• 대한한의학방제학회지
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• 제28권4호
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• pp.407-428
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• 2020

Objectives : The purpose of this study is to review the effect of Guaruhaebaekbaekju-tang (GHBJ), Guaruhaebaekbanha-tang (GHBH) and Jisilhaebaekgyeji-tang (JHGJ) by summarizing Korean and English articles. Methods : The study was based on 23 papers published since 1995. Papers were searched on seven domestic electronic databases including Koreantk, NDSL, RISS, KISS, OASIS, Koreamed and Library of Korea University and three international electronic databases including PUBMED, Embase and Science Direct. Results : 1. 23 research papers were collected, including 13 in vitro studies, 6 in vivo studies, 2 case reports and 2 literature studies. 2. GHBJ, GHBH and JHGJ showed significant myocardial protective and anti-hyperlipidemic and anti-inflammatory effects. In addition, researches on anti-oxidant, thrombosis, and atherosclerosis have been conducted in various ways. 3. It can be confirmed that these studies are related to Chest and back pain (胸背痛), Insomnia by chest paralysis (胸痺不得臥), Stabbing pain that radiates from chest to back (心痛徹背), Chest numbness (心中痞), Obstruction of qi in the chest (留氣結在胸), Fullness sensation in chest (胸滿) among the terms. Conclusion : Through these results, close association was found between classic description and modern research about GHBJ, GHBH and JHGJ, and the possibility of providing objective evidence was confirmed. To improve the quality of the study, large scale studies will be required to evaluate the authority of GHBJ, GHBH and JHGJ.

• 대한본초학회지
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• 제36권4호
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• pp.1-7
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• 2021

Objective : As more and more people are interested in appearance in modern society, the increasing number of hair loss population can have an important impact on psychological and social problems such as depression and inappropriate interpersonal symptoms. Therefore, much research is being done on treatments for alopecia using herbal extracts with relatively few side effects. This study was investigated about the effect of Achyranthis Radix (AR) extract with ethanol solvent on hair growth. Methods : We determined the promoting efficacy of AR-ethanol extract compared with minoxidil (MNXD) on the growth of human hair dermal papilla cells (HDPCs). Cell viability was measured by MTT assay and cell proliferation was confirmed by cell cycle analysis from flow cytometry in HDPCs. Also, we monitored the safe concentration range through MTT assay. And protein expression of hair growth-related genes (insulin-like growth factor 1 (IGF-1), Wnt3a, Protein kinase B (Akt), Extracellular signal-regulated kinase (Erk)) was monitored by western blot. Results : On cell cycle analysis, the G2/M phase was higher than that of the DW group in AR ethanol extract group at 0.05 and 0.1 mg/㎖. All protein expression levels of HDPCs were increased in AR ethanol extract groups and the MNXD group, compared to the DW group, respectively. Conclusion : As mentioned above, AR extract increased cell proliferation and the protein expression of IGF-1, Wnt3a, Akt, Erk in HDPCs. These results suggest that AR ethanol extract has promoted hair growth and it might be potential hair growth supplement.

• 한국방사선학회논문지
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• 제14권5호
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• pp.537-543
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• 2020

현대사회의 노인 인구는 첨단 의료기술과 최소 침습 수술로 인해 빠르게 성장하고 있다. 따라서 의료기기를 사용하는 경향이 증가하기 때문에 병원성 감염이 우려된다. 따라서 현대 의학의 최우선 목표는 감염예방이다. 최근 3D 프린팅을 이용하여 환자 맞춤형 임플란트 이식술이 늘고 있다. 대표적 재료로 이용되는 것이 수산화인회석이다. 현재 HA 디스크 멸균을 위한 흡수선량 기준이 없으므로, HA 디스크 표면에 오염된 대장균과 충치균을 감마선 코발트와 선형 가속기를 이용하여 각 흡수선량 0, 0.5, 1.0, 3.0, 5.0 kGy로 조사 후, 십진 희석법으로 검체에서 균 수를 측정하였다. 멸균 후 대장균, 충치균의 생존 비교분석을 위해 비모수 검정법을 시행하였으며, 그 결과 대장균은 1 kGy 이상, 충치균은 3 kGy 이상에서 멸균되었다. 방사선 멸균 흡수선량 권고사항보다 낮은 수치에서 멸균을 시행하는 것도 가능할 것으로 생각된다.

