• Journal of Welding and Joining
• /
• v.22 no.6
• /
• pp.50-56
• /
• 2004

MlAB(magnetically impelled arc butt) welding is a sort of pressure welding method by melting two pipe sections with high speed rotating arc and upsetting two pipes in the axial direction. The electro-magnetic force, the driving force of the arc rotation, is generated by interaction of arc current and magnetic field induced from the magnetic flux generator in the welding system. In this study, an openable coil system for the generation of magnetic flux and a 3-dimensional numerical model for analyzing the electro-magnetic field were proposed. Through the fundamental numerical analyses, a magnetic concentrator was adopted for smoothing the magnetic flux density distribution in the circumferential direction. And then a series of numerical analysis were performed for investigating the effect of system parameters on the magnetic flux density distribution in the interested welding area.. Numerical quantitative analyses showed that magnetic flux density distribution generated from the proposed coil system is mainly dependent on the exciting current in the coil and the position of coil or concentrator from the pipe outer surface. And the gap between pipe ends and arc current are also considered as important factors on arc rotating behavior.

• Transactions on Semiconductor Engineering
• /
• v.2 no.3
• /
• pp.19-26
• /
• 2024

Semiconductors are considered as one of the essential technologies in modern electronic devices and systems. Thus, it is required to predict and propose the semiconductor technology development roadmap. This study describes the key semiconductor technology issues, research and development trends, and their future roadmap, in the four areas such as the semiconductor device More-Moore integration technology, system-specific application processor technology, artificial intelligence/machine learning (AI/ML) processor technology, and outside system connectivity via optical and wireless communication.

• Journal of Pharmaceutical Investigation
• /
• v.16 no.4
• /
• pp.139-147
• /
• 1986

A singly charged methyl orange(MO) anion was found to be extracted with chlorpheniramine maleate(CPM) as a 1 : 1 complex in chloroform. Of various solvents, MO-chloroform system gave a yellow color for CPM, while in the absence of CPM, an organic phase showed almost no color. In this way, the spectrophotometric method was investigated for the determination of CPM by solvent extraction. The addition of alcoholic bolic acid solution to the solvent extract gave a higher color stability and transparency at least 5 days, but the extract alone lost its color intensity significantly. CPM is determined by measuring the absorbance of the extracts over a range of $1{\sim}7{\times}10^{-4}M\;(39{\sim}273\;{\mu}g/ml)$ in aqueous solution at 423 nm. The molar absorptivity was $2.26{\times}10^3\;l,\;mol^{-1},\;cm^{-1}$. The absorbance of the extract was constant in the range of pH $3.7{\sim}4.6$. This novel method was applied for the determination of CPM in artificial and commercial preparations in comparison with the analytical method of CPM tablets in K.P.IV. The results obtained showed that the former was better in accuracy and time consumption than the latter.

• Journal of Microbiology and Biotechnology
• /
• v.17 no.11
• /
• pp.1885-1889
• /
• 2007

The tissue blot immunobinding assay (TBIA) is widely used for the detection and localization of plant viruses in various plant tissues. The basic experimental procedures of TBIA sampling and blotting were simplified using commercially available micropipette tips. This method was termed the ring-blot immunobinding assay (R-BIA), as the blot on the membrane forms a ring shape. The detection efficacy of R-BIA was tested for two chili pepper viruses, pepper mild mottle tobamovirus (PMMoV) and pepper mottle potyvirus (PepMoV), following the optimized serological procedures of TBIA (length of the incubation period and BSA concentration, and primary and secondary antibodies). Sensitivity of the R-BIA was about 1 ng/ml of purified PMMoV in pepper leaf sap from a healthy pepper plant. R-BIA also showed high specificity in the detection of PMMoV and PepMoV. Moreover, the modified sampling and blotting procedures were simpler and more reliable than other TBIA methods (such as whole-leaf blotting and crushed-leaf blotting), suggesting that the R-BIA may be used for medium- to large-scale detection of plant viruses in laboratories with minimal facilities.

