• 제목/요약/키워드: Minimal change

검색결과 490건 처리시간 0.027초

미세변화신증후군 환아에서 Tumor Necrosis Factor-${\alpha}$의 혈중 및 요중 변화와 알부민 투과성에 미치는 영향 (Changes of Plasma and Urinary $TNF-{\alpha}$ in Children with Minimal Change Nephrotic Syndrome and Its Role in Albumin Permeability)

  • 조민현;이환석;오현희;정기영;구자훈;고철우
    • Childhood Kidney Diseases
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    • 제7권1호
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    • pp.16-22
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    • 2003
  • 목적 : 미세변화신증후군은 소아 원발성 신증후군의 가장 흔한 원인이다. 최근 $TNF-{\alpha}$가 미세변화신증후군의 병인기전과 밀접한 관계가 있다고 보고되고 있다. 이에 저자들은 미세변화신증후군 환아에서의 $TNF-{\alpha}$의 변화를 살펴보고 $TNF-{\alpha}$가 사구체 기저막의 투과성에 미치는 직접적인 영향을 알아보기 위하여 본 연구를 시행하였다. 방법 : 대상 환아는 신생검으로 미세변화신증후군이 확진된 만 2-15세 사이의 소아로서 이들에게서 혈액과 요를 채취하여 ELISA 방법으로 $TNF-{\alpha}$를 측정하였고, Millicell system을 사용하여 알부민에 대한 투과성을 측정하였다. 결과 : 재발시에 요중 $TNF-{\alpha}$는 대조군과 관해시에 비하여 유의하게 증가되어 있었으나(P<0.01), 혈중 $TNF-{\alpha}$는 유의한 변화를 보여주지 않았다. Millicell system을 이용한 알부민 투과성에 대한 실험결과 생리적인 농도 이상의 $TNF-{\alpha}$에서 알부민에 대한 투과성에 특이한 변화가 관찰되지 않았다. 결론 : 이상의 결과를 종합할 때 $TNF-{\alpha}$는 미세변화신증후군의 발병기전에서 일차적인 역할을 한다기 보다는 아마도 질환자체에 의한 이차적인 현상에 의하여 요중에서 증가된 것으로 생각된다.

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기온 변화는 폐경후 안면홍조의 침 치료 효과에 영향을 미치는가? (Can Ambient Temperature Change Affect the Efficacy of Acupuncture on the Postmenopausal Hot Flash?)

  • 노진주;안홍엽;김동일
    • 대한한방부인과학회지
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    • 제20권4호
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    • pp.123-131
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    • 2007
  • Purpose: To find the correlation between ambient temperature change and the efficacy of acupuncture on the postmenopausal hot flash. Methods: 52 patients entered a randomized clinical trial which was to verify the efficacy of acupuncture on postmenopausal hot flash. Participants were treated with optimal/minimal acupuncture in the course of 13 weeks. 34 of 52 visited for the temperature-rising period(Group 1), while 18 of 52 for the temperature-falling period(Group 2), 100mm hot flash VAS and average temperature were taken 18 times from each person. Linear mixed effects model was used to find the correlation between temperature and hot flash VAS score(p-value<0.05). Group1/2, optimal/minimal acupuncture, age, age of menarche, height, weight, percent body fat, BMI, waist-hip ratio, past history of hysterectomy and HRT were also examined. Results: Period of treatment had influence on the hot flash VAS. As time went by, hot flash decreased(p<.0000). Participants who underwent minimal acupuncture showed higher hot flash VAS(p=0.0479) and as waist-hip ratio rose, hot flash increased(p<.0000). As the temperature rose, hot flash VAS score became lower(p=0.0143) and it was because 34 of 52 participants were treated for the temperature-rising period. Group 1/2 had no interrelation with hot flash(p=0.5741). Conclusion: Hot flash diminished as participants were treated with acupuncture, independently of whether the ambient temperature rises or falls.

