface-averaged lift coefficient for the smooth cylinder is larger than that for the wavy and torsional cylinders. The time-averaged local heat transfer rate for the wavy and torsional cylinders shows different distribution along the circumferential direction, compared to that for the smooth cylinder because of the shape change in the spanwise direction for the cases of the wavy and torsional cylinders.

• The Korean Journal of Physiology and Pharmacology
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• v.24 no.6
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• pp.463-472
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• 2020

Direct reprogramming, also known as a trans-differentiation, is a technique to allow mature cells to be converted into other types of cells without inducing a pluripotent stage. It has been suggested as a major strategy to acquire the desired type of cells in cell-based therapies to repair damaged tissues. Studies related to switching the fate of cells through epigenetic modification have been progressing and they can bypass safety issues raised by the virus-based transfection methods. In this study, a protocol was established to directly convert fully differentiated fibroblasts into diverse mesenchymal-lineage cells, such as osteoblasts, adipocytes, chondrocytes, and ectodermal cells, including neurons, by means of DNA demethylation, immediately followed by culturing in various differentiating media. First, 24 h exposure of 5-azacytidine (5-aza-CN), a well-characterized DNA methyl transferase inhibitor, to NIH-3T3 murine fibroblast cells induced the expression of stem-cell markers, that is, increasing cell plasticity. Next, 5-aza-CN treated fibroblasts were cultured in osteogenic, adipogenic, chondrogenic, and neurogenic media with or without bone morphogenetic protein 2 for a designated period. Differentiation of each desired type of cell was verified by quantitative reverse transcriptase-polymerase chain reaction/western blot assays for appropriate marker expression and by various staining methods, such as alkaline phosphatase/alizarin red S/oil red O/alcian blue. These proposed procedures allowed easier acquisition of the desired cells without any transgenic modification, using direct reprogramming technology, and thus may help make it more available in the clinical fields of regenerative medicine.

• Korean Journal of Ecology and Environment
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• v.48 no.3
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• pp.188-194
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• 2015

River channel dredging and riparian development have been influenced morphology and quantity of natural river habitat. We compared distribution of riverside land and alluvial island in the Nakdong River with field survey and remote sensing analysis after the 4 Large River Project in South Korea. We digitized geomorphological elements, includes main channel, riverside land, and alluvial island by using georeferenced aerial photos taken in pre-dredging (2008) and post-dredging (2012) periods. Field survey was followed in 2012 for a ground truth of digitized boundaries and identification of newly constructed wetland types such as pond, channel, branch, and riverine type. We found that during the dredging period, riverside land and alluvial island were lost by 20.2% and 72.7%, respectively. Modification rate of riverside land was higher in the section of river kilometer 50~90, 140~180, and 210~270. Alluvial island had higher change rate in the section of river kilometer 50~70, 190~210, and 270~310. Average change rate for the riverside land and alluvial island was $-1.02{\pm}0.14km^2{\cdot}10km^{-1}$ and $-0.05{\pm}0.05km^2{\cdot}10km^{-1}$, respectively. Channel shaped wetlands (72.5%) constituted large portion of newly constructed wetlands.

• Membrane and Water Treatment
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• v.8 no.4
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• pp.355-367
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• 2017

In India, the current operation of condenser cooling system & effluent disposal system in existing power plants aims to reduce drawal of seawater and to achieve Zero Liquid Discharge to meet the demands of statutory requirements, water scarcity and ecological system. Particularly in the Steam-Electric power plants, condenser cooling system adopts Once through cooling (OTC) system which requires more drawal of seawater and effluent disposal system adopts sea outfall system which discharges hot water into sea. This paper presents an overview of closed-loop technology for condenser cooling system and to achieve Zero Liquid Discharge plant in Steam-Electric power plants making it lesser drawal of seawater and complete elimination of hot water discharges into sea. The closed-loop technology for condenser cooling system reduces the drawal of seawater by 92% and Zero Liquid Discharge plant eliminates the hot water discharges into sea by 100%. Further, the proposed modification generates revenue out of selling potable water and ZLD free flowing solids at INR 81,97,20,000 per annum (considering INR 60/Cu.m, 330 days/year and 90% availability) and INR 23,760 per annum (considering INR 100/Ton, 330 days/year and 90% availability) respectively. This proposed modification costs INR 870,00,00,000 with payback period of less than 11 years. The conventional technology can be replaced with this proposed technique in the existing and upcoming power plants.