• Proceedings of the Korea Information Processing Society Conference
• /
• 2002.11a
• /
• pp.123-126
• /
• 2002

근래 들어 무선 인터넷이 가능한 고성능의 휴대형 단말들이 널리 보급되어 감에 따라, 모바일 기업 응용에 대한 요구가 증가하고 있다. 모바일 기업 응용에서는 모바일 클라이언트와 기업 서버간의 데이터 동기화가 필수적이다. 왜냐하면, 모바일 클라이언트는 그 특성상 기업 서버에 항상 접속해 있을 수 없기 때문이다. 하지만 이러한 모바일 기업 응용을 작성하기 위해서는 확장성 이형성, 자원제약, 보안등과 같은 여러 기술적인 문제들을 해결해야만 한다. 따라서 본 논문에서는 이러한 기술적인 문제들 뿐만 아니라 데이터 동기화 부분을 처리해 줌으로써 응용 개발자들에게 오직 데이터 동기화를 위한 추상화된 인터페이스만을 제공해주는 데이터 동기화 미들웨어 시스템인 MoIM-Sync 시스템의 설계 및 구현에 관해 기술한다. 우리 시스템은 구현 언어로 Java를, 동기화 프로토콜로 표준 동기화 프로토콜인 SyncML을 사용함으로써 이형성 문제를 극복하였으며, 3 계층 구조를 통해 확장성 및 기존 동기화 시스템/서버 시스템들과의 연동 문제를 해결하였다.

• Applied Biological Chemistry
• /
• v.49 no.4
• /
• pp.259-265
• /
• 2006

Effect of the fungicide mepanipyrim on the resistant and sensitive isolates of Botrytis cinerea was studied in vitro and also tested to control Botrytis rot of strawberry, cucumber and grape in the field. These isolates were selected by relative mycelial growth and spore germination on potato dextrose agar(PDA) incorporated with $100{\mu}g\;a.i./ml$ of benomyl and procymidone, respectively, compared to the unamended PDA. Mycelial growth of the selected resistant isolates was significantly inhibited by mepanipyrim but the inhibition rate was similar to other fungicides belong to benzimidazole or dicarboximide, although spore germination was not inhibited even by the higher concentration of mepanipyrim. When the benomyl and procymidone resistant isolates were inoculated to cucumber leaves, lesion development was significantly inhibited with application of $250{\mu}g\;a.i./ml$ of mepanipyrim but not with that of benomyl and procymidone. In addition, when $250{\mu}g\;a.i./ml$ of mepanipyrim was applied to strawberry, cucumber, and grape in the field, the control of Botrytis rot was significantly different from that of the untreated control(Duncan's multiple range test, p<0.05). The results suggested that mepanipyrim might be an alternative fungicide for the control of benomyl- and procymidone-resistant pathogens of Botrytis rot.

• Tuberculosis and Respiratory Diseases
• /
• v.43 no.3
• /
• pp.359-366
• /
• 1996

Background : Eosinophilic leukocytes are prominent cellular participants in the pathogenesis of allergic disease and asthma. Chemotaxis is still a very useful method in evaluating the response of human eosinophil to novel modulators. Degranulated mast cells and activated T lymphocytes are responsible for the pathophysiology of asthma and tryptase is one of most important proteases released after activation of mast cells. The purpose of this study was to investigate the actions of trypsin and chymotrypsin on eosinophils in terms of chemotaxis and activation. Method : Eosinophils were isolated by negative immunoselection from the peripheral blood of atopic donors. Chemotaxis was studied by using micro-Boyden chambers and ECP release was assayed by fluoroimmunoassay. Results : Eosinophil showed a chemotactic response to trypsin. Maximal chemotactic response was with $1000{\mu}g/ml$ trypsin ($56.52{\pm}14.50$/HPF) which was comparable to PAP. But chymotrypsin showed no significant chemotactic response to eosinophils. Trypsin at the concentration of 10, 100, $1000{\mu}g/ml$ induced secretion of ECP, which at the concentration of $10{\mu}g/ml$ represented about 2.7 times of the spontaneous rate of release. Soybean protease inhibitor reduced trypsin induced ECP release. Conclusion : Trypsin can induce chemotactic response to eosinophils and activation of eosinophils that can induce secretion of ECP. On the contrary, chymotrypsin showed no direct effect on eosinophils. We propose a role of trypsin on the chemotaxis and activation of eosinophils.

