• 한국컴퓨터정보학회논문지
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• 제28권2호
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• pp.161-170
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• 2023

본 연구는 고용주의 장애인 고용에 대한 인식과 고용만족도 간의 관계와 이들 간의 관계에서 장애인 고용기업기여도 인식의 매개효과와 교육훈련지원 유무의 조절효과를 검증하는데 있다. 본 연구 목적을 위하여 한국장애인고용공단에서 실시한 「2021년도 장애인고용실태조사」 자료 가운데 4,332업체를 대상으로 재구성하였다. 자료분석은 SPSS 23.0과 AMOS 23.0을 이용하였으며, 변수 간의 관계를 파악하기 위해 구조방정식모형 분석을 수행하였다. 연구결과 고용주의 장애인고용인식과 고용만족도 간에 유의미한 영향관계가 있으며 고용 기업기여도의 부분매개효과를 확인할 수 있었다. 또한 교육훈련지원 유무에 따른 부분적 조절효과가 있는 것으로 나타났다. 본 연구 결과를 통해 장애인고용률을 높이기 위해 환경조성에 영향을 줄 수 있는 요인을 다각도로 고찰하였다는 데에 의의가 있으며, 이런 결과를 바탕으로 장애인고용률을 높이기 위한 시사점을 제시하였다.

• 대한본초학회지
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• 제28권4호
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• pp.93-100
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• 2013

Objectives : This study was to evaluate the anti-inflammatory and anti-pruritic effects of WSY-1075 composited with Corni Fructus, Angelica gigantis Radix, Lycii Fructus, Ginseng Radix, Cervi parvum Cornu and Cinnamomi Cortex in rat peritoneal mast cells (RPMCs) and scratching mouse model. Methods : WSY-1075 was prepared by extracting with 30% ethanol. In the present study, we investigated the effect of WSY-1075 on the production of tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$), interleukin-$1{\beta}$ (IL-$1{\beta}$) and histamine in rat peritoneal mast cells (RPMCs) activated with phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187, and on the scratching behavior in mice treated with pruriogens. Results : WSY-1075 was not cytotoxic effect in used all concentration. PMA plus A23187 treatment significantly increased TNF-${\alpha}$, IL-$1{\beta}$ and IL-6 production compared with media control in RPMCs. However, TNF-${\alpha}$, $IL1{\beta}$ and IL-6 production increased by PMA plus A23187 treatment were significantly inhibited by WSY-1075 (200 ${\mu}g/mL$ and 400 ${\mu}g/mL$). WSY-1075 also inhibited the histamine release from RPMCs stimulated by compound 48/80, which promotes histamine release. Moreover, WSY-1075 administration had an inhibitory effects on the scratching behavior induced by pruritogen (compound 48/80, histamine, serotonin and substence P) in ICR mice. Conclusion : These results suggest that WSY-1075 administration (200 mg/kg or 400 mg/kg) has the anti-inflammatory and anti-pruritic effects on the activated rat peritoneal mast cell and mouse pruritus. WSY-1075 has a potential use as a composition of medicinal plants for treatment against inflammation- and pruritus-related disease.

• 문화기술의 융합
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• 제7권4호
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• pp.67-74
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• 2021

본 연구는 장애인평생교육의 내부 토대를 탐색하는 데 목적을 두어 실시되었다. 이를 위한 내용 의미의 구성체계에 대해 장애인평생교육을 기준으로 주체를 의미하는 '의(of)', 목적을 의미하는 '을 위한(for)', 실천적 주요 기반을 의미하는 '으로부터(from)'와 같이 세 가지 요소로 분류 구성하였다. 연구 방법은 장애인평생교육 지원체제의 내부 토대를 형성하기 위해 학문적 근거나 실천적 적용 모델 및 방안을 논의하거나 실제화한 선행연구를 통한 문헌분석이 일차적으로 고려되었으며, 이차적으로는 문헌분석의 근거를 기초로 하여 연구 내용의 구체성을 제고하기 위해 전문가 회의를 실시하였다. 연구 내용은 장애인평생교육의 내부 토대를 형성하기 위하여 요구되는 주체, 목적, 실천적 주요기반을 종합하여 발달장애 토대화와 학교 토대화와 같이 크게 두 가지로 제시되었다. 위 두 가지 토대 요인에 의하여 장애인평생교육 지원체제의 내부적 보편성을 일차적으로 확립하고, 연계적으로 감각장애 유형 및 일반평생교육 분야와 융합하는 측면이 반영되었다. 연구 결과, 장애인평생교육 지원체제 전반의 장기적 안정성 측면이 분석되었다.

