• Applied Chemistry for Engineering
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• v.25 no.2
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• pp.142-146
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• 2014

The separation of nitrogen heterocyclic compound (NHC) contained in a model coal tar fraction of nine components system was investigated by distribution equilibrium. The model coal tar fraction comprising NHC group (NHCs; indole (In), quinoline (Q), iso-quinoline (iQ), quinaldine(Qu)), bicyclic aromatic compound group (BACs; 1-methylnaphthalene (1MN), 2-methylnaphthalene (2MN), dimethylnaphthalene (DMN)), biphenyl (Bp) and phenyl ether (Pe) and the aqueous methanol were used as the raw materials and the solvent of this work, respectively. A batch-stirred tank was used as the liquid-liquid contact unit of this work. The distribution coefficient of NHCs increased by increasing the equilibrium operation temperature, whereas the selectivity of NHCs with respect to BACs decreased. Decreasing the initial volume ratio of water to the solvent resulted in deteriorating the selectivity of NHCs in reference to BACs, but improving the distribution coefficients of NHCs. At a fixed experimental condition, the sequence of the distribution coefficient and the selectivity with reference to BACs for each groups was increased in order of NHCs > Bp > BACs > Pe and NHCs > Bp> Pe, respectively. Also, the sequence of the distribution coefficient for entire compounds was in order of In > iQ = Q > Qu > Bp > 1MN = 2MN > Pe > DMN. The maximum yield of NHCs and the selectivity of NHCs based on BACs obtained by methanol extraction were 94 and 23%, respectively. Furthermore, the recovery process for NHCs from coal tar was studied by using the experimental results from this work.

• Parasites, Hosts and Diseases
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• v.62 no.1
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• pp.42-52
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• 2024

Antimalarial drugs are an urgently need and crucial tool in the campaign against malaria, which can threaten public health. In this study, we examined the cytotoxicity of the 9 antimalarial compounds chemically synthesized using SKM13-2HCl. Except for SKM13-2HCl, the 5 newly synthesized compounds had a 50% cytotoxic concentration (CC₅₀) >100 μM, indicating that they would be less cytotoxic than SKM13-2HCl. Among the 5 compounds, only SAM13-2HCl outperformed SKM13-2HCl for antimalarial activity, showing a 3- and 1.3-fold greater selective index (SI) (CC₅₀/IC₅₀) than SKM13-2HCl in vitro against both chloroquine-sensitive (3D7) and chloroquine -resistant (K1) Plasmodium falciparum strains, respectively. Thus, the presence of morpholine amide may help to effectively suppress human-infectious P. falciparum parasites. However, the antimalarial activity of SAM13-2HCl was inferior to that of the SKM13-2HCl template compound in the P. berghei NK65-infected mouse model, possibly because SAM13-2HCl had a lower polarity and less efficient pharmacokinetics than SKM13-2HCl. SAM13-2HCl was more toxic in the rodent model. Consequently, SAM13-2HCl containing morpholine was selected from screening a combination of pharmacologically significant structures as being the most effective in vitro against human-infectious P. falciparum but was less efficient in vivo in a P. berghei-infected animal model when compared with SKM13-2HCl. Therefore, SAM13-2HCl containing morpholine could be considered a promising compound to treat chloroquine-resistant P. falciparum infections, although further optimization is crucial to maintain antimalarial activity while reducing toxicity in animals.

• Annals of Hepato-Biliary-Pancreatic Surgery
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• v.27 no.4
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• pp.428-432
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• 2023

Minimally invasive pancreatoduodenectomy (MIS PD) is a well reported technique with several advantages over conventional open pancreatoduodenectomy. In comparison to distal pancreatectomy, the adoption of MIS PD has been slow due to the technical challenges involved, particularly in the reconstruction phase of the pancreatojejunostomy (PJ) anastomosis. Hence, we introduce a lowcost model for PJ anastomosis simulation in MIS PD. We fashioned a model of a cut pancreas and limb of jejunum using economical and easily accessible materials comprising felt fabric and the modelling compound, Play-Doh. Surgeons can practice MIS PJ suturing using this model to help mount their individual learning curve for PJ creation. Our video demonstrates that this model can be utilized in simulation practice mimicking steps during live surgery. Our model is a cost-effective and easily replicable tool for surgeons looking to simulate MIS PJ creation in preparation for MIS PD.

• Journal of the Korean Ceramic Society
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• v.40 no.4
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• pp.371-374
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• 2003

Various types of equation for mixing rule on permittivity of mixture have been proposed, but none of these is not perfect because of the inconsistency between the actual geometrical configuration and the basic model for calculation. Serial model and parallel model are lower and upper extremes of mixing manner, the apparent permittivity of any other type of mixture stay between these two extreme states. For the random mixture of the stumpy fine particles, customarily the logarithmic mixing rule has been applied. But, the logarithmic mixing rule does not give the proper value of permittivity in low or high mixing rate of constituent. The author proposed the new mixing rule that gives better consistency with measured value in whole mixing range compared to the logarithmic rule. In this paper, a desirable refinement on the equation proposed in the previous paper is made to adapt to thr configuration image of actual compound and then the equation has been expanded to the complex permittivity to apply the mixing rule on the dissipative materials cases.

