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각종(各種) 갑상선질환(甲狀腺疾患)에서 합성(合成) TRH 정주후(靜注後) 혈중(血中) TSH 변동(變動)에 관(關)한 연구(硏究) (TSH Response to the Intravenous Administation of Synthetic TRH in Various Thyroid Diseases)

  • 최성재;김광원;이문호
    • 대한핵의학회지
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    • 제14권1호
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    • pp.1-8
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    • 1980
  • Serum TSH levels were measured by radioimmunoassay before and after intravenous administration of synthetic thyrotropin-releasing hormone (TRH) to 15 normal subjects and 55 patients with primary thyroid disease (14 patients with euthyroidism, 24 patients with thyrotoxicosis and 17 patients with hypothyroidism) to evaluate pituitary TSH reserve and its diagnostic availability. The observed results were as follows. 1. In normal subjects, serum TSH responses to synthetic TRH were $3.2{\pm}1.0$ at 0min (baseline TSH level), $8.0{\pm}4.0$ at 10min, $11.7{\pm}5.0$ at 20min, $13.7{\pm}7.1$ at 30min, $9.7{\pm}5.0$ at 60min., $5.2{\pm}2.0$ at 120min. and $3.6{\pm}0.4{\mu}U/ml$ at 180 min. Serum TSH peaked at $20{\sim}30$ minutes and returned nearly to baseline at 180minutes. 2. In euthyroid group, serum TSH responses to synthetic TRH were $3.3{\pm}1.6$ at 0min, $8.6{\pm}8.0$ at 10min, $10.9{\pm}8.5$ at 20min, $12.5{\pm}8.4$ at 30min, $9.0{\pm}5.9$ at 60min, $5.6{\pm}2.6$ at 120min and $3.5{\pm}1.3{\mu}U/ml$ at 180min. No significant difference revealed between euthyroid group and normal subjects (p>0.05). 3. In hyperthyroid group, serum TSH responses to synthetic TRH were $1.5{\pm}0.6$ at 0min, $2.2{\pm}0.8$ at 10min., $2.3{\pm}1.0$ at 20min., $2.4{\pm}1.5$ at 30min., $2.1{\pm}1.1$ at 60min., $1.9{\pm}0.2$ at 120min. and $1.5{\pm}0.8{\mu}U/ml$ at 180min., No response to TRH showed. 4. In hypothyroid group, mean values of serum TSH response to synthetic TRH were 42.0 at 0min., 60.6 at 10min., 124.8 at 20min., 123.0 at 30min., 101.6 at 60min., 64.3 at 120min. and $15.5{\mu}U/ml$ at 180 min., Patients with primary hypothyroidism showed an exaggerated TSH response to synthetic TRH despite their high basal TSH. 5. Side effects attending synthetic TRH administration were transient nausea (59.0%), desire to micturate (59.0%), feeling of flushing(19.7%), dizziness (45.9%), metallic taste (9.8%) and headache (19.7%). Any side effect didn't show in 16.4%. These symptoms began almost immediately after TRH intravenous injection and lasted several minutes, and not related to dose or response in the person experiencing it.

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대학도서관 자료처리 원가계산에 관한 연구

  • 이경호;심의순
    • 한국도서관정보학회지
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    • 제10권
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    • pp.157-191
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    • 1983
  • The purpose of the study is to build a general cost a counting model for university libraries, to clarify the possible areas of its a n.0, pplication by employing job cost accounting and process cost accounting methods. System analysis is performed as to the fields of acquisition, processing (cataloging & classification), and book shelving system. The existing operation processes and time required for each operation of these three systems are analyzed, from which detailed system flowcharts were drawn and job descriptions and the content of job were identified. The results of the study can be summarized as follows: (1) The processing time of one book in each systems: Oriental books. a. Acquisition system. the time required the time required in case of job cost case of job cost accounting after purchasing, 8 min. 21 sec. the time required in case of process cost accounting 15 min. 7 sec. b. Processing system. the time required for non-duplicate, 34 min. 40 sec. the time required for duplicate, 8 min. 49 sec. the time required for purchasing of more than the time required two copies at a time. 4 min. 44 sec. c. Book shelving system. the time required. 1 min. 43 sec. Western books. a. Acquisition system the required in case of job cost accounting, 9 min. 1 sec. the time required in case of process cost accounting. 15 min. 7 sec. b. Processing system. the time required for non-duplicate, 32 min. 58 sec. the time required for duplicate, 9 min. 26 sec. the time required for purchasing of more than two copies at a time. 5 min. 33 sec. c. Book shelving system. the time required. 1 min. 43 sec. (2) Total sum of processing time and processing cost per book. Oriental books (including material cost) the time required. cost. a. non-duplicate, 51 min. 30 sec. 2, 791 won b. duplicate, 25 min. 39 sec. 1, 580 won c. purchasing of more than two copies as a time, 21 min. 34 sec. 1, 368 won Western books(including material cost) a. non-duplicate, 49 min. 48 sec. 3, 189 won b. duplicate, 26 min. 16 sec. 1, 846 won c. purchasing of more than two copies at a time. 22 min. 23 sec. 1, 388 won