• 한국근적외분광분석학회:학술대회논문집
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• 한국근적외분광분석학회 2001년도 NIR-2001
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• pp.1246-1246
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• 2001

The quality of meat is highly variable in many properties. This variability originates from both animal production and meat processing. At the pre-slaughter stage, animal factors such as breed, sex, age contribute to this variability. Environmental factors include feeding, rearing, transport and conditions just before slaughter (Hildrum et al., 1995). Meat can be presented in a variety of forms, each offering different opportunities for adulteration and contamination. This has imposed great pressure on the food manufacturing industry to guarantee the safety of meat. Tissue and muscle speciation of flesh foods, as well as speciation of animal derived by-products fed to all classes of domestic animals, are now perhaps the most important uncertainty which the food industry must resolve to allay consumer concern. Recently, there is a demand for rapid and low cost methods of direct quality measurements in both food and food ingredients (including high performance liquid chromatography (HPLC), thin layer chromatography (TLC), enzymatic and inmunological tests (e.g. ELISA test) and physical tests) to establish their authenticity and hence guarantee the quality of products manufactured for consumers (Holland et al., 1998). The use of Near Infrared Reflectance Spectroscopy (NIRS) for the rapid, precise and non-destructive analysis of a wide range of organic materials has been comprehensively documented (Osborne et at., 1993). Most of the established methods have involved the development of NIRS calibrations for the quantitative prediction of composition in meat (Ben-Gera and Norris, 1968; Lanza, 1983; Clark and Short, 1994). This was a rational strategy to pursue during the initial stages of its application, given the type of equipment available, the state of development of the emerging discipline of chemometrics and the overwhelming commercial interest in solving such problems (Downey, 1994). One of the advantages of NIRS technology is not only to assess chemical structures through the analysis of the molecular bonds in the near infrared spectrum, but also to build an optical model characteristic of the sample which behaves like the “finger print” of the sample. This opens the possibility of using spectra to determine complex attributes of organic structures, which are related to molecular chromophores, organoleptic scores and sensory characteristics (Hildrum et al., 1994, 1995; Park et al., 1998). In addition, the application of statistical packages like principal component or discriminant analysis provides the possibility to understand the optical properties of the sample and make a classification without the chemical information. The objectives of this present work were: (1) to examine two methods of sample presentation to the instrument (intact and minced) and (2) to explore the use of principal component analysis (PCA) and Soft Independent Modelling of class Analogy (SIMCA) to classify muscles by quality attributes. Seventy-eight (n: 78) beef muscles (m. longissimus dorsi) from Hereford breed of cattle were used. The samples were scanned in a NIRS monochromator instrument (NIR Systems 6500, Silver Spring, MD, USA) in reflectance mode (log 1/R). Both intact and minced presentation to the instrument were explored. Qualitative analysis of optical information through PCA and SIMCA analysis showed differences in muscles resulting from two different feeding systems.

• 대한본초학회지
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• 제24권4호
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• pp.215-224
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• 2009

Objectives : Atopic dermatitis is a chronic inflammatory disease characterized by typically distributed eczematous skin lesion with pruritus, lichenification and dry skin. In this study, we performed to assess the therapeutic effects of co-treatment of Chenilyeomgamibang (CGB) and Chenggihaedok-san (CHS, C&C) on the TNCB(trinitrochlorobenzene)-induced atopic dermatitis in NC/Nga mice, characterized by the onset of atopic dermatitis along with an increase the number of inflammatory cells and dysregulation of Th2 cytokines. Methods : Defined amount of CGB was sprayed on mice skin and CHS was simultaneously orally administrated to TNCB treated NC/Nga mice for 5 weeks. The immune cell types were caracterized by flow cytometry using each specific antibody. The amount of Th2 cytokines in serum and splenocytes culture supernatant were measured by ELISA. Results : Administration of C&C significantly reduced clinical dermatitis severity including pruritus, edema, eczematous and erythema. Histological findings indicated that the thickening of epidermis/dermis and dermal infiltration of inflammatory cells were dramatically reduced. Flow cytometry analysis showed that infiltrated immune cell numbers of CCR3+, B220+/IgE+, Gr-1+/CD11b+, and CD117+ were significantly reduced in C&C-treated dorsal skin lesion. Furthermore, T cell composition rate in PBMC was also dramatically decreased by the treatment. C&C greatly down-regulated production of Th2 cytokines including IL-4, IL-5, IL-13 in the serum. The down- regulatory effects of C&C on these Th2 cytokines production were also detected in CD3/ CD28 activated splenocytes. Conclusions : These results indicated that C&C is a plausible therapeutic agent for treatment of atopic dermatitis through regulating the Th2 skewed immune system.

