• 대한수의학회지
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• 제56권3호
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• pp.155-160
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• 2016

This study was conducted to evaluate three different mixed formulations of sodium hyaluronate (SH) and carboxymethyl cellulose (CMC) using a low-humidity air flow-induced rat dry eye model and determine the most suitable mixture. The total thickness of the cornea, corneal epithelial thickness, corneal stroma thickness, damaged corneal epithelium percentage region, thickness of the bulbar conjunctiva epithelium, number of goblet cells, goblet cell occupation percentage region, and damaged bulbar conjunctiva epithelium percentage region were measured by histomorphological evaluation. After 5 h exposure to drying airflow, the thickness of the cornea and conjunctiva was decreased with desquamation of the corneal and conjunctiva epithelium. However, these dry eye symptoms were markedly inhibited by treatment with the reference and test formulations. More favorable effects on decreased thickness were detected in response to the CMC than the SH. However, SH had a greater protective effect against corneal and conjunctiva epithelial damage. The application of a mixture of 0.1% SH and 0.2% CMC showed more favorable effects on the corneal and conjunctival damage and the stabilization of the ocular surface than SH or CMC alone.

• 한국HCI학회:학술대회논문집
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• 한국HCI학회 2007년도 학술대회 2부
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• pp.15-20
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• 2007

본 연구는 시선 추적 방법(Eye-Tracking Method)을 이용한 디지털 컨버전스 제품의 정보 설계 및 평가에 관한 방법론을 제시하였다. Eye-tracking 데이터는 visual search의 효율성 뿐 아니라 타겟의 유의미성이나 가시성등을 측정하는데 유익하다. 응시 횟수와 응시 시간을 통하여 사용자의 심성 모형에 따른 시선 행위와 제품 메뉴 구조간의 전체적인 일치도를 정량적으로 분석하였고, 각 메뉴 item의 세부적인 인지 반응 정도를 평가하였다. 컨버전스 제품의 한 예로 휴대폰을 선정하여 실험을 실시하였으며, 활성화 확산 실험(SAT)을 수행하여 메뉴 항목 상호간의 인지반응 정도를 통한 문제점을 도출한 후 사용자 시나리오를 작성하였다. 1차 테스트를 통하여 피실험자의 시나리오 수행 시 어려움을 알 수 있었으며, 1차 테스트의 결과와 인터뷰 결과를 바탕으로 프로토타입의 메뉴명을 개선하여 2차 테스트를 실시하였다. 실험 결과 개선 전보다 후의 응시 횟수, 응시 시간 또한 감소하여 수행도가 향상됨으로 메뉴 구조의 개선된 결과를 가져왔다. 본 연구는 인간의 눈 움직임 측정치 결과를 토대로 사용자 심성 모형에 부합하여 누구나 접근이 쉬운 정보 구조를 설계할 수 있었다. 그러므로 본 연구에서 제시하는 Eye-tracking Method는 디지털 컨버전스로 인한 복잡한 정보 구조의 설계와 평가에 기여할 것으로 보인다.

• 대한의용생체공학회:의공학회지
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• 제40권5호
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• pp.143-150
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• 2019

To evaluate the toxicity of ophthalmic drug, the Draize test and Bovine Corneal Opacity and Permeability (BCOP) test commonly used. In Draize test, experimental animals were under stress and pain due to long-term exposure of drug. In addition, regarding physiological functions, animal model is not perfectly reflected a human eye condition. Although some models such as $EpiOcular^{TM}$, HCE model, LabCyte Cornea-Model, and MCTT $HCE^{TM}$ were already presented advanced cornea ex-vivo model to replace animal test. In this sense, cornea tissue structure mimicked ex-vivo toxicity model was fabricated in this study. The corneal epithelial cells (CECs) and keratocytes (CKs) isolated from rabbit eyeball were seeded on non-patterned silk film (n-pSF) and patterned silk film (pSF) at $32,500cells/cm^2$ and $6,500cells/cm^2$. Sequentially, n-pSF and pSF were stacked to mimic a multi-layered stroma structure. The thickness of films was about $15.63{\mu}m$ and the distance of patterns was about $3{\mu}m$. H&E stain was performed to confirm the cell proliferation on silk film. F-actin of CKs was also stained with Phalloidin to observe the cytoskeletal alignment along with patterns of the pSF. In the results, CECs and CKs were shown the good cell attachment on the n-pSF and pSFs. Proliferated cells expressed the specific phenotype of cornea epithelium and stroma. In conclusion, we successfully established the ex-vivo cornea toxicity model to replace the eye irritation tests. In further study, we will set up the human ex-vivo cornea toxicity model and then will evaluate the drug screening efficacy.

