• 통합자연과학논문집
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• 제8권1호
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• pp.75-79
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• 2015

Thromboxane A2 receptors (TXA2-R) are the G protein coupled receptors localized on cell membranes and intracellular structures and play pathophysiological role in various thrombosis/hemostasis, modulation of the immune response, acute myocardial infarction, inflammatory lung disease, hypertension and nephrotic disease. TXA2 receptor antagonists have been evaluated as potential therapeutic agents for asthma, thrombosis and hypertension. The role of TXA2 in wide spectrum of diseases makes this as an important drug target. Hence in the present study, homology modeling of TXA2 receptor was performed using the crystal structure of squid rhodopsin and night blindness causing G90D rhodopsin. 20 models were generated using single and multiple templates based approaches and the best model was selected based on the validation result. We found that multiple template based approach have given better accuracy. The generated structures can be used in future for further binding site and docking analysis.

• 대한기계학회논문집
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• 제19권4호
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• pp.1005-1012
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• 1995

This paper proposes a new approach for modeling sweep surfaces. The overall modeling procedure consists of following steps : (1)remeshing the section curves based on the curve lengths ; (2)remeshing the guide curve and the boundary curves based on a given sweeping rule ; (3)obtaining intermediate section curves at the remeshed points of the guide curve by blending the initial section curves ; (4)compensation of the intermediate section curves ; (5)interpolating the initial and intermediate curves using Hermite interpolant. The resulting sweep surface is expressed in a G$^{2}$ bicubic parametric spline surface.

• 한국지하수토양환경학회지:지하수토양환경
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• 제8권3호
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• pp.8-12
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• 2003

The centrifuge test result on capped sediment was compared to the advection- dispersion equation proposed for one layered to predict contaminant transport parameters. The fitted contaminant transport parameters for the centrifuge test results were one to three orders of magnitude greater than the estimated parameters from the advection-dispersion equation. This indicates that the centrifuge model over estimated the contaminant transport phenomena. Thus, the centrifuge provides a non-conservative approach to modeling contaminant transport. It should be also noted that the advection-dispersion equation used in this study is a one layered model. Two layered modeling approaches are more appropriate for modeling this data since there are two layers with different partitioning coefficients. Further research is required to model the centrifuge test using two-layered advection-dispersion models.

• 한국생물정보학회:학술대회논문집
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• 한국생물정보시스템생물학회 2005년도 BIOINFO 2005
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• pp.197-201
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• 2005

When we want to find out the regulatory relationships between genes from gene expression data, dimensionality is one of the big problem. In general, the size of search space in modeling the regulatory relationships grows in O(n$^2$) while the number of genes is increasing. However, hopefully it can be reduced to O(kn) with selected k by applying divide and conquer heuristics which depend on some assumptions about genetic network. In this paper, we approach the modeling problem in divide-and-conquer manner. We applied clustering to make the problem into small sub-problems, then hierarchical model process is applied to those small sub-problems.

• 동력기계공학회지
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• 제2권2호
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• pp.73-80
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• 1998

The identification of drilling joint dynamics which consists of drilling and structural dynamics and the on-line time series detection of malfunction process is substantial not only for the investigation of the static and dynamic characteristics but also for the analytic realization of diagnostic and control systems in drilling. Therefore, We have discussed on the comparative assessment of two recursive time series modeling algorithms that can represent the drilling operation and detect the abnormal geometric behaviors in precision roundshape machining such as turning, drilling and boring in precision diemaking. For this purpose, simulation and experimental work were performed to show the malfunctional behaviors for drilling operation. For this purpose, a new two recursive approach (Recursive Extended Instrument Variable Method : REIVM, Recursive Least Square Method : RLSM) may be adopted for the on-line system identification and monitoring of a malfunction behavior of drilling process, such as chipping, wear, chatter and hole lobe waviness.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2007년도 춘계학술대회A
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• pp.1057-1062
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• 2007

The purpose of this study is to find out design parameters of vibrating screen, such as particles motion, specific gravity, shape, and kinetic friction. In order to approach this problem, four materials of construction wastes, wood, styrofoam, concrete, and sand are used for dynamic modeling. To present friction between the particles material and tilt plates material, these particles model is applied in order to verify effectively. Generally, the vibrating screen is composed of three assemblies such as screen, wastes guide, supported of screen. This model regards vibrator as system of screen fixed tilt plates. The model is analyzed to present what kind of particles motion while the system is vibrating. and this vibration system has been implemented in a ADAMS dynamaic program. This modeling is consist of dynamic model separation state on particle size. This study make good technique to verify in theory.

• Journal of Mechanical Science and Technology
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• 제18권6호
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• pp.1010-1018
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• 2004

This study presents the methodological aspects of combustion instability modeling and provides the numerical results of the model (sub-scale) combustion chamber, regarding geometrical dimensions and operating conditions, which are for determining the combustion stability boundaries using the model chamber. An approach to determine the stability limits and acoustic characteristics of injectors is described intensively. Procedures for extrapolation of the model operating parameters to the actual conditions are presented, which allow the hot-fire test data to be presented by parameters of the combustion chamber pressure and mixture (oxidizer/fuel) ratio, which are customary for designers. Tests with the model chamber, based on the suggested scaling method, are far more cost-effective than with the actual (full-scale) chamber and useful for injector screening at the initial stage of the combustor development in a viewpoint of combustion instabilities.

• Water Engineering Research
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• 제2권3호
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• pp.161-169
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• 2001

Present study deals with the development of a numerical model for the estimation of net annual recharge by coupling the Galerkin's finite element flow simulationl model with the Gauss-Newton-Marquardt optimization technique. The developed coupled numerical model is applied for estimating net annual recharge for Mahi Right Bank Canal (MRBC) project the norms of Groundwater Resources Estimation committee (1984, 1997) and Indian Agricultural research Institute(1983). It is observed that the estimated net recharge by inverse modeling is closer to the net recharge estimated using the water balance approach. Further it is observed that the computed head distribution from the estimated recharge agree closely with the observed head distribution. The study concludes that the developed model for inverse modeling can be successfully applied to large groundwater system involving regional aquifers where reliable recharge estimation always requires considerable time and financial resources.

• Environmental Engineering Research
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• 제14권1호
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• pp.13-18
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• 2009

In this study, specific pollutant releases during the Asian monsoon season were estimated and the information was applied to the non-point pollutant sources management from two forested watersheds of the Soyang Lake. The two watersheds are part of the 2,703 km2 Soyang Lake watershed in the northern region of the Han River. The outlets of the two watersheds were respectively analyzed for continuous water quality concentration and for discharge during various single rainfall events. Statistical power function methods are utilized to compare stream discharge and pollutant flux release during the study period. Based on the monitoring data during the study period, the specific load flux method using simulated discharge was conducted and validated in the two watersheds. The model predictions corresponded well with the measured and calculated pollutant releases. The modeling approach taken in this study was found to be applicable for the two forested watersheds.

• 대한산업공학회지
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• 제27권1호
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• pp.37-46
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• 2001

Business process(workflow) analysis has been recognized as a core step to building information systems. However, most analysts have recognized that deriving consistent business process artifacts even in a simple business domain is very difficult, since most analysis methods give the designers narrative and/or diagrammatic tools that do not support rigorous analysis rules. This often generates inconsistent analysis results, leading to create useless information systems and resulting in tremendous budget wastes. To overcome this weakness, this paper presents a declarative business process modeling method called contract-collaboration net(cc-net), which is not only somewhat formal but also useful to the practitioners. A case study on bank domain is presented to illustrate our approach.