• 한국지하수토양환경학회지:지하수토양환경
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• 제28권2호
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• pp.1-11
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• 2023

Groundwater-surface water interaction was evaluated using water quality parameters (temperature and electrical conductivity), distributions of stable water isotopes (δ²H and δ ¹⁸O), and Rn-222 in lagoon water, groundwater, and seawater at three coastal lagoons (Songji (SJ), Youngrang (YR), and Sunpo (SP) Lagoon) in South Korea. From the results of composition and distributions of δ²H and δ¹⁸O, it was found that groundwater fraction of lagoon water in YR Lagoon (76%) was slightly higher than those of SJ (42%), and SP (63%) Lagoon. Based on Rn-222 mass balance model, groundwater discharge into SJ Lagoon in summer 2020 was estimated to be (3.2±1.1)×10³ m³ day^-1, which showed a similar or an order of magnitude higher than the results of previous studies conducted in coastal lagoons. This study can provide advanced techniques to evaluate groundwater-surface water interaction in coastal lagoons, wetlands, and lakes, and help to determine the effects of groundwater on coastal ecosystems.

• 서비스연구
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• 제13권2호
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• pp.204-226
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• 2023

본 연구는 최근 새로운 고객 참여방식으로 자리매김한 고객 투표를 통한 마케팅 의사결정 방식에 주목하였다. 이는 서비스 산업에서도 중요한 고객 임파워먼트 전략(Customer Empowerment Strategy, CES)의 하나인 선택형 임파워먼트 형태라고 할 수 있다. 선택형 임파워먼트 중 투표방식의 장단점에 국한되어 있는 선행연구와는 달리 본 연구에서는 다수의 최종안이 선정되는 상황을 상정하고, 고객이 하나의 후보에 투표하는 단수투표 시스템과 복수의 후보에 투표하는 다중투표 시스템 간의 차이를 고객의 지속적 투표 참여 의사와 투표 참여 행태를 통해 분석하였다. 또한, 이러한 투표 시스템 간의 차이를 만드는 요인을 투표 결과의 불확실성으로 보고 그 매개효과를 검증하였다. 연구 가설의 검증을 위해 사람과 상품을 대상으로 투표를 하는 두 개의 실험을 진행하였으며, 다중선형회귀분석과 매개효과 분석을 실시하였다. 그 결과, 상품 투표의 경우 다중투표 시스템은 고객 참여 의사와 전략적 투표 행태를 증가시키는 것으로 나타났으나, 사람에 대한 투표의 경우 전략적 투표 행태에만 유의한 영향을 미치는 것으로 나타났다. 또한, 불확실성은 다중투표 시스템의 효과를 매개하지 않아 간접효과는 없는 것으로 나타났다. 본 연구는 학술적으로 선택형 임파워먼트를 세분화시킴으로써 향후 연구에서 고객 참여 방식을 구체화 했다는 점과 실무적으로 기업의 투표 시스템 선택에 방향성을 제시한다는 측면에서 기여점이 있다.

• 디지털융복합연구
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• 제20권1호
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• pp.257-263
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• 2022

코로나 시대를 맞고 있는 현 시대에 '언택트화'가 가속화 되어 가면서 보드게임의 긍정적 가능성이 새롭게 부각되고 있다. 이러한 상황은 앞으로 보드게임을 이전보다 재미있고 질 높은 그리고 교육적으로 어떻게 개발을 하느냐에 따라 보드게임 산업 발전에 긍정적인 영향을 줄 수 있는 기회라고 볼 수 있을 것이다. 이를 위해 본 연구는 보드게임 개발자 및 전문가들의 더욱 발전적인 보드게임 개발을 위해 선행적 연구 및 방법론 중 보드게임 개발 시 중요한 요인들에 대한 상대적 중요도를 도출하는 방법론을 제시해 보고자 한다. 이는 보드게임 개발자, 전문가를 대상으로 보드게임 개발 시의 중요한 요인들을 델파이법을 통해 도출하고, 도출된 요인들의 상대적 중요도에 대한 순위를 위해 순위형식의 델파이법을 사용하였다. 본 연구에서는 보드게임 중 놀이카드 개발 모형에 초점을 맞추었다. 우선순위 분석결과, 개발 및 기획 구성, 선행연구 분석, 초안제작, 제작, 타당화, 적용 및 평가 순으로 그 중요도가 도출이 되었다. 본 연구의 결과는 기업에서 보드게임을 개발하고자 할 때 중요도에 따라 개발의 우선순위를 정하고 활용할 수 있는 실무적인 지침을 제공할 것으로 본다.