• The Korean Journal of Pain
• /
• v.25 no.4
• /
• pp.228-237
• /
• 2012

Background: Milnacipran is a balanced serotonin norepinephrine reuptake inhibitor with minimal side effects and broad safety margin. It acts primarily on the descending inhibitory pain pathway in brain and spinal cord. In many animal studies, intrathecal administration of milnacipran is effective in neuropathic pain management. However, there is no study for the neurological safety of milnacipran when it is administered neuraxially. This study examined the neurotoxicity of epidural milnacipran by observing behavioral and sensory-motor changes with histopathological examinations of spinal cords in rats. Methods: Sixty rats were divided into 3 groups, with each group receiving epidural administration of either 0.3 ml (3 mg) of milnacipran (group M, n = 20), 0.3 ml of 40% alcohol (group A, n = 20), or 0.3 ml of normal saline (group S, n = 20). Results: There were no abnormal changes in the behavioral, sensory-motor, or histopathological findings in all rats of groups M and S over a 3-week observation period, whereas all rats in group A had abnormal changes. Conclusions: Based on these findings, the direct epidural administration of milnacipran in rats did not present any evidence of neurotoxicity in behavioral, sensory-motor and histopathological evaluations.

• The Korean Journal of Physiology and Pharmacology
• /
• v.12 no.4
• /
• pp.193-197
• /
• 2008

The influence of alpha-fetoprotein (AFP) on the bone marrow (BM) natural suppressor (NS) cells of intact Ehrlich carcinoma -bearing CBA mice was studied. Bone marrow NS cells were fractionated into three fractions by isopycnic centrifugation on percoll gradients: NS1 (${\rho}$=1.080 g/ml), NS2 (${\rho}$=1.090 g/ml) and NS3 (1.100> ${\rho}$ > 1.090 g/ml). These fractions were highly different in their sensitivity to known NS cell inductors (interleukin (IL)-2, IL-3 or histamine). None of the NS fractions isolated from the intact mice spontaneously produced antiproliferative activity, however, they showed a high level of NS (antiproliferative and natural killer cell inhibitory) activity under the influence of AFP. A single injection of AFP to intact mice led to an increase of spontaneous NS activity and the inhibition of natural killer cell activity. NS activity, especially NS2, was increased in when tumor cells were subcutaneously inoculated three days after AFP injection. In the AFP-treated mice, the tumor mass at 14 days was 60% larger than that in the untreated mice. Our data confirmed that AFP is a tumor marker that can inhibit cancer immunity and plays a role in cancer pathogenesis.

• Journal of Sericultural and Entomological Science
• /
• v.47 no.2
• /
• pp.88-92
• /
• 2005

In order to make pure dyestuff extract from polygonum tinctoria, we tried to traditionally-using cockle shell which the extracted water should be filtered in indigo for 8 hours and at the $40^{\circ}C$, and 4.0 pH. The 1.631g of powder dye could be produced when the 10.0 ml of aqueous ammonia was added into the solution, which had been filtered for 8 hours with the 300 g of indigo plant and the 2.51 of water. The main components of two maded -dye which has traditionally made of this and has purely made of that compared by TLC, HPLC, LC/MC techniques. Finally, the antibacterial activities and deodorization ratio of silk fabrics with natural indigo were carried out, too.