• 제목/요약/키워드: Mitigating Factor

검색결과 56건 처리시간 0.032초

Butyrate and taurine exert a mitigating effect on the inflamed distal intestine of European sea bass fed with a high percentage of soybean meal

  • Rimoldi, Simona;Finzi, Giovanna;Ceccotti, Chiara;Girardello, Rossana;Grimaldi, Annalisa;Ascione, Chiara;Terova, Genciana
    • Fisheries and Aquatic Sciences
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    • 제19권10호
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    • pp.40.1-40.14
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    • 2016
  • Background: Due to the paucity of oceanic resources utilized in the preparation of diets for cultured fish, commercial feed producers have been trying to replace fishmeal (FM) using alternative protein sources such as vegetable protein meals (VMs). One of the main drawbacks of using VMs in fish feed is related to the presence of a variety of anti-nutritional factors, which could trigger an inflammation process in the distal intestine. This reduces the capacity of the enterocytes to absorb nutrients leading to reduced fish growth performances. Methods: We evaluated the mitigating effects of butyrate and taurine used as feed additives on the morphological abnormalities caused by a soybean meal (SBM)-based diet in the distal intestine of sea bass (Dicentrarchus labrax). We used three experimental diets, containing the same low percentage of FM and high percentage of SBM; two diets were supplemented with either 0.2% sodium butyrate or taurine. Histological changes in the intestine of fish were determined by light and transmission electron microscopy. Infiltration of $CD45^+$ leucocytes in the lamina propria and in the submucosa was assessed by immunohistochemistry. We also quantified by One-Step Taqman$^{(R)}$ real-time RT-PCR the messenger RNA (mRNA) abundance of a panel of genes involved in the intestinal mucosa inflammatory response such as $TNF{\alpha}$ (tumor necrosis factor alpha) and interleukins: IL-8, IL-$1{\beta}$, IL-10, and IL-6. Results: Fish that received for 2 months the diet with 30% soy protein (16.7% SBM and 12.8% full-fat soy) developed an inflammation in the distal intestine, as confirmed by histological and immunohistochemistry data. The expression of target genes in the intestine was deeply influenced by the type of fish diet. Fish fed with taurine-supplemented diet displayed the lowest number of mRNA copies of IL-$1{\beta}$, IL-8, and IL-10 genes in comparison to fish fed with control or butyrate-supplemented diets. Dietary butyrate caused an upregulation of the $TNF{\alpha}$ gene transcription. Among the quantified interleukins, IL-6 was the only one to be not influenced by the diet. Conclusions: Histological and gene expression data suggest that butyrate and taurine could have a role in normalizing the intestinal abnormalities caused by the SBM, but the underling mechanisms of action seem different.

Determining Correlation between Experiences of a Sensory Courtyard and DAS (Depression, Anxiety and Stress)

  • Nam, Jinvo;Kim, Keunho
    • 인간식물환경학회지
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    • 제24권4호
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    • pp.403-413
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    • 2021
  • Background and objective: There is growing concern about the effects of modern society on mental health, coming with Covid-19-related caveats on depression, anxiety, and stress (DAS). This can be a subject to provide alternative methods which alleviate DAS. In line with this context, sensory gardens are widely acknowledged to stimulate the five major senses (sight, sound, taste, touch, and smell) and can have a significant (positive) impact on mental health. However, there is limited empirical evidence on the effect of these gardens with regard to alleviating DAS - particularly with respect to urban society This is a gab in knowledge how such limits can be addressed. Accordingly, this present study is clearly needed in order to verify if there are any correlations between sensory gardens and (positive) effects on DAS. The aim of this study was therefore to understand current levels of DAS in a high density building with a sensory garden in a courtyard and determine correlations between experiences in the sensory courtyard and levels of DAS. Methods: The Depression Anxiety and Stress Scale (DASS-21) was employed to test the level of DAS. Results: Additionally, 13 different factors associated with experiences in the building, including the stimulation of the five major senses in the sensory courtyard, were measured to reveal their contribution to mitigating depression, anxiety, and stress. It is noted that the average levels of DAS were 7.91, 7.77 and 9.01 respectively indicating that the mental health of participants requires mental health management. However, results show that factors associated with the sensory courtyard could improve mental health. For example, new social relationships, walking with colleagues, and the stimulation of each of the five major senses in the sensory garden could improve DAS. Conclusion: This illustrates that external experiences are more effective at mitigating depression, anxiety, and stress than internal ones. Factor analysis revealed four components: stimulating the five senses; internal and external facilities; internet-based device use; and new social relationships. There was a strong positive correlation between new social relationships and walking with colleagues. There were also strong positive correlations among the stimulation of each of the five senses. In conclusion, there are strong indications that sensory courtyards can help alleviate DAS and should therefore be promoted, particularly in the current Covid-19 situation wherein the physical and mental health of the public at large are threatened. Accordingly, courtyard design should be rethought in light of the relationship between the positive impact of sensory gardens and mental health.

