• Title/Summary/Keyword: Moderate Effect

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Effect of clomipramine in a dog with cataplexy

  • Jeong, Soo-Yeon;Kang, Min-Hee;Park, Hee-Myung
    • Korean Journal of Veterinary Research
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    • v.53 no.2
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    • pp.129-131
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    • 2013
  • A 5-year-old, castrated male, Maltese was presented with history of acute flaccid paralysis. The dog was presented with sudden loss of muscle tone and involuntary movements of hind limbs. Neurologic examination revealed reduced postural reaction in the bilateral hind limbs. MRI of brain showed moderate hydrocephalus, but other examination results were normal. Based on the characteristic episodes and examination results, canine cataplexy was suspected. Treatment was initiated with clomipramine as cataplexy control. Clinical signs resolved with 3-month medication. This case demonstrates therapeutic diagnosis of cataplexy. To the author's knowledge, this is the first report of cataplexy treating with clomipramine.

Quality of Popped Rice with Deep-frying for Salyeotgangjung (유탕처리된 쌀엿강정용 팽화쌀의 품질)

  • 김명애
    • Korean journal of food and cookery science
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    • v.17 no.5
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    • pp.478-482
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    • 2001
  • This experiment was carried out to clarify the effect of frying temperature and gelatinization method on the quality of popped rice for Salyeotgangjung. Frying at 220$^{\circ}C$ or 230$^{\circ}C$ gave a good expansion and score of sensory evaluation. But the frying oil began to smoke at 230$^{\circ}C$. There was no significant difference in the quality of popped rices between the treatments of minimum gelatinization after washing rice and moderate gelatinization after soaking for 80 minutes at 30$^{\circ}C$. In conclusion, frying washed rice with minimum gelatinization at 220$^{\circ}C$ would be considered as the best method for making Salyeotganagjung.

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Effect of the Ni Content and W Grain Size on the High Temperature Com-pressive Properties of W-Ni Activated Sintered Parts (Ni 함량과 W 결정립 크기에 따른 W-Ni 활성소결체의 고온압축 특성)

  • 박영삼;오승탁;양주환;김영도;문인형
    • Journal of Powder Materials
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    • v.11 no.2
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    • pp.149-157
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    • 2004
  • High temperature deformation behavior of activated sintered W powder compacts was investigated. The compression tests were carried out in the temperature range between 900 and 110$0^{\circ}C$ at the strain rate of $10^{-3}s^{-1}$. The sintered specimens of Ni-doped submicron W powder compacts showed decrease in W grain size with increasing the Ni content. As the result, the flow stress was significantly increased with increasing the Ni content. We obtained Ni-activated sintered W compacts with the relative density of 94 $\pm$ l%and the average grain size of less than 5${\mu}{\textrm}{m}$. A moderate true strain up to 0.60 was obtained without fracture even at 110$0^{\circ}C$ with the strain rate of $10^{-3}s^{-1}$ for the activated W compact despite adding the 1.0 wt%Ni to submicron W powder.

Design and Synthesis of 3-(3-Chloro-4-substituted phenyl)-4-(pyridin-4-yl)-1Hpyrazole- 1-carboxamide Derivatives and Their Antiproliferative Activity Against Melanoma Cell Line

  • El-Gamal, Mohammed I.;Oh, Chang-Hyun
    • Bulletin of the Korean Chemical Society
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    • v.32 no.3
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    • pp.821-828
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    • 2011
  • Design and synthesis of new 3,4-diarylpyrazole-1-carboxamide derivatives are described. Their antiproliferative activity against A375 human melanoma cell line was tested and the effect of substituents on the diarylpyrazole scaffold was investigated. The pharmacological results indicated that most of the synthesized compounds showed moderate activity against A375, compared with Sorafenib. On the other hand, compounds Ia, Ie, IIb, and IIh were more potent than Sorafenib. In addition, compound IIa was equipotent to Sorafenib. Among all of these derivatives, compound IIb which has diethylamino and phenolic moieties showed the most potent antiproliferative activity against A375 human melanoma cell line. Virtual screening was carried out through docking of the most potent compound IIb into the domain of V600E-b-Raf and the binding mode was studied.

Synthesis of New 6-(4-Fluorophenyl)-5-(2-substituted pyrimidin-4-yl)imidazo[2,1-b] thiazole Derivatives and their Antiproliferative Activity against Melanoma Cell Line

  • Park, Jin-Hun;Oh, Chang-Hyun
    • Bulletin of the Korean Chemical Society
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    • v.31 no.10
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    • pp.2854-2860
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    • 2010
  • Synthesis of a new series of pyrimidinyl-imidazo[2,1-b]thiazole derivatives is described. Their antiproliferative activity against A375 human melanoma cell line was tested and the effect of substituents on the pyrimidinyl ring side chain was investigated. The biological results indicated that most of the newly synthesized compounds showed moderate activity against A375, compared with Sorafenib. Among all of these derivatives, the cyclic sulfamide derivatives IIIa, IIIb, and IIIe showed the most potent antiproliferative activity against A375 human melanoma cell line. The IC50 values of compounds IIIa,b were in nanomolar scale. In addition, compound IIIe ($IC_{50}=1.9\;{\mu}M$) also demonstrated more potent antiproliferative activity compared with Sorafenib ($IC_{50}=5.6\;{\mu}M$).

