• The Korean Journal of Applied Statistics
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• v.13 no.1
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• pp.197-206
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• 2000

For estimating missing cells in contingency table, we suggest an iterative method which extends IPF (Iterative Proportional Fitting) method. The suggested m~thod is not restricted by the number and the location of missing cells, and does not distort the given quasi-independency.

• Journal of the Korean Statistical Society
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• v.27 no.1
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• pp.133-152
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• 1998

The central composite design is widely used in the response surface analysis, because it can fit the second order model with small experimental points. In practice, the experimental data are not always obtained on all the points. When there are missing observations, many problems due to the missing cells can occur. In this paper, the influence of a missing cell on the central composite design is discussed. First, the influences of a missing cell on the variances of estimated regression coefficents are compared as $\alpha$ varies. Second, how the average predition variance is affected by a missing sell is discussed. And the influence on rotatability is investigated. Third, the influence of a missing cell on optimality, especially on D-optimality and A-optimality, is examined.

• Proceedings of the Korean Statistical Society Conference
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• 2005.11a
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• pp.31-36
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• 2005

An identification and characterization of susceptibility genes for common complex multifactorial diseases is a challengeable task, in which the effect of single genetic variation will be likely dependent on other genetic variations(gene-gene interaction) and environmental factors (gene-environment interaction). To address is issue, the multifactor dimensionality reduction (MDR) has been proposed and implemented by Ritchie et al. (2001), Moore et al. (2002), Hahn et al.(2003) and Ritchie et al. (2003). With MDR, multilocus genotypes effectively reduce the dimension of genotype predictors from n to one, which improves the identification of polymorphism combinations associated with disease risk. However, MDR cannot handle missing observations appropriately, in which missing observation is treated as an additional genotype category. This approach may suffer from a sparseness problem since when high-order interactions are considered, an additional missing category would make the contingency table cells more sparse. We propose a new MDR approach with minimum loss of sample sizes by considering missing data over all possible multifactor classes. We evaluate the proposed MDR by using the prediction errors and cross validation consistency.

• Journal of Biosystems Engineering
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• v.21 no.2
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• pp.123-133
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• 1996

An automatic drum seeder was developed to improve the seeding operation. It consisted of a conveyor to transfer seedling trays, a seed-hopper to supply seeds, a drum to drop seeds on the tray, and an air blower to remove extra seeds. A photo sensor was used to detect the transfer of seedling trays, and its signal was fed into microcomputer which operated a stepping motor driving the drum. The seeds were adhered to the surface of drum by vacuum pressure, and were dropped into tray cells by compressed air. An air connection unit was devised to alternate between vacuum pressure and compressed air. A control program for the system, written in C language, could operate the drum at the given number of revolutions and revolutions per minute. The results showed that the air connection unit could operate well and the seeds were dropped satisfactorily into tray cells. In case of cabbage and perilla seeds, which are regular and spherical shape, the missing rate was low and the single seeding rate was more than 97%. Low missing rate and high multiple seeding rate were observed in lettuce seeds which have narrow ends with tight weight. The missing rate of pepper seed was very high because of heavy weight and irregular shape. To improve the performance of the seeder, adjustment of vacuum pressure based upon shape and weight of the seeds, careful selection of the material of drum, maintenance of consistent air blower pressure, and replacement of stepping motor to DC motor are recommended.

• Communications for Statistical Applications and Methods
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• v.10 no.2
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• pp.575-583
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• 2003

We proposed imputation strategies for the Population and Housing Census 2000 in Korea. The total area of floor space and marital status which have relatively high non-response rates in the Census are considered to develope the effective missing value imputation procedures. The Classification and Regression Tree(CART) is employed to construct the imputation cells for hot-deck imputation, as well as to predict missing value by model-based approach. We compare three imputation methods which include CART model-based imputation, hot-deck imputation based on CART and logical hot-deck imputation proposed by The Korea National Statistical Office. The results suggest that the proposed hot-deck imputation based on CART is very efficient and strongly recommendable.

• Animal cells and systems
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• v.4 no.3
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• pp.201-214
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• 2000

Two quite different types of plant cells are analysed with regard to transduction of the gravity stimulus: (i) Unicellular rhizoids and protonemata of characean green algae; these are tube-like, tip-growing cells which respond to the direction of gravity. (ii) Columella cells located in the center of the root cap of higher plants; these cells (statocytes) perceive gravity. The two cell types contain heavy particles or organelles (sataoliths) which sediment in the field of gravity, thereby inducing the graviresponse. Both cell types were studied under microgravity conditions ($10^{-4}$/ g) in sounding rockets or spacelabs. From video microscopy of living Chara cells and different experiments with both cell types it was concluded that the position of statoliths depends on the balance of two forces, i.e. the gravitational force and the counteracting force mediated by actin microfilaments. The actomyosin system may be the missing link between the gravity-dependent movement of statoliths and the gravity receptor(s); it may also function as an amplifier.

