• 통합자연과학논문집
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• 제10권2호
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• pp.85-94
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• 2017

Fibroblast growth factor receptor (FGFR) belongs to the family of receptor tyrosine kinase. They play important roles in cell proliferation, differentiation, development, migration, survival, wound healing, haematopoiesis and tumorigenesis. FGFRs are reported to cause several types of cancers in humans which make it an important drug target. In the current study, HQSAR analysis was performed on a series of recently reported 1H-Pyrazolo [3,4-b]pyridine derivatives as FGFR antagonists. The model was developed with Atom (A) and bond (B) connection (C), chirality (Ch), hydrogen (H) and donor/acceptor (DA) parameters and with different set of atom counts to improve the model. A reasonable HQSAR model ($q^2=0.701$, SDEP=0.654, NOC=5, $r^2=0.926$, SEE=0.325, BHL=71) was generated which showed good predictive ability. The contribution map depicted the atom contribution in inhibitory effect. A contribution map for the most active compound (compound 24) indicated that hydrogen and nitrogen atoms in the side chains of ring B as well as hydrogen atoms in the side chain of ring C and the nitrogen atom in the ring D contributed positively to the activity in inhibitory effect whereas, the lowest active compound (compound 04) showed negative contribution to inhibitory effect. Thus results of our study can provide insights in the designing potent and selective FGFR kinase inhibitors.

• 한국건설관리학회:학술대회논문집
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• 한국건설관리학회 2006년도 정기학술발표대회 논문집
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• pp.467-470
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• 2006

모든 건설공사의 기초를 이루는 토공사는 건설기계의 사용으로 오늘날까지 많은 발전을 이루어 왔으나, 공기단축 및 원가절감에 있어 중요한 요소인 토공장비의 적정한 조합시공방안이 체계적으로 정립되어 있지 않고 경험에 의존하여 수행되는 상태로 관련분야에 대한 체계적인 연구가 필요한 실정이다. 합리적인 기계화 토공은 공사에 투입될 장비의 성능 및 특성, 공사의 종류, 규모 및 주위의 여건 등을 사전에 철저히 파악해야 하며, 사용 가능한 몇 가지 규격의 장비를 선정하여 최적조합시공을 계획해야 한다. 이에 본 연구에서는 시스템 다이내믹스 기법을 활용하여 토공작업의 여러 단계 중 기계화 토공장비의 굴착 후 적재 및 운반단계를 대상으로 토공장비의 최적조합시공에 의한 토공량 산정 모형을 구축한다. 이 연구의 결과로 도출되는 토공장비의 최적조합시공모형은 토공계획을 담당하는 관리자가 토공장비의 선정에 있어 최단시간에 합리적인 판단을 하게 해줄 것으로 기대된다.

• Journal of Ginseng Research
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• 제46권3호
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• pp.496-504
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• 2022

Background: Cigarette smoke (CS) is considered a principal cause of chronic obstructive pulmonary disease (COPD) and is associated with mucus hypersecretion and airway inflammation. Ginsenoside compound K (CK), a product of ginsenoside metabolism, has various biological activities. Studies on the effects of CK for the treatment of COPD and mucus hypersecretion, including the underlying signaling mechanism, have not yet been conducted. Methods: To study the protective effects and molecular mechanism of CK, phorbol 12-myristate 13-acetate (PMA)-induced human airway epithelial (NCI-H292) cells were used as a cellular model of airway inflammation. An experimental mouse COPD model was also established via CS inhalation and intranasal administration of lipopolysaccharide. Mucin 5AC (MUC5AC), monocyte chemoattractant protein-1, tumor necrosis factor-α (TNF-α), and interleukin-6 secretion, as well as elastase activity and reactive oxygen species production, were determined through enzyme-linked immunosorbent assay. Inflammatory cell influx and mucus secretion in mouse lung tissues were estimated using hematoxylin and eosin and periodic acid-schiff staining, respectively. PKCδ and its downstream signaling molecules were analyzed via western blotting. Results: CK prevented the secretion of MUC5AC and TNF-α in PMA-stimulated NCI-H292 cells and exhibited a protective effect in COPD mice via the suppression of inflammatory mediators and mucus secretion. These effects were accompanied by an inactivation of PKCδ and related signaling in vitro and in vivo. Conclusion: CK suppressed pulmonary inflammation and mucus secretion in COPD mouse model through PKC regulation, highlighting the compound's potential as a useful adjuvant in the prevention and treatment of COPD.