• Journal of the Korean Data and Information Science Society
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• v.21 no.1
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• pp.1-9
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• 2010

This paper suggests a mixed-effects model for analyzing split-plot data when there is a repeated measures factor that affects on the response variable. Covariance structures are discussed among the observations because of the assumption of a repeated measures factor as one of explanatory variables. As a plausible covariance structure, compound symmetric covariance structure is assumed for analyzing data. The restricted maximum likelihood (REML)method is used for estimating fixed effects in the model.

• Journal of the Korean Wood Science and Technology
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• v.17 no.3
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• pp.28-44
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• 1989

This experiment was carried out to contribute to the synthetic methods of ligin model compounds. The ligin model compounds of arylglycerol-${\beta}$-arylether structure were synthesized in high yield through three or four reaction steps. The starting compound was commercial 3, 4, 5-trimethoxyace tophenone and the final compounds were 1-(2-methoxyphenoxy)-2 - (3, 4, 5 - trimethoxyphenyl)-ethanol(IV), 1-(3, 4, 5-trimethoxyphenyl)-2-(2-methoxy-phenoxy)-propandiol-1,3 (VI), 1-(2, 6-dimethoxyphenoxy)-2-(3, 4, 5-trimethoxyphenyl)-ethanol (VIII), and 1-(3, 4, 5-trimethoxyphenyl)-2-(2, 6-dimethoxyphenoxy)-propandiol-1, 3 (X). The structures of synthetic compounds were identified by IR, $^1H$-NMR spectroscopy and Mass spectrometry.

• Proceedings of the Korea Technology Innovation Society Conference
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• 2001.11a
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• pp.307-337
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• 2001

In this paper, we propose the valuation frame of the IT(Information Technology) ventures using ROV(Real Options Valuation) model. Generally, ROV can comprises the traditional valuation method such as DCF(Discounted Cash Flow), which can measure only the tangible value of a firm from the expected future earnings, in that ROV can additionally measure the intangible value such as the strategic value of a firm in the uncertain environment. We set up the hypothetic IT venture future investment plan and assume that there are a growth option and a switching option consequently along the investment time horizon, which are caused by each characteristics of ventures and IT technologies, especially modularity. In the case that there are several embedded real options in the firm's investment plan in a row, we should apply the compound option pricing model as a real option valuation model in order to consider the value interaction between real options. In an addition, we present the results of optimal investment timing analysis using real options approach and compare them. with those of the original assumed investment timing.

• Journal of the Korean Society for Industrial and Applied Mathematics
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• v.12 no.2
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• pp.81-95
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• 2008

In this paper, the negative Polya-Eggenberger distribution has been introduced by compounding negative binomial distribution with beta distribution of I-kind which generates a number of univariate contagious or compound (or mixture of) distributions as its particular cases. The distribution is unimode, over dispersed and all of its positive and negative integer moments exist. The difference equation of the proposed model shows that it is a member of the Ord's family of distribution. Some of its interesting properties have been explored besides different methods of estimation been discussed. Finally, the parameters of the proposed model have been estimated by using a computer programme in R-software. Application of the proposed model to some data, available in the literature, has been given and its goodness of fit demonstrated.

• Proceedings of the SAREK Conference
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• 2005.11a
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• pp.235-240
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• 2005

Recently urban utility plants in urban areas of Korea, such as energy supply systems, municipal waste incineration systems, sewage treatment systems and so on, have caused some critical troubles, for instance the insensitive response to the seasonal or daily variation of loads, the low system efficiency and inefficient use of energy because of the large-scale system located a great distance. Therefor the design method of optimal integrated system model of various urban utility plants proposed in this study suitably to the present situation of Korea. Also, the effect analysis for the introduction of compound utility plants was studied for a new town model on a 60,000 persons scale. As the results we found that the complex plant was superior to individual urban utility plant in side of the initial investment expenses, the operating cost and other reasons.

• Bulletin of the Korean Chemical Society
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• v.33 no.1
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• pp.149-152
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• 2012

The (S)-(+)-decursin and its analogues are reported as potent inhibitors of melanin production in B16 murine melanoma cells. In order to understand the factors responsible for potency as well as inhibition of potency of (S)-(+)-decursin and its analogues, three-dimensional quantitative structure-activity relationship (3D-QSAR) studies were performed. Since receptor structures are not available, a pharmacophore model was constructed. Using PHASE, we generated 3 different models and selected the seven-site model, which returned excellent statistical values ($r^2$ = 0.9127, $Q^2$ = 0.6878, Pearson-R = 0.9014). Using the generated pharmacophore model, we screened a natural products library and obtained 4'-epi-decursin as the most related compound. 4'-epidecursin is similar to (S)-(+)-decursin, but shows additional interaction possibilities with tyrosinase. The study thus sheds some light on possibility of developing more potent tyrosinase inhibitors.