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Insulin이 흰쥐의 LDH Isozyme에 미치는 영향 (The Effect of Insulin on Lactate Dehydrogenase Isozyme in the Liver, Muscle and Serum of Albino Rats.)

  • 임중기;최기송
    • 약학회지
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    • 제20권1호
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    • pp.92-96
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    • 1976
  • A series of experimental groups has been studied in the state of hypolycemia caused by a single intraperitoneal injection of insulin after 24 hrs of fasting albino rats and then the variation of LDH activities and LDH isozyme patterns in the liver, muscle and serum had been reported. The total LDH activity has been elevated in the liver and the muscle above the average level for control group, but increased continusly during 20 min and decreased in the 20-45 min intervals and increased again 45 min in the serum. The change of LDH isozyme patterns had been shown that in the liver LDH$_{5}$ was increased, LDH$_{4}$ was decreased and in the muscle LDH$_{1}$ was diminished by 30 min ws restored again after 45 min and LDH$_{2}$ decreased about 94 percentage at 30 min, decreased by 45 min and increased greater again after 45 min and in the muscle LDH$_{3}$, LDH$_{4}$, and LDH$_{5}$ were increased to the greatest by 20 min, decreased in 20-45 min intervals and increased again after 45 min.

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Impact Analysis of NBTI/PBTI on SRAM VMIN and Design Techniques for Improved SRAM VMIN

  • Kim, Tony Tae-Hyoung;Kong, Zhi Hui
    • JSTS:Journal of Semiconductor Technology and Science
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    • 제13권2호
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    • pp.87-97
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    • 2013
  • Negative bias temperature instability (NBTI) and positive bias temperature instability (PBTI) are critical circuit reliability issues in highly scaled CMOS technologies. In this paper, we analyze the impacts of NBTI and PBTI on SRAM $V_{MIN}$, and present a design solution for mitigating the impact of NBTI and PBTI on SRAM $V_{MIN}$. Two different types of SRAM $V_{MIN}$ (SNM-limited $V_{MIN}$ and time-limited $V_{MIN}$) are explained. Simulation results show that SNM-limited $V_{MIN}$ is more sensitive to NBTI while time-limited $V_{MIN}$ is more prone to suffer from PBTI effect. The proposed NBTI/PBTI-aware control of wordline pulse width and woldline voltage improves cell stability, and mitigates the $V_{MIN}$ degradation induced by NBTI/PBTI.

운동검사시간이 최대산소섭취량과 정체현상에 미치는 영향 (The Effect of Duration Protocols on VO2max and Presence of Plateau)

  • 김도연;윤병곤
    • 생명과학회지
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    • 제19권12호
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    • pp.1712-1717
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    • 2009
  • 이 연구의 목적은 자전거 에르고미터 점증 부하 운동 검사를 통하여 4가지 다른 운동 검사시간 프로토콜(protocol)이 최대 산소 섭취량($VO_2$max)과 산소 섭취량 정체($VO_2$plateau)에 어떠한 영향을 미치는지를 비교 분석하는 것이다. 연구를 위하여 설정된 운동 시간 프로토콜은 5, 8, 12 그리고 16분이다. 평균 이상의 자전거 운동 능력을 지닌 20명의 자발적 피 실험자들이 연구에 참여하였다. 8분 프로토콜의 평균 최대 산소 섭취량($3.66{\pm}0.88\;l/min$)은 통계적으로(p<0.05) 12분($3.49{\pm}0.76\;l/min$)과 16분 프로토콜의($3.45{\pm}0.73\;l/min$) 최대 산소 섭취량보다 높게 제시되었다. 5분 프로토콜의 평균 최대 산소 섭취량은 두 번째로 높은 수치를 나타냈으나, 통계적으로 12분과 16분 프로토콜의 최대 산소 섭취량과는 다르지 않았다(p>0.05). 평균 최대 운동 강도(average maximal power output)는 운동 검사시간들이 영향을 미치는 것으로 나타났다. 5분 프로토콜의 평균 최대 운동 강도가 8분 프로토콜 보다 12%, 12분 프로토콜 보다 24%, 그리고 16분 프로토콜 보다 35% 높게 나타났다. 산소 섭취량 정체($VO_2$plateau)는 5분 프로토콜에서 12.5%, 8분 프로토콜에서 56.25%, 12분 프로토콜에서 37.5%, 그리고 16분 프로토콜에서 56.25%의 빈도를 보였다. 이 연구는 평균 이상의 운동 능력을 지닌 피 실험자에게는 6분에서 10분 사이의 검사시간이 적합하다고 제안하고 있다.

