Journal of Pharmaceutical Investigation
- Volume 16 Issue 4
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- Pages.139-147
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- 1986
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
Spectrophotometric Determination of Chlorpheniramine Maleate with Methyl Orange
메칠오렌지에 의한 말레인산클로르페니라민의 분광광도 정량
- Chun, In-Koo (Department of Pharmacy, Dongduck Women's University)
- 전인구 (동덕여자대학 약학과)
- Published : 1986.12.20
Abstract
A singly charged methyl orange(MO) anion was found to be extracted with chlorpheniramine maleate(CPM) as a 1 : 1 complex in chloroform. Of various solvents, MO-chloroform system gave a yellow color for CPM, while in the absence of CPM, an organic phase showed almost no color. In this way, the spectrophotometric method was investigated for the determination of CPM by solvent extraction. The addition of alcoholic bolic acid solution to the solvent extract gave a higher color stability and transparency at least 5 days, but the extract alone lost its color intensity significantly. CPM is determined by measuring the absorbance of the extracts over a range of
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