• 제어로봇시스템학회:학술대회논문집
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• 1991.10b
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• pp.1718-1723
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• 1991

The determination of a production sequence is an important problem in a batch process operation. In this paper a new algorithm for a near optimal production sequence of N product in an M unit serial multiproduct batch process is proposed. The basic principle is the same as that of Johnson's algorithm for two-unit UIS system. Test results on a number of selected examples exhibit the superiority over previously reported results. In addition, a tabulation technique is presented to calculate the makespan of a given sequence of production for all processing units under UIS mode.

• Biotechnology and Bioprocess Engineering:BBE
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• v.5 no.2
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• pp.130-135
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• 2000

The characteristics of two different modes of perfusion culture, intermittent and continuous bleedings, were investigated by culturing the hybridoma cells producing von Willebrand Factor (vWF) monoclonal antibody (McAb) in a 15 L bioreactor without clogging the filter. Both culture methods exhibited similar profiles of cell density and metabolite concentrations during the culture period at the cell concentration of around 1${\times}$107 cells/mL. When the perfusion rate was increased, the intermittrnt bleeding culture showed problems of ammonia accumulation and decrease of cell viability. The continuous bleeding culture in terms of nutrient consumption and metabolite production kinetics. But the analysis of specific oxygen consumption rate showed that the specific oxygen consumption rate of intermittent bleeding culture was similar to that of exponential growth phase. The continuous bleeding culture showed higher specific oxygen consumption rate of intermittent bleeding culture. finally we proved the possibility of long-term operation of continuous bleeding culture and produced approximately 40 g of vWF McAb in a 15L bioreactor after one-month operation.

• Journal of the Korean Society for Precision Engineering
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• v.18 no.1
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• pp.111-116
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• 2001

A practical scheme to reduce failure of the PCB(Printed Circuit Board) of a monitor is introduced using deformed mode shape under mechanical shock. When the monitor is given critical shock loads, cracks are commonly initiated at the tip of a hole on the PCB. Accordingly, a deformed mode shape of the PCB is obtained using a FEM code to define a weak point on the PCB under mechanical shock, and then the position and direction of the hole is determined to prevent the failure at the critical mode shape. Also, the stress intensity factor around the weak point on the PCB is calculated to check the possibility of fracture by normal tensile stress. In conclusion, present research is useful to assist the practical design of components-layout on the PCB.

• Journal of the Korean Society for Precision Engineering
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• v.33 no.12
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• pp.985-992
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• 2016

Bearings have various uses in industrial equipment. The lifetime of bearings is often lesser than anticipated at the time of purchase, due to environmental wear, processing, and machining errors. Bearing conditions are important, since defects and damage can lead to significant issues in production processes. In this study, we developed a method to diagnose faults in the bearing conditions. The faults were determined using kurtosis, average, and standard deviation. An intrinsic mode function for the data from the selected axis was extracted using empirical mode decomposition. The intrinsic mode function was obtained based on the frequency, and the learning data of ANN (Artificial Neural Network) was concluded, following which the normal and fault conditions of the bearing were classified.

• Transactions of the Korean hydrogen and new energy society
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• v.29 no.4
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• pp.307-316
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• 2018

In this study, the failure mode and effect analysis (FMEA) of hydrogen production process by using the Thermococcus onnurineus NA1 was conducted and advanced methodology to compensate the weakness of previous FMEA methodology was applied. To bring out more quantitative and precise FMEA result for bio-hydrogen production process, fuzzy logic and potential loss cost estimated from ASPEN Capital Cost Estimator (ACCE) was introduced. Consequently, risk for releasing the flammable gases via internal leakage of steam tube which to control the operating temperature of main reactor was caution status in FMEA result without applying the fuzzification and ACCE. Moreover, probability of the steam tube plugging caused by solid property like medium was still caution status. As to apply the fuzzy logic and potential loss cost estimated from ACCE, a couple of caution status was unexpectedly upgraded to high dangerous status since the potential loss cost of steam tube for main reactor and decrease in product gases are higher than expected.

• KSBB Journal
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• v.8 no.4
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• pp.341-350
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• 1993

As an effort to develop an alternative transportation fuel, the production of methanol from methane gas was studied using the resting cells of an obligatory methanotroph, Methylosinus trichosporium OB3b. The reaction was carried out in high concentration phosphate buffer solutions with the flask-grown cells containing the exclusively cytoplasmic methane monooxygenase (sMMO) activity. The methanol accumulation rate was observed to be 79nmo1/mg·min during the initial 4.5hr. Phosphate-dependent inhibition was found for both sMMO and methanol dehydrogenase (MDH) activities, and the inhibition constants were 185mM and 42mM, respectively. The inhibition mode was noncompetitive. Methanol was found to be very inhibitory to the sMMO activity and the inhibition constant (noncompetitive) was 21mM when propylene was used as substrate. The sMO activity in the resting cells was declined very fast and the rate became very high during the methanol production. These results indicate that the use of M. trichosporium OB3b as a biocatalyst for the methanol production is heavily dependent on the stable maintenance of the whole-cell SMO activity as well as the effective alleviation of product inhibition.