시변 채널에서 Bit-Interleaved Coded OFDM을 위한 적응 변조 기법 (Adaptive Bit-Interleaved Coded OFDM over Time-Varying Channels)

  • 최진수;성창경;문성현;이인규
    • 대한전자공학회논문지TC
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    • 제46권1호
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    • pp.32-39
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    • 2009
  • 송신 단에서 채널 상태 정보를 알고 있는 폐루프 시스템은 개방 루프 시스템에 비하여 더 효율적인 전송을 수행할 수 있다. 그러나 실제 시스템은 제한된 피드백 채널을 가지므로 송신단에서 완벽한 채널 정보를 알 수 없으며, 따라서 부분 채널 정보를 활용하는 시스템의 설계가 중요한 요소로 부각되고 있다. 특히, 모바일 환경에서는 사용자의 이동성으로 인하여 채널 상태가 유동적으로 변화하며 이는 성능의 열화를 초래한다. 본 논문에서는 비트 인터리버와 결합한 부호화된 직교 주파수 다중 분할(BIC-OFDM; Bit-Interleaved Coded Orthogonal Frequency Division Multiplexing) 시스템을 위하여 채널 변화에 적절히 대응하는 적응 변조 코딩 기법을 제안한다. 합리적인 피드백 정보량을 통해, 제안하는 기법은 도플러 확산에 의한 채널 변화를 보상하여 향상된 성능을 제공한다. 실험 결과를 통해 제안하는 기법이 정확한 비트 에러율의 추정을 통한 성능 이득을 가짐을 확인한다.

기술상용화 요인이 중소기업 성과에 미치는 영향 (Effect of Technology Commercialization Factors on Small and Medium Enterprises Performance)

  • 조기동;김준우
    • 디지털융복합연구
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    • 제12권9호
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    • pp.83-92
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    • 2014
  • 21세기에 있어서 기업들은 무역장벽이 무너지는 등 경영환경이 급변하고 있는 추세이다. 이러한 현상은 기술의 발전과 함께 점차 가속화하고 있으며, 기술의 중요성은 기업에 있어 더욱 절실하게 되었다. 이러한 관점에서 본 연구는 중소기업을 대상으로 기술상용화에 대한 기업성과와의 관계를 규명하고자 하였다. 기존 연구를 토대로 기술상용화에 대한 요인을 재무적, 인적, 전략으로 구분하고 성과를 재무적 성과와 기술적 성과를 구분하여 회귀분석을 이용하여 측정하였다. 연구 결과 모든 요인들이 기업 성과와 밀접한 관계를 나타내었으며, 이러한 연구를 통하여 중소기업들이 성과를 높이기 위해 언급된 세 요인을 모두 중시할 필요가 있을 것으로 판단된다.

Biotic and spatial factors potentially explain the susceptibility of forests to direct hurricane damage

  • Kim, Daehyun;Millington, Andrew C.;Lafon, Charles W.
    • Journal of Ecology and Environment
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    • 제43권4호
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    • pp.364-375
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    • 2019
  • Background: Ecologists continue to investigate the factors that potentially affect the pattern and magnitude of tree damage during catastrophic windstorms in forests. However, there still is a paucity of research on which trees are more vulnerable to direct damage by winds rather than being knocked down by the fall of another tree. We evaluated this question in a mixed hardwood-softwood forest within the Big Thicket National Preserve (BTNP) of southeast Texas, USA, which was substantially impacted by Hurricane Rita in September 2005. Results: We showed that multiple factors, including tree height, shade-tolerance, height-to-diameter ratio, and neighborhood density (i.e., pre-Rita stem distribution) significantly explained the susceptibility of trees to direct storm damage. We also found that no single factor had pervasive importance over the others and, instead, that all factors were tightly intertwined in a complex way, such that they often complemented each other, and that they contributed simultaneously to the overall susceptibility to and patterns of windstorm damage in the BTNP. Conclusions: Directly damaged trees greatly influence the forest by causing secondary damage to other trees. We propose that directly and indirectly damaged (or susceptible) trees should be considered separately when assessing or predicting the impact of windstorms on a forest ecosystem; to better predict the pathways of community structure reorganization and guide forest management and conservation practices. Forest managers are recommended to adopt a holistic view that considers and combines various components of the forest ecosystem when establishing strategies for mitigating the impact of catastrophic winds.