• Proceedings of the Korean Nuclear Society Conference
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• 1996.05a
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• pp.185-190
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• 1996

RFSP is a computer program to do fuel management calculations for CANDU reactors. Its main function is to calculate neutron flux and power distributions using two-energy-group, three dimensional neutron diffusion theory. However, up to now the treatment has not been true two-group but actually "one-and-half groups". In other words, the previous (1.5-group) version of RFSP lumps the fast fission term into the thermal fission term. This is based on the POWDERPUFS-V Westcott convention. Also, there is no up-scattering term or bundle power over cell flux (H1 factor) for the fast group. While POWDERPUFS-V provides only 1.5 group properties, true two-group cross sections for the design and analysis of CAUDU reactors can be obtained from WIMS-AECL. To treat the full two-group properties, the previous RFSP version was modified by adding the fast fission, up-scatter terms, and H1 factor. This two-group version of RFSP is a convenient tool to accept lattice properties from any advanced lattice code (e.g. WIMS-AECL DRAGON, HELIOS...) and to apply to advanced fuel cycles. In this study, the modification to implement the true two-group treatment was performed only in the subroutines of the ＊SIMULATE module of RFSP. This module is the appropriate one to modify first, since it is used for the tracking of reactor operating histories. The modified two-group RFSP was evaluated with true two-group cross sections from WIMS-AECL. Some tests were performed to verify the modified two-group RFSP and to evaluate the effects of fast fission and up-scatter for three core conditions and four cases corresponding to each condition. The comparisons show that the two-group results are quite reasonable and serve as a verification of the modifications made to RFSP. To assess the long-term impact of the full 2-group treatment, it is necessary to simulate a long period (several months) of reactor history. It will also be necessary to implement the full two-group treatment of reactivity devices and assess the reactivity-device worths.ce worths.

• Journal of Korean Neurosurgical Society
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• v.65 no.1
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• pp.57-63
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• 2022

Objective : To study the factors relating to operative treatment for spinal metastasis in Thailand during 2005-2014 and to determine the hospital costs, mortality rate, and incidence of perioperative complication. Methods : Inpatient reimbursement data from 2005 to 2014 was reviewed from three national healthcare organizations, including the National Health Security Office, the Social Security Office, and the Comptroller General's Department. The search criteria were secondary malignant neoplasm of bone and bone marrow patients (International Classification of Diseases 10th revision, Thai modification codes [ICD 10-TM], C79.5 and C79.8) who underwent spinal surgical treatment (ICD 9th revision, clinical modification procedure with extension codes [ICD 9-CM], 03.0, 03.4, 03.09, and 81.0) during 2005-2014. Epidemiology, comorbidity, and perioperative complication were analyzed. Results : During the study period, the number of spinal metastasis patients who underwent operative treatment was significantly increased from 0.30 to 0.59 per 100000 (p<0.001). More males (56.14%) underwent surgical treatment for spinal metastasis than females. The most common age group was 45-64 (55.1%). The most common primary tumor sites were the unknown origin, lung, breast, prostate, and hepatocellular/bile duct. Interestingly, the proportion of hepatocellular/bile duct, breast, and lung cancer was significantly increased (p<0.001). The number of patients who had comorbidity or in-hospital complication significantly increased over time (p<0.01); however, the in-hospital mortality rate decreased. Conclusion : During the last decade, operative treatment for spinal metastasis increased in Thailand. The overall in-hospital complication rate increased; however, the in-hospital mortality rate decreased.

• Journal of Korea Water Resources Association
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• v.55 no.10
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• pp.843-854
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• 2022

For the rip current warning system to reduce rip-current accidents, the implementation method producing the risk index was modified. To produce fast response from the warning system based on real-time observations, the method employed the numerical results (i.e., rip current likelihoods according to the possible scenario) obtained in advance. In this study, instead of using the empirical curve-fitting functions of the previous method, the present modification utilized two-dimensional distributions (i.e., wave height and period, wave height and tidal elevation, wave height and direction, wave height and spreading of frequency-directional spectrum) of rip current likelihoods stacked in a database of the system. The wave and tidal observations in 2021 at the Haeundae coast were applied to the modified system, and its performances at several real events recorded in CCTV images were presented.

• Korean Journal of Food Science and Technology
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• v.26 no.2
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• pp.110-116
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• 1994

In order to study the effects of enzyme modification on the physico-chemical and functional properties of myofibrillar protein prepared from the frozen sardine, Sardinops melanostica, the protein was hydrolyzed with pepsin under the enzyme-substrate ratio 1:100 at $37^{\circ}C$ and pH 1.65 for 1, 4, 8, 12, and 24 hr, respectively. The properties of pepsin-modified sardine myofibriliar protein were determined. The extents of proteolysis with pepsin as a fuction of time was showed a typical enzyme hydorlysis curve with an initial region of 4 hour period followed by plateau region. The SDS-acrylamide slab gel electrophoresis patterns of pepsin-modified proteins showed mainly disappearances of minor protein bands, but no changes of main protein bands. The gel filtration patterns through Sephadex G-75 of sardine myofibrillar protein showed two big peaks and three small peaks. All the small peaks were disappearanced by proteolysis with pepsin in one hour. and during the period of proteolysis the fast big peak became gradually smaller and the late big peak eluted more slowly. By proteolysis, the emulsifying activity and emulsifying capacity of sardine myofibrillar protein were all decreased. The effects of pepsin-modification on emulsifying capacity were greater than those on emulsifying activity of protein. The aeration capacity of the protein was increased about 1.9 folds and the foam stability decreased to 0.6 folds of control by pepsin-modification. The pepsin-modified sardine myofibrillar proteins showed about 0.6 folds of heat coagulation and 1.4 folds of viscosity of control. The pH dependence of solubilities of sardine myofibrillar protein showed two isoelectric areas of pH 5 and 9. The pepsin-modified protein showed more clear pH dependences at the early stage but not at the late stage of proteolysis.