• 건축역사연구
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• 제19권6호
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• pp.121-135
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• 2010

This study was to analyze the architectural characteristics and facade construction of brick masonry auditorium through the Auditorium of Namsan Primary School in 1936. The results of this study were described separately as follows. 1. The auditorium is located away from the school buildings, and its plane is a chamber of rectangle type with an entrance installed on each of the four sides. 2. The external appearance is Renaissance eclectic style, laid red bricks on the lower wall of the window and having a mansard roof. The front and the rear are symmetric with respect to the projected wall at the center. 3. As to the structure of the building, a concrete lower wall was built on the concrete continuous footing, and the brick wall was constructed on the lower wall. The roof is queen post roof truss, and the wall girders were installed on the brick wall. 4. The auditorium has had a number of repairing and maintenance works, which changed the roof and windows outside and the floor, walls, ceiling, etc. inside. 5. The decorative elements of external appearance include lower wall, brick wall, entrances, windows, roof, and dormer windows. The brick wall gives verticality and solidity to the surface of the wall, and the lower wall and wall girders are connected like a cornice of the wall. The surface of the mansard roof and dormer windows express a stable vertically oriented shape.

• 대한본초학회지
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• 제37권6호
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• pp.9-17
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• 2022

Objective : In modern society, liver diseases such as liver fibrosis are on the rise as inflammation and wound healing processes of the liver are repeated due to factors such as drinking, smoking, and stress. This study was conducted to evaluate the effect of Saenggangeonbi-tang (SGGBT) on thioacetamide (TAA)-induced liver fibrosis. Methods : The mice were divided into 4 groups for examination (n=6): Normal group (Nor), distilled water-treated liver fibrosis mice (Con), silymarin 50 mg/kg-treated liver fibrosis mice (Sily), SGGBT 200 mg/kg-treated liver fibrosis mice (S200). Liver fibrosis was established in the mice via TAA for 8 weeks (1 week 100 mg/kg, 2,3 weeks 200 mg/kg, 4-8 weeks 400 mg/kg, three times a week, intraperitoneal injection) and they were administered silymarin and SGGBT (every day, oral administration) with the TAA. Results : SGGBT significantly decreased the levels of aspartate aminotransferase, alanine aminotransferanse, ammonia, and myeloperoxidase in serum increased by liver fibrosis. As a result of confirming H&E and MT staining, it was confirmed that SGGBT reduced damage and inflammatory cell infiltration in liver tissue, and alleviated changes in collagen fiber deposition and histological fibrosis. Also, it was confirmed through PAS staining that it reduced glycogen deposition in liver tissue. In addition, SGGBT significantly decreased the NADPH oxidases as well as significantly modulated the expression of MMP-2 and TIMP-2. Conclusions : These results suggest that SGGBT regulates the expression of MMP/TIMP protein through inhibition of oxidative stress and alleviates liver fibrosis by reducing collagen and glycogen deposition in liver tissue.

• 대한예방한의학회지
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• 제20권1호
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• pp.99-110
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• 2016

In Korea and China, traditional medicine's holistic approaches, based on the views of whole-body and whole-person, have been applied to make the solution of health problem. However, these holistic approaches of traditional korea or chinese medicine have been limited in interpreting their theories in a view of modern scientific aspects of medicine. This limitation seems to be mainly due to the reductionism approaches of modern scientific medicine. Traditionally, science has taken a reductionism approach; dissecting biological systems into their constituent parts and studying them in isolation. However, systems biology based on omics technologies is providing a new thought and method for traditional medicine's research and interpretation. Systems biology uses integrity study as the characteristic and bioinformatic technology as the key method for connecting reductionism and holism. Therefore, it has much in common with the theory of traditional medicine. It was reviewed that how systems biology is applied to traditional medicine in Korea and China. Also it was suggested that more future researches on interpretation between traditional medicine and systems biology must be focused on personalized medicine since systems biology will have a major impact on future personalized therapeutic approaches.

• 한국주거학회:학술대회논문집
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• 한국주거학회 2008년 추계학술발표대회 논문집
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• pp.217-221
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• 2008

The goal of this research is to analyze interrelationship for layout of dwelling house and variation of its side plane by introducing concept of space in order to address as to how Korean traditional houses had been formed and varied in the middle of advancing modern city. In addition, this paper also has its meaning in a way that it identified how Korean traditional houses have been changed, and thus make residents more comfortable to live there by reviving their past characteristics, and make users have traditional food culture. Targeted area for this paper is limited to south-eastern area of Daegu such as Namsanjung, Myeongchijung, Sijangjung, Shinjung and Dalsungjng which was group dwelling houses of people of Chosun Dynasty during Japanese colonial rule' era ($1910{\sim}1945$). Among those places, the paper has chosen a place where Korea traditional houses were well preserved, variation of road and fields was less 1930s, and residential type is easy to effectively compared. As the result of this research, time when traditional cities were changed into new type of city residential area is believed to be around 1930s, and traditional residential area, through its transitional process, is believed to be changed to modern residential area. It also indicates that change of organizational road and fields directly had influence on change of houses.