치과위생사의 감정부조화와 직무만족도 간의 관계에서 소진의 매개효과와 조직적 지지의 조절효과 (Mediating effects of burnout and moderating effects of organizational support on the relationship between emotional dissonance and job satisfaction in dental hygienists)

  • 김초롱;최준선
    • 한국치위생학회지
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    • 제18권4호
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    • pp.489-499
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    • 2018
  • Objectives: The purpose of this study was to investigate the mediating effects of burnout and to identify the moderating effects of individual factors and organizational factors on the relationship between emotional dissonance and job satisfaction. Methods: This cross-sectional study included 270 dental hygienists working full-time at dental care facilities. The data on the socio-demographic characteristics, emotional dissonance, burnout, job satisfaction, and individual and organizational factors were collected. The individual (self-efficacy and ego resilience) and organizational (social support, organizational support and wage satisfaction) factors were considered as the moderating variable. For statistical analyses, t-test, one-way ANOVA and multiple linear regression were used. Results: Burnout was found to be a significant mediator on the relationship between emotional dissonance and job satisfaction(p<0.001). The variables moderating the relationship between emotional dissonance and burnout were identified as social support, organizational support and wage satisfaction (p<0.05), while the variables moderating the relationship between burnout and job satisfaction were wage satisfaction and ego resilience (p<0.05). Conclusions: To prevent the decrease in job satisfaction due to emotional dissonance, the management of dental care facilities should have a better understanding of burnout in dental hygienists, which requires individual and organizational efforts to be moderated. In addition, as organizational support has been identified as the factor mitigating the negative effects of emotional dissonance, it is highly necessary to adopt the preceptor system, improve communication systems and expand welfare policies of organizations.

Uncertainty investigation and mitigation in flood forecasting

  • Nguyen, Hoang-Minh;Bae, Deg-Hyo
    • 한국수자원학회:학술대회논문집
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    • 한국수자원학회 2018년도 학술발표회
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    • pp.155-155
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    • 2018
  • Uncertainty in flood forecasting using a coupled meteorological and hydrological model is arisen from various sources, especially the uncertainty comes from the inaccuracy of Quantitative Precipitation Forecasts (QPFs). In order to improve the capability of flood forecast, the uncertainty estimation and mitigation are required to perform. This study is conducted to investigate and reduce such uncertainty. First, ensemble QPFs are generated by using Monte - Carlo simulation, then each ensemble member is forced as input for a hydrological model to obtain ensemble streamflow prediction. Likelihood measures are evaluated to identify feasible member. These members are retained to define upper and lower limits of the uncertainty interval and assess the uncertainty. To mitigate the uncertainty for very short lead time, a blending method, which merges the ensemble QPFs with radar-based rainfall prediction considering both qualitative and quantitative skills, is proposed. Finally, blending bias ratios, which are estimated from previous time step, are used to update the members over total lead time. The proposed method is verified for the two flood events in 2013 and 2016 in the Yeonguol and Soyang watersheds that are located in the Han River basin, South Korea. The uncertainty in flood forecasting using a coupled Local Data Assimilation and Prediction System (LDAPS) and Sejong University Rainfall - Runoff (SURR) model is investigated and then mitigated by blending the generated ensemble LDAPS members with radar-based rainfall prediction that uses McGill algorithm for precipitation nowcasting by Lagrangian extrapolation (MAPLE). The results show that the uncertainty of flood forecasting using the coupled model increases when the lead time is longer. The mitigation method indicates its effectiveness for mitigating the uncertainty with the increases of the percentage of feasible member (POFM) and the ratio of the number of observations that fall into the uncertainty interval (p-factor).