• 한국정밀공학회지
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• 제19권1호
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• pp.172-179
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• 2002

In a robot/vision system, the vision sensor, typically a CCD array sensor, is mounted on the robot hand. The problem of determining the relationship between the camera frame and the robot hand frame is refered to as the hand-eye calibration. In the literature, various methods have been suggested to calibrate camera and for sensor registration. Recently, one-step approach which combines camera calibration and sensor registration is suggested by Horaud & Dornaika. In this approach, camera extrinsic parameters are not need to be determined at all configurations of robot. In this paper, by modifying the camera model and including the lens distortion effect in the perspective transformation matrix, a new one-step approach is proposed in the hand-eye calibration.

• BMB Reports
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• 제48권3호
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• pp.153-158
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• 2015

As FK506 binding proteins (FK506BPs) are known to play an important role in the regulation of a variety of biological processes related to cell survival, this study was designed to examined the protective effects of FK506 binding protein 12 (FK506BP) on low humidity air flow induced dry eye in a rat model using transduced PEP-1-FK506BP. After the topical application of PEP-1-FK506BP, tear volumes were markedly increased and significant prevention of cornea damage was observed compared with dry eye rats. Further, immunohistochemical analysis demonstrated that PEP-1-FK506BP markedly prevented damage to the cornea, the bulbar conjunctiva, and the palpebral conjunctiva epithelial lining compared with dry eye rats. In addition, caspase-3 and PARP expression levels were found to be decreased. These results demonstrated that topical application of PEP-1-FK506BP significantly ameliorates dry eye injury in an animal model. Thus, we suggest that PEP-1-FK506BP can be developed as a new ophthalmic drop to treat dry eye diseases.

• 한국초등과학교육학회지:초등과학교육
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• 제33권2호
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• pp.273-285
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• 2014

Purpose of this study is to analyze eye movements of pre-service teachers and elementary students about a visual material of the change on the lunar phases. Eye-Tracker was used for analysis for eye-fixation time and eye movement at the structure, behavior, function question on the visual material. The Results were as follows. First, the pre-service teacher checked the visual materials from a holistic perspective depending on the function questions and fixed eye-fixation on the moon of the behavior question concerned. On the contrary, elementary school student only checked function of the moon located in the upper part and eye-fixation focus was spread here and there regardless of the questions. Second, the pre-service teacher gazed at the sun, earth and moon in a consecutive order depending on the questions to identify their spatial relations and checked location of the moon related to the question. On the contrary, the elementary school student did not view relations between earth, sun and moon from a spatial perspective. These findings indicate that the pre-service teacher conjures up the mechanism of the change on the lunar phases and confirms it in visual materials by visualizing change on the lunar phase model from earth's point of view while the elementary school student fails to take advantage of visual materials to visualize it from earth's point of view.

• 대한공간정보학회지
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• 제19권4호
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• pp.101-108
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• 2011

우리나라에서 남극에 장보고기지를 건설하는 계획을 추진하고 있으며 이를 위해 기지 부근 지형에 대한 상세한 정보가 필요하다. 본 연구에서는 위성영상을 이용하여 장보고기지 건설을 위한 지형도를 제작하는 것을 목적으로 연구를 수행하였다. 이를 위해 장보고기지 주변의 현지측량 및 장비의 사전테스트를 수행하였다. 또한 GeoEye-1 위성영상의 센서모델링을 위해 RPC-편의 보정을 수행하였으며 최소 두 점의 기준점이 실질적으로 필요한 것으로 나타났다. 지형도 제작은 영상의 해상도와 현지 보완측량이 불가능한 점을 고려하여 약 1/2,500의 도화축척이 적합하였다. 장보고기지 주변의 상세한 지형정보 제공을 위하여 영상정합에 의하여 수치표고모델을 생성하였으며 현지측량한 GPS-RTK 자료와 비교하였으며 약 0.6m의 수직위치정확도를 나타내었다.