• 한국환경복원기술학회지
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• 제22권1호
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• pp.33-45
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• 2019

Compound disaster is the type that increases the impact affected by two or more hazard events, and attention to compound disaster and multi-hazards risk is growing due to potential damages which are difficult to predict. The objective of this study is to analyze the possible impacts of post-fire landslide scenario quantitatively by using TRIGRS (Transient Rainfall Infiltration and Grid-Based Regional Slope-Stability Analysis), a physics-based landslide model. In the case of wildfire, soil organic material and density are altered, and saturated hydraulic conductivity decrease because of soil exposed to high temperature. We have included the change of soil saturated hydraulic conductivity into the TRIGRS model through literature review. For a case study, we selected the area of $8km^2$ in Pyeongchang County. The landslide modeling process was calibrated before simulate the post-wildfire impact based on landslide inventory data to reduce uncertainty. As a result, the mean of the total factor of safety values in the case of landslide was 2.641 when rainfall duration is 1 hour with rainfall intensity of 100mm per day, while the mean value for the case of post-wildfire landslide was lower to 2.579, showing potential landslide occurrence areas appear more quickly in the compound disaster scenario. This study can be used to prevent potential losses caused by the compound disaster such as post-wildfire debris flow or landslides.

• 산업기술연구
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• 제21권B호
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• pp.31-35
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• 2001

The phase forming ability and formation enthalpies(${\Delta}H$) of Si-M(M = Ti, Cu, Ni, Zr) compound alloys were predicted by Miedema's model. The silicon compound alloys were synthesized by mechanical alloying and then characterized for the phase formation by X -ray diffraction. The electrochemical properties as the anode materials for lithium ion batteries were investigated using a galvanostatic method. It appears that the electrochemical characteristics of Si-M alloys can be predicted from the thermodynamic criteria for the phase formation using the Miedema's model.

• Korean Journal of Hydrosciences
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• 제8권
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• pp.41-56
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• 1997

A new routing computer model for the symmetric compound channel called the ASRMCS(Apparent Shear Force Muskingum-Cunge Method in Symmetry) has been developed. The Muskingum-Cunge routing method is adapted. The Apparent Shear Force (ASF) between the deep main channel and the shallow floodplan flow is introduced while the flow is routed. The nonlinear parameter method is applied. The temporal and spatial increments are varied according to the flow rate. The adaptation of above schemes is tested against the routed hydrographs using the DAMBRK model. The results of general routing practice of Muskingum-Cunge Method(GPMC) are also compared with those of above two models. The results of the new model match remarkably well with those of DAMBRK. The routed hydrographs show a smooth variation from the inflow boundary condition without any distortions caused by the difference of cross-section shape. However, the results of GPMC, showing early rise and fall of routed hydrograph, have considerable differences from those of the ASFMCS and DAMBRK.

• Environmental Engineering Research
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• 제16권3호
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• pp.149-157
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• 2011

Nanofiltration (NF) experiments were conducted to investigate fouling of Al-hydroxide precipitate and the influence of organic compound, inorganic compound, and their combination, i.e., multiple foulants. $CaCl_2$ and $MgSO_4$ were employed as surrogates of inorganic compounds while humic acid was used as surrogate of organic compound. The flux attained from NF experiments was fitted with the mathematical fouling model to evaluate the potential fouling mechanisms. Al-hydroxide fouling with a cake formation mechanism had little effect on the NF membrane fouling regardless of the Al concentration. The NF fouling by Al-hydroxide precipitate was deteriorated in presence of inorganic matter. The effect of Mg was more critical in increasing the fouling than Ca. This is because the Mg ions enhanced the resistances of the cake layer accumulated by the Al-hydroxide precipitate on the membrane surfaces. However, the fouling with Mg was dramatically mitigated by adding humic acid. It is interesting to observe that the removal of the conductivity was enhanced to 61.2% in presence of Mg and humic acid from 30.9% with Al-hydroxide alone. The influence of dissolved matter (i.e., colloids) was more negative than particulate matter on the NF fouling for Al-hydroxide precipitate in presence of inorganic and organic matter.