A Study on the Household's Debt and its Determinants (가계의 부채보유여부 및 부채액에 대한 영향요인 분석)

  • 김순미
    • Journal of Families and Better Life
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    • v.14 no.2
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    • pp.157-170
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    • 1996
  • Even if holding debt may be a rational means for household to maximize utility under any circumstance and any time through the family life cycle most households have some difficulty to determin and keep the moderate debt amount. The purpose of this study is to identify the characteristics of household's debt and the factor associated with debt. Data used in this study consisted of 4,009 households. The results of this study were as follows; Among 4,009 households 1,400 housholds?(34.9%) owed. Age education and occupation of household header liquid and real asset and housing ownership had significant effects on whether household having debt. The real and liquid asset had significantly positive relation with the liabilities of financial agency whereas the occupation of household header liquid asset and unearned income with private liabilities. Finally age education and occupation of household header home ownership and liquid asset had significantly negative effect on the total a ount of debt while earned and unearned income and real asset had positive one.

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Dynamic Response and Carrier Velocity in Organic Field-Effect Transistors

  • Cobb, Brian;Wang, Liang;Dunn, Lawrence;Dodabalapur, Ananth
    • 한국정보디스플레이학회:학술대회논문집
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    • 2009.10a
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    • pp.60-63
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    • 2009
  • In this letter we report on the carrier velocity of polycrystalline pentacene transistors as a function of electric field. We performed a series of measurements on devices with a range of channel lengths. At moderate electric fields (<$5{\times}10^5$ V/cm), the characteristics are similar to those of disordered or amorphous organic semiconductors. The highest velocities we have measured are near $6{\times}10^4$ cm/s at room temperature. We perform quasi-static and dynamic measurements to measure carrier velocity. These results fill an important void between experimental results that have been obtained with disordered/amorphous organic semiconductors and single crystals.

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An Effect of Pressure Fluctuations of a Combustion Chamber on the Modulation of Equivalence Ratio in the Channel of the Burner (연소실 압력 변동이 버너내부의 당량비 변조에 미치는 영향)

  • Hong, Jung-Goo;Oh, Kwang-Chul;Shin, Hyun-Dong
    • Transactions of the Korean Society of Mechanical Engineers B
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    • v.31 no.2 s.257
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    • pp.202-207
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    • 2007
  • In order to understand the phenomena of combustion instability, an experimental study was conducted at the moderate pressure and ambient temperature conditions. The flame behavior and the pressure fluctuations were measured in a dump combustor. Various types of combustion modes occurred in accordance with the equivalence ratio and the fuel supplying conditions. The fluctuation of pressure, heat release and equivalence ratio were measured by piezoelectric pressure sensor, high speed Intensified Charge Coupled Device (HICCD) camera and gas chromatography respectively. Two representative modes were self-excited pressure oscillations at the resonance of combustion chamber (200Hz) and instabilities related to the modulated fuel flow rate through the fuel holes (10Hz). It is found that, especially in an unchoked fuel flow condition, the modulation of the fuel flow rate affects the characteristics of flame behavior and pressure fluctuations in a lean premixed flame.

Behavior of small particles in isotropic turbulence in the presence of gravity (중력이 존재하는 등방성 난류에서 작은 입자의 유동)

  • Cho, Seong-Gee;Yeo, Kyong-Min;Lee, Chang-Hoon
    • Proceedings of the KSME Conference
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    • 2008.11b
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    • pp.2396-2400
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    • 2008
  • The motion of small heavy particles in homogeneous isotropic turbulence in the present of gravity is investigated using Direct Numerical Simulations (DNS) at moderate Reynolds number. The Lagrangian velocity and acceleration statistics of particles and of flow for a wide range of Stokes number, defined as the ratio of the particle response time to Kolmogorov time scale of turbulence, were obtained for the direction of the gravity and normal direction, respectively. It is found that particles lose their correction faster than the case without gravity. Then, a significant increase in the average settling velocity was observed for a certain range of Stokes number. Our focus is placed on gravitational effect on very small particles. Our simulations show that as the Stokes number reduces to zero, their mean settling velocity approaches the terminal velocity in still fluid.

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Rare Odontalgia of Mandibular Teeth Associated with Migraine: A Case Report

  • Im, Yeong-Gwan;Kang, Jin-Kyu
    • Journal of Oral Medicine and Pain
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    • v.43 no.3
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    • pp.92-96
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    • 2018
  • A 39-year-old male presented with severe pain in right posterior mandibular teeth and temporal area. Initially, the pain in the mandibular teeth was moderate, but the concomitant headache was unbearably severe. His medical history was non-contributory. The clinical and radiographic examination failed to reveal any pathology in the region. There was no tenderness to palpation in the temporalis and masseter muscles or temporomandibular joints. The clinical impression was migraine. The pain in the teeth and headache were aborted using ergotamine tartrate and sumatriptan succinate. Atenolol prevented further pain, while amitriptyline and imipramine had no effect. Migraine can present as non-odontogenic pain in the mandibular teeth, although not as frequently as in the maxillary teeth. A correct diagnosis is essential to avoid unnecessary dental treatments and to manage pain effectively. Clinicians should be able to identify migraine with non-odontogenic dental pain and establish a proper diagnosis through a comprehensive evaluation.