• Survey Research
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• v.4 no.2
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• pp.1-21
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• 2003

We proposed imputation strategies for marital status in the Population and Housing Census 2000 in Korea to illustrate the effective missing value imputation methods for social survey. The marital status which have relatively high non-response rates in the Census are considered to develope the effective missing value imputation procedures. The Classification and Regression Tree(CART)is employed to construct the imputation cells for hot-deck imputation, as well as to predict the missing value by model-based approach. We compare to imputation methods which include the CART model-based imputation and the sequential hot-deck imputation based on CART. Also we check whether different modeling for each region provides the more improved results. The results suggest that the proposed hot-deck imputation based on CART is very efficient and strongly recommendable. And the results show that different modeling for each region is not necessary.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.2
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• pp.601-606
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• 2015

Background: Prostate cancer is predominately a disease of older men, with a median age of diagnosis of 68 years and 71% of cancer deaths occurring in those over 75 years of age. While prostate cancer screening is not recommended for men >70 years, fit elderly men with controlled comorbidities may have a relatively long life expectancy. We compare the use of age related PSA with the detection of primary malignant circulating prostate cells mCPCs to detect clinically significant PC in this population. Materials and Methods: All men undergoing PC screening with a PSA >4.0ng/ml underwent TRUS 12 core prostate biopsy (PB). Age, PSA, PB results defined as cancer/no-cancer, Gleason, number of positive cores and percentage infiltration were registered. Men had an 8ml blood sample taken for mCPC detection; mononuclear cells were obtained using differential gel centrifugation and mCPCs were identified using immunocytochemistry with anti-PSA and anti-P504S. A mCPC was defined as a cell expressing PSA and P504S; a positive test as at least one mCPC detected/sample. Diagnostic yields for subgroups were calculated and the number of avoided PBs registered. Esptein criteria were used to define small grade tumours. Results: A total of 610 men underwent PB, 398 of whom were aged <70yrs. Men over 70 yrs had: a higher median PSA, 6.24ng/ml versus 5.59ng/ml (p=0.04); and a higher frequency of cancer detected 90/212 (43%) versus 134/398 (34%) (p=0.032). Some 34/134 cancers in men <70yrs versus 22/90 (24%) of men >70yrs complied with criteria for active surveillance. CPC detection: 154/398 (39%) men <70yrs were CPC (+), specificity for cancer 86%, sensitivity 88%, 14/16 with a false (-) result had a small low grade PC. In men >70 years, 88/212 (42%) were CPC (+); specificity 92%, sensitivity 87%, 10/12 with a false (-) had small low grade tumours. False (+) results were more common in younger men 36/154 versus 10/88 (p<0.02). With a PSA cutoff of 6.5ng/ml, in men <70yrs, 108 PB would be avoided, missing 56 cancers of which 48 were clinically significant. Using CPC detection, 124 biopsies would be avoided, missing only 2 clinically significant cancers. In men >70 yrs using a PSA >6.5ng/ml would have resulted in 108 PB with 34 PC detected, of which 14(41%) were small low grade tumours. Conclusions: The use of CPC detection in the fit elderly significantly decreases the number of PBs without missing clinically significant cancers, indicating superiority to the use of age-related PSA.

• BMB Reports
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• v.30 no.4
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• pp.299-301
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• 1997

The asialoglycoprotein receptor (ASGPR) was the first described mammalian lectin that mediates the specific binding and internalization of galactose/N-acetylgalactosamine-terminating glycoproteins by hepatic parenchymal cells. H1 and H2 are known as essential subunits of the functional ASGPR. There were close similarities in ASGPR H2 subunits between cultured cell line HepG2 and normal human liver cells including identical sequences at both termini. It was therefore expected that there may be some similarities between the subunits from normal liver cells and fetal liver cells. The two subunits of human fetal liver ASGPR. designated FL-H1 and FL-H2. were cloned from cDNA library by peR and the sequences were compared with the known HI and H2 sequences of HepG2, and the H1 sequence of nornal human liver cells. The results showed that FL-H1 was identical to H1 of HepG2. Whereas FL-H2 contains a 15-bp miniexon, but missing 57-bp at the near upstream from the membrane-spanning domain compared to H2 of HepG2 and normal human liver cells indicating that FL-H2 resulted from a differential splicing compared to HepG2 and normal liver cells.

• ETRI Journal
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• v.27 no.6
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• pp.691-696
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• 2005

In asynchronous transfer mode (ATM) networks, fixed length cells of 53 bytes are transmitted. A cell may be discarded during transmission due to buffer overflow or a detection of errors. Cell discarding seriously degrades transmission quality. The quality degradation can be reduced by employing efficient forward error control (FEC) to recover discarded cells. In this paper, we present the design and implementation of decoding equipment for FEC in ATM networks based on a single parity check (SPC) product code using very-large-scale integration (VLSI) technology. FEC allows the destination to reconstruct missing data cells by using redundant parity cells that the source adds to each block of data cells. The functionality of the design has been tested using the Model Sim 5.7cXE Simulation Package. The design has been implemented for a $5{\times}5$ matrix of data cells in a Virtex-E XCV 3200E FG1156 device. The simulation and synthesis results show that the decoding function can be completed in 81 clock cycles with an optimum clock of 56.8 MHz. A test bench was written to study the performance of the decoder, and the results are presented.