• Archives of Plastic Surgery
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• 제39권5호
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• pp.452-456
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• 2012

Background Phosphatidylcholine (PPC) and deoxycholate (DCA) compound has been recently used for the purpose of partial lipolysis and is valued for its efficacy and lower invasiveness compared to liposuction and dermolipectomy used previously. In this article, the authors discuss the efficacy of the PPC dissolved in DCA via an experimental rat study model, along with suggesting a useful animal experimental model for the study of adipose tissue and lipolysis. Methods Bilateral inguinal fat pads of an experimental rat were elevated with the deep inferior epigastric vessel as the sole vascular pedicle. Normal saline was injected on one side as a control group and a PPC and DCA compound was injected on the other side. After 4 days, the rats were euthanized for microscopic tissue examination. The pathology was scored by a sem-iquantitative system in 4 categories: normal fat amount, fat necrosis, inflammatory activity, and stage of fibrosis. A Wilcoxon signed-rank test powered by SPSS packet program was used for statistical analysis and to determine significance. Results Microscopic examination was performed on the obtained samples, and the experimental data of all four categories showed significant histologic differences compared to the control group. All of the data also showed statistical significance by the Wilcoxon signed-rank test (P<0.01). Conclusions In the inguinal fat pad rat model, the control group and the experimental group had a differed significantly in the amount of normal fat tissue, inflammation, necrosis, and fibrosis. We recommend the rat inguinal fat pad model used in this study, as it is likely to be useful in related research.

• 물과 미래
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• 제27권4호
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• pp.95-104
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• 1994

사행특성을 가진 복합하도에서의 홍수파해석을 위하여 사행도 모형을 개발하였다. 사행도 모형을 지배 방정식, 질량보존 오차 및 홍수파 해석 등을 통하여 기존의 세가지 홍수터 모형과 비교하였다. 사행도 모형에 의한 오차는 1.5-1.8% 정도로 나타났으나 분리하도 모형의 경우에는 1.5, 2.0의 사행도에서 각각 9.1, 27.4%로 큰 오차가 발생하였다. 사행도 모형은 홍수터를 가진 사행하도에서의 홍수전달 특성해석을 위하여 적용되었다. 사행도 모형에 의한 수치실험 결과, 홍수터의 조도와 홍수터의 하폭이 증가할수록, 사행도가 감소할수록 감쇠비와 유하시간비는 증가하였다. 본 모형은 보합하도 단면을 가지며 사행하는 국내 하천에서의 부정류 해석에 적용성이 클 것으로 판단되었다.

• 한국태양에너지학회:학술대회논문집
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• 한국태양에너지학회 2012년도 춘계학술발표대회 논문집
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• pp.140-145
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• 2012

The purpose of this study is to understand the change of impression by comparing the uniformity lighting with the compound lighting. In previous study, we proposed a light controlling method to harmonize daylight from a window and artificial lights from a ceiling and obtained the results to support our method. We referred this method as the Adjusted Compound-Lighting Model (AC Model). The model claims that lighting in a room with a side-window are perceived as harmonious when the overall light distribution in the room is well approximated by a compound of lights from the window and the entire ceiling. The experiment is carried out with the scaled-models and mock-up spaces that were supposed to be an office space. One is lit by the uniform lighting and the other by the compound lighting in each experimental space. In order to present varying illuminance distributions, thetwo variables were used in this study. One was the ratio of thelight from the window and ceiling in the standard and evaluation box. The standard box was provided by the ratio of 20% to 40% from the window and 80% to 60% from the ceiling as two lighting ratio patterns [Wu20(=Cu80) and Wu40(=Cu60)]. And the evaluation box was provided by the light ratio of 0% to 40 from the window and 100% to 60% from the ceiling [Wcp0(=Ccp100), Wcp20(=Ccp80) and Wcp40(=Ccp60)]. The other variable was themean illuminance level in both boxes. Two level of mean illuminance (700lx and 300lx) were used in this experiment. Each lighting condition was established at equal horizontal mean illuminance level, held constant near 700lx or 300lx in both boxes. Both of them were similar in the shape of distribution when there were same ratios of lights from the window and the ceiling. Subjects were asked to evaluate the point of difference by semantic differential rating on their overall impression after comparing with two rooms. The results showed that the impressions of compound lighting were more positive score than that of uniformity lighting on the items of 'dim-bright', 'dislike-like', 'artificial-natural' and 'closed-open', and that there was no significant difference in impressions between two spaces on other items.