• 대한인간공학회지
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• 제26권2호
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• pp.149-155
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• 2007

Recently, various devices requiring text input such as mobile phone IPTV, PDA and UMPC are emerging. The frequency of text entry for them is also increasing. This study was focused on the evaluation of Korean text entry interface. Various models to evaluate text entry interfaces have been proposed. Most of models were based on human cognitive process for text input. The cognitive process was divided into two components; visual scanning process and finger movement process. The time spent for visual scanning process was modeled as Hick-Hyman law, while the time for finger movement was determined as Fitts' law. There are three questions on the model-based evaluation of text entry interface. Firstly, are human cognitive processes (visual scanning and finger movement) during the entry of text sequentially occurring as the models. Secondly, is it possible to predict real text input time by previous models. Thirdly, does the human cognitive process for text input vary according to users' text entry speed. There was time gap between the real measured text input time and predicted time. The time gap was larger in the case of participants with high speed to enter text. The reason was found out investigating Eye-Hand Coordination during text input process. Differently from an assumption that visual scan on the keyboard is followed by a finger movement, the experienced group performed both visual scanning and finger movement simultaneously. Arrival Lead Time was investigated to measure the extent of time overlapping between two processes. 'Arrival Lead Time' is the interval between the eye fixation on the target button and the button click. In addition to the arrival lead time, it was revealed that the experienced group uses the less number of fixations during text entry than the novice group. This result will contribute to the improvement of evaluation model for text entry interface.

• 한국HCI학회:학술대회논문집
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• 한국HCI학회 2009년도 학술대회
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• pp.601-605
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• 2009

$180^{\circ}$ 이상의 영역을 획득하는 어안렌즈(fish-eye lens)는 최소의 카메라로 최대 시야각을 확보할 수 있는 장점으로 인해 차량 장착 시도가 늘고 있다. 운전자에게 현실감 있는 영상을 제공하고 센서로 이용하기 위해서는 캘리브레이션을 통해 방사왜곡(radial distortion)에 따른 기하학적인 왜곡 보정이 필요하다. 그런데 차량용 어안렌즈의 경우, 대각선 어안렌즈로 일반 원상 어안렌즈로 촬영한 둥근 화상의 바깥둘레에 내접하는 부분을 잘라낸 직사각형 영상과 같으며, 수직, 수평 화각에 따라 왜곡이 비대칭구조로 설계되었다. 본 논문에서는, 영상의 특징점(feature points)을 이용하여 차량용 어안렌즈에 적합한 카메라 모델 및 캘리브레이션 기법을 소개한다. 캘리브레이션한 결과, 제안한 방법은 화각이 다른 차량용 어안렌즈에도 적용 가능하다.

• 한국광학회지
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• 제13권3호
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• pp.266-271
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• 2002

구면수차와 Stiles-Crawford 효과를 기준으로 4개의 굴절비구면을 가지는 모형안을 최적화 기법으로 설계하였다. 구속조건으로는 측정된 안구의 곡률반경 , 중심두께, 비구면도, 구면수차를 사용하였다. 또한 동공에서의 Stiles-Crawford 효과를 고려하여 최적화하였다 최적화의 결과로 얻은 모형안의 근축영역값들은 유효초점거리 20.8169mm, 상측정점초점거리 15.4820mm, 물측정점초점거리 -13.8528mm, 상거리 15.7150mm이다. 본 논문의 모형안은 한국인 정시 75안을 대상으로 측정되어진 자료를 바탕으로 국내에서 처음으로 제작된 정밀모형안이다.