• 한국지역지리학회지
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• 제19권1호
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• pp.75-96
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• 2013

물은 단순히 자연 자체라기보다 사회적 구성물이다. 따라서 물에 관한 연구는 자연/사회를 이분법적으로 구분하는 근대 과학적 접근에서 '사회적 자연'으로 이해하는 구성주의적 및 정치생태학적 접근으로의 전환을 요구한다. 특히 도시의 물은 자연적 순환과는 다른 인위적 생산-유통-소비-배출-처리 과정, 즉 사회적 순환과정을 통해 흐른다. 도시에서 물의 사회적 순환체계는 도시의 근대화 과정 속에서 발전한다. 이 논문은 이러한 자연의 사회적 구성주의에 바탕을 두고 도시 물의 사회적 순환을 개념화하고, 대구시를 사례로 물의 사회적 순환체계의 발달, 즉 물의 근대화 과정을 역사적으로 분석하고자 한다. 대구시의 물의 근대화 과정에 따른 사회적 순환체계의 발달은 4 단계, 물의 근대화 도입 시기, 물의 본격적 근대화 시기, 물의 성찰적 근대화 시기, 물의 신자유주의화 시기로 구분된다. 이러한 대구시 물의 사회적 순환체계의 발달은 도시의 공간적 팽창과 도시적 생활양식을 뒷받침하면서 도시 인구의 증가와 경제 발전에 기여했다. 그러나 현재 대구의 물의 사회적 순환체계는 취수장 이전, 정수시설의 과잉, 수돗물에 대한 불신, 물 이용의 불평등, 물 요금의 현실화, 도시 내 공단 폐수, 물 환경의 창조적 파괴, 물의 민영화 등 다양한 문제들을 안고 있다.

• 센서학회지
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• 제29권1호
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• pp.19-26
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• 2020

Electrocardiogram (ECG) classification has become an essential task of modern day wearable devices, and can be used to detect cardiovascular diseases. State-of-the-art Artificial Intelligence (AI)-based ECG classifiers have been designed using various artificial neural networks (ANNs). Despite their high accuracy, ANNs require significant computational resources and power. Herein, three different ANNs have been compared: multilayer perceptron (MLP), convolutional neural network (CNN), and spiking neural network (SNN) only for the ECG classification. The ANN model has been developed in Python and Theano, trained on a central processing unit (CPU) platform, and deployed on a PYNQ-Z2 FPGA board to validate the model using a Jupyter notebook. Meanwhile, the hardware accelerator is designed with Overlay, which is a hardware library on PYNQ. For classification, the MIT-BIH dataset obtained from the Physionet library is used. The resulting ANN system can accurately classify four ECG types: normal, atrial premature contraction, left bundle branch block, and premature ventricular contraction. The performance of the ECG classifier models is evaluated based on accuracy and power. Among the three AI algorithms, the SNN requires the lowest power consumption of 0.226 W on-chip, followed by MLP (1.677 W), and CNN (2.266 W). However, the highest accuracy is achieved by the CNN (95%), followed by MLP (76%) and SNN (90%).

• 한국한의학연구원논문집
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• 제14권2호
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• pp.67-73
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• 2008

Background: Qigong is one of energy-healing intervention used to prevent and cure ailments and to improve health through regular practice. Although Qigong-neither itself nor its postulated mechanism of action-is within the paradigm of modern Western medical science, effects on the human body could be possible. Objectives: This study aims to know effect of Qigong training in a University student's physical, mental health and self-esteem. Method: There are 120 students who take a Yangsaengkigong(養生氣功) course in D University college of oriental medicine during four weeks beginning in April 10th 2008. I researched 41 of them trained about effect of Qigong training. Result: Qigong training made significant change in self-esteem measurement and SCL-90-R. And there wasn't significant change in KHP and happiness index. Conclusions: The depth study for the each Qigong is needed. Specifically, I think it should be a clinical studies and qualitative research methods for evaluation are needed.