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최소 가공용 사과의 품종별 갈변정도 (Browning Degree of Various Apple Cultivars for Minimal Processing)

  • 홍정진;설희경;정은호;김영봉;홍광표
    • 한국식품영양학회지
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    • 제31권5호
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    • pp.689-695
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    • 2018
  • This study was carried out to select apple cultivars suited for the fresh cutting or minimal processing as investigating correlation between total phenol and ascorbic acid as browning factors and the enzymatic browning degree. In soluble solid-acid ratio, 'Gamhong' and 'Arisoo' were highest value of 71.69 and 71.52 compared with other cultivars. And the change of lightness (${\Delta}L$) and color (${\Delta}E$) in 'Gamhong' and 'Arisoo' showed lower than other cultivars while 'Arkansas black' was highest change of lightness and color as ${\Delta}L$ 8.27, ${\Delta}E$ 13.86 respectively. Total phenol and ascorbic acid contents in 'Arkansas black' were highest such as 334.3 mg GAE/100 g and 9.22 mg/100 g, respectively. And polyphenol oxidase (PPO) activity also was the highest such as 14.43unit in 'Arkansas black'. The correlation test showed browning of apple was significantly dependent on ${\Delta}L$, ${\Delta}E$, total phenol, ascorbic acid contents and PPO activity (p<0.01). On the contrary, no significant correlation had been determined between the browning and ascorbic acid oxidase (AAO) activity. Thus, it seemed that the browning of apple was not only due to oxidation of ascorbic acid but also total phenol. It was suggested that 'Gamhong' and 'Arisoo' were suitable for fresh cutting or minimal processing.

A Bayesian Inference for Power Law Process with a Single Change Point

  • Kim, Kiwoong;Inkwon Yeo;Sinsup Cho;Kim, Jae-Joo
    • International Journal of Quality Innovation
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    • 제5권1호
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    • pp.1-9
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    • 2004
  • The nonhomogeneous poisson process (NHPP) is often used to model repairable systems that are subject to a minimal repair strategy, with negligible repair times. In this situation, the system can be characterized by its intensity function. There have been many NHPP models according to intensity functions. However, the intensity function of system in use can be changed because of repair or its aging. We consider the single change point model as the modification of the power law process. The shape parameter of its intensity function is changed before and after the change point. We detect the presence of the change point using Bayesian methodology. Some numerical results are also presented.

A Fundamental Study for Creating 3D CG Animation of an Assembly Work

  • Yamanaka, Hiroki;Matsumoto, Toshiyuki;Shinoda, Shinji;Niwa, Akira
    • Industrial Engineering and Management Systems
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    • 제11권2호
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    • pp.188-195
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    • 2012
  • This paper presents a new mode of expressing a 3D assembly work for creating a 3D CG animation without judgment by human from minimal required information. In the field of manufacturing, there are favorable movements in the utilization of 3D CAD for 3D simulation to shorten lead time for product development and pre-production. But simulating an assembly work has troubles to need huge quantity of manually input data. This paper discusses what minimal necessary information for creating 3D CG animations of assembly works is, focusing on the features of assembly works. Furthermore, a new mode of expressing a 3D assembly work is proposed as "state/change transition diagrams" (SCTD), which express arbitrary scenes in an assembly work as "state" and describe a sequential assembly work with "state" and "change", and the outline of its stepwise generation algorithm is also described. SCTD can be converted to a 3D CG animation of an assembly work without judgment by human. This paper focuses on the creating 3D CG animation of assembly works which workers use only their both hands.

미세변화형 신증후군 환아에서 발생한 우측총장골동맥 혈전증 1례 (A Case of Thromboembolic Complication in Right Common Iliac Artery in a Child with Minimal Change Nephrotic Syndrome)

  • 남현주;김지홍;김병길;장병철
    • Childhood Kidney Diseases
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    • 제2권1호
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    • pp.69-72
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    • 1998
  • Thromboemolism is one of the severe complications of nephrotic syndrome. And arterial thromboembolism is rare than venous thromboembolism. Hypercoagulability is the main pathophysiologic factors of thromboembolism in nephrotic syndrome with severe hypoalbuminemia. We experienced one case of arterial thromboembolism which occured in right common iliac artery. It was seen in a 6 year-old male child that presented with generalized edema and rigth ankle joint pain. Emergency embolectomy and anticoagulant therapy (heparin and antithrombin III) was performed. He didn't have to be amputated and recovered to self ambulation. This is an uncommon case that successful recovery was possible by early diagnosis and invasive surgical management with proper anticoagulant therapy.