• Journal of Animal Environmental Science
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• v.12 no.3
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• pp.133-140
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• 2006

The climate of stall significantly influences on animal production ability. High concentration of ammonia gas, $CO_2$ and lots of dust are found in modern densely raising stall system, as results, they provide a negative influence on animal and farmer health, and production ability. Therefore, it is necessary to keep clean the inside air of stall to increase the productivity. An air cleaner of wet type, consisting of a fan, a motor, rotating discs, a dust collector, a water bowl, an ozone generator etc, has been developed to clean the stall air. The work principle is that the inside air is sucked through the fan, and the rotating discs make water into fineness spray and blow into the stall. The rest water flows down to the dust collector. In the present study, we measured the dust, ammonia gas, odor, temperature and humidity in a swine stall that were installed two wet air cleaners with 700 fattening swine with On-mode and Off-mode of wet air cleaners. The dust measure was divided into 3 categories, TSP, $PM_{10}$, and $PM_{2.5}$. In summer, the TSP in on-mode were maximum $0.259mg/m^3$ and minimum $0.128mg/m^3$, and the average was $0.195mg/m^3$. These are comparable to the data from Off-mode stall that maximum $0.308mg/m^3$, minimum $0.139mg/m^3$, and average $0.277mg/m^3$. However, $PM_{10}$ and $PM_{2.5}$ showed any significant differences between the tests. The concentrations of ammonia gas in Off-mode stall were maximum 13.8 ppm and minimum 5.9 ppm, and the average was 8.47 ppm. However in On-mode stall the ammonia gas concentrations were maximum 10.5 ppm and minimum 5.5 ppm, and the average was 7.63 ppm. The concentration of ammonia gas in On-mode was 10% in average lower than off-mode stall. Odor was measured by olfactometer. In the Off-mode stall, the odor unit were maximum 420 $Ou/m^3$ and minimum $300\;OU/m^3$, and the average was $367\;OU/m^3$, but in the On-mode stall the odor unit were maximum $330\;OU/m^3$ and minimum $210\;OU/m^3$, and the average was $253\;OU/m^3$. Odor removal efficiency was about 31% in On-mode stall.

• Journal of the Korean Society for Nondestructive Testing
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• v.27 no.3
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• pp.231-238
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• 2007

Ultrasonic inspection of austenitic steel weldments is a truly difficult task due to complicated wave propagation phenomena such as beam skewing, splitting and distortion. In order to understand these phenomena and design proper inspection procedures, simulation is increasingly paid more attention to. This article addresses a ray tracing based approach to determine incident angle and position of optimal wave mode ultrasonic beam for flaw detection in anisotropic and inhomogeneous austenitic steel weldments. Specially, the optimal mode of ultrasonic wave wave is selected by ray tracing simulation, and an optimization approach based on ray tracing and bi-section search is proposed in order to find the ray path connecting two given points in weldments. With help of this approach, the optimal incident angle and position of ultrasonic beam can be determined for a given flaw position.

• YAKHAK HOEJI
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• v.49 no.5
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• pp.422-427
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• 2005

Our previous data showed the protein isolated from Coptidis Rhizoma (CRP) had antifungal activity. In present study, we examined mode of action of the CRP and its activity against subcutaneous candidiasis due to C. albicans yeast cells. Results showed that the CRP blocked hyphal production from yeast form of C. albicans. The CRP also activated RAW 264.7 monocyte/macrophage cell line, which resulted in nitiric oxide (NO) production from the cells. This activation seemed to increase macrophage phagocytosis to destroy the invaders. Like other antimicrobial peptides, CRP was influenced by ionic strength, thus resulting in a decrease of antifungal activity. In murine model of a subcutaneous candidiasis, the sizes of infected areas of the nude mice given the CRP after subcutaneous injection of C. albicans yeast cells to the dorsal skin were $90\%$ less than those of the nude mice groups that received DPBS instead of the CRP. All data indicate that the CRP, which appeared to act like an antimicrobial peptide and to inhibit the morphological transition from blastoconidia, was effec­tive against the subcutaneous disease.

• International Journal of Quality Innovation
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• v.8 no.1
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• pp.137-153
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• 2007

Failure mode and effects analysis (FMEA) is a preventive technique in reliability management field. The successful implementation of FMEA technique can avoid or reduce the probability of system failure and achieve good product quality. The FMEA technique had applied in vest scopes which include aerospace, automatic, electronic, mechanic and service industry. The marking process is one of the back ends testing process that is the final process in semiconductor process. The marking process failure can cause bad final product quality and return although is not a primary process. So, how to improve the quality of marking process is one of important production job for semiconductor testing factory. This research firstly implements FMEA technique in laser marking process improvement on semiconductor testing factory and finds out which subsystem has priority failure risk. Secondly, a CCD position solution for priority failure risk subsystem is provided and evaluated. According analysis result, FMEA and CCD position implementation solution for laser marking process improvement can increase yield rate and reduce production cost. Implementation method of this research can provide semiconductor testing factory for reference in laser marking process improvement.