효소처리를 달리한 조직대두단백을 이용하여 제조한 콩까스의 품질특성 (The Quality Characteristics of Soy Cutlets Using Textured Soy Protein Treated with Different Enzymes)

  • 김은비;김은주;이한나;이민경;오종신;김선옥;이숙영
    • 한국식생활문화학회지
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    • 제23권4호
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    • pp.507-513
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    • 2008
  • The development of soy cutlets containing textured soy protein (TSP) as a meat analog was studied. In order to decrease the beany flavor and to increase the texture, TSP was treated with 0.3% Flavourzyme or 0.1% Protamex for 10 or 20 min, respectively. The degree of hydrolysis for TSP treated with Protamex was higher than that treated with Flavourzyme. Hydrolysis was observed to increase as the reaction time was increased for both Flavourzyme and Protamex. The water holding capacity of TSP treated with Protamex for 10 min was the highest, and that treated with Flavourzyme for 20 min was similar to that of Protamex treatment for 20 min. The oil binding capacity of TSP treated with Protamex for 20 min was the highest. The hardness of the soy cutlets using TSP treated with Flavourzyme for 10 min was higher than that treated for 20 min, while that of Protamex treated for 20 min was higher than that treated for 10 min. The cohesiveness of the soy cutlets using TSP treated with Flavourzyme or Protamex for 10 min was higher than those treated for 20 min. The chewiness of the soy cutlets treated with Flavourzyme for 10 min was higher than for those treated for 20 min, while those treated with Protamex for 20 min was higher than those treated for 10 min. The springiness of TSP treated with Flavourzyme for 20 min was higher than those treated for 10 min, and higher than those treated with Protamex for 10 or 20 min. For sensory evaluation, the beany flavor of the soy cutlets treated with Protamex for 20 min was the weakest. The flavor and chewiness of both a pork cutlet and a soy cutlet treated with Protamex for 20 min were the best. In the overall quality, soy cutlets treated with Protamex for 20 min was the most desirable. In conclusion, soy cutlets treated with 0.1% Protamex for 20 min could be a reasonable substitute of pork cutlets.

Merging Algorithm for Relaxed Min-Max Heaps Relaxed min-max 힙에 대한 병합 알고리즙

  • 민용식
    • The Journal of the Acoustical Society of Korea
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    • 제14권1E호
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    • pp.73-82
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    • 1995
  • 본 논문은 relaxed min-max heap을 병합시키기 위하여 이용된 새로운 자료구조인 개선된 relaxed min-max-pair 힙으로서, 두개의 relaxed min-max 힙 즉, 크기가 n인 relaxed min-max nheap과 크기가 k인 relaxed min-max kheap으로 구성된 우선 순위 큐를 병합시키기 위한 순차적 알고리즘을 제시하고자 한다. 본 논문에서 제시된 방법은 [8]에 제시된 방법에서 relaxed min-max 힙을 병합시키기 위해서 이용된 blossomed tree와 lazying 방법을 제거하여도 병합이 되는 새로운 기법을 제시하였다. 결과적으로 본 논문에서 제세된 방법은 두개의 relaxed min-max 힙의 크기가 서로 다른 경우로서, 이때 크기 $k{\leq}{\lfloor}log(size(nheap)){\rfloor}$인 경우, 시간 복잡도가 O(log(log(n/k))*log(k)) 이고 공간복잡도가 O(n+k)임을 볼수가 있다.