• 한방재활의학과학회지
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• 제33권3호
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• pp.1-15
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• 2023

Objectives We aimed to find out the improvement effect of Baekhogainsam-tang (Baihu Jia Renshen-tang, BIT) on metabolic syndrome and alteration of microbiota and gene expression. Methods We used male C57BI/6 mice and randomly assigned them into three groups. Normal control group was fed 10% kcal% fat diet, high-fat diet (HFD) group was fed 45% kcal% fat diet and 10% fructose water. BIT group was fed same diet as HFD group and treated by BIT for once daily, 6 days per week, total 8 weeks. We measured their body weight and food intake every week and performed oral glucose tolerance test 1 week before the end of the study. Then we collected the blood sample to measure triglyceride, total cholesterol, high-density lipoprotein cholesterol, insulin, and hemoglobin A1c. We harvested tissue of liver, muscle, fat, and large intestine for quantitative polymerase chain reaction (qPCR) and histopathological examination. Fresh fecal samples were collected from each animal to verify alterations of gut microbiota and we used RNA from liver tissue for microarray analysis. Results The body weight and fat weight of BIT group were reduced compared to HFD group. The qPCR markers usually up-regulated in metabolic syndrome were decreased in BIT group. Bacteroides were higher in BIT group than other groups. There were also differences in gene expressions between two groups such as Cyp3a11 and Scd1. Conclusions We could find out BIT can ameliorate metabolic syndrome and suggest its effect is related to gut microbiota composition and gene expression pattern.

• 운동영양학회지
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• 제16권2호
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• pp.65-71
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• 2012

Oxygen is the final acceptor of electron transport from fat and carbohydrate oxidation, which is the rate-limiting factor for cellular ATP production. Under altitude hypoxia condition, energy reliance on anaerobic glycolysis increases to compensate for the shortfall caused by reduced fatty acid oxidation [1]. Therefore, training at altitude is expected to strongly influence the human metabolic system, and has the potential to be designed as a non-pharmacological or recreational intervention regimen for correcting diabetes or related metabolic problems. However, most people cannot accommodate high altitude exposure above 4500 M due to acute mountain sickness (AMS) and insulin resistance corresponding to a increased levels of the stress hormones cortisol and catecholamine [2]. Thus, less stringent conditions were evaluated to determine whether glucose tolerance and insulin sensitivity could be improved by moderate altitude exposure (below 4000 M). In 2003, we and another group in Austria reported that short-term moderate altitude exposure plus endurance-related physical activity significantly improves glucose tolerance (not fasting glucose) in humans [3,4], which is associated with the improvement in the whole-body insulin sensitivity [5]. With daily hiking at an altitude of approximately 4000 M, glucose tolerance can still be improved but fasting glucose was slightly elevated. Individuals vary widely in their response to altitude challenge. In particular, the improvement in glucose tolerance and insulin sensitivity by prolonged altitude hiking activity is not apparent in those individuals with low baseline DHEA-S concentration [6]. In addition, hematopoietic adaptation against altitude hypoxia can also be impaired in individuals with low DHEA-S. In short-lived mammals like rodents, the DHEA-S level is barely detectable since their adrenal cortex does not appear to produce this steroid [7]. In this model, exercise training recovery under prolonged hypoxia exposure (14-15% oxygen, 8 h per day for 6 weeks) can still improve insulin sensitivity, secondary to an effective suppression of adiposity [8]. Genetically obese rats exhibit hyperinsulinemia (sign of insulin resistance) with up-regulated baseline levels of AMP-activated protein kinase and AS160 phosphorylation in skeletal muscle compared to lean rats. After prolonged hypoxia training, this abnormality can be reversed concomitant with an approximately 50% increase in GLUT4 protein expression. Additionally, prolonged moderate hypoxia training results in decreased diffusion distance of muscle fiber (reduced cross-sectional area) without affecting muscle weight. In humans, moderate hypoxia increases postprandial blood distribution towards skeletal muscle during a training recovery. This physiological response plays a role in the redistribution of fuel storage among important energy storage sites and may explain its potent effect on changing body composition. Conclusion: Prolonged moderate altitude hypoxia (rangingfrom 1700 to 2400 M), but not acute high attitude hypoxia (above 4000 M), can effectively improve insulin sensitivity and glucose tolerance for humans and antagonizes the obese phenotype in animals with a genetic defect. In humans, the magnitude of the improvementvaries widely and correlates with baseline plasma DHEA-S levels. Compared to training at sea-level, training at altitude effectively decreases fat mass in parallel with increased muscle mass. This change may be associated with increased perfusion of insulin and fuel towards skeletal muscle that favors muscle competing postprandial fuel in circulation against adipose tissues.