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Interleukin-13 Increases Podocyte Apoptosis in Cultured Human Podocytes

  • Lee, Keum Hwa;Oh, Ji Young;Seong, Su-Bin;Ha, Tae-Sun;Shin, Jae Il
    • Childhood Kidney Diseases
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    • 제22권1호
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    • pp.22-27
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    • 2018
  • Purpose: Podocytes are important architectures that maintain the crucial roles of glomerular filtration barrier functions. Despite this structural importance, however, the mechanisms of the changes in podocytes that can be an important pathogenesis of minimal change nephrotic syndrome (MCNS) are not clear yet. The aim of this study was to investigate whether apoptosis is induced by interleukin (IL)-13 in cultured human podocytes. Methods: Human podocytes were treated with different IL-13 doses and apoptotic cells were analyzed using terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL assay) and fluorescence-activated cell sorting (FACS). Results: The IL-13 increased the number of TUNEL-positive cells in a dose-dependent manner at 6 and 18 hours (P<0.05 and P<0.05, respectively). The apoptosis rate was appeared to be increased slightly in the IL-13-stimulated podocytes (8.63%, 13.02%, and 14.46%; 3, 10 and 30 ng/mL, respectively) than in the control cells (7.66%) at 12 hours by FACS assay. Conclusion: Our study revealed that IL-13 expression may increase podocyte apoptosis. Blocking the IL-13 signal pathway can potentially play an important role in regulating the apoptosis of podocytes.

Effect of Gender Difference on the Functional Asymmetry during Preferred Walking Speed

  • Hyun, Seunghyun;Ryew, Checheong
    • International journal of advanced smart convergence
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    • 제9권2호
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    • pp.49-57
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    • 2020
  • We have not identified on what gender difference during gait at a pace of one's preferred velocity effects on the function of bilateral lower limb. This study was undertaken to investigate a difference of gait strategy by gender during gait at a one's preferred velocity of participants of adult male and female (n=20). Cinematographic data for motion analysis, ground reaction force (GRF) variables, and muscle volume of lower limb were analyzed. Significant difference of variables on movement of center of mass whole body, joint angle and moment of lower limb, and ground reaction force were tested by 2-way ANOVA analysis (P<0.05). Male group showed more muscle volume than female, and both showed more volume in dominant leg than non-dominant. Main effect by bilateral leg during gait showed higher difference in right than left leg in change of vertical position of center of mass (maximal, minimal). Main effect by gender in vertical change of position and velocity of center of mass showed higher difference in male than female (maximal, minimal). Hip joint showed more flexed and extended angle in male than female, and also dorsiflexion of ankle and flexion moment of knee and hip joint showed higher in male than female group. Therefore, this result was assumed that dominant showed furthermore more contribution for propulsive function than non-dominant leg. Gender difference showed in strategy controlling of biomechanical characteristics, and perhaps influenced by muscle volume.

Eosinophilic gastroenteritis in an 18-year-old male with prolonged nephrotic syndrome

  • Choi, Da Min;Pyun, Jung Eun;Yim, Hyung Eun;Yoo, Kee Hwan;Shim, Jung Ok;Lee, Eun Jung;Won, Nam Hee
    • Clinical and Experimental Pediatrics
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    • 제59권sup1호
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    • pp.72-75
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    • 2016
  • Eosinophilic gastroenteritis is a rare disease characterized by prominent eosinophilic tissue infiltration of the gastrointestinal tract. Here, we report a case of eosinophilic gastroenteritis in an 18-year-old patient with prolonged nephrotic syndrome who presented with abdominal pain and peripheral hypereosinophilia. During the previous 2 years, he had visited local Emergency Department several times because of epigastric pain and nausea. He had been treated with steroid-dependent nephrotic syndrome since 3 years of age. Tests ruled out allergic and parasitic disease etiologies. Gastroduodenoscopy with biopsy revealed marked eosinophilic infiltration in the duodenum. Renal biopsy findings indicated minimal change disease spectrum without eosinophilic infiltration. The oral deflazacort dosage was increased, and the patient was discharged after abdominal pain resolved. To our knowledge, this is the first report of eosinophilic gastroenteritis in a patient with minimal change disease.