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A frequency tracking semi-active algorithm for control of edgewise vibrations in wind turbine blades

  • Arrigan, John;Huang, Chaojun;Staino, Andrea;Basu, Biswajit;Nagarajaiah, Satish
    • Smart Structures and Systems
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    • 제13권2호
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    • pp.177-201
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    • 2014
  • With the increased size and flexibility of the tower and blades, structural vibrations are becoming a limiting factor towards the design of even larger and more powerful wind turbines. Research into the use of vibration mitigation devices in the turbine tower has been carried out but the use of dampers in the blades has yet to be investigated in detail. Mitigating vibrations will increase the design life and hence economic viability of the turbine blades and allow for continual operation with decreased downtime. The aim of this paper is to investigate the effectiveness of Semi-Active Tuned Mass Dampers (STMDs) in reducing the edgewise vibrations in the turbine blades. A frequency tracking algorithm based on the Short Time Fourier Transform (STFT) technique is used to tune the damper. A theoretical model has been developed to capture the dynamic behaviour of the blades including the coupling with the tower to accurately model the dynamics of the entire turbine structure. The resulting model consists of time dependent equations of motion and negative damping terms due to the coupling present in the system. The performances of the STMDs based vibration controller have been tested under different loading and operating conditions. Numerical analysis has shown that variation in certain parameters of the system, along with the time varying nature of the system matrices has led to the need for STMDs to allow for real-time tuning to the resonant frequencies of the system.

유휴지를 활용한 최적의 도시 녹지 공간 탐색 - 녹지연결성과 열 환경 개선을 목적으로 - (Exploration of Optimal urban green space using unused land - To improve green connectivity and thermal environment -)

  • 김은섭;이동근;윤은주;박채연
    • 한국환경복원기술학회지
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    • 제22권5호
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    • pp.45-56
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    • 2019
  • Urban green areas are generally composed of relatively small and fragmented patches, but it is a critical factor for the quality of an urban environment. They have positive effects such as increasing green connectivity, reducing runoff, and mitigating urban heat. But, there is a lack of urban greening plans that consider the comprehensive effects of green space in real urban areas. To fill this gap in this literature, this study identifies a planning model that determines the optimal locations for maximizing green areas' multiple effects(e.g., heat mitigation and enhancement of connectivity) by using unused lots. This model also considers minimizing costs using meta-heuristic optimization algorithms. As a results, we finds 50 optimal plans that considers two effects within the limited cost in Nowon-gu. The optimal plans show the trade-off effect between connectivity, heat mitigation and cost. They also show the critical unused land lots for urban greening that are commonly selected in various plans. These optimal plans can effectively inform quantitative effectiveness of green space and their trade-off. We expect that our model will contribute to the improvement of green planning processes in reality.

Effects of dietary arginine in ameliorating the deleterious effects induced by mycotoxins on growth, immune system, body organs in growing pigs

  • Joseph, Moturi;SeYoung, Yoon;Abdolreza, Hosseindoust;SangHun, Ha;Habeeb, Tajudeen;JunYoung, Mun;SooJin, Sa;JinSoo, Kim
    • Journal of Animal Science and Technology
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    • 제64권4호
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    • pp.727-739
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    • 2022
  • Mycotoxin contamination in pig feeds has a negative impact on growth performance, the immune system, and major body organs. Arginine (Arg) plays an important role in animals' body biochemistry and physiology. This study aimed to determine the effect of dietary Arg supplementation on mitigating the negative effects of mycotoxins in growing pigs. A total of 72 growing pigs (Landrace × Large white) with initial mean body weight (BW) = 55 ± 2.5 kg were allotted to four treatment groups with three replicates per group of six pigs per replicate in a completely randomized design. The treatments included a non-toxin diet with 1.2% Arg (NT1.2) and mycotoxin-challenged treatments supplemented with 1.2% Arg (TX1.2), 1.3% Arg (TX1.3), and 1.4% Arg (TX1.4). Statistical analysis of data included the effects of dietary level of Arg. The results indicated a significantly higher BW (p < 0.05), average daily gain (p < 0.05), and gain-to-feed ratio (p < 0.05) in the NT1.2 group than in the TX1.2, TX1.3, and TX1.4 groups. The relative weight of the liver was higher (p < 0.05) in the TX1.2 compared to that of the NT1.2 group, although it was not different from that of TX1.3 and TX1.4. The level of tumor necrosis factor-alpha was significantly up-regulated (p < 0.05) in the liver tissue of the TX1.2 group compared to that of the other treatments. Overall, dietary Arg supplementation remedied liver injury and alleviated the compromised immune system caused by mycotoxin toxicity.