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다단계 네트워크에서 웜홀 라우팅 방식의 효율적인 멀티캐스트 알고리즘 연구 (A Study on The Efficient Multicast Algorithm of Wormhole Routing Method in Multistage Networks)

  • 김소은;김창수;최계현
    • 한국멀티미디어학회논문지
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    • 제2권2호
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    • pp.184-194
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    • 1999
  • 본 논문은 양방향 스위치(bidirectional switchs)를 가진 다단계 상호연결망(MIN, Multistage Interconn nection Network)에서 중첩된 목적지 노드로 다중 메시지를 전송할 때 야기되는 스위치간의 블럭킹(blocking) 을 최소화하기 위한 알고리즘을 제시한다. U~MIN(Unicast MIN) 알고리즘[4]에 의해 제시되었던 다중 전송 트리는 하나의 소스 노드로부터 여러 개의 목적지 노드로 메시지를 전송하는 단순한 멀티캐스트를 수행하는 데 있어서는 매우 유용하지만, 다중 멀티캐스트를 수행하는데 있어서는 섬각한 채널 경쟁을 야기한다. 따라서 간접통신망에서 동시에 같은 목적지 노드를 가진 멀티캐스트가 발생했을 때 기존의 U-MIN 알고리즘에서 발생하는 심각한 채널 경쟁을 최소화하기 위한 방법으로 본 논문에서는 SPU-MIN(Source Partitioned U Unicast MIN) 알고리즘에 의한 새로운 멀티캐스트 트리를 제시한다 본 논문에서의 메시지 전송 방법은 웹흘 라우팅 기법에 기반한 반전(turnaround) 라우팅 알고리즘을 이용한다.

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Relaxed min-max 힙을 병합하는 병렬 알고리즘 (A Parallel Algorithm for Merging Relaxed Min-Max Heaps)

  • 민용식
    • 한국정보처리학회논문지
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    • 제5권5호
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    • pp.1162-1171
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    • 1998
  • 본 논문에서는 relaxed min-max heap을 병합시키기 위하여 새로운 자료구조인 개선된 relaxed min-max-pair 힙을 제시함과 동시에, 두개의 relaxed min-max 힙, 즉 크기가 n인 relaxed min-max nheap과 크기가 k인 relaxed min-max kheap으로 구성된 우선 순위 큐를 병합시키기 위한 병렬 알고리즘을 제시하고자 한다. 본 논문에서는 [9]의 방법으로부터 relaxed min-max 힙을 병합 시키기 위해서 이용된 blossomed tree와 lazying 방법을 제거하여도 병합되는 새로운 방법을 제시하였다. 결과적으로 본 논문에 제시된 방법은 max($2^{i-1}$,[(m+1/4)])개의 프로세서를 이용할 경우, 시간 복잡도가 O(log(log(n/k))${\times}$log(k))임을 볼 수가 있다. 그리고 크기가 서로 다른 두 개의 relaxed min-max heap으로 구성된 8백만개의 데이터를 병합시키기 위해서, MasPar 머쉰에서 64개의 프로세서를 이용하여 실행시킨 결과 35.205의 Speedup을 얻었다.

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위상 결합을 기반으로 한 연결 망 설계 및 시뮬레이션 (Design and Simulation of Interconnection Network Based on Topological Combination)

  • 장창수;최창훈
    • 한국통신학회논문지
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    • 제29권6B호
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    • pp.563-574
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    • 2004
  • 본 논문에서는 정적 네트워크 위상과 동적 위상을 결합한 새로운 부류의 MIN(Multistage Interconnection Network)인 Combine MIN을 제안한다. Combine MIN은 단일 경로 성질을 갖는 MIN보다도 적은 하드웨어 비용을 가지면서도 다중 경로를 제공한다. 또한 Combine MIN은 빈번한 통신을 갖는 프로세서-메모리에 짧은 경로의 지름길 경로 및 다중 경로를 제공함으로써 지역화된 통신에 적합하게 구성할 수 있게 설계되었다. 성능 평가를 위한 시뮬레이션 결과에 따르면 Combine MIN은 높은 지역화된 통신에서 같은 네트워크 크기를 갖는 기존의 MIN보다 우수한 성능을 보였다. 따라서 Combine MIN은 공유 메모리 다중 프로세서 시스템에서 지역화된 통신구조를 갖는 병렬 응용 분야에서 효율적으로 활